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Select item 111433591.

Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein

Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson

Nat Commun. 2024; 15: 4663. Published online 2024 May 31. doi: 10.1038/s41467-024-49016-3

Correction in:: Nat Commun. 2024; 15: 6413.

PMCID:: PMC11143359

Abstract Article PDF–3.3M

Select item 110403772.

Lymphocyte‐Activation Gene 3 Facilitates Pathological Tau Neuron‐to‐Neuron Transmission

Chan Chen, Ramhari Kumbhar, Hu Wang, Xiuli Yang, Kundlik Gadhave, Cyrus Rastegar, Yasuyoshi Kimura, Adam Behensky, Sumasri Kotha, Grace Kuo, Sruthi Katakam, Deok Jeong, Liang Wang, Anthony Wang, Rong Chen, Shu Zhang, Lingtao Jin, Creg J. Workman, Dario A. A. Vignali, Olga Pletinkova, Hongpeng Jia, Weiyi Peng, David W. Nauen, Philip C. Wong, Javier Redding‐Ochoa, Juan C. Troncoso, Mingyao Ying, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao

Adv Sci (Weinh) 2024 Apr; 11(16): 2303775. Published online 2024 Feb 7. doi: 10.1002/advs.202303775

PMCID:: PMC11040377

Abstract Article PDF–5.7M

Select item 109629483.

Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function

John L. Silberstein, Jasper Du, Kun-Wei Chan, Jessica A. Frank, Irimpan I. Mathews, Yong Bin Kim, Jia You, Qiao Lu, Jia Liu, Elliot A. Philips, Phillip Liu, Eric Rao, Daniel Fernandez, Grayson E. Rodriguez, Xiang-Peng Kong, Jun Wang, Jennifer R. Cochran

Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12): e2310866121. Published online 2024 Mar 14. doi: 10.1073/pnas.2310866121

PMCID:: PMC10962948

Abstract Article PDF–2.1M

Select item 104778734.

Cerebral Microvascular Injury Induced by Lag3‐Dependent α‐Synuclein Fibril Endocytosis Exacerbates Cognitive Impairment in a Mouse Model of α‐Synucleinopathies

Qingxi Zhang, Qingrui Duan, Yuyuan Gao, Peikun He, Rui Huang, Haifeng Huang, Yanyi Li, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang

Adv Sci (Weinh) 2023 Sep; 10(25): 2301903. Published online 2023 Jun 28. doi: 10.1002/advs.202301903

PMCID:: PMC10477873

Abstract Article PDF–36M

Select item 101911765.

LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition

Qianqian Ming, Daiana P. Celias, Chao Wu, Aidan R. Cole, Srishti Singh, Charlotte Mason, Shen Dong, Timothy H. Tran, Gaya K. Amarasinghe, Brian Ruffell, Vincent C. Luca

Nat Immunol. Author manuscript; available in PMC 2023 May 17.

Published in final edited form as: Nat Immunol. 2022 Jul; 23(7): 1031–1041. Published online 2022 Jun 27. doi: 10.1038/s41590-022-01238-7

PMCID:: PMC10191176

Abstract Article PDF–4.3M

Select item 92145316.

Signatures of glial activity can be detected in the CSF proteome

Timo Eninger, Stephan A. Müller, Mehtap Bacioglu, Manuel Schweighauser, Marius Lambert, Luis F. Maia, Jonas J. Neher, Sarah M. Hornfeck, Ulrike Obermüller, Gernot Kleinberger, Christian Haass, Philipp J. Kahle, Matthias Staufenbiel, Lingyan Ping, Duc M. Duong, Allan I. Levey, Nicholas T. Seyfried, Stefan F. Lichtenthaler, Mathias Jucker, Stephan A. Kaeser

Proc Natl Acad Sci U S A. 2022 Jun 14; 119(24): e2119804119. Published online 2022 Jun 6. doi: 10.1073/pnas.2119804119

PMCID:: PMC9214531

Abstract Article PDF–2.2M

Select item 85258717.

Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function

Dunia Garcia Cruz, Raghavendra R. Giri, Daylin Gamiotea Turro, Jeremy L. Balsbaugh, Adam J. Adler, Annabelle Rodriguez

J Immunol. 2021 Nov 1; 207(9): 2374–2384. Published online 2021 Nov 1. doi: 10.4049/jimmunol.2001188

PMCID:: PMC8525871

Abstract Article PDF–3.2M

Select item 84220758.

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi

EMBO Mol Med. 2021 Sep 7; 13(9): e14745. Published online 2021 Jul 26. doi: 10.15252/emmm.202114745

PMCID:: PMC8422075

Abstract Article PDF–2.9M

Select item 82560399.

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

Shengnan Zhang, Yu-Qing Liu, Chunyu Jia, Yeh-Jun Lim, Guoqin Feng, Enquan Xu, Houfang Long, Yasuyoshi Kimura, Youqi Tao, Chunyu Zhao, Chuchu Wang, Zhenying Liu, Jin-Jian Hu, Meng-Rong Ma, Zhijun Liu, Lin Jiang, Dan Li, Renxiao Wang, Valina L. Dawson, Ted M. Dawson, Yan-Mei Li, Xiaobo Mao, Cong Liu

Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2011196118. Published online 2021 Jun 25. doi: 10.1073/pnas.2011196118

PMCID:: PMC8256039

Abstract Article PDF–2.8M

Select item 675118210.

Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma

Dan Tian, Lu Yang, Song Wang, Yanbing Zhu, Wen Shi, Chunpan Zhang, Hua Jin, Yue Tian, Hufeng Xu, Guangyong Sun, Kai Liu, Zhongtao Zhang, Dong Zhang

Nat Commun. 2019; 10: 4246. Published online 2019 Sep 18. doi: 10.1038/s41467-019-12243-0

PMCID:: PMC6751182

Abstract Article PDF–2.6M

Select item 646370211.

Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation

Takeo K. Maeda, Daisuke Sugiura, Il-mi Okazaki, Takumi Maruhashi, Taku Okazaki

J Biol Chem. 2019 Apr 12; 294(15): 6017–6026. Published online 2019 Feb 13. doi: 10.1074/jbc.RA119.007455

PMCID:: PMC6463702

Abstract Article PDF–3.2M

Select item 636596812.

Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG3

Jun Wang, Miguel F. Sanmamed, Ila Datar, Tina Tianjiao Su, Lan Ji, Jingwei Sun, Ling Chen, Yusheng Chen, Gefeng Zhu, Weiwei Yin, Linghua Zheng, Ting Zhou, Ti Badri, Sheng Yao, Shu Zhu, Agedi Boto, Mario Sznol, Ignacio Melero, Dario A. A. Vignali, Kurt Schalper, Lieping Chen

Cell. Author manuscript; available in PMC 2020 Jan 10.

Published in final edited form as: Cell. 2019 Jan 10; 176(1-2): 334–347.e12. Published online 2018 Dec 20. doi: 10.1016/j.cell.2018.11.010

PMCID:: PMC6365968

Abstract Article PDF–2.5M

Select item 616844613.

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression

Yingjun Liu, Silvia Sorce, Mario Nuvolone, Julie Domange, Adriano Aguzzi

Sci Rep. 2018; 8: 14600. Published online 2018 Oct 2. doi: 10.1038/s41598-018-32712-8

PMCID:: PMC6168446

Abstract Article PDF–2.8M

Select item 605727514.

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

Andreia C. Lino, Van Duc Dang, Vicky Lampropoulou, Anna Welle, Jara Joedicke, Jelka Pohar, Quentin Simon, Jessie Thalmensi, Aurelia Baures, Vinciane Flühler, Imme Sakwa, Ulrik Stervbo, Stefanie Ries, Luc Jouneau, Pierre Boudinot, Takeshi Tsubata, Takahiro Adachi, Andreas Hutloff, Thomas Dörner, Ursula Zimber-Strobl, Alex F. de Vos, Katja Dahlke, Gunnar Loh, Sarantis Korniotis, Christian Goosmann, Jean-Claude Weill, Claude-Agnès Reynaud, Stefan H.E. Kaufmann, Jörn Walter, Simon Fillatreau

Immunity. 2018 Jul 17; 49(1): 120–133.e9. doi: 10.1016/j.immuni.2018.06.007

PMCID:: PMC6057275

Abstract Article

Select item 588776615.

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

Marina Wierz, Sandrine Pierson, Léa Guyonnet, Elodie Viry, Audrey Lequeux, Anaïs Oudin, Simone P. Niclou, Markus Ollert, Guy Berchem, Bassam Janji, Coralie Guérin, Jerome Paggetti, Etienne Moussay

Blood. 2018 Apr 5; 131(14): 1617–1621. Prepublished online 2018 Feb 13. doi: 10.1182/blood-2017-06-792267

PMCID:: PMC5887766

Article

Select item 566201816.

LAG-3 confers a competitive disadvantage upon antiviral CD8+ T cell responses

Kevin D. Cook, Jason K. Whitmire

J Immunol. Author manuscript; available in PMC 2017 Oct 30.

Published in final edited form as: J Immunol. 2016 Jul 1; 197(1): 119–127. Published online 2016 May 20. doi: 10.4049/jimmunol.1401594

PMCID:: PMC5662018

Abstract Article PDF–1.3M

Select item 560982417.

LAG-3 limits regulatory T cell proliferation and function in autoimmune diabetes

Qianxia Zhang, Maria Chikina, Andrea L. Szymczak-Workman, William Horne, Jay K. Kolls, Kate M. Vignali, Daniel Normolle, Maria Bettini, Creg J. Workman, Dario A.A. Vignali

Sci Immunol. Author manuscript; available in PMC 2017 Sep 22.

Published in final edited form as: Sci Immunol. 2017 Mar 31; 2(9): eaah4569. doi: 10.1126/sciimmunol.aah4569

PMCID:: PMC5609824

Abstract Article PDF–923K

Select item 551061518.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S. Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin, Ho Chul Kang, Jianmin Zhang, Jinchong Xu, Rong Chen, Hyejin Park, Shaida A. Andrabi, Sung Ung Kang, Rafaella Araújo Gonçalves, Yu Liang, Shu Zhang, Chen Qi, Sharon Lam, James A. Keiler, Joel Tyson, Donghoon Kim, Nikhil Panicker, Seung Pil Yun, Creg J. Workman, Dario A.A. Vignali, Valina L. Dawson, Han Seok Ko, Ted M. Dawson

Science. Author manuscript; available in PMC 2017 Jul 14.

Published in final edited form as: Science. 2016 Sep 30; 353(6307): aah3374. doi: 10.1126/science.aah3374

PMCID:: PMC5510615

Abstract Article PDF–2.9M

Select item 515970619.

DR3 signaling modulates the function of Foxp3⁺ regulatory T cells and the severity of acute graft-versus-host disease

Hidekazu Nishikii, Byung-Su Kim, Yasuhisa Yokoyama, Yan Chen, Jeanette Baker, Antonio Pierini, Maite Alvarez, Melissa Mavers, Kristina Maas-Bauer, Yuqiong Pan, Shigeru Chiba, Robert S. Negrin

Blood. 2016 Dec 15; 128(24): 2846–2858. Prepublished online 2016 Oct 19. doi: 10.1182/blood-2016-06-723783

PMCID:: PMC5159706

Abstract Article

Select item 487646220.

Gut environment-induced intraepithelial autoreactive CD4⁺ T cells suppress central nervous system autoimmunity via LAG-3

Atsushi Kadowaki, Sachiko Miyake, Ryoko Saga, Asako Chiba, Hideki Mochizuki, Takashi Yamamura

Nat Commun. 2016; 7: 11639. Published online 2016 May 20. doi: 10.1038/ncomms11639

PMCID:: PMC4876462

Abstract Article PDF–2.8M

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