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Items: 1 to 20 of 30

1.
Delineation of metabolic responses of Npc1−/−nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin
Charina M. Ramirez, Anna M. Taylor, Adam M. Lopez, Joyce J. Repa, Stephen D. Turley
Steroids. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Steroids. 2020 Dec; 164: 108725. Published online 2020 Sep 2. doi: 10.1016/j.steroids.2020.108725
PMCID:
PMC7680374
AbstractArticlePDF–939K
2.
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function
Adam M. Lopez, Ryan D. Jones, Joyce J. Repa, Stephen D. Turley
Am J Physiol Gastrointest Liver Physiol. 2018 Oct 1; 315(4): G454–G463. Published online 2018 Jun 7. doi: 10.1152/ajpgi.00124.2018
PMCID:
PMC6230690
AbstractArticle
3.
Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation
Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying Xiong, Shu-Yuan Guo, Hui-Yong Yin, Xu Lin, Qin Li, Catherine CY Chang, Ta-Yuan Chang, Bo-Liang Li, Bao-Liang Song
Nat Cell Biol. Author manuscript; available in PMC 2017 Dec 12.
Published in final edited form as: Nat Cell Biol. 2017 Jul; 19(7): 808–819. Published online 2017 Jun 12. doi: 10.1038/ncb3551
Correction in:
Nat Cell Biol. 2017 Nov 29; 19(12): 1441.
PMCID:
PMC5518634
AbstractArticlePDF–1.3M
4.
Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss
Manya Warrier, Jun Zhang, Kanwardeep Bura, Kathryn Kelley, Martha D. Wilson, Lawrence L. Rudel, J. Mark Brown
Lipids. Author manuscript; available in PMC 2017 Feb 1.
Published in final edited form as: Lipids. 2016 Feb; 51(2): 151–157. Published online 2016 Jan 4. doi: 10.1007/s11745-015-4116-7
PMCID:
PMC5221701
AbstractArticlePDF–316K
5.
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
Wei Yang, Yibing Bai, Ying Xiong, Jin Zhang, Shuokai Chen, Xiaojun Zheng, Xiangbo Meng, Lunyi Li, Jing Wang, Chenguang Xu, Chengsong Yan, Lijuan Wang, Catharine C. Y. Chang, Ta-Yuan Chang, Ti Zhang, Penghui Zhou, Bao-Liang Song, Wanli Liu, Shao-cong Sun, Xiaolong Liu, Bo-liang Li, Chenqi Xu
Nature. Author manuscript; available in PMC 2016 Apr 29.
Published in final edited form as: Nature. 2016 Mar 31; 531(7596): 651–655. Published online 2016 Mar 16. doi: 10.1038/nature17412
PMCID:
PMC4851431
AbstractArticlePDF–4.0M
6.
Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs
Jahangir Iqbal, Mohamed Boutjdir, Lawrence L. Rudel, M. Mahmood Hussain
J Lipid Res. 2014 Nov; 55(11): 2261–2275. doi: 10.1194/jlr.M047951
PMCID:
PMC4617129
AbstractArticlePDF–1.2M
7.
Targeted Knockdown of Hepatic SOAT2 with Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr−/− Mice
John T. Melchior, John D. Olson, Kathryn L. Kelley, Martha D. Wilson, Janet K. Sawyer, Kerry M. Link, Lawrence L. Rudel
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Sep; 35(9): 1920–1927. Published online 2015 Jul 30. doi: 10.1161/ATVBAHA.115.305747
PMCID:
PMC4552612
AbstractArticlePDF–1.2M
8.
Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver
Adam M. Lopez, Kenneth S. Posey, Stephen D. Turley
Biochem Biophys Res Commun. Author manuscript; available in PMC 2015 Nov 7.
Published in final edited form as: Biochem Biophys Res Commun. 2014 Nov 7; 454(1): 162–166. Published online 2014 Oct 18. doi: 10.1016/j.bbrc.2014.10.063
PMCID:
PMC4312202
AbstractArticlePDF–429K
9.
Cholesterol Esters (CE) Derived from Hepatic Sterol O-Acyltransferase 2 (SOAT2) are Associated with More Atherosclerosis than CE from Intestinal SOAT2
Jun Zhang, Janet K. Sawyer, Stephanie M. Marshall, Kathryn L. Kelley, Matthew A. Davis, Martha D. Wilson, J. Mark Brown, Lawrence L. Rudel
Circ Res. Author manuscript; available in PMC 2015 Oct 24.
Published in final edited form as: Circ Res. 2014 Oct 24; 115(10): 826–833. Published online 2014 Sep 19. doi: 10.1161/CIRCRESAHA.115.304378
PMCID:
PMC4209196
AbstractArticlePDF–895K
10.
Acute Sterol O-Acyltransferase 2 (SOAT2) Knockdown Rapidly Mobilizes Hepatic Cholesterol for Fecal Excretion
Stephanie M. Marshall, Anthony D. Gromovsky, Kathryn L. Kelley, Matthew A. Davis, Martha D. Wilson, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Lawrence L. Rudel, J. Mark Brown, Ryan E. Temel
PLoS One. 2014; 9(6): e98953. Published online 2014 Jun 5. doi: 10.1371/journal.pone.0098953
PMCID:
PMC4047063
AbstractArticlePDF–1.2M
11.
Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice
Matteo Pedrelli, Padideh Davoodpour, Chiara Degirolamo, Monica Gomaraschi, Mark Graham, Alice Ossoli, Lilian Larsson, Laura Calabresi, Jan-Åke Gustafsson, Knut R. Steffensen, Mats Eriksson, Paolo Parini
PLoS One. 2014; 9(4): e93552. Published online 2014 Apr 2. doi: 10.1371/journal.pone.0093552
PMCID:
PMC3973598
AbstractArticlePDF–1.7M
12.
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis
John T. Melchior, Janet K. Sawyer, Kathryn L. Kelley, Ramesh Shah, Martha D. Wilson, Roy R. Hantgan, Lawrence L. Rudel
J Lipid Res. 2013 Sep; 54(9): 2495–2503. doi: 10.1194/jlr.M039644
PMCID:
PMC3735946
AbstractArticlePDF–880K
13.
ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation
Tam M. Nguyen, Janet K. Sawyer, Kathryn L. Kelley, Matthew A. Davis, Carol R. Kent, Lawrence L. Rudel
J Lipid Res. 2012 Aug; 53(8): 1598–1609. doi: 10.1194/jlr.M026823
PMCID:
PMC3540850
AbstractArticlePDF–1.1M
14.
Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine
Chang Xie 谢畅, Zhang-Sen Zhou 周章森, Na Li 李钠, Yan Bian 卞艳, Yong-Jian Wang 王永建, Li-Juan Wang 王丽娟, Bo-Liang Li 李伯良, Bao-Liang Song 宋保亮
J Lipid Res. 2012 Oct; 53(10): 2092–2101. doi: 10.1194/jlr.M027359
PMCID:
PMC3435542
AbstractArticlePDF–2.0M
15.
Cellular Pregnenolone Esterification by Acyl-CoA:Cholesterol Acyltransferase
Maximillian A. Rogers, Jay Liu, Mark M. Kushnir, Elena Bryleva, Alan L. Rockwood, A. Wayne Meikle, David Shapiro, Boris L. Vaisman, Alan T. Remaley, Catherine C. Y. Chang, Ta-Yuan Chang
J Biol Chem. 2012 May 18; 287(21): 17483–17492. Published online 2012 Apr 2. doi: 10.1074/jbc.M111.331306
PMCID:
PMC3366839
AbstractArticlePDF–1.7M
16.
Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood
Jun Zhang, Kathryn L. Kelley, Stephanie M. Marshall, Matthew A. Davis, Martha D. Wilson, Janet K. Sawyer, Robert V. Farese, Jr, J. Mark Brown, Lawrence L. Rudel
J Lipid Res. 2012 Jun; 53(6): 1144–1152. doi: 10.1194/jlr.M024356
PMCID:
PMC3351821
AbstractArticlePDF–1.2M
17.
Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation
Tam M. Nguyen, Janet K. Sawyer, Kathryn L. Kelley, Matthew A. Davis, Lawrence L. Rudel
J Lipid Res. 2012 Jan; 53(1): 95–104. doi: 10.1194/jlr.M018820
PMCID:
PMC3243485
AbstractArticlePDF–878K
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
20.
Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1
Stephen D. Turley, Mark A. Valasek, Joyce J. Repa, John M. Dietschy
Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5): G1012–G1022. Published online 2010 Aug 19. doi: 10.1152/ajpgi.00190.2010
PMCID:
PMC2993165
AbstractArticle

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