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Items: 1 to 20 of 35

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Peptidylarginine Deiminase 2 Regulates Expression of DGCR8 Affecting miRNA Biogenesis in Gonadotrope Cells
Brett A. Ralston, Lamia Khan, Stanley B. DeVore, Trent A. Bronnenberg, Joseph W. Flock, Ari O. Sequoia, Paul R. Thompson, Amy M. Navratil, Brian D. Cherrington
Reproduction. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Reproduction. 2023 Aug 1; 166(2): 125–134. Published online 2023 Jul 3. doi: 10.1530/REP-22-0482
PMCID:
PMC10561559
AbstractArticlePDF–1.8M
3.
Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation
Alexandra Cîrciumaru, Marcelo Gomes Afonso, Heidi Wähämaa, Akilan Krishnamurthy, Monika Hansson, Linda Mathsson-Alm, Márton Keszei, Ragnhild Stålesen, Lars Ottosson, Charlotte de Vries, Miriam A. Shelef, Vivianne Malmström, Lars Klareskog, Anca I. Catrina, Caroline Grönwall, Aase Hensvold, Bence Réthi
Biomolecules. 2023 Apr; 13(4): 630. Published online 2023 Mar 31. doi: 10.3390/biom13040630
PMCID:
PMC10135477
AbstractArticlePDF–2.9M
4.
Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells
Noura N. Ballasy, Elizabeth A. Bering, Caroline Kokorudz, Bethany N. Radford, Xiang Zhao, Wendy Dean, Myriam Hemberger
Cells. 2022 Aug; 11(16): 2466. Published online 2022 Aug 9. doi: 10.3390/cells11162466
PMCID:
PMC9406452
AbstractArticlePDF–7.3M
5.
PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis
Bo Sun, Beverly Tomita, Ari Salinger, Ronak R. Tilvawala, Ling Li, Hana Hakami, Tao Liu, Konstantin Tsoyi, Ivan O. Rosas, Dieter P. Reinhardt, Paul R. Thompson, I-Cheng Ho
Matrix Biol. Author manuscript; available in PMC 2022 Aug 1.
Published in final edited form as: Matrix Biol. 2021 Aug; 102: 70–84. Published online 2021 Jul 15. doi: 10.1016/j.matbio.2021.07.001
PMCID:
PMC8502204
AbstractArticlePDF–1.6M
6.
Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis
Yuzi Tian, Shibin Qu, Hasan B. Alam, Aaron M. Williams, Zhenyu Wu, Qiufang Deng, Baihong Pan, Jing Zhou, Baoling Liu, Xiuzhen Duan, Jianjie Ma, Santanu Mondal, Paul R. Thompson, Kathleen A. Stringer, Theodore J. Standiford, Yongqing Li
JCI Insight. 2020 Oct 15; 5(20): e138873. Published online 2020 Oct 15. doi: 10.1172/jci.insight.138873
PMCID:
PMC7605547
AbstractArticlePDF–5.9M
7.
Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-induced Endotoxic Shock
Zhenyu Wu, Qiufang Deng, Baihong Pan, Hasan B. Alam, Yuzi Tian, Umar F. Bhatti, Baoling Liu, Santanu Mondal, Paul R. Thompson, Yongqing Li
Inflammation. Author manuscript; available in PMC 2021 Aug 1.
Published in final edited form as: Inflammation. 2020 Aug; 43(4): 1436–1445. doi: 10.1007/s10753-020-01221-0
PMCID:
PMC7384922
AbstractArticlePDF–743K
8.
Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination
Bo Sun, Hui-Hsin Chang, Ari Salinger, Beverly Tomita, Mandar Bawadekar, Caitlyn L. Holmes, Miriam A. Shelef, Eranthie Weerapana, Paul R. Thompson, I-Cheng Ho
JCI Insight. 2019 Nov 14; 4(22): e129687. Published online 2019 Nov 14. doi: 10.1172/jci.insight.129687
PMCID:
PMC6948856
AbstractArticlePDF–9.3M
9.
PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination
Ana Mendanha Falcão, Mandy Meijer, Antonella Scaglione, Puneet Rinwa, Eneritz Agirre, Jialiang Liang, Sara C. Larsen, Abeer Heskol, Rebecca Frawley, Michael Klingener, Manuel Varas-Godoy, Alexandre A.S.F. Raposo, Patrik Ernfors, Diogo S. Castro, Michael L. Nielsen, Patrizia Casaccia, Gonçalo Castelo-Branco
Cell Rep. 2019 Apr 23; 27(4): 1090–1102.e10. Published online 2019 Apr 23. doi: 10.1016/j.celrep.2019.03.108
PMCID:
PMC6486480
AbstractArticle
10.
Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT−/− mouse model of preeclampsia
Shutan Liao, Hao Wu, Ruiying Chen
Clin Hypertens. 2018; 24: 11. Published online 2018 Sep 15. doi: 10.1186/s40885-018-0097-1
PMCID:
PMC6138905
AbstractArticlePDF–1.0M
11.
Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development
Atsumi Tsuji-Hosokawa, Kenichi Kashimada, Tomoko Kato, Yuya Ogawa, Risa Nomura, Kei Takasawa, Rowena Lavery, Andrea Coschiera, David Schlessinger, Vincent R. Harley, Shuji Takada, Tomohiro Morio
Sci Rep. 2018; 8: 13263. Published online 2018 Sep 5. doi: 10.1038/s41598-018-31376-8
PMCID:
PMC6125343
AbstractArticlePDF–1.7M
12.
STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1α activation
Dongyao Yan, Hao-Wei Wang, Robert L. Bowman, Johanna A. Joyce
Cell Rep. Author manuscript; available in PMC 2017 Aug 16.
Published in final edited form as: Cell Rep. 2016 Sep 13; 16(11): 2914–2927. doi: 10.1016/j.celrep.2016.08.035
PMCID:
PMC5559199
AbstractArticlePDF–1.0M
13.
Identification of Padi2 as a novel angiogenesis-regulating gene by genome association studies in mice
Mehrdad Khajavi, Yi Zhou, Amy E. Birsner, Lauren Bazinet, Amanda Rosa Di Sant, Alex J. Schiffer, Michael S. Rogers, Subrahmanian Tarakkad Krishnaji, Bella Hu, Vy Nguyen, Leonard Zon, Robert J. D’Amato
PLoS Genet. 2017 Jun; 13(6): e1006848. Published online 2017 Jun 15. doi: 10.1371/journal.pgen.1006848
PMCID:
PMC5491319
AbstractArticlePDF–12M
14.
Peptidylarginine Deiminase 2 is Required for Tumor Necrosis Factor Alpha-Induced Citrullination and Arthritis, but Not Neutrophil Extracellular Trap Formation
Mandar Bawadekar, Daeun Shim, Chad J. Johnson, Thomas F. Warner, Ryan Rebernick, Dres Damgaard, Claus H. Nielsen, Ger J. M. Pruijn, Jeniel E. Nett, Miriam A. Shelef
J Autoimmun. Author manuscript; available in PMC 2018 Jun 1.
Published in final edited form as: J Autoimmun. 2017 Jun; 80: 39–47. Published online 2017 Feb 7. doi: 10.1016/j.jaut.2017.01.006
PMCID:
PMC5422119
AbstractArticlePDF–1.2M
15.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
16.
Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development
Xiaoqian Zhang, Xiaoqiu Liu, Mei Zhang, Tingting Li, Aaron Muth, Paul R. Thompson, Scott A. Coonrod, Xuesen Zhang
Sci Rep. 2016; 6: 38727. Published online 2016 Dec 8. doi: 10.1038/srep38727
PMCID:
PMC5144008
AbstractArticlePDF–1.5M
17.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
18.
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates
Jeremy A. Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A. Dalley, Sheila Shapouri, Kimberly A. Smith, Susan M. Sunkin, Amy Bernard, Jeffrey L. Bennett, Chang-Kyu Lee, Michael J. Hawrylycz, Allan R. Jones, David G. Amaral, Nenad Sestan, Fred H. Gage, Ed S. Lein
Development. 2013 Nov 15; 140(22): 4633–4644. doi: 10.1242/dev.097212
PMCID:
PMC3817946
AbstractArticle
19.
Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis
Mario A. Moscarello, Helena Lei, Fabrizio G. Mastronardi, Shawn Winer, Hubert Tsui, Zhen Li, Cameron Ackerley, Li Zhang, Reinout Raijmakers, D. Denise Wood
Dis Model Mech. 2013 Mar; 6(2): 467–478. Published online 2012 Nov 1. doi: 10.1242/dmm.010520
PMCID:
PMC3597028
AbstractArticle
20.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M

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