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Items: 1 to 20 of 130

1.
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion
Xuzi Zhao, Deshun Liu, Yan Zhao, Zhecheng Wang, Yue Wang, Zhao Chen, Shili Ning, Guangzhi Wang, Lu Meng, Jihong Yao, Xiaofeng Tian
Cell Death Dis. 2024 Feb; 15(2): 154. Published online 2024 Feb 20. doi: 10.1038/s41419-024-06504-0
PMCID:
PMC10879504
AbstractArticlePDF–5.2M
2.
Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders
Huilun H. Wang, Liangguang L. Lin, Zexin J. Li, Xiaoqiong Wei, Omar Askander, Gerarda Cappuccio, Mais O. Hashem, Laurence Hubert, Arnold Munnich, Mashael Alqahtani, Qi Pang, Margit Burmeister, You Lu, Karine Poirier, Claude Besmond, Shengyi Sun, Nicola Brunetti-Pierri, Fowzan S. Alkuraya, Ling Qi
J Clin Invest. 2024 Jan 16; 134(2): e170054. Published online 2024 Jan 16. doi: 10.1172/JCI170054
PMCID:
PMC10786691
AbstractArticlePDF–11M
3.
Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery
Katharine Umphred-Wilson, Stanley Adoro
J Clin Invest. 2024 Jan 16; 134(2): e175448. Published online 2024 Jan 16. doi: 10.1172/JCI175448
PMCID:
PMC10786685
AbstractArticlePDF–736K
4.
Exogenous H2S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydration
Shiwu Zhang, Mengyi Wang, Hongxia Li, Qianzhu Li, Ning Liu, Shiyun Dong, Yajun Zhao, Kemiao Pang, Jiayi Huang, Cheng Ren, Yan Wang, Zhen Tian, Fanghao Lu, Weihua Zhang
J Cachexia Sarcopenia Muscle. 2023 Dec; 14(6): 2719–2732. Published online 2023 Oct 30. doi: 10.1002/jcsm.13347
PMCID:
PMC10751422
AbstractArticlePDF–3.4M
5.
SYVN1 ubiquitinates FoxO1 to induce β-catenin nuclear translocation, PD-L1-mediated metastasis, and immune evasion of hepatocellular carcinoma
Wei Xie, Lei Shi, Hu Quan, Hua Xiao, Jie Chen, Jia Liu, Jean de Dieu Habimana, Rongqi Huang, Jia Luo, Pan Chen, Zhiyuan Li
Cell Oncol (Dordr) 2023; 46(5): 1285–1299. Published online 2023 Apr 26. doi: 10.1007/s13402-023-00811-y
PMCID:
PMC10618324
AbstractArticlePDF–9.4M
6.
SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma
Meng Zhao, Chen Huang, Lexin Yang, Boyu Pan, Shuting Yang, Jiao Chang, Yu Jin, Gang Zhao, Dongsheng Yue, Shuo Qie, Li Ren
Cell Death Dis. 2023 Oct; 14(10): 666. Published online 2023 Oct 10. doi: 10.1038/s41419-023-06208-x
PMCID:
PMC10564934
AbstractArticlePDF–6.4M
7.
Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex
Kohei Kawaguchi, Miki Yamamoto-Hino, Yoshiko Murakami, Taroh Kinoshita, Satoshi Goto
Cell Struct Funct. 2021; 46(2): 65–71. Published online 2021 Jun 30. doi: 10.1247/csf.21019
PMCID:
PMC10511060
AbstractArticlePDF–567K
8.
SYVN1 Promotes STAT3 Protein Ubiquitination and Exerts Antiangiogenesis Effects in Retinopathy of Prematurity Development
Shimei Chen, Jian Zhang, Dandan Sun, Yidong Wu, Junwei Fang, Xiaoling Wan, Shenping Li, Shuchang Zhang, Qing Gu, Qing Shao, Jun Dong, Xun Xu, Fang Wei, Qiao Sun
Invest Ophthalmol Vis Sci. 2023 Aug; 64(11): 8. Published online 2023 Aug 4. doi: 10.1167/iovs.64.11.8
PMCID:
PMC10408771
AbstractArticlePDF–8.1M
9.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
10.
HRD1 functions as a tumor suppressor in ovarian cancer by facilitating ubiquitination-dependent SLC7A11 degradation
Yanyan Wang, Shanfeng Wang, Wenjuan Zhang
Cell Cycle. 2023; 22(9): 1116–1126. Published online 2023 Feb 21. doi: 10.1080/15384101.2023.2178102
PMCID:
PMC10081055
AbstractArticlePDF–2.2M
11.
Downregulation of miR-221–3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1
Chang-Jiang Shao, Hai-Lang Zhou, Xu-Zhu Gao, Chun-Fang Xu
Transl Oncol. 2023 Jun; 32: 101649. Published online 2023 Mar 21. doi: 10.1016/j.tranon.2023.101649
PMCID:
PMC10040875
AbstractArticlePDF–6.1M
12.
A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase
Jingjing Ruan, Dongdong Liang, Wenjing Yan, Yongwang Zhong, Daniel C. Talley, Ganesha Rai, Dingyin Tao, Christopher A. LeClair, Anton Simeonov, Yinghua Zhang, Feihu Chen, Nancy L. Quinney, Susan E. Boyles, Deborah M. Cholon, Martina Gentzsch, Mark J. Henderson, Fengtian Xue, Shengyun Fang
Mol Biol Cell. 2022 Nov 1; 33(13): ar120. Published online 2022 Nov 1. doi: 10.1091/mbc.E22-06-0233
PMCID:
PMC9634977
AbstractArticlePDF–5.8M
13.
The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission
Lihua Sun, Hongjuan Ye, Hui Tian, Lirong Xu, Junjie Cai, Caixia Zhang, Rongxiang Wang, Hui Yang, Shuang Zhao, Jiaozhi Zhang, Shaorong Gao
Oxid Med Cell Longev. 2022; 2022: 3639302. Published online 2022 Sep 19. doi: 10.1155/2022/3639302
PMCID:
PMC9526636
AbstractArticlePDF–2.8M
14.
miR-602 Activates NRF2 Antioxidant Pathways to Protect HBMECs from OGD/R-Induced Oxidative Stress via Targeting KEAP1 and HRD1
Chunli Ma, Lei Yang, Qiang Gao, Lihua Wang
Dis Markers. 2022; 2022: 6967573. Published online 2022 Sep 24. doi: 10.1155/2022/6967573
PMCID:
PMC9526584
AbstractArticlePDF–1.1M
15.
A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis
Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun
Cell Death Dis. 2022 Sep; 13(9): 824. Published online 2022 Sep 26. doi: 10.1038/s41419-022-05274-x
PMCID:
PMC9512801
AbstractArticlePDF–6.7M
16.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
17.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
18.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
19.
The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside
Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang
J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009
PMCID:
PMC9058836
AbstractArticlePDF–2.9M
20.
Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction
Sunan Li, Rongrong Li, Iqbal Ahmad, Xiaomeng Liu, Silas F. Johnson, Liangliang Sun, Yong-Hui Zheng
Nat Commun. 2022; 13: 2242. Published online 2022 Apr 26. doi: 10.1038/s41467-022-30026-y
PMCID:
PMC9042822
AbstractArticlePDF–7.5M

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