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Items: 1 to 20 of 52

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
3.
Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia
Guido Zagnoli-Vieira, Jan Brazina, Kris Van Den Bogaert, Wim Huybrechts, Guy Molenaers, Keith W. Caldecott, Hilde Van Esch
Hum Genet. 2023; 142(9): 1417–1427. Published online 2023 Aug 10. doi: 10.1007/s00439-023-02589-3
PMCID:
PMC10449949
AbstractArticlePDF–2.7M
4.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
5.
A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation
Yulemi Gonzalez Quesada, Luc DesGroseillers
Int J Mol Sci. 2022 Oct; 23(19): 11588. Published online 2022 Sep 30. doi: 10.3390/ijms231911588
PMCID:
PMC9569955
AbstractArticlePDF–2.1M
6.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
7.
Human transcription factor protein interaction networks
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5
PMCID:
PMC8828895
AbstractArticlePDF–1.7M
8.
Identification of proximal SUMO-dependent interactors using SUMO-ID
Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland
Nat Commun. 2021; 12: 6671. Published online 2021 Nov 18. doi: 10.1038/s41467-021-26807-6
PMCID:
PMC8602451
AbstractArticlePDF–11M
9.
PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα
Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz
iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686
PMCID:
PMC8220391
AbstractArticlePDF–4.4M
10.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
11.
DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
Sourav Saha, Yilun Sun, Shar-yin Naomi Huang, Simone Andrea Baechler, Lorinc Sandor Pongor, Keli Agama, Ukhyun Jo, Hongliang Zhang, Yuk-Ching Tse-Dinh, Yves Pommier
Cell Rep. Author manuscript; available in PMC 2021 Feb 4.
Published in final edited form as: Cell Rep. 2020 Dec 29; 33(13): 108569. doi: 10.1016/j.celrep.2020.108569
PMCID:
PMC7859927
AbstractArticlePDF–2.1M
12.
TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
Md. Rasel Al Mahmud, Kenichiro Ishii, Cristina Bernal‐Lozano, Irene Delgado‐Sainz, Masakazu Toi, Shusuke Akamatsu, Manabu Fukumoto, Masatoshi Watanabe, Shunichi Takeda, Felipe Cortés‐Ledesma, Hiroyuki Sasanuma
Genes Cells. 2020 Jul; 25(7): 450–465. Published online 2020 May 5. doi: 10.1111/gtc.12770
PMCID:
PMC7497232
AbstractArticlePDF–1.2M
13.
Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2
Matthew J Schellenberg, C Denise Appel, Amanda A Riccio, Logan R Butler, Juno M Krahn, Jenna A Liebermann, Felipe Cortés-Ledesma, R Scott Williams
Nucleic Acids Res. 2020 Jun 19; 48(11): 6310–6325. Published online 2020 May 1. doi: 10.1093/nar/gkaa318
PMCID:
PMC7293035
AbstractArticlePDF–5.0M
14.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
15.
Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism
Johanna Hietamäki, Louise C Gregory, Sandy Ayoub, Anna-Pauliina Iivonen, Kirsi Vaaralahti, Xiaonan Liu, Nina Brandstack, Andrew J Buckton, Tiina Laine, Johanna Känsäkoski, Matti Hero, Päivi J Miettinen, Markku Varjosalo, Emma Wakeling, Mehul T Dattani, Taneli Raivio
J Clin Endocrinol Metab. 2020 Jun; 105(6): 1748–1758. Published online 2020 Feb 15. doi: 10.1210/clinem/dgaa078
PMCID:
PMC7138537
AbstractArticle
16.
Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation
Autumn C. Holmes, Guido Zagnoli-Vieira, Keith W. Caldecott, Bert L. Semler
Viruses. 2020 Feb; 12(2): 166. Published online 2020 Jan 31. doi: 10.3390/v12020166
PMCID:
PMC7077319
AbstractArticlePDF–4.4M
17.
Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
Shar-yin Naomi Huang, Yves Pommier
Int J Mol Sci. 2019 Jun; 20(12): 3015. Published online 2019 Jun 20. doi: 10.3390/ijms20123015
PMCID:
PMC6628236
AbstractArticlePDF–1.0M
18.
Genetic Variants of FOXP2 and KIAA0319/TTRAP/THEM2 Locus Are Associated with Altered Brain Activation in Distinct Language-Related Regions
Philippe Pinel, Fabien Fauchereau, Antonio Moreno, Alexis Barbot, Mark Lathrop, Diana Zelenika, Denis Le Bihan, Jean-Baptiste Poline, Thomas Bourgeron, Stanislas Dehaene
J Neurosci. 2012 Jan 18; 32(3): 817–825. doi: 10.1523/JNEUROSCI.5996-10.2012
PMCID:
PMC6621137
AbstractArticlePDF–1.6M
19.
Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes
Ka Cheong Lee, Rebecca L. Swan, Zbyslaw Sondka, Kay Padget, Ian G. Cowell, Caroline A. Austin
Int J Mol Sci. 2018 Jul; 19(7): 2056. Published online 2018 Jul 14. doi: 10.3390/ijms19072056
PMCID:
PMC6073685
AbstractArticlePDF–2.6M
20.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations
Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo
Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2
PMCID:
PMC5864832
AbstractArticlePDF–4.5M

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