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Select item 87112361.

Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase

Julie Ducharme, Irina F. Sevrioukova, Christopher J. Thibodeaux, Karine Auclair

Biochemistry. Author manuscript; available in PMC 2022 Jul 20.

Published in final edited form as: Biochemistry. 2021 Jul 20; 60(28): 2259–2271. Published online 2021 Jul 1. doi: 10.1021/acs.biochem.1c00178

PMCID:: PMC8711236

Abstract Article PDF–2.4M

Select item 59676312.

Structural and kinetic studies of Asp632 mutants and fully-reduced NADPH-cytochrome P450 oxidoreductase define the role of Asp632 loop dynamics in control of NADPH binding and hydride transfer

Chuanwu Xia, Freeborn Rwere, Sangchoul Im, Anna L. Shen, Lucy Waskell, Jung-Ja P. Kim

Biochemistry. Author manuscript; available in PMC 2018 May 24.

Published in final edited form as: Biochemistry. 2018 Feb 13; 57(6): 945–962. Published online 2018 Jan 30. doi: 10.1021/acs.biochem.7b01102

PMCID:: PMC5967631

Abstract Article PDF–1.7M

Select item 55551803.

Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1

Eric Gonzalez, F. Peter Guengerich

J Biol Chem. 2017 Aug 11; 292(32): 13168–13185. Published online 2017 Jul 6. doi: 10.1074/jbc.M117.794917

PMCID:: PMC5555180

Abstract Article PDF–2.7M

Select item 49381854.

Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone

Freeborn Rwere, Chuanwu Xia, Sangchoul Im, Mohammad M. Haque, Dennis J. Stuehr, Lucy Waskell, Jung-Ja P. Kim

J Biol Chem. 2016 Jul 8; 291(28): 14639–14661. Published online 2016 May 9. doi: 10.1074/jbc.M116.724625

PMCID:: PMC4938185

Abstract Article PDF–3.6M

Select item 43352245.

Kinetic and Structural Characterization of the Interaction between the FMN Binding Domain of Cytochrome P450 Reductase and Cytochrome c

Rui Huang, Meng Zhang, Freeborn Rwere, Lucy Waskell, Ayyalusamy Ramamoorthy

J Biol Chem. 2015 Feb 20; 290(8): 4843–4855. Published online 2014 Dec 15. doi: 10.1074/jbc.M114.582700

PMCID:: PMC4335224

Abstract Article PDF–2.6M

Select item 40522716.

Probing the Transmembrane Structure and Dynamics of Microsomal NADPH-cytochrome P450 oxidoreductase by Solid-State NMR

Rui Huang, Kazutoshi Yamamoto, Meng Zhang, Nataliya Popovych, Ivan Hung, Sang-Choul Im, Zhehong Gan, Lucy Waskell, Ayyalusamy Ramamoorthy

Biophys J. 2014 May 20; 106(10): 2126–2133. doi: 10.1016/j.bpj.2014.03.051

PMCID:: PMC4052271

Abstract Article PDF–1005K

Select item 34434097.

Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis

Chan-Hyun Na, Drew R. Jones, Yanling Yang, Xusheng Wang, Yanji Xu, Junmin Peng

J Proteome Res. Author manuscript; available in PMC 2013 Sep 7.

Published in final edited form as: J Proteome Res. 2012 Sep 7; 11(9): 4722–4732. Published online 2012 Aug 15. doi: 10.1021/pr300536k

PMCID:: PMC3443409

Abstract Article PDF–4.2M

Select item 31780598.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 31022499.

UNCOVERING THE ROLE OF HYDROPHOBIC RESIDUES IN CYTOCHROME P450-CYTOCHROME P450 REDUCTASE INTERACTIONS

Cesar Kenaan, Haoming Zhang, Erin V. Shea, Paul F. Hollenberg

Biochemistry. Author manuscript; available in PMC 2012 May 17.

Published in final edited form as: Biochemistry. 2011 May 17; 50(19): 3957–3967. Published online 2011 Apr 22. doi: 10.1021/bi1020748

PMCID:: PMC3102249

Abstract Article PDF–1.3M

Select item 309123210.

Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding

Chuanwu Xia, Djemel Hamdane, Anna L. Shen, Vivian Choi, Charles B. Kasper, Naw May Pearl, Haoming Zhang, Sang-Choul Im, Lucy Waskell, Jung-Ja P. Kim

J Biol Chem. 2011 May 6; 286(18): 16246–16260. Published online 2011 Feb 23. doi: 10.1074/jbc.M111.230532

PMCID:: PMC3091232

Abstract Article PDF–2.0M

Select item 279756611.

Modulation of the Cytochrome P450 Reductase Redox Potential by the Phospholipid Bilayer

Aditi Das, Stephen G. Sligar

Biochemistry. Author manuscript; available in PMC 2010 Dec 29.

Published in final edited form as: Biochemistry. 2009 Dec 29; 48(51): 12104–12112. doi: 10.1021/bi9011435

PMCID:: PMC2797566

Abstract Article PDF–2.0M

Select item 271243612.

CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis

Murali Subramanian, Michael Low, Charles W. Locuson, Timothy S. Tracy

Drug Metab Dispos. 2009 Aug; 37(8): 1682–1689. Published online 2009 May 15. doi: 10.1124/dmd.109.026500

PMCID:: PMC2712436

Abstract Article PDF–216K

Select item 267014313.

Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

Djemel Hamdane, Chuanwu Xia, Sang-Choul Im, Haoming Zhang, Jung-Ja P. Kim, Lucy Waskell

J Biol Chem. 2009 Apr 24; 284(17): 11374–11384. doi: 10.1074/jbc.M807868200

PMCID:: PMC2670143

Abstract Article PDF–627K

Select item 266248814.

Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain

Catherine N. Hall, Robert G. Keynes, John Garthwaite

Biochem J. 2009 Apr 15; 419(Pt 2): 411–418. Prepublished online 2009 Jan 20. Published online 2009 Mar 27. doi: 10.1042/BJ20082419

PMCID:: PMC2662488

Abstract Article PDF–417K

Select item 264792615.

Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production

Yoshihiko Inaoka, Takashi Yazawa, Tetsuya Mizutani, Koichi Kokame, Kenji Kangawa, Miki Uesaka, Akihiro Umezawa, Kaoru Miyamoto

Reprod Biol Endocrinol. 2008; 6: 62. Published online 2008 Dec 16. doi: 10.1186/1477-7827-6-62

PMCID:: PMC2647926

Abstract Article PDF–838K

Select item 238696116.

CYP2C9 protein interactions with cytochrome b₅: Effects on the coupling of catalysis

Charles W. Locuson, Larry C. Wienkers, Jeffrey P. Jones, Timothy S. Tracy

Drug Metab Dispos. Author manuscript; available in PMC 2008 Jul 1.

Published in final edited form as: Drug Metab Dispos. 2007 Jul; 35(7): 1174–1181. Published online 2007 Apr 19. doi: 10.1124/dmd.107.014910

PMCID:: PMC2386961

Abstract Article PDF–759K

Select item 227980617.

Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase

Yuichiro Higashimoto, Masakazu Sugishima, Hideaki Sato, Hiroshi Sakamoto, Keiichi Fukuyama, Graham Palmer, Masato Noguchi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2009 Mar 21.

Published in final edited form as: Biochem Biophys Res Commun. 2008 Mar 21; 367(4): 852–858. Published online 2008 Jan 14. doi: 10.1016/j.bbrc.2008.01.016

PMCID:: PMC2279806

Abstract Article PDF–1.0M

Select item 199354918.

Functional expression and characterization of cytochrome P450 52A21 from Candida albicans* : FATTY ACID ω-HYDROXYLATION IN A NEW PROTEIN FRAMEWORK*

Donghak Kim, Max J. Cryle, James J. De Voss, Paul R. Ortiz de Montellano

Arch Biochem Biophys. Author manuscript; available in PMC 2008 Aug 15.

Published in final edited form as: Arch Biochem Biophys. 2007 Aug 15; 464(2): 213–220. Published online 2007 Mar 16. doi: 10.1016/j.abb.2007.02.032

PMCID:: PMC1993549

Abstract Article PDF–1.0M

Select item 127607519.

Recruitment of governing elements for electron transfer in the nitric oxide synthase family

M. Jáchymová, P. Martásek, S. Panda, L. J. Roman, M. Panda, T. M. Shea, Y. Ishimura, J.-J. P. Kim, B. S. S. Masters

Proc Natl Acad Sci U S A. 2005 Nov 1; 102(44): 15833–15838. Published online 2005 Oct 25. doi: 10.1073/pnas.0506522102

PMCID:: PMC1276075

Abstract Article PDF–429K

Select item 119936420.

Diversity and Function of Mutations in P450 Oxidoreductase in Patients with Antley-Bixler Syndrome and Disordered Steroidogenesis

Ningwu Huang, Amit V. Pandey, Vishal Agrawal, William Reardon, Pablo D. Lapunzina, David Mowat, Ethylin Wang Jabs, Guy Van Vliet, Joseph Sack, Christa E. Flück, Walter L. Miller

Am J Hum Genet. 2005 May; 76(5): 729–749. Published online 2005 Mar 25. doi: 10.1086/429417