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Select item 114249781.

DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

Monika Nedomova, Stefanie Haberecht-Müller, Sophie Möller, Simone Venz, Michaela Prochazkova, Jan Prochazka, Frantisek Sedlak, Kallayanee Chawengsaksophak, Elke Hammer, Petr Kasparek, Michael Adamek, Radislav Sedlacek, Jan Konvalinka, Elke Krüger, Klara Grantz Saskova

iScience. 2024 Oct 18; 27(10): 110893. Published online 2024 Sep 5. doi: 10.1016/j.isci.2024.110893

PMCID:: PMC11424978

Abstract Article PDF–6.1M

Select item 103927392.

Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury

Yanping Li, Jingyuan Xu, Weiting Chen, Xingxing Wang, Zhibo Zhao, Yuqi Li, Linkun Zhang, Junkui Jiao, Qin Yang, Qiuying Ding, Ping Yang, Li Wei, Yao Chen, Yaxi Chen, Xiong Z. Ruan, Lei Zhao

Autophagy. 2023; 19(9): 2504–2519. Published online 2023 Apr 23. doi: 10.1080/15548627.2023.2196876

PMCID:: PMC10392739

Abstract Article PDF–8.0M

Select item 103810423.

UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1

Haoxian Zhou, Chen Xie, Yujie Xie, Yunru He, Yanlian Chen, Canfeng Zhang, Yan Zhang, Yong Zhao, Haiying Liu

PLoS Genet. 2023 Jul; 19(7): e1010856. Published online 2023 Jul 18. doi: 10.1371/journal.pgen.1010856

PMCID:: PMC10381042

Abstract Article PDF–3.4M

Select item 93768614.

RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control

Harihar Milaganur Mohan, Hanna Trzeciakiewicz, Amit Pithadia, Emily V. Crowley, Regina Pacitto, Nathaniel Safren, Bryce Trotter, Chengxin Zhang, Xiaogen Zhou, Yang Zhang, Venkatesha Basrur, Henry L. Paulson, Lisa M. Sharkey

Cell Mol Life Sci. 2022 Mar; 79(3): 176. Published online 2022 Mar 5. doi: 10.1007/s00018-022-04170-z

PMCID:: PMC9376861

Abstract Article PDF–6.1M

Select item 89990755.

GABA_A Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice

Tabea Kürten, Natascha Ihbe, Timo Ueberbach, Ute Distler, Malte Sielaff, Stefan Tenzer, Thomas Mittmann

Int J Mol Sci. 2022 Apr; 23(7): 3902. Published online 2022 Mar 31. doi: 10.3390/ijms23073902

PMCID:: PMC8999075

Abstract Article PDF–2.2M

Select item 88067756.

miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1)

Ying Ding, Jingyu Wang, Jun Lu

Bioengineered. 2021; 12(1): 6771–6781. Published online 2021 Sep 13. doi: 10.1080/21655979.2021.1964892

PMCID:: PMC8806775

Abstract Article PDF–2.2M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78936428.

TBX1 is required for normal stria vascularis and semicircular canal development

Cong Tian, Kenneth R. Johnson

Dev Biol. Author manuscript; available in PMC 2021 Feb 19.

Published in final edited form as: Dev Biol. 2020 Jan 1; 457(1): 91–103. Published online 2019 Sep 21. doi: 10.1016/j.ydbio.2019.09.013

PMCID:: PMC7893642

Abstract Article PDF–3.5M

Select item 75393889.

Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Shaoteng Wang, Micaela Tatman, Mervyn J. Monteiro

Acta Neuropathol Commun. 2020; 8: 164. Published online 2020 Oct 7. doi: 10.1186/s40478-020-01039-9

PMCID:: PMC7539388

Abstract Article PDF–18M

Select item 652283010.

Decreased expression of ubiquilin-1 following neonatal hypoxia-ischemic brain injury in mice

Li Luo, Yilin Liu, Xing Tu, Xuxin Ren, Wenyan Zhao, Jing Liu, Li Zhang, Weiqiang Chen, Pei Zhang, Weicai Wang, Lanhai Lü, Mengxia Wang

Mol Med Rep. 2019 Jun; 19(6): 4597–4602. Published online 2019 Apr 15. doi: 10.3892/mmr.2019.10168

PMCID:: PMC6522830

Abstract Article PDF–676K

Select item 579152711.

Overexpression of ubiquilin-1 alleviates Alzheimer’s disease-caused cognitive and motor deficits and reduces amyloid-β accumulation in mice

Oludotun O. Adegoke, Fangfang Qiao, Yanying Liu, Kirsty Longley, Shelley Feng, Hongmin Wang

J Alzheimers Dis. Author manuscript; available in PMC 2018 Jan 31.

Published in final edited form as: J Alzheimers Dis. 2017; 59(2): 575–590. doi: 10.3233/JAD-170173

PMCID:: PMC5791527

Abstract Article PDF–1.7M

Select item 546288612.

Enhanced proteostasis in post-ischemic stroke mouse brains by ubiquilin-1 promotes functional recovery

Yanying Liu, Fangfang Qiao, Hongmin Wang

Cell Mol Neurobiol. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Cell Mol Neurobiol. 2017 Oct; 37(7): 1325–1329. Published online 2016 Dec 7. doi: 10.1007/s10571-016-0451-3

PMCID:: PMC5462886

Abstract Article PDF–770K

Select item 540828913.

Reduced body weight gain in ubiquilin‐1 transgenic mice is associated with increased expression of energy‐sensing proteins

Fangfang Qiao, Kirsty R. Longley, Shelley Feng, Sabrina Schnack, Hongbo Gao, Yifan Li, Evelyn H. Schlenker, Hongmin Wang

Physiol Rep. 2017 Apr; 5(8): e13260. Published online 2017 Apr 18. doi: 10.14814/phy2.13260

PMCID:: PMC5408289

Abstract Article PDF–1.0M

Select item 501612214.

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4^CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

Dolores Del Prete, Richard C. Rice, Anjali M. Rajadhyaksha, Luciano D'Adamio

J Biol Chem. 2016 Aug 12; 291(33): 17209–17227. Published online 2016 Jun 20. doi: 10.1074/jbc.M116.733626

PMCID:: PMC5016122

Abstract Article PDF–1.8M

Select item 500381615.

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

Roland Hjerpe, John S. Bett, Matthew J. Keuss, Alexandra Solovyova, Thomas G. McWilliams, Clare Johnson, Indrajit Sahu, Joby Varghese, Nicola Wood, Melanie Wightman, Georgina Osborne, Gillian P. Bates, Michael H. Glickman, Matthias Trost, Axel Knebel, Francesco Marchesi, Thimo Kurz

Cell. 2016 Aug 11; 166(4): 935–949. doi: 10.1016/j.cell.2016.07.001

PMCID:: PMC5003816

Abstract Article

Select item 452071516.

Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis

Erik T. Sakowski, Stefan Koster, Cynthia Portal Celhay, Heidi S. Park, Elina Shrestha, Stefanie E. Hetzenecker, Katie Maurer, Ken Cadwell, Jennifer A. Philips

PLoS Pathog. 2015 Jul; 11(7): e1005076. Published online 2015 Jul 30. doi: 10.1371/journal.ppat.1005076

PMCID:: PMC4520715

Abstract Article PDF–2.6M

Select item 451912917.

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

Jun Hamazaki, Shoshiro Hirayama, Shigeo Murata

PLoS Genet. 2015 Jul; 11(7): e1005401. Published online 2015 Jul 29. doi: 10.1371/journal.pgen.1005401

PMCID:: PMC4519129

Abstract Article PDF–11M

Select item 395358918.

Ubiquilin-1 Protects Cells from Oxidative Stress and Ischemic Stroke Caused Tissue Injury in Mice

Yanying Liu, Lanhai Lü, Casey L. Hettinger, Gaofeng Dong, Dong Zhang, Khosrow Rezvani, Xuejun Wang, Hongmin Wang

J Neurosci. 2014 Feb 19; 34(8): 2813–2821. doi: 10.1523/JNEUROSCI.3541-13.2014

PMCID:: PMC3953589

Abstract Article PDF–2.4M

Select item 391400119.

Unbiased Screen Reveals Ubiquilin-1 and -2 Highly Associated with Huntingtin Inclusions

Nicola J. Rutherford, Jada Lewis, Amy K. Clippinger, Michael A. Thomas, Jennifer Adamson, Pedro E. Cruz, Ashley Cannon, Guilian Xu, Todd E. Golde, Gerry Shaw, David R. Borchelt, Benoit I. Giasson

Brain Res. Author manuscript; available in PMC 2014 Aug 2.

Published in final edited form as: Brain Res. 2013 Aug 2; 1524: 62–73. Published online 2013 Jun 15. doi: 10.1016/j.brainres.2013.06.006

PMCID:: PMC3914001

Abstract Article PDF–1.9M

Select item 335134520.

The Syk-binding Ubiquitin Ligase c-Cbl Mediates Signaling-dependent B Cell Receptor Ubiquitination and B Cell Receptor-mediated Antigen Processing and Presentation

Bhuvana Katkere, Sarah Rosa, James R. Drake

J Biol Chem. 2012 May 11; 287(20): 16636–16644. Published online 2012 Mar 26. doi: 10.1074/jbc.M112.357640

PMCID:: PMC3351345

Abstract Article PDF–3.1M

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