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Select item 109848731.

RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs : RASGRP1 regulates myoblast proliferation and differentiation

Liyao Xiao, Jiaxin Qiao, Yiyang Huang, Baohua Tan, Linjun Hong, Zicong Li, Gengyuan Cai, Zhenfang Wu, Enqin Zheng, Shanshan Wang, Ting Gu

Acta Biochim Biophys Sin (Shanghai) 2024 Mar 25; 56(3): 452–461. Published online 2024 Feb 28. doi: 10.3724/abbs.2024011

PMCID:: PMC10984873

Abstract Article PDF–2.4M

Select item 105297022.

Induced loss of Rasgrp1 in peripheral CD4+ T cells of conditional Rasgrp1-deficient mice reveals an essential role for Rasgrp1 in TCR/CD28-induced Ras-MAPK signaling

Yating Chang, Praveen Manivannan, Abbas Doosti, Philip E. Lapinski, Di Chen, Jeroen Roose, Philip D. King

J Immunol. Author manuscript; available in PMC 2024 Sep 15.

Published in final edited form as: J Immunol. 2023 Sep 15; 211(6): 917–922. doi: 10.4049/jimmunol.2300138

PMCID:: PMC10529702

Abstract Article PDF–1.5M

Select item 96690013.

RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth

Cong Wang, Xue Li, Binbin Xue, Changping Yu, Luoling Wang, Rilin Deng, Hui Liu, Zihao Chen, Yingdan Zhang, Suping Fan, Chaohui Zuo, Hungyu Sun, Haizhen Zhu, Jianli Wang, Songqing Tang

Nat Commun. 2022; 13: 7001. Published online 2022 Nov 16. doi: 10.1038/s41467-022-34659-x

PMCID:: PMC9669001

Abstract Article PDF–5.4M

Select item 89835114.

Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras^Q61R/+ mice

Zhi Wen, Remington Finn, Xin Gao, Lin Li, Alexander Hebert, Erik A. Ranheim, Yun Zhou, Grant Yun, Jeroen P. Roose, Joshua J. Coon, Rita Shiang, Renren Wen, Menggang Yu, Demin Wang, Jing Zhang

Leukemia. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Leukemia. 2022 Apr; 36(4): 1167–1170. Published online 2022 Jan 26. doi: 10.1038/s41375-022-01510-7

PMCID:: PMC8983511

Article PDF–606K

Select item 83519015.

Nras^Q61R/+ and Kras^−/− cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors

Zhi Wen, Grant Yun, Alexander Hebert, Guangyao Kong, Erik A. Ranheim, Remington Finn, Adhithi Rajagoplan, Shuyi Li, Yun Zhou, Mei Yu, Alisa Damnernsawad, Jeroen P. Roose, Joshua J. Coon, Renren Wen, Demin Wang, Jing Zhang

Blood. 2021 Jun 10; 137(23): 3259–3271. Prepublished online 2021 Jan 19. doi: 10.1182/blood.2020009082

PMCID:: PMC8351901

Abstract Article

Select item 83132396.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82655667.

The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain

Maria Elena Martinez, Arturo Hernandez

Front Neurosci. 2021; 15: 703730. Published online 2021 Jun 29. doi: 10.3389/fnins.2021.703730

PMCID:: PMC8265566

Abstract Article PDF–8.3M

Select item 78944798.

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

Matthijs J.D. Baars, Thera Douma, Dimitre R. Simeonov, Darienne R. Myers, Kayla Kulhanek, Saikat Banerjee, Susan Zwakenberg, Marijke P. Baltissen, Mojtaba Amini, Sytze de Roock, Femke van Wijk, Michiel Vermeulen, Alexander Marson, Jeroen P. Roose, Yvonne Vercoulen

Eur J Immunol. 2021 Feb; 51(2): 471–482. Published online 2020 Nov 16. doi: 10.1002/eji.201948451

PMCID:: PMC7894479

Abstract Article PDF–2.0M

Select item 76555579.

Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

Laila Karra, Damia Romero-Moya, Olga Ksionda, Milana Krush, Zhaohui Gu, Marsilius Mues, Philippe Depeille, Charles Mullighan, Jeroen P. Roose

Oncogene. Author manuscript; available in PMC 2021 Mar 28.

Published in final edited form as: Oncogene. 2020 Nov; 39(45): 6920–6934. Published online 2020 Sep 28. doi: 10.1038/s41388-020-01469-8

PMCID:: PMC7655557

Abstract Article PDF–1.8M

Select item 732981010.

Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation

Mihee Oh, Sun Young Kim, Jung-Eun Gil, Jeong-Su Byun, Dong-Wook Cha, Bonsu Ku, Woonghee Lee, Won-Kon Kim, Kyoung-Jin Oh, Eun-Woo Lee, Kwang-Hee Bae, Sang Chul Lee, Baek-Soo Han

Sci Rep. 2020; 10: 10755. Published online 2020 Jul 1. doi: 10.1038/s41598-020-67549-7

PMCID:: PMC7329810

Abstract Article PDF–1.9M

Select item 719518611.

RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease

Mehdi Eshraghi, Uri Nimrod Ramírez-Jarquín, Neelam Shahani, Tommaso Nuzzo, Arianna De Rosa, Supriya Swarnkar, Nicole Galli, Oscar Rivera, George Tsaprailis, Catherina Scharager-Tapia, Gogce Crynen, Qin Li, Marie-Laure Thiolat, Erwan Bezard, Alessandro Usiello, Srinivasa Subramaniam

Sci Adv. 2020 May; 6(18): eaaz7001. Published online 2020 May 1. doi: 10.1126/sciadv.aaz7001

PMCID:: PMC7195186

Abstract Article PDF–3.2M

Select item 695411612.

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

John C. Charpentier, Di Chen, Philip E. Lapinski, Jackson Turner, Irina Grigorova, Joel A. Swanson, Philip D. King

Nat Commun. 2020; 11: 180. Published online 2020 Jan 10. doi: 10.1038/s41467-019-13997-3

PMCID:: PMC6954116

Abstract Article PDF–2.8M

Select item 671220713.

Transcriptomic Signatures of Postnatal and Adult Intrinsically Photosensitive Ganglion Cells

Daniel J. Berg, Katherine Kartheiser, Megan Leyrer, Alexandra Saali, David M. Berson

eNeuro. 2019 Jul-Aug; 6(4): ENEURO.0022-19.2019. Prepublished online 2019 Aug 6. Published online 2019 Aug 23. doi: 10.1523/ENEURO.0022-19.2019

PMCID:: PMC6712207

Abstract Article PDF–12M

Select item 669383614.

RasGRP1 is a potential biomarker for stratifying anti-EGFR therapy response in colorectal cancer

Oghenekevwe M. Gbenedio, Caroline Bonnans, Delphine Grun, Chih-Yang Wang, Ace J. Hatch, Michelle R. Mahoney, David Barras, Mary Matli, Yi Miao, K. Christopher Garcia, Sabine Tejpar, Mauro Delorenzi, Alan P. Venook, Andrew B. Nixon, Robert S. Warren, Jeroen P. Roose, Philippe Depeille

JCI Insight. 2019 Aug 8; 4(15): e127552. Published online 2019 Aug 8. doi: 10.1172/jci.insight.127552

PMCID:: PMC6693836

Abstract Article PDF–5.3M

Select item 659312615.

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells

Darienne R. Myers, Emilia Norlin, Yvonne Vercoulen, Jeroen P. Roose

Cell Rep. Author manuscript; available in PMC 2019 Jun 26.

Published in final edited form as: Cell Rep. 2019 May 7; 27(6): 1858–1874.e6. doi: 10.1016/j.celrep.2019.04.037

PMCID:: PMC6593126

Abstract Article PDF–1.3M

Select item 636808816.

TGF-β suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis

Mariko Takami, Christina Cunha, Shinichiro Motohashi, Toshinori Nakayama, Makio Iwashima

Eur J Immunol. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Eur J Immunol. 2018 Dec; 48(12): 1938–1943. Published online 2018 Oct 24. doi: 10.1002/eji.201847587

PMCID:: PMC6368088

Abstract Article PDF–435K

Select item 564298917.

CD275-Independent IL-17–Producing T Follicular Helper–like Cells in Lymphopenic Autoimmune-Prone Mice

Christopher Smith, Janet E. Buhlmann, Xiaogan Wang, Amber Bartlett, Bing Lim, Robert A. Barrington

J Immunol. Author manuscript; available in PMC 2017 Oct 16.

Published in final edited form as: J Immunol. 2016 Jun 15; 196(12): 4935–4946. Published online 2016 May 16. doi: 10.4049/jimmunol.1402193

PMCID:: PMC5642989

Abstract Article PDF–939K

Select item 555158118.

Thymic progenitors of TCRαβ⁺ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development

Dominic P. Golec, Romy E. Hoeppli, Laura M. Henao Caviedes, Jillian McCann, Megan K. Levings, Troy A. Baldwin

J Exp Med. 2017 Aug 7; 214(8): 2421–2435. doi: 10.1084/jem.20170844

PMCID:: PMC5551581

Abstract Article PDF–2.2M

Select item 554853619.

RasGRP1 Is an Essential Signaling Molecule For Development of B1a Cells With Autoantigen Receptors

Benchang Guo, Thomas L. Rothstein

J Immunol. Author manuscript; available in PMC 2017 Aug 8.

Published in final edited form as: J Immunol. 2016 Mar 15; 196(6): 2583–2590. Published online 2016 Feb 5. doi: 10.4049/jimmunol.1502132

PMCID:: PMC5548536

Abstract Article PDF–776K

Select item 534493220.

Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus

Jennifer Larimore, Stephanie A. Zlatic, Miranda Arnold, Kaela S. Singleton, Rebecca Cross, Hannah Rudolph, Martha V. Bruegge, Andrea Sweetman, Cecilia Garza, Eli Whisnant, Victor Faundez

Front Genet. 2017; 8: 28. Published online 2017 Mar 10. doi: 10.3389/fgene.2017.00028