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Items: 1 to 20 of 94

1.
Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells
Saori Suzuki, Makoto Nakasato, Tsukasa Shibue, Isao Koshima, Tadatsugu Taniguchi
Cancer Sci. 2009 Apr; 100(4): 759–769. Published online 2009 Mar 9. doi: 10.1111/j.1349-7006.2009.01096.x
PMCID:
PMC11158019
AbstractArticlePDF–6.3M
2.
The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation
Yingchun Ling, Lingmin Hu, Jie Chen, Mingyong Zhao, Xinyang Dai
Clinics (Sao Paulo) 2024 Jan-Dec; 79: 100373. Published online 2024 Apr 30. doi: 10.1016/j.clinsp.2024.100373
PMCID:
PMC11070595
AbstractArticlePDF–2.7M
3.
Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p
Jin Shi, Fan Ding, Dezhu Dai, Xudong Song, Xu Wu, Dongsheng Yan, Xiao Han, Guoquan Tao, Weijie Dai
Sci Rep. 2024; 14: 6568. Published online 2024 Mar 19. doi: 10.1038/s41598-024-57099-7
PMCID:
PMC10951337
AbstractArticlePDF–10M
4.
NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy
Sofian Al Shboul, Mohammed El-Sadoni, Ahmad Alhesa, Nisreen Abu Shahin, Dua Abuquteish, Ola Abu Al Karsaneh, Elham Alsharaiah, Mohammad A. Ismail, Liliya Tyutyunyk-Massey, Moureq R. Alotaibi, Victoria Neely, Hisashi Harada, Tareq Saleh
Sci Rep. 2023; 13: 15903. Published online 2023 Sep 23. doi: 10.1038/s41598-023-42994-2
PMCID:
PMC10517932
AbstractArticlePDF–2.1M
5.
Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies
Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi
Clin Cancer Res. Author manuscript; available in PMC 2023 Jul 17.
Published in final edited form as: Clin Cancer Res. 2023 Jan 17; 29(2): 446–457. doi: 10.1158/1078-0432.CCR-22-2088
PMCID:
PMC9852224
AbstractArticlePDF–2.1M
6.
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity
Julia Joung, Paul C. Kirchgatterer, Ankita Singh, Jang H. Cho, Suchita P. Nety, Rebecca C. Larson, Rhiannon K. Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V. Maus, Feng Zhang
Nat Commun. 2022; 13: 1606. Published online 2022 Mar 25. doi: 10.1038/s41467-022-29205-8
PMCID:
PMC8956604
AbstractArticlePDF–3.9M
7.
The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents
Gerlinde Karbon, Manuel D. Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl, Andreas Villunger
Cell Death Dis. 2021 Dec; 12(12): 1151. Published online 2021 Dec 13. doi: 10.1038/s41419-021-04415-y
PMCID:
PMC8668920
AbstractArticlePDF–2.4M
8.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
9.
Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer
Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie, Jun Zhang
Cell Death Dis. 2021 Mar; 12(3): 265. Published online 2021 Mar 12. doi: 10.1038/s41419-021-03557-3
Correction in:
Cell Death Dis. 2021 Apr; 12(4): 369.
PMCID:
PMC7954848
AbstractArticlePDF–5.3M
10.
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia
Hiroaki Ochiiwa, Guzhanuer Ailiken, Masataka Yokoyama, Kazuyuki Yamagata, Hidekazu Nagano, Chihoko Yoshimura, Hiromi Muraoka, Keiji Ishida, Tomonori Haruma, Akitoshi Nakayama, Naoko Hashimoto, Kazutaka Murata, Motoi Nishimura, Yusuke Kawashima, Osamu Ohara, Shuichi Ohkubo, Tomoaki Tanaka
Oncogene. 2021; 40(7): 1217–1230. Published online 2021 Jan 8. doi: 10.1038/s41388-020-01586-4
PMCID:
PMC7892340
AbstractArticlePDF–3.2M
11.
Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism
Luciana Isaja, Sofía Mucci, Jonathan Vera, María Soledad Rodríguez-Varela, Mariela Marazita, Olivia Morris-Hanon, Guillermo Agustín Videla-Richardson, Gustavo Emilio Sevlever, María Elida Scassa, Leonardo Romorini
Sci Rep. 2020; 10: 20653. Published online 2020 Nov 26. doi: 10.1038/s41598-020-77792-7
PMCID:
PMC7692563
AbstractArticlePDF–5.5M
12.
Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity
Lisha Zhou, Jin Zhu, Wangyang Chen, Yanyu Jiang, Tao Hu, Yinxia Wang, Xiaoling Ye, Mengxi Zhan, Chenghao Ji, Zhuoming Xu, Xinran Wang, Yuanlong Gu, Lijun Jia
Cell Death Dis. 2020 Nov; 11(11): 975. Published online 2020 Nov 12. doi: 10.1038/s41419-020-03184-4
PMCID:
PMC7665193
AbstractArticlePDF–2.5M
13.
BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer
Ashkan Shahbandi, Sonia G. Rao, Ashlyn Y. Anderson, Wesley D. Frey, Joy O. Olayiwola, Nathan A. Ungerleider, James G. Jackson
Cell Death Differ. 2020 Nov; 27(11): 3097–3116. Published online 2020 May 26. doi: 10.1038/s41418-020-0564-6
PMCID:
PMC7560696
AbstractArticlePDF–9.8M
14.
CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa, Saskia Diana Günther, Martin Krönke, Thorsten Hoppe, Hamid Kashkar
Cell Death Dis. 2020 Sep; 11(9): 740. Published online 2020 Sep 10. doi: 10.1038/s41419-020-02923-x
PMCID:
PMC7484759
AbstractArticlePDF–2.6M
15.
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex
Tirta Mario Djajawi, Lei Liu, Jia-nan Gong, Allan Shuai Huang, Ming-jie Luo, Zhen Xu, Toru Okamoto, Melissa J. Call, David C. S. Huang, Mark F. van Delft
Cell Death Differ. 2020 Aug; 27(8): 2484–2499. Published online 2020 Feb 24. doi: 10.1038/s41418-020-0517-0
PMCID:
PMC7370232
AbstractArticlePDF–3.3M
16.
MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation
Seiji Arai, Andreas Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P Balk
eLife. 2020; 9: e54954. Published online 2020 Jun 2. doi: 10.7554/eLife.54954
PMCID:
PMC7297531
AbstractArticlePDF–5.1M
17.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
18.
The essentials of developmental apoptosis
Anne K. Voss, Andreas Strasser
Version 1. F1000Res. 2020; 9: F1000 Faculty Rev-148. Published online 2020 Feb 26. doi: 10.12688/f1000research.21571.1
PMCID:
PMC7047912
AbstractArticlePDF–2.0M
19.
The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells
Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn
eLife. 2019; 8: e44288. Published online 2019 Jul 11. doi: 10.7554/eLife.44288
PMCID:
PMC6701926
AbstractArticlePDF–3.3M
20.
NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death
Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel, Anas Younes
Proc Natl Acad Sci U S A. 2018 Nov 20; 115(47): 12034–12039. Published online 2018 Nov 7. doi: 10.1073/pnas.1806928115
PMCID:
PMC6255185
AbstractArticlePDF–1.1M

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