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Select item 112109131.

PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins

Hui-Chen Hsieh, I-Hsiang Huang, Shao-Wen Chang, Po-Lin Chen, Yu-Cheng Su, Shuying Wang, Wei-Jiun Tsai, Ping-Hung Chen, Raffi V. Aroian, Chang-Shi Chen

Autophagy. 2024; 20(6): 1335–1358. Published online 2024 Jan 23. doi: 10.1080/15548627.2024.2306655

PMCID:: PMC11210913

Abstract Article PDF–7.6M

Select item 112027362.

Lack of T04C9.1, the Homologue of Mammalian APPL2, Leads to Premature Ageing and Shortens Lifespan in Caenorhabditis elegans

Zirui Li, Zhiqiang Chen, Lianghao Zhao, Jiaqi Sun, Lin Yin, Yuwei Jiang, Xiaotong Shi, Ziye Song, Lu Zhang

Genes (Basel) 2024 Jun; 15(6): 659. Published online 2024 May 22. doi: 10.3390/genes15060659

PMCID:: PMC11202736

Abstract Article PDF–5.5M

Select item 110199323.

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng, Kang Shen, Goncalo Dias do Vale, Jeffrey G. McDonald, Dengke K. Ma

Cell Rep. Author manuscript; available in PMC 2024 Apr 16.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113899. Published online 2024 Mar 5. doi: 10.1016/j.celrep.2024.113899

PMCID:: PMC11019932

Abstract Article PDF–1.8M

Select item 105593134.

Endoplasmic Reticulum Exit Sites scale with somato-dendritic size in neurons

Ruben Land, Richard Fetter, Xing Liang, Christopher P. Tzeng, Caitlin A. Taylor, Kang Shen

Mol Biol Cell. 2023 Oct 1; 34(11): ar106. Published online 2023 Sep 21. doi: 10.1091/mbc.E23-03-0090

PMCID:: PMC10559313

Abstract Article PDF–3.0M

Select item 105386575.

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

Hannah J. Smith, Anne Lanjuin, Arpit Sharma, Aditi Prabhakar, Ewelina Nowak, Peter G. Stine, Rohan Sehgal, Klement Stojanovski, Benjamin D. Towbin, William B. Mair

PLoS Genet. 2023 Sep; 19(9): e1010938. Published online 2023 Sep 18. doi: 10.1371/journal.pgen.1010938

PMCID:: PMC10538657

Abstract Article PDF–2.1M

Select item 104418036.

Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways

Yi-Ting Tsai, Chen-Hsi Chang, Hsin-Yue Tsai

PLoS Genet. 2023 Aug; 19(8): e1010869. Published online 2023 Aug 9. doi: 10.1371/journal.pgen.1010869

PMCID:: PMC10441803

Abstract Article PDF–3.9M

Select item 103514427.

LAMTOR1 ubiquitination restricts its interaction with the vacuolar-type H⁺-ATPase, promotes autophagy and is controlled by USP32

Alexandra Hertel, Stefan Eimer, Anja Bremm

Autophagy. 2023; 19(8): 2406–2407. Published online 2023 Mar 1. doi: 10.1080/15548627.2023.2184958

PMCID:: PMC10351442

Abstract Article PDF–211K

Select item 102364458.

Increased Alcohol Dehydrogenase 1 activity promotes longevity

Abbas Ghaddar, Vinod K. Mony, Swarup Mishra, Samuel Berhanu, James C. Johnson, Elisa Enriquez-Hesles, Emma Harrison, Aaroh Patel, Mary Kate Horak, Jeffrey S. Smith, Eyleen J. O’Rourke

Curr Biol. Author manuscript; available in PMC 2024 Mar 27.

Published in final edited form as: Curr Biol. 2023 Mar 27; 33(6): 1036–1046.e6. Published online 2023 Feb 17. doi: 10.1016/j.cub.2023.01.059

PMCID:: PMC10236445

Abstract Article PDF–1.3M

Select item 101779299.

AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans

Tinka Vidovic, Alexander Dakhovnik, Oleksii Hrabovskyi, Michael R. MacArthur, Collin Y. Ewald

Int J Mol Sci. 2023 May; 24(9): 7850. Published online 2023 Apr 25. doi: 10.3390/ijms24097850

PMCID:: PMC10177929

Abstract Article PDF–3.0M

Select item 999209510.

A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes

Gholamreza Fazeli, Roni Levin-Konigsberg, Michael C. Bassik, Christian Stigloher, Ann M. Wehman

Curr Biol. Author manuscript; available in PMC 2024 Feb 27.

Published in final edited form as: Curr Biol. 2023 Feb 27; 33(4): 607–621.e7. Published online 2023 Jan 17. doi: 10.1016/j.cub.2022.12.041

PMCID:: PMC9992095

Abstract Article PDF–2.5M

Select item 992494811.

Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1‐imidazoline receptor

Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald, João Pedro de Magalhães

Aging Cell. 2023 Feb; 22(2): e13774. Published online 2023 Jan 20. doi: 10.1111/acel.13774

PMCID:: PMC9924948

Abstract Article PDF–4.3M

Select item 988544012.

Intracellular lipid surveillance by small G protein geranylgeranylation

Abigail Watterson, Lexus Tatge, Naureen Wajahat, Sonja L. B. Arneaud, Rene Solano Fonseca, Shaghayegh T. Beheshti, Patrick Metang, Melina Mihelakis, Kielen R. Zuurbier, Chase D. Corley, Ishmael Dehghan, Jeffrey G. McDonald, Peter M. Douglas

Nature. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Nature. 2022 May; 605(7911): 736–740. Published online 2022 May 18. doi: 10.1038/s41586-022-04729-7

PMCID:: PMC9885440

Abstract Article PDF–4.2M

Select item 982067013.

Isocitrate Dehydrogenase Alpha-1 Modulates Lifespan and Oxidative Stress Tolerance in Caenorhabditis elegans

Zhi-Han Lin, Shun-Ya Chang, Wen-Chi Shen, Yen-Hung Lin, Chiu-Lun Shen, Sin-Bo Liao, Yu-Chun Liu, Chang-Shi Chen, Tsui-Ting Ching, Horng-Dar Wang

Int J Mol Sci. 2023 Jan; 24(1): 612. Published online 2022 Dec 29. doi: 10.3390/ijms24010612

PMCID:: PMC9820670

Abstract Article PDF–2.9M

Select item 971087314.

Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression

Robyn Branicky, Ying Wang, Arman Khaki, Ju-Ling Liu, Maximilian Kramer-Drauberg, Siegfried Hekimi

Sci Adv. 2022 Dec; 8(48): eadc9851. Published online 2022 Nov 30. doi: 10.1126/sciadv.adc9851

PMCID:: PMC9710873

Abstract Article PDF–2.2M

Select item 962984915.

Bidirectional regulation of structural damage on autophagy in the C. elegans epidermis

Rong Fu, Xiaowan Jiang, Yuyan Yang, Chunxia Wang, Yun Zhang, Yi Zhu, Huimin Zhang

Autophagy. 2022; 18(11): 2731–2745. Published online 2022 Mar 20. doi: 10.1080/15548627.2022.2047345

PMCID:: PMC9629849

Abstract Article PDF–3.0M

Select item 948099016.

Nutrient sensing pathways regulating adult reproductive diapause in C. elegans

Moriah Eustice, Daniel Konzman, Jeff M. Reece, Salil Ghosh, Jhullian Alston, Tyler Hansen, Andy Golden, Michelle R. Bond, Lara K. Abramowitz, John A. Hanover

PLoS One. 2022; 17(9): e0274076. Published online 2022 Sep 16. doi: 10.1371/journal.pone.0274076