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Select item 114940481.

Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway

Hongshuang Wang, Ziheng Wei, Chang Xu, Fang Fang, Zheng Wang, Yan Zhong, Xiangting Wang

Sci Rep. 2024; 14: 24787. Published online 2024 Oct 21. doi: 10.1038/s41598-024-76219-x

PMCID:: PMC11494048

Abstract Article PDF–12M

Select item 114367942.

Nur77 protects the bladder urothelium from intracellular bacterial infection

Christina A. Collins, Chevaughn Waller, Ekaterina Batourina, Lokesh Kumar, Cathy L. Mendelsohn, Nicole M. Gilbert

Nat Commun. 2024; 15: 8308. Published online 2024 Sep 27. doi: 10.1038/s41467-024-52454-8

PMCID:: PMC11436794

Abstract Article PDF–2.8M

Select item 113804513.

Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy

Junyan Wang, Haowen Zhuang, Lianqun Jia, Xinyong He, Sicheng Zheng, Kangshou Ji, Kang Xie, Tong Ying, Ying Zhang, Chun Li, Xing Chang

Int J Biol Sci. 2024; 20(11): 4458–4475. Published online 2024 Aug 19. doi: 10.7150/ijbs.95853

PMCID:: PMC11380451

Abstract Article PDF–12M

Select item 110954314.

Progressive reduction of nuclear receptor Nr4a1 mediates age‐dependent cognitive decline

Jiang Chen, Zhi Zhang, Ying Liu, Lili Huang, Yi Liu, Dan Yang, Xinyu Bao, Pinyi Liu, Yuhan Ge, Qingqing Li, Xin Shu, Lushan Xu, Yun Stone Shi, Xiaolei Zhu, Yun Xu

Alzheimers Dement. 2024 May; 20(5): 3504–3524. Published online 2024 Apr 11. doi: 10.1002/alz.13819

PMCID:: PMC11095431

Abstract Article PDF–11M

Select item 109572225.

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

Weiwei Shi, Tiffany J. Cassmann, Aditya Vijay Bhagwate, Taro Hitosugi, W.K. Eddie Ip

Cell Rep. Author manuscript; available in PMC 2024 Mar 21.

Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113746. Published online 2024 Feb 7. doi: 10.1016/j.celrep.2024.113746

PMCID:: PMC10957222

Abstract Article PDF–3.3M

Select item 108447456.

Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways

Lin Lu, Soohwa Jang, Jiaqi Zhu, Qing Qin, Lijun Sun, Jianxin Sun

Redox Biol. 2024 Apr; 70: 103056. Published online 2024 Jan 24. doi: 10.1016/j.redox.2024.103056

PMCID:: PMC10844745

Abstract Article PDF–6.1M

Select item 107539517.

Gut Commensal Segmented Filamentous Bacteria Fine-Tune T Follicular Regulatory Cells to Modify the Severity of Systemic Autoimmune Arthritis

Nicholas A. Bates, Anna Li, Tingting Fan, Madeline P. Cutcliffe, Caitlyn B. Dagenet, Kiah C. Sleiman, Heqing Ma, Shekha Tahsin, Candace S. Garrett, Jesse Altemus, Hsin-Jung Joyce Wu

J Immunol. Author manuscript; available in PMC 2023 Dec 28.

Published in final edited form as: J Immunol. 2021 Mar 1; 206(5): 941–952. Published online 2021 Jan 18. doi: 10.4049/jimmunol.2000663

PMCID:: PMC10753951

Abstract Article PDF–2.4M

Select item 107028378.

Trained immunity induced by high‐salt diet impedes stroke recovery

Tze‐Yen Lin, Danye Jiang, Wan‐Ru Chen, Jhih Syuan Lin, Xin‐Yu Zhang, Chih‐Hung Chen, Chia‐Lang Hsu, Liang‐Chuan Lai, Ping‐Hung Chen, Kai‐Chien Yang, Lauren H Sansing, Che‐Feng Chang

EMBO Rep. 2023 Dec; 24(12): e57164. Published online 2023 Nov 15. doi: 10.15252/embr.202357164

PMCID:: PMC10702837

Abstract Article PDF–39M

Select item 105881169.

NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration

Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman, Jeremy A. Lavine

J Neuroinflammation. 2023; 20: 238. Published online 2023 Oct 19. doi: 10.1186/s12974-023-02928-1

PMCID:: PMC10588116

Abstract Article PDF–7.4M

Select item 1057629010.

Nr4a1 marks a distinctive ILC2 activation subset in the mouse inflammatory lung

Shasha Xu, Yu Zhang, Xingjie Liu, Huisheng Liu, Xinya Zou, Linlin Zhang, Jing Wang, Zhiwei Zhang, Xiang Xu, Mingxia Li, Kairui Li, Shuyue Shi, Ying Zhang, Zhichao Miao, Jie Zha, Yong Yu

BMC Biol. 2023; 21: 218. Published online 2023 Oct 13. doi: 10.1186/s12915-023-01690-3

PMCID:: PMC10576290

Abstract Article PDF–14M

Select item 1050379411.

Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion

Yunfeng Liu, Shan Su, Sarah Shayo, Weili Bao, Mouli Pal, Kai Dou, Patricia A. Shi, Banu Aygun, Sally Campbell-Lee, Cheryl A. Lobo, Avital Mendelson, Xiuli An, Deepa Manwani, Hui Zhong, Karina Yazdanbakhsh

J Clin Invest. 2023 Sep 15; 133(18): e172087. Published online 2023 Sep 15. doi: 10.1172/JCI172087

PMCID:: PMC10503794

Abstract Article PDF–4.1M

Select item 1036531412.

Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization

Pinyi Liu, Yan Chen, Zhi Zhang, Zengqiang Yuan, Jian-Guang Sun, Shengnan Xia, Xiang Cao, Jian Chen, Cun-Jin Zhang, Yanting Chen, Hui Zhan, Yuexinzi Jin, Xinyu Bao, Yue Gu, Meijuan Zhang, Yun Xu

PLoS Biol. 2023 Jul; 21(7): e3002199. Published online 2023 Jul 24. doi: 10.1371/journal.pbio.3002199

PMCID:: PMC10365314

Abstract Article PDF–3.9M

Select item 1028349913.

Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis

Qian Zhang, Yun Huang, Chenchen Gong, Yan Tang, Jie Xiong, Difen Wang, Xu Liu

Immun Inflamm Dis. 2023 Jun; 11(6): e883. Published online 2023 Jun 21. doi: 10.1002/iid3.883

PMCID:: PMC10283499

Abstract Article PDF–2.3M

Select item 1019323114.

Alternatively activated lung alveolar and interstitial macrophages promote fungal growth

Ashley B. Strickland, Yanli Chen, Donglei Sun, Meiqing Shi

iScience. 2023 May 19; 26(5): 106717. Published online 2023 Apr 23. doi: 10.1016/j.isci.2023.106717

PMCID:: PMC10193231

Abstract Article PDF–6.1M

Select item 1018660615.

Oxidative stress impairs the Nur77‐Sirt1 axis resulting in a decline in organism homeostasis during aging

Yang Yu, Xiaoyu Song, Xiaoxun Wang, Lixia Zheng, Guojing Ma, Weiwei Liu, Han Su, Xiyan Liu, Tingting Liu, Liu Cao, Difei Wang

Aging Cell. 2023 May; 22(5): e13812. Published online 2023 Mar 7. doi: 10.1111/acel.13812

PMCID:: PMC10186606

Abstract Article PDF–43M

Select item 1016945216.

Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation

Yilin Tao, Chengyuan Tang, Ju Wei, Yi Shan, Xi Fang, Ying Li

Mol Med. 2023; 29: 63. Published online 2023 May 9. doi: 10.1186/s10020-023-00657-y

PMCID:: PMC10169452

Abstract Article PDF–2.3M

Select item 1015421117.

MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation

Domien Vanneste, Qiang Bai, Shakir Hasan, Wen Peng, Dimitri Pirottin, Joey Schyns, Pauline Maréchal, Cecilia Ruscitti, Margot Meunier, Zhaoyuan Liu, Céline Legrand, Laurence Fievez, Florent Ginhoux, Coraline Radermecker, Fabrice Bureau, Thomas Marichal

Nat Immunol. 2023; 24(5): 827–840. Published online 2023 Mar 16. doi: 10.1038/s41590-023-01468-3

PMCID:: PMC10154211

Abstract Article PDF–12M

Select item 1006754118.

Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes

Stephan Culemann, Katharina Knab, Maximilien Euler, Anja Wegner, Hilal Garibagaoglu, Jochen Ackermann, Kim Fischer, Deborah Kienhöfer, Georgiana Crainiciuc, Jonas Hahn, Anika Grüneboom, Falk Nimmerjahn, Stefan Uderhardt, Andrés Hidalgo, Georg Schett, Markus H. Hoffmann, Gerhard Krönke

J Exp Med. 2023 Jun 5; 220(6): e20220525. Published online 2023 Mar 28. doi: 10.1084/jem.20220525

PMCID:: PMC10067541

Abstract Article PDF–4.4M

Select item 989095719.

Nr4a1-dependent non-classical monocytes are important for macrophage-mediated wound healing in the large intestine

Karin Heidbreder, Katrin Sommer, Maximilian Wiendl, Tanja M. Müller, Imke Atreya, Kai Hildner, Markus F. Neurath, Sebastian Zundler

Front Immunol. 2022; 13: 1040775. Published online 2023 Jan 18. doi: 10.3389/fimmu.2022.1040775

PMCID:: PMC9890957

Abstract Article PDF–4.9M

Select item 984122920.

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice

Xinyu Cai, Yue Jiang, Zhiwen Cao, Mei Zhang, Na Kong, Lina Yu, Yedong Tang, Shuangbo Kong, Wenbo Deng, Haibin Wang, Jianxin Sun, Lijun Ding, Ruiwei Jiang, Haixiang Sun, Guijun Yan

eBioMedicine. 2023 Feb; 88: 104433. Published online 2023 Jan 7. doi: 10.1016/j.ebiom.2022.104433