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Select item 109210651.

Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life

David R Amici, Sammy Alhayek, Austin T Klein, Yi-Zhi Wang, Anika P Wilen, Weimin Song, Pei Zhu, Abhishek Thakkar, McKenzi A King, Adam WT Steffeck, Milad J Alasady, Clara Peek, Jeffrey N Savas, Marc L Mendillo

Life Sci Alliance. 2024 May; 7(5): e202302370. Published online 2024 Mar 7. doi: 10.26508/lsa.202302370

PMCID:: PMC10921065

Abstract Article PDF–2.4M

Select item 106927272.

Hepatic Huwe1 loss protects mice from non-alcoholic fatty liver disease through lipid metabolic rewiring

William W. Feng, Scott Bang, Eric M. Takacs, Cora Day, Katherine J. Crawford, Ruba Al-Sheyab, Dara B. Almufarrej, Wendy Wells, Serguei Ilchenko, Takhar Kasumov, Ning Kon, Colleen M. Novak, Wei Gu, Manabu Kurokawa

iScience. 2023 Dec 15; 26(12): 108405. Published online 2023 Nov 7. doi: 10.1016/j.isci.2023.108405

PMCID:: PMC10692727

Abstract Article PDF–7.0M

Select item 98690493.

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Aslam, Paul C. M. van den Berk, Chantal Stappenbelt, Matilda Ayidah, Joyce J. I. Catsman, Iris N. Pardieck, Maaike Kreft, Ramon Arens, Jeroen E. J. Guikema, Heinz Jacobs

Front Immunol. 2022; 13: 986863. Published online 2023 Jan 9. doi: 10.3389/fimmu.2022.986863

PMCID:: PMC9869049

Abstract Article PDF–12M

Select item 97246574.

The AAA‐ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle

Dina Aweida, Shenhav Cohen

EMBO Rep. 2022 Dec; 23(12): e55175. Published online 2022 Oct 24. doi: 10.15252/embr.202255175

PMCID:: PMC9724657

Abstract Article PDF–3.0M

Select item 94819335.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94334466.

Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury

Yan Wu, Huike Jiao, Yangbo Yue, Kang He, Yuting Jin, Jiang Zhang, Jing Zhang, Yuehan Wei, Hanyan Luo, Zhenyue Hao, Xuyun Zhao, Qiang Xia, Qing Zhong, Jing Zhang

Cell Death Differ. 2022 Sep; 29(9): 1705–1718. Published online 2022 Mar 8. doi: 10.1038/s41418-022-00957-6

PMCID:: PMC9433446

Abstract Article PDF–5.4M

Select item 86606317.

HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1

Jianqin Li, Yalin Xia, Xiaoru Fan, Xiaofang Wu, Feiyun Yang, Shaoyan Hu, Zhaoyue Wang

Front Cell Dev Biol. 2021; 9: 708562. Published online 2021 Nov 25. doi: 10.3389/fcell.2021.708562

PMCID:: PMC8660631

Abstract Article PDF–4.4M

Select item 81109468.

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Lachlan Harris, Piero Rigo, Thomas Stiehl, Zachary B. Gaber, Sophie H.L. Austin, Maria del Mar Masdeu, Amelia Edwards, Noelia Urbán, Anna Marciniak-Czochra, François Guillemot

Cell Stem Cell. 2021 May 6; 28(5): 863–876.e6. doi: 10.1016/j.stem.2021.01.003

PMCID:: PMC8110946

Abstract Article

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 785315210.

BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells

Hye In Cho, Min Seong Kim, Jina Lee, Byong Chul Yoo, Kyung Hee Kim, Kwang-Min Choe, Yeun Kyu Jang

Cell Death Differ. 2020 Dec; 27(12): 3273–3288. Published online 2020 Jun 18. doi: 10.1038/s41418-020-0577-1

PMCID:: PMC7853152

Abstract Article PDF–5.1M

Select item 768575911.

HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection

Yu Guo, Longjun Li, Tao Xu, Xiaomin Guo, Chaoming Wang, Yihui Li, Yanan Yang, Dong Yang, Bin Sun, Xudong Zhao, Genze Shao, Xiaopeng Qi

J Clin Invest. 2020 Dec 1; 130(12): 6301–6316. Published online 2020 Oct 26. doi: 10.1172/JCI138234

PMCID:: PMC7685759

Abstract Article PDF–9.0M

Select item 761689412.

Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages

Osamu Masuil, Catherine Corbel, Koji Nagao, Takaho A. Endo, Fuyuko Kezuka, Patricia Diabangouaya, Manabu Nakayama, Mami Kumon, Yoko Koseki, Chikashi Obuse, Haruhiko Koseki, Edith Heard

Nat Cell Biol. Author manuscript; available in PMC 2024 Dec 5.

Published in final edited form as: Nat Cell Biol. 2023 Jan 1; 25(1): 134–144. Published online 2023 Jan 12. doi: 10.1038/s41556-022-01047-y

PMCID:: PMC7616894

Abstract Article PDF–4.9M

Select item 749510613.

X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development

Alaa A. Eisa, Scott Bang, Katherine J. Crawford, Emily M. Murphy, William W. Feng, Souvik Dey, Wendy Wells, Ning Kon, Wei Gu, Lisa M. Mehlmann, Srinivasan Vijayaraghavan, Manabu Kurokawa

iScience. 2020 Sep 25; 23(9): 101523. Published online 2020 Sep 2. doi: 10.1016/j.isci.2020.101523

PMCID:: PMC7495106

Abstract Article PDF–6.3M

Select item 626277714.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Abstract Article

Select item 624418315.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 605572816.

Hepatic PPARα function is controlled by polyubiquitination and proteasome‐mediated degradation through the coordinated actions of PAQR3 and HUWE1

Zilong Zhao, Daqian Xu, Zheng Wang, Lin Wang, Ruomei Han, Zhenzhen Wang, Lujian Liao, Yan Chen

Hepatology. 2018 Jul; 68(1): 289–303. Published online 2018 Apr 26. doi: 10.1002/hep.29786

PMCID:: PMC6055728

Abstract Article PDF–1.2M

Select item 592777117.

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Gian-Luca McLelland, Thomas Goiran, Wei Yi, Geneviève Dorval, Carol X Chen, Nadine D Lauinger, Andrea I Krahn, Sepideh Valimehr, Aleksandar Rakovic, Isabelle Rouiller, Thomas M Durcan, Jean-François Trempe, Edward A Fon

eLife. 2018; 7: e32866. Published online 2018 Apr 20. doi: 10.7554/eLife.32866

PMCID:: PMC5927771

Abstract Article PDF–9.1M

Select item 573663518.

Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis

Rohini Bose, Kai Sheng, Adel R. Moawad, Gurpreet Manku, Cristian O’Flaherty, Teruko Taketo, Martine Culty, Kin Lam Fok, Simon S. Wing

Sci Rep. 2017; 7: 17759. Published online 2017 Dec 19. doi: 10.1038/s41598-017-17902-0

PMCID:: PMC5736635

Abstract Article PDF–2.6M

Select item 564508219.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 560700220.

TGFβR signalling controls CD103⁺CD11b⁺ dendritic cell development in the intestine

C. C. Bain, J. Montgomery, C. L. Scott, J. M. Kel, M. J. H. Girard-Madoux, L. Martens, T. F. P. Zangerle-Murray, J. Ober-Blöbaum, D. Lindenbergh-Kortleve, J. N. Samsom, S. Henri, T. Lawrence, Y. Saeys, B. Malissen, M. Dalod, B. E. Clausen, A. McI. Mowat

Nat Commun. 2017; 8: 620. Published online 2017 Sep 20. doi: 10.1038/s41467-017-00658-6

PMCID:: PMC5607002

Abstract Article PDF–2.0M

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