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Items: 1 to 20 of 139

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Conditional knockout of REST/NRSF in excitatory neurons reduces seizure susceptibility to chemical kindling
Giulia Natali, Caterina Michetti, Alicja Krawczun-Rygmaczewska, Thomas Floss, Fabrizia Cesca, Fabio Benfenati
Front Cell Neurosci. 2023; 17: 1267609. Published online 2023 Nov 16. doi: 10.3389/fncel.2023.1267609
PMCID:
PMC10687554
AbstractArticlePDF–2.1M
3.
A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease
Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner
Nat Commun. 2023; 14: 7030. Published online 2023 Nov 2. doi: 10.1038/s41467-023-42704-6
PMCID:
PMC10622455
AbstractArticlePDF–3.5M
4.
CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis
Janardhan Keshav Karapurkar, Min-Seong Kim, Jencia Carminha Colaco, Bharathi Suresh, Neha Sarodaya, Dong-Ho Kim, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna
J Exp Clin Cancer Res. 2023; 42: 121. Published online 2023 May 12. doi: 10.1186/s13046-023-02694-1
PMCID:
PMC10176696
AbstractArticlePDF–11M
5.
TGF-β2 Regulates Transcription of the K+/Cl− Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons
Anastasia Rigkou, Attila Magyar, Jan Manuel Speer, Eleni Roussa
Cells. 2022 Dec; 11(23): 3861. Published online 2022 Nov 30. doi: 10.3390/cells11233861
PMCID:
PMC9739967
AbstractArticlePDF–3.4M
6.
Mapping Brain Gene Coexpression in Daytime Transcriptomes Unveils Diurnal Molecular Networks and Deciphers Perturbation Gene Signatures
Nan Wang, Peter Langfelder, Matthew Stricos, Lalini Ramanathan, Jeffrey B. Richman, Raymond Vaca, Mary Plascencia, Xiaofeng Gu, Shasha Zhang, T. Katherine Tamai, Liguo Zhang, Fuying Gao, Koliane Ouk, Xiang Lu, Leonya Ivanov, Tom Vogt, Qing Richard Lu, A. Jennifer Morton, Christopher Colwell, Jeffrey S. Aaronson, Jim Rosinski, Steve Horvath, X. William Yang
Neuron. Author manuscript; available in PMC 2023 Oct 19.
Published in final edited form as: Neuron. 2022 Oct 19; 110(20): 3318–3338.e9. doi: 10.1016/j.neuron.2022.09.028
PMCID:
PMC9665885
AbstractArticlePDF–4.5M
7.
Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis
Ashley S. Cloud, Faezeh Koohestani, Michelle M. McWilliams, Sornakala Ganeshkumar, Sumedha Gunewardena, Amanda Graham, Warren B. Nothnick, Vargheese M. Chennathukuzhi
Proc Natl Acad Sci U S A. 2022 Nov 1; 119(44): e2205524119. Published online 2022 Oct 25. doi: 10.1073/pnas.2205524119
PMCID:
PMC9636955
AbstractArticlePDF–2.0M
8.
PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes
Tomi Tuomainen, Nikolay Naumenko, Maija Mutikainen, Anastasia Shakirzyanova, Sarah Sczelecki, Jennifer L. Estall, Jorge L. Ruas, Pasi Tavi
Cells. 2022 Oct; 11(19): 2944. Published online 2022 Sep 20. doi: 10.3390/cells11192944
PMCID:
PMC9564192
AbstractArticlePDF–3.2M
9.
The transcriptional coactivator Eya1 exerts transcriptional repressive activity by interacting with REST corepressors and REST-binding sequences to maintain nephron progenitor identity
Jun Li, Chunming Cheng, Jinshu Xu, Ting Zhang, Bengu Tokat, Georgia Dolios, Aarthi Ramakrishnan, Li Shen, Rong Wang, Pin-Xian Xu
Nucleic Acids Res. 2022 Oct 14; 50(18): 10343–10359. Published online 2022 Sep 21. doi: 10.1093/nar/gkac760
PMCID:
PMC9561260
AbstractArticlePDF–9.9M
10.
Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through Kv7.4 channel upsurge in auditory neurons and hair cells
Haiwei Zhang, Hongchen Li, Mingshun Lu, Shengnan Wang, Xueya Ma, Fei Wang, Jiaxi Liu, Xinyu Li, Haichao Yang, Fan Zhang, Haitao Shen, Noel J Buckley, Nikita Gamper, Ebenezer N Yamoah, Ping Lv
eLife. 2022; 11: e76754. Published online 2022 Sep 20. doi: 10.7554/eLife.76754
PMCID:
PMC9525063
AbstractArticlePDF–21M
11.
Deletion of RE1-silencing transcription factor in striatal astrocytes exacerbates manganese-induced neurotoxicity in mice
Edward Pajarillo, Mark Demayo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son, Michael Aschner, Eunsook Lee
Glia. Author manuscript; available in PMC 2023 Oct 1.
Published in final edited form as: Glia. 2022 Oct; 70(10): 1886–1901. Published online 2022 May 31. doi: 10.1002/glia.24226
PMCID:
PMC9378447
AbstractArticlePDF–1.6M
12.
Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia
Linda Su-Feher, Anna N. Rubin, Shanni N. Silberberg, Rinaldo Catta-Preta, Kenneth J. Lim, Athena R. Ypsilanti, Iva Zdilar, Christopher S. McGinnis, Gabriel L. McKinsey, Thomas E. Rubino, Jr., Michael J. Hawrylycz, Carol Thompson, Zev J. Gartner, Luis Puelles, Hongkui Zeng, John L. R. Rubenstein, Alex S. Nord
Proc Natl Acad Sci U S A. 2022 Apr 12; 119(15): e2108760119. Published online 2022 Apr 4. doi: 10.1073/pnas.2108760119
PMCID:
PMC9169651
AbstractArticlePDF–3.9M
13.
A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs
Yan Ting Shue, Alexandros P. Drainas, Nancy Yanzhe Li, Sarah M. Pearsall, Derrick Morgan, Nasa Sinnott-Armstrong, Susan Q. Hipkins, Garry L. Coles, Jing Shan Lim, Anthony E. Oro, Kathryn L. Simpson, Caroline Dive, Julien Sage
Nat Commun. 2022; 13: 2690. Published online 2022 May 16. doi: 10.1038/s41467-022-30416-2
PMCID:
PMC9110333
AbstractArticlePDF–7.0M
14.
Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway
Hongchen Li, Mingshun Lu, Haiwei Zhang, Shengnan Wang, Fei Wang, Xueya Ma, Jiaxi Liu, Xinyu Li, Haichao Yang, Haitao Shen, Ping Lv
Cell Death Dis. 2022 Apr; 13(4): 343. Published online 2022 Apr 13. doi: 10.1038/s41419-022-04774-0
PMCID:
PMC9007975
AbstractArticlePDF–8.0M
15.
Mutation of the murine Prickle1 (R104Q) causes phenotypes analogous to human symptoms of epilepsy and autism
Yue Ban, Ting Yu, Jingyi Wang, Xiaojia Wang, Can Liu, Clayton Baker, Yimin Zou
Exp Neurol. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Exp Neurol. 2022 Jan; 347: 113880. Published online 2021 Sep 28. doi: 10.1016/j.expneurol.2021.113880
PMCID:
PMC8718102
AbstractArticlePDF–2.1M
16.
REST and Stress Resistance in the Aging Kidney
Sato Magassa, Liviu Aron, Clément Hoguin, Pierre Isnard, Fabiola Terzi, Christophe Legendre, Bruce A. Yankner, Guillaume Canaud
J Am Soc Nephrol. 2021 Aug; 32(8): 1974–1986. Published online 2021 Aug. doi: 10.1681/ASN.2021020231
PMCID:
PMC8455262
AbstractArticle
17.
REST is a major negative regulator of endocrine differentiation during pancreas organogenesis
Meritxell Rovira, Goutham Atla, Miguel Angel Maestro, Vane Grau, Javier García-Hurtado, Maria Maqueda, Jose Luis Mosquera, Yasuhiro Yamada, Julie Kerr-Conte, Francois Pattou, Jorge Ferrer
Genes Dev. 2021 Sep 1; 35(17-18): 1229–1242. doi: 10.1101/gad.348501.121
PMCID:
PMC8415321
AbstractArticlePDF–7.3M
18.
The Genome-Wide Binding Profile for Human RE1 Silencing Transcription Factor Unveils a Unique Genetic Circuitry in Hippocampus
James C. McGann, Michael A. Spinner, Saurabh K. Garg, Karin A. Mullendorff, Randall L. Woltjer, Gail Mandel
J Neurosci. 2021 Aug 4; 41(31): 6582–6595. doi: 10.1523/JNEUROSCI.2059-20.2021
PMCID:
PMC8336698
AbstractArticlePDF–3.3M
19.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
20.
Mechanism of REST/NRSF regulation of clustered protocadherin α genes
Yuanxiao Tang, Zhilian Jia, Honglin Xu, Lin-tai Da, Qiang Wu
Nucleic Acids Res. 2021 May 7; 49(8): 4506–4521. Published online 2021 Apr 13. doi: 10.1093/nar/gkab248
PMCID:
PMC8096226
AbstractArticlePDF–4.6M

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