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Items: 1 to 20 of 26

1.
Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice
Ying Zhi, Kerui Fan, Shuang Liu, Kai Hu, Xinyan Zan, Ling Lin, Yongqiang Yang, Xianqiong Gong, Kun Chen, Li Tang, Longjiang Li, Jiayi Huang, Shujun Zhang, Li Zhang
Mol Med. 2024; 30: 99. Published online 2024 Jul 9. doi: 10.1186/s10020-024-00867-y
PMCID:
PMC11234765
AbstractArticlePDF–13M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Lack of HCAR1, the lactate GPCR, signaling promotes autistic-like behavior
Mohammad Ali Mohammad Nezhady, Gael Cagnone, Jean-Sébastien Joyal, Sylvain Chemtob
Cell Commun Signal. 2023; 21: 196. Published online 2023 Nov 9. doi: 10.1186/s12964-023-01188-z
PMCID:
PMC10634184
AbstractArticlePDF–3.3M
4.
Lactate secreted via MCT4 from bone-colonizing breast cancer excites sensory neurons via GPR81
Tatsuo Okui, Masahiro Hiasa, Kazuaki Hasegawa, Tomoya Nakamura, Kisho Ono, Soichiro Ibaragi, Takahiro Kanno, Akira Sasaki, Toshiyuki Yoneda
Int J Oncol. 2023 Mar; 62(3): 39. Published online 2023 Feb 8. doi: 10.3892/ijo.2023.5487
PMCID:
PMC9946803
AbstractArticlePDF–5.2M
5.
Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue
Marc Briquet, Anne-Bérengère Rocher, Maxime Alessandri, Nadia Rosenberg, Haissa de Castro Abrantes, Joel Wellbourne-Wood, Céline Schmuziger, Vanessa Ginet, Julien Puyal, Etienne Pralong, Roy Thomas Daniel, Stefan Offermanns, Jean-Yves Chatton
J Cereb Blood Flow Metab. 2022 Sep; 42(9): 1650–1665. Published online 2022 Mar 3. doi: 10.1177/0271678X221080324
PMCID:
PMC9441721
AbstractArticlePDF–1.3M
6.
Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice
Hyeon-Young Min, Jiyeon Hwang, Yuna Choi, Young-Hwan Jo
Am J Physiol Endocrinol Metab. 2022 Sep 1; 323(3): E231–E241. Published online 2022 Jul 13. doi: 10.1152/ajpendo.00084.2022
PMCID:
PMC9423771
AbstractArticle
7.
Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia
Lauritz Kennedy, Emilie R Glesaaen, Vuk Palibrk, Marco Pannone, Wei Wang, Ali Al-Jabri, Rajikala Suganthan, Niklas Meyer, Marie Landa Austbø, Xiaolin Lin, Linda H Bergersen, Magnar Bjørås, Johanne E Rinholm
eLife. 2022; 11: e76451. Published online 2022 Aug 9. doi: 10.7554/eLife.76451
PMCID:
PMC9363115
AbstractArticlePDF–4.3M
8.
Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult
Prabhas Chaudhari, Ankush Madaan, José Carlos Rivera, Iness Charfi, Tiffany Habelrih, Xin Hou, Mohammad Nezhady, Gregory Lodygensky, Graciela Pineyro, Thierry Muanza, Sylvain Chemtob
J Cereb Blood Flow Metab. 2022 Jul; 42(7): 1294–1308. Published online 2022 Feb 2. doi: 10.1177/0271678X221077499
PMCID:
PMC9207492
AbstractArticlePDF–1.9M
9.
Lactate activates hypothalamic POMC neurons by intercellular signaling
P. Órdenes, P. S. Villar, E. Tarifeño-Saldivia, M. Salgado, R. Elizondo-Vega, Ricardo C. Araneda, María A. García-Robles
Sci Rep. 2021; 11: 21644. Published online 2021 Nov 4. doi: 10.1038/s41598-021-00947-7
PMCID:
PMC8569171
AbstractArticlePDF–5.2M
10.
Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development
Samuel Laroche, Aurélie Stil, Philippe Germain, Hosni Cherif, Sylvain Chemtob, Jean-François Bouchard
Cells. 2021 Jul; 10(7): 1640. Published online 2021 Jun 30. doi: 10.3390/cells10071640
PMCID:
PMC8303161
AbstractArticlePDF–2.7M
11.
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
Eman Khatib-Massalha, Suditi Bhattacharya, Hassan Massalha, Adi Biram, Karin Golan, Orit Kollet, Anju Kumari, Francesca Avemaria, Ekaterina Petrovich-Kopitman, Shiri Gur-Cohen, Tomer Itkin, Isabell Brandenburger, Asaf Spiegel, Ziv Shulman, Zachary Gerhart-Hines, Shalev Itzkovitz, Matthias Gunzer, Stefan Offermanns, Ronen Alon, Amiram Ariel, Tsvee Lapidot
Nat Commun. 2020; 11: 3547. Published online 2020 Jul 15. doi: 10.1038/s41467-020-17402-2
PMCID:
PMC7363928
AbstractArticlePDF–3.7M
12.
Hydrocarboxylic acid receptor 1 in BAT regulates glucose uptake in mice fed a high-fat diet
Eunjin Kwon, Taesik Yoo, Hye-Young Joung, Young-Hwan Jo
PLoS One. 2020; 15(1): e0228320. Published online 2020 Jan 30. doi: 10.1371/journal.pone.0228320
PMCID:
PMC6992197
AbstractArticlePDF–1.2M
13.
The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits
Haíssa de Castro Abrantes, Marc Briquet, Céline Schmuziger, Leonardo Restivo, Julien Puyal, Nadia Rosenberg, Anne-Bérengère Rocher, Stefan Offermanns, Jean-Yves Chatton
J Neurosci. 2019 Jun 5; 39(23): 4422–4433. doi: 10.1523/JNEUROSCI.2092-18.2019
PMCID:
PMC6554634
AbstractArticlePDF–1.5M
14.
Inhibition of G Protein‐Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury
Zhe Shen, Lei Jiang, Yang Yuan, Tian Deng, Yan‐Rong Zheng, Yan‐Yan Zhao, Wen‐Lu Li, Jia‐Ying Wu, Jian‐Qing Gao, Wei‐Wei Hu, Xiang‐Nan Zhang, Zhong Chen
CNS Neurosci Ther. 2015 Mar; 21(3): 271–279. Published online 2014 Dec 11. doi: 10.1111/cns.12362
PMCID:
PMC6495224
AbstractArticlePDF–1.7M
15.
GPR81, a cell-surface receptor for lactate, regulates intestinal homeostasis and protects mice from experimental colitis
Punithavathi Ranganathan, Arulkumaran Shanmugam, Daniel Swafford, Amol Suryawanshi, Pushpak Bhattacharjee, Mohamed S Hussein, Pandelakis A Koni, Puttur D Prasad, Zoya B Kurago, Muthusamy Thangaraju, Vadivel Ganapathy, Santhakumar Manicassamy
J Immunol. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: J Immunol. 2018 Mar 1; 200(5): 1781–1789. Published online 2018 Jan 31. doi: 10.4049/jimmunol.1700604
PMCID:
PMC5858928
AbstractArticlePDF–948K
16.
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Cecilie Morland, Krister A. Andersson, Øyvind P. Haugen, Alena Hadzic, Liv Kleppa, Andreas Gille, Johanne E. Rinholm, Vuk Palibrk, Elisabeth H. Diget, Lauritz H. Kennedy, Tomas Stølen, Eivind Hennestad, Olve Moldestad, Yiqing Cai, Maja Puchades, Stefan Offermanns, Koen Vervaeke, Magnar Bjørås, Ulrik Wisløff, Jon Storm-Mathisen, Linda H. Bergersen
Nat Commun. 2017; 8: 15557. Published online 2017 May 23. doi: 10.1038/ncomms15557
PMCID:
PMC5457513
AbstractArticlePDF–1.5M
17.
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner
Agustina Errea, Delphine Cayet, Philippe Marchetti, Cong Tang, Jerome Kluza, Stefan Offermanns, Jean-Claude Sirard, Martin Rumbo
PLoS One. 2016; 11(11): e0163694. Published online 2016 Nov 15. doi: 10.1371/journal.pone.0163694
PMCID:
PMC5112849
AbstractArticlePDF–1.7M
18.
Lactate Reduces Organ Injury in Toll-like Receptor- and Inflammasome-Mediated Inflammation via GPR81-mediated Suppression of Innate Immunity
Rafaz Hoque, Ahmad Farooq, Ayaz Ghani, Fred Gorelick, Wajahat Zafar Mehal
Gastroenterology. Author manuscript; available in PMC 2015 Jun 1.
Published in final edited form as: Gastroenterology. 2014 Jun; 146(7): 1763–1774. Published online 2014 Mar 20. doi: 10.1053/j.gastro.2014.03.014
PMCID:
PMC4104305
AbstractArticlePDF–1.1M
19.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
20.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M

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