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Items: 1 to 20 of 60

1.
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice
Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J. Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M. Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kang, Gandhari Maity, Aaron Novikoff, Sebastian Parlee, Ekta Pathak, Sonja C. Schriever, Michael Sterr, Siegfried Ussar, Qian Zhang, Richard DiMarchi, Matthias H. Tschöp, Paul T. Pfluger, Jonathan D. Douros, Timo D. Müller
Mol Metab. 2024 May; 83: 101915. Published online 2024 Mar 14. doi: 10.1016/j.molmet.2024.101915
PMCID:
PMC10973979
AbstractArticlePDF–2.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice
Ellen C. Furber, Karissa Hyatt, Kyla Collins, Xinxin Yu, Brian A. Droz, Adrienne Holland, Jessica L. Friedrich, Samantha Wojnicki, Debra L. Konkol, Libbey S. O’Farrell, Hana E. Baker, Tamer Coskun, Philipp E. Scherer, Christine M. Kusminski, Michael E. Christe, Kyle W. Sloop, Ricardo J. Samms
Diabetes. 2024 Feb; 73(2): 292–305. Published online 2023 Nov 7. doi: 10.2337/db23-0172
PMCID:
PMC10796301
AbstractArticlePDF–980K
4.
Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia
Yuya Takahashi, Hiroki Fujita, Yusuke Seino, Satoko Hattori, Shihomi Hidaka, Tsuyoshi Miyakawa, Atsushi Suzuki, Hironori Waki, Daisuke Yabe, Yutaka Seino, Yuichiro Yamada
J Cachexia Sarcopenia Muscle. 2023 Dec; 14(6): 2703–2718. Published online 2023 Oct 27. doi: 10.1002/jcsm.13346
PMCID:
PMC10751449
AbstractArticlePDF–3.5M
5.
Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant
Lucie Yammine, Belén Picatoste, Nazish Abdullah, Rosemary A. Leahey, Emma F. Johnson, Nicolás Gómez-Banoy, Carolina Rosselot, Jennifer Wen, Tahmina Hossain, Marcus D. Goncalves, James C. Lo, Adolfo Garcia-Ocaña, Timothy E. McGraw
Mol Metab. 2023 Dec; 78: 101831. Published online 2023 Nov 2. doi: 10.1016/j.molmet.2023.101831
PMCID:
PMC10665708
AbstractArticlePDF–4.2M
6.
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O’Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann
JCI Insight. 2023 May 22; 8(10): e164921. Published online 2023 May 22. doi: 10.1172/jci.insight.164921
PMCID:
PMC10322681
AbstractArticlePDF–4.4M
7.
Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis
Gemma Pujadas, Laurie L. Baggio, Kiran Deep Kaur, Brent A. McLean, Xiemin Cao, Daniel J. Drucker
Mol Metab. 2022 Nov; 65: 101586. Published online 2022 Aug 31. doi: 10.1016/j.molmet.2022.101586
PMCID:
PMC9478451
AbstractArticlePDF–4.4M
8.
Impacts of Glucose-Dependent Insulinotropic Polypeptide on Orthodontic Tooth Movement-Induced Bone Remodeling
Taisuke Yamauchi, Megumi Miyabe, Nobuhisa Nakamura, Mizuho Ito, Takeo Sekiya, Saki Kanada, Rina Hoshino, Tatsuaki Matsubara, Ken Miyazawa, Shigemi Goto, Keiko Naruse
Int J Mol Sci. 2022 Aug; 23(16): 8922. Published online 2022 Aug 10. doi: 10.3390/ijms23168922
PMCID:
PMC9408871
AbstractArticlePDF–3.0M
9.
A brainstem circuit for nausea suppression
Chuchu Zhang, Lindsay K. Vincelette, Frank Reimann, Stephen D. Liberles
Cell Rep. Author manuscript; available in PMC 2022 Jul 7.
Published in final edited form as: Cell Rep. 2022 Jun 14; 39(11): 110953. doi: 10.1016/j.celrep.2022.110953
PMCID:
PMC9260880
AbstractArticlePDF–2.2M
10.
Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice
Xin-shang Wang, Yong-li Jiang, Liang Lu, Ban Feng, Xue Ma, Kun Zhang, Shao-yu Guan, Le Yang, Qing-yu Fan, Xiao-chen Zhu, Fan Yang, Jing-yu Qi, Liu-kun Yang, Xu-bo Li, Ming-gao Zhao, Wen Jiang, Zhen Tian, Shui-bing Liu
Front Endocrinol (Lausanne) 2022; 13: 887238. Published online 2022 May 30. doi: 10.3389/fendo.2022.887238
PMCID:
PMC9196593
AbstractArticlePDF–15M
11.
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation
Alessia Costa, Minrong Ai, Nicolas Nunn, Isabella Culotta, Jenna Hunter, Mehdi Boutagouga Boudjadja, Lourdes Valencia-Torres, Gabriella Aviello, David J. Hodson, Brandy M. Snider, Tamer Coskun, Paul J. Emmerson, Simon M. Luckman, Giuseppe D'Agostino
Mol Metab. 2022 Jan; 55: 101407. Published online 2021 Nov 26. doi: 10.1016/j.molmet.2021.101407
PMCID:
PMC8689241
AbstractArticlePDF–2.3M
12.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
13.
Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice
Tina Ovlund, Giovanni Pacini, Bo Ahrén
Front Endocrinol (Lausanne) 2021; 12: 680153. Published online 2021 Jun 8. doi: 10.3389/fendo.2021.680153
PMCID:
PMC8217865
AbstractArticlePDF–1.6M
14.
The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice
Bo Ahrén, Yuichiro Yamada, Yutaka Seino
Front Endocrinol (Lausanne) 2021; 12: 665537. Published online 2021 May 27. doi: 10.3389/fendo.2021.665537
PMCID:
PMC8190331
AbstractArticlePDF–1.2M
15.
Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms
Jonathan E. Campbell
Mol Metab. 2021 Apr; 46: 101139. Published online 2020 Dec 5. doi: 10.1016/j.molmet.2020.101139
PMCID:
PMC8085569
AbstractArticlePDF–1003K
16.
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
Qian Zhang, Challa Tenagne Delessa, Robert Augustin, Mostafa Bakhti, Gustav Colldén, Daniel J. Drucker, Annette Feuchtinger, Cristina Garcia Caceres, Gerald Grandl, Alexandra Harger, Stephan Herzig, Susanna Hofmann, Cassie Lynn Holleman, Martin Jastroch, Susanne Keipert, Maximilian Kleinert, Patrick J. Knerr, Konxhe Kulaj, Beata Legutko, Heiko Lickert, Xue Liu, Gerd Luippold, Dominik Lutter, Emilija Malogajski, Marta Tarquis Medina, Stephanie A. Mowery, Andreas Blutke, Diego Perez-Tilve, Ciro Salinno, Laura Sehrer, Richard D. DiMarchi, Matthias H. Tschöp, Kerstin Stemmer, Brian Finan, Christian Wolfrum, Timo D. Müller
Cell Metab. 2021 Apr 6; 33(4): 833–844.e5. doi: 10.1016/j.cmet.2021.01.015
PMCID:
PMC8035082
AbstractArticle
17.
GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice
Irina Efimova, Inbar Steinberg, Isabel Zvibel, Anat Neumann, Dana Fernanda Mantelmacher, Daniel J. Drucker, Sigal Fishman, Chen Varol
Front Immunol. 2021; 12: 643144. Published online 2021 Feb 25. doi: 10.3389/fimmu.2021.643144
PMCID:
PMC7947693
AbstractArticlePDF–1.8M
18.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
19.
GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue
Jonathan E. Campbell, Jacqueline L. Beaudry, Berit Svendsen, Laurie L. Baggio, Andrew N. Gordon, John R. Ussher, Chi Kin Wong, Fiona M. Gribble, David A. D’Alessio, Frank Reimann, Daniel J. Drucker
Diabetes. 2022 May; 71(5): 1115–1127. Published online 2022 Feb 22. doi: 10.2337/db21-1166
PMCID:
PMC7612781
AbstractArticlePDF–4.1M
20.
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
Elizabeth A. Killion, Michelle Chen, James R. Falsey, Glenn Sivits, Todd Hager, Larissa Atangan, Joan Helmering, Jae Lee, Hongyan Li, Bin Wu, Yuan Cheng, Murielle M. Véniant, David J. Lloyd
Nat Commun. 2020; 11: 4981. Published online 2020 Oct 5. doi: 10.1038/s41467-020-18751-8
PMCID:
PMC7536395
AbstractArticlePDF–1.4M

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