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Select item 105676411.

Hydrogen‐rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR‐124‐3p

Xiaofei Xue, Wang Xi, Wei Li, Jian Xiao, Zhinong Wang, Yufeng Zhang

ESC Heart Fail. 2023 Oct; 10(5): 3077–3090. Published online 2023 Aug 21. doi: 10.1002/ehf2.14492

PMCID:: PMC10567641

Abstract Article PDF–3.2M

Select item 100389922.

Calpain activity is negatively regulated by a KCTD7–Cullin-3 complex via non-degradative ubiquitination

Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello

Cell Discov. 2023; 9: 32. Published online 2023 Mar 24. doi: 10.1038/s41421-023-00533-3

PMCID:: PMC10038992

Abstract Article PDF–15M

Select item 97246573.

The AAA‐ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle

Dina Aweida, Shenhav Cohen

EMBO Rep. 2022 Dec; 23(12): e55175. Published online 2022 Oct 24. doi: 10.15252/embr.202255175

PMCID:: PMC9724657

Abstract Article PDF–3.0M

Select item 94447984.

Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion

Ting Cao, Shuai Fan, Dong Zheng, Grace Wang, Yong Yu, Ruizhen Chen, Long-Sheng Song, Guo-Chang Fan, Zhuxu Zhang, Tianqing Peng

Basic Res Cardiol. Author manuscript; available in PMC 2022 Sep 6.

Published in final edited form as: Basic Res Cardiol. 2019 Mar 15; 114(3): 17. Published online 2019 Mar 15. doi: 10.1007/s00395-019-0726-1

PMCID:: PMC9444798

Abstract Article PDF–1.8M

Select item 92334395.

Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang, Chien-Yu Lin, Yu-Mei Lin, Luc Buée, Nicolas Sergeant, David Blum, Yijuang Chern, Guey-Shin Wang

J Neurosci. 2022 Jun 22; 42(25): 5102–5114. doi: 10.1523/JNEUROSCI.2006-21.2022

PMCID:: PMC9233439

Abstract Article PDF–3.5M

Select item 90978386.

Calpain‐1 mediates vascular remodelling and fibrosis via HIF‐1α in hypoxia‐induced pulmonary hypertension

Haiyan Deng, Xiaoxue Tian, Hening Sun, Huan Liu, Meili Lu, Hongxin Wang

J Cell Mol Med. 2022 May; 26(10): 2819–2830. Published online 2022 Apr 1. doi: 10.1111/jcmm.17295

PMCID:: PMC9097838

Abstract Article PDF–12M

Select item 89361937.

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

Stephen P. Chelko, Gizem Keceli, Andrea Carpi, Nunzianna Doti, Jacopo Agrimi, Angeliki Asimaki, Carlos Bueno Beti, Matthew Miyamoto, Nuria Amat-Codina, Djahida Bedja, An-Chi Wei, Brittney Murray, Crystal Tichnell, Chulan Kwon, Hugh Calkins, Cynthia A. James, Brian O’Rourke, Marc K. Halushka, Edon Melloni, Jeffrey E. Saffitz, Daniel P. Judge, Menotti Ruvo, Richard N. Kitsis, Peter Andersen, Fabio Di Lisa, Nazareno Paolocci

Sci Transl Med. Author manuscript; available in PMC 2022 Mar 21.

Published in final edited form as: Sci Transl Med. 2021 Feb 17; 13(581): eabf0891. doi: 10.1126/scitranslmed.abf0891

PMCID:: PMC8936193

Abstract Article PDF–3.6M

Select item 87332328.

The mitochondrial protease LONP1 maintains oocyte development and survival by suppressing nuclear translocation of AIFM1 in mammals

Xiaoqiang Sheng, Chuanming Liu, Guijun Yan, Guangyu Li, Jingyu Liu, Yanjun Yang, Shiyuan Li, Zhongxun Li, Jidong Zhou, Xin Zhen, Yang Zhang, Zhenyu Diao, Yali Hu, Chuanhai Fu, Bin Yao, Chaojun Li, Yu Cao, Bin Lu, Zhongzhou Yang, Yingying Qin, Haixiang Sun, Lijun Ding

EBioMedicine. 2022 Jan; 75: 103790. Published online 2021 Dec 30. doi: 10.1016/j.ebiom.2021.103790

PMCID:: PMC8733232

Abstract Article PDF–4.2M

Select item 85792429.

Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy

Aicha Saadane, Yunpeng Du, Wallace B. Thoreson, Masaru Miyagi, Emma M. Lessieur, Jianying Kiser, Xiangyi Wen, Bruce A. Berkowitz, Timothy S. Kern

Am J Pathol. 2021 Oct; 191(10): 1805–1821. doi: 10.1016/j.ajpath.2021.06.006

PMCID:: PMC8579242

Abstract Article PDF–2.9M

Select item 833573710.

miR-140-5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1

Qiwen Yu, Sanyang Chen, Hongwei Tang, Han Yang, Jiakai Zhang, Xiaoyi Shi, Jie Li, Wenzhi Guo, Shuijun Zhang

Mol Med Rep. 2021 Sep; 24(3): 675. Published online 2021 Jul 22. doi: 10.3892/mmr.2021.12314

PMCID:: PMC8335737

Abstract Article PDF–3.1M

Select item 805844411.

Exosome-mediated improvement in membrane integrity and muscle function in dystrophic mice

Ling Leng, Xue Dong, Xianjun Gao, Ning Ran, Mengyuan Geng, Bingfeng Zuo, Yingjie Wu, Wei Li, Hua Yan, Gang Han, HaiFang Yin

Mol Ther. 2021 Apr 7; 29(4): 1459–1470. Published online 2020 Dec 15. doi: 10.1016/j.ymthe.2020.12.018

PMCID:: PMC8058444

Abstract Article PDF–4.1M

Select item 793877012.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 771694413.

Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes

Anastasia Kyselova, Amro Elgheznawy, Ilka Wittig, Juliana Heidler, Alexander W. Mann, Wolfram Ruf, Ingrid Fleming, Voahanginirina Randriamboavonjy

Basic Res Cardiol. 2020; 115(6): 75. Published online 2020 Dec 1. doi: 10.1007/s00395-020-00833-9

PMCID:: PMC7716944

Abstract Article PDF–8.5M

Select item 723606014.

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell

iScience. 2020 May 22; 23(5): 101132. Published online 2020 May 1. doi: 10.1016/j.isci.2020.101132

PMCID:: PMC7236060

Abstract Article PDF–6.1M

Select item 715837515.

Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease

Jonasz J Weber, Eva Haas, Yacine Maringer, Stefan Hauser, Nicolas L P Casadei, Athar H Chishti, Olaf Riess, Jeannette Hübener-Schmid

Hum Mol Genet. 2020 Apr 15; 29(6): 892–906. Published online 2020 Jan 21. doi: 10.1093/hmg/ddaa010

PMCID:: PMC7158375

Abstract Article PDF–1.5M

Select item 681582516.

MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition

Lichun Guan, Zhimei Che, Xiangdong Meng, Yong Yu, Minghui Li, Ziqin Yu, Hui Shi, Dicheng Yang, Min Yu

J Cell Mol Med. 2019 Nov; 23(11): 7830–7843. Published online 2019 Sep 9. doi: 10.1111/jcmm.14662

PMCID:: PMC6815825

Abstract Article PDF–2.3M

Select item 667182117.

Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

Catherine M. Cowan, Mannie M. Y. Fan, Jing Fan, Jacqueline Shehadeh, Lily Y. J. Zhang, Rona K. Graham, Michael R. Hayden, Lynn A. Raymond

J Neurosci. 2008 Nov 26; 28(48): 12725–12735. doi: 10.1523/JNEUROSCI.4619-08.2008

PMCID:: PMC6671821

Abstract Article PDF–700K

Select item 667123718.

Spatial Learning Impairment, Enhanced CDK5/p35 Activity, and Downregulation of NMDA Receptor Expression in Transgenic Mice Expressing Tau-Tubulin Kinase 1

Shinji Sato, Jiqing Xu, Satoshi Okuyama, Lindsey B. Martinez, Shannon M. Walsh, Michael T. Jacobsen, Russell J. Swan, Joshua D. Schlautman, Pawel Ciborowski, Tsuneya Ikezu

J Neurosci. 2008 Dec 31; 28(53): 14511–14521. doi: 10.1523/JNEUROSCI.3417-08.2008

PMCID:: PMC6671237

Abstract Article PDF–709K

Select item 662376319.

Bax and Calpain Mediate Excitotoxic Oligodendrocyte Death Induced by Activation of Both AMPA and Kainate Receptors

María Victoria Sánchez-Gómez, Elena Alberdi, Esther Pérez-Navarro, Jordi Alberch, Carlos Matute

J Neurosci. 2011 Feb 23; 31(8): 2996–3006. doi: 10.1523/JNEUROSCI.5578-10.2011

PMCID:: PMC6623763

Abstract Article PDF–1.7M

Select item 659666820.

Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity

Kaori Sugiyama, Tomomi Aida, Masatoshi Nomura, Ryoichi Takayanagi, Hanns U. Zeilhofer, Kohichi Tanaka

J Neurosci. 2017 Sep 6; 37(36): 8830–8844. doi: 10.1523/JNEUROSCI.0730-17.2017

PMCID:: PMC6596668

Abstract Article PDF–4.9M

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