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Items: 1 to 20 of 180

1.
Gasdermin D silencing alleviates airway inflammation and remodeling in an ovalbumin-induced asthmatic mouse model
Jinxiang Wu, Pin Wang, Xinyu Xie, Xiaoqi Yang, Shuangmei Tang, Jiping Zhao, Tian Liu, Junfei Wang, Jintao Zhang, Tongliang Xia, Xin Feng
Cell Death Dis. 2024 Jun; 15(6): 400. Published online 2024 Jun 7. doi: 10.1038/s41419-024-06777-5
PMCID:
PMC11161474
AbstractArticlePDF–6.2M
2.
Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis
Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu, Ruoni Lin, Qiaoqiao Pei, Jing Nie, Ning Luo, Xiaoyan Li, Wei Chen, Haiping Mao, Yi Zhou, Xueqing Yu
Cell Commun Signal. 2024; 22: 308. Published online 2024 Jun 3. doi: 10.1186/s12964-024-01681-z
PMCID:
PMC11149269
AbstractArticlePDF–10M
3.
GSDMD/Drp1 signaling pathway mediates hippocampal synaptic damage and neural oscillation abnormalities in a mouse model of sepsis-associated encephalopathy
Qun Fu, Yi-Bao Zhang, Chang-Xi Shi, Ming Jiang, Kai Lu, Zi-Hui Fu, Jia-Ping Ruan, Jing Wu, Xiao-Ping Gu
J Neuroinflammation. 2024; 21: 96. Published online 2024 Apr 16. doi: 10.1186/s12974-024-03084-w
PMCID:
PMC11020266
AbstractArticlePDF–6.7M
4.
LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation
Yuhang Wang, Joyce Z. Gao, Taylor Sakaguchi, Thorsten Maretzky, Prajwal Gurung, Nandakumar S. Narayanan, Sarah Short, Yiqin Xiong, Zizhen Kang
Cells. 2024 Apr; 13(7): 565. Published online 2024 Mar 23. doi: 10.3390/cells13070565
PMCID:
PMC11011703
AbstractArticlePDF–6.0M
5.
Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis
Xing-Nian Zhou, Quan Zhang, Hong Peng, Yu-Jie Qin, Yu-Hong Liu, Lu Wang, Ming-Liang Cheng, Xin-Hua Luo, Hong Li
World J Gastroenterol. 2024 Mar 21; 30(11): 1588–1608. Published online 2024 Mar 21. doi: 10.3748/wjg.v30.i11.1588
PMCID:
PMC11008418
AbstractArticlePDF–18M
6.
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation
Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, Jacob S. Yount
Nat Commun. 2024; 15: 2751. Published online 2024 Mar 29. doi: 10.1038/s41467-024-47067-0
PMCID:
PMC10980740
AbstractArticlePDF–4.1M
7.
Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis
Do-Wan Shim, Jun-Cheol Eo, Saeyoung Kim, Inhwa Hwang, BoYoung Nam, Jae-Eun Shin, Seung Hyeok Han, Je-Wook Yu
Exp Mol Med. 2024 Feb; 56(2): 370–382. Published online 2024 Feb 1. doi: 10.1038/s12276-024-01162-w
PMCID:
PMC10907614
AbstractArticlePDF–4.7M
8.
Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction
Shunli Liang, Linsheng Xu, Xilin Xin, Rongbo Zhang, You Wu
PeerJ. 2024; 12: e16818. Published online 2024 Feb 9. doi: 10.7717/peerj.16818
PMCID:
PMC10860548
AbstractArticlePDF–6.5M
9.
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease
Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy, Shady Estfanous, Owen Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, Abbey A. Saadey, Brooke Laster, Pearlly Yan, Amy Webb, Xiaoli Zhang, Maciej Pietrzak, Olga N. Kokiko-Cochran, Hazem E. Ghoneim, Amal O. Amer
Alzheimers Res Ther. 2024; 16: 29. Published online 2024 Feb 8. doi: 10.1186/s13195-024-01390-2
PMCID:
PMC10851453
AbstractArticlePDF–1.9M
10.
Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi
Cell Death Dis. 2024 Feb; 15(2): 115. Published online 2024 Feb 7. doi: 10.1038/s41419-024-06505-z
PMCID:
PMC10850491
AbstractArticlePDF–7.0M
11.
Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death
Fengxia Ma, Laxman Ghimire, Qian Ren, Yuping Fan, Tong Chen, Arumugam Balasubramanian, Alan Hsu, Fei Liu, Hongbo Yu, Xuemei Xie, Rong Xu, Hongbo R. Luo
Nat Commun. 2024; 15: 386. Published online 2024 Jan 9. doi: 10.1038/s41467-023-44669-y
PMCID:
PMC10776763
AbstractArticlePDF–4.6M
12.
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
Fan Yu, Zhen Zhang, Yiping Leng, Alex F. Chen
Inflamm Res. 2024; 73(1): 5–17. Published online 2023 Nov 14. doi: 10.1007/s00011-023-01812-1
PMCID:
PMC10776498
AbstractArticlePDF–1.7M
13.
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice
Stefan A. Fattinger, Luca Maurer, Petra Geiser, Elliott M. Bernard, Ursina Enz, Suwannee Ganguillet, Ersin Gül, Sanne Kroon, Benjamin Demarco, Vanessa Mack, Markus Furter, Manja Barthel, Pawel Pelczar, Feng Shao, Petr Broz, Mikael E. Sellin, Wolf-Dietrich Hardt
Proc Natl Acad Sci U S A. 2023 Nov 28; 120(48): e2315503120. Published online 2023 Nov 21. doi: 10.1073/pnas.2315503120
PMCID:
PMC10691232
AbstractArticlePDF–7.1M
14.
The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes
Markus Spurlock, Weijun An, Galina Reshetnikova, Rong Wen, Hua Wang, Michelle Braha, Gabriela Solis, Stefan Kurtenbach, Orlando J. Galindez, Juan Pablo de Rivero Vaccari, Tsung-Han Chou, Vittorio Porciatti, Valery I. Shestopalov
Cells. 2023 Nov; 12(22): 2626. Published online 2023 Nov 15. doi: 10.3390/cells12222626
PMCID:
PMC10670000
AbstractArticlePDF–6.1M
15.
Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection
Sarah Rosli, Christopher M. Harpur, Maggie Lam, Alison C. West, Christopher Hodges, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate
Cell Death Dis. 2023 Nov; 14(11): 727. Published online 2023 Nov 9. doi: 10.1038/s41419-023-06258-1
PMCID:
PMC10636052
AbstractArticlePDF–3.3M
16.
An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2
Carissa K. Harvest, Taylor J. Abele, Chen Yu, Cole J. Beatty, Megan E. Amason, Zachary P. Billman, Morgan A. DePrizio, Fernando W. Souza, Carolyn A. Lacey, Vivien I. Maltez, Heather N. Larson, Benjamin D. McGlaughon, Daniel R. Saban, Stephanie A. Montgomery, Edward A. Miao
Nat Commun. 2023; 14: 6686. Published online 2023 Oct 21. doi: 10.1038/s41467-023-42218-1
PMCID:
PMC10590453
AbstractArticlePDF–14M
17.
Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
Rakshanya Sekar, Yvette Wooff, Adrian V. Cioanca, Melan Kurera, Chinh Ngo, Si Ming Man, Riccardo Natoli
J Neuroinflammation. 2023; 20: 239. Published online 2023 Oct 20. doi: 10.1186/s12974-023-02927-2
PMCID:
PMC10588253
AbstractArticlePDF–13M
18.
Muscimol inhibits plasma membrane rupture and ninjurin-1(NINJ1) oligomerization during pyroptosis
Andreas B. den Hartigh, Wendy P. Loomis, Marisa J. Anderson, Bente Frølund, Susan L. Fink
Commun Biol. 2023; 6: 1010. Published online 2023 Oct 5. doi: 10.1038/s42003-023-05354-4
Correction in:
Commun Biol. 2024; 7: 310.
PMCID:
PMC10556065
AbstractArticlePDF–1.9M
19.
Chopped! Newfound GSDMD cleavage facilitates tolerance to food allergens
Liam B. Healy, Gang Du, Hao Wu
Trends Immunol. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Trends Immunol. 2023 Aug; 44(8): 571–573. Published online 2023 Jul 4. doi: 10.1016/j.it.2023.06.006
PMCID:
PMC10529924
AbstractArticlePDF–339K
20.
NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity
Martin S. Minns, Karl Liboro, Tatiane S. Lima, Serena Abbondante, Brandon A. Miller, Michaela E. Marshall, Jolynn Tran Chau, Alicia Roistacher, Arne Rietsch, George R. Dubyak, Eric Pearlman
Nat Commun. 2023; 14: 5832. Published online 2023 Sep 20. doi: 10.1038/s41467-023-41391-7
PMCID:
PMC10511713
AbstractArticlePDF–2.1M

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