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Select item 115781791.

Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA–induced dyskinetic behaviors

Beatriz E. Nielsen, Christopher P. Ford

Sci Adv. 2024 Nov 22; 10(47): eadp6301. Published online 2024 Nov 20. doi: 10.1126/sciadv.adp6301

PMCID:: PMC11578179

Abstract Article PDF–6.1M

Select item 115297112.

High mitochondrial DNA levels accelerate lung adenocarcinoma progression

Mara Mennuni, Stephen E. Wilkie, Pauline Michon, David Alsina, Roberta Filograna, Markus Lindberg, David E. Sanin, Florian Rosenberger, Alina Schaaf, Erik Larsson, Erika L. Pearce, Nils-Göran Larsson

Sci Adv. 2024 Nov 1; 10(44): eadp3481. Published online 2024 Nov 1. doi: 10.1126/sciadv.adp3481

PMCID:: PMC11529711

Abstract Article PDF–2.2M

Select item 109952643.

RORα–GABP–TFAM axis alleviates myosteatosis with fatty atrophy through reinforcement of mitochondrial capacity

Hyeon‐Ji Kim, Sang‐Heon Lee, Cheolhee Jeong, Yong‐Hyun Han, Mi‐Ock Lee

J Cachexia Sarcopenia Muscle. 2024 Apr; 15(2): 615–630. Published online 2024 Jan 25. doi: 10.1002/jcsm.13432

PMCID:: PMC10995264

Abstract Article PDF–5.2M

Select item 109150014.

Mito-metformin protects against mitochondrial dysfunction and dopaminergic neuronal degeneration by activating upstream PKD1 signaling in cell culture and MitoPark animal models of Parkinson’s disease

Muhammet Ay, Adhithiya Charli, Monica Langley, Ahyoung Jang, Piyush Padhi, Huajun Jin, Vellareddy Anantharam, Balaraman Kalyanaraman, Arthi Kanthasamy, Anumantha G. Kanthasamy

Front Neurosci. 2024; 18: 1356703. Published online 2024 Feb 21. doi: 10.3389/fnins.2024.1356703

PMCID:: PMC10915001

Abstract Article PDF–6.9M

Select item 107170605.

Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension

Lei Ma, Yanxia Wang, Xiaoqian Li, Zefang Wang, Bo Zhang, Ying Luo, Yousheng Wu, Zhichao Li, Wen Niu

Respir Res. 2023; 24: 310. Published online 2023 Dec 13. doi: 10.1186/s12931-023-02631-y

PMCID:: PMC10717060

Abstract Article PDF–2.9M

Select item 106117306.

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein, Gabriela F. Gubert, Konrad Knöpper, Ana Maria Mansilla, Arman Öner, Remi Doucet-Ladevèze, Werner Schmitz, Bart Ghesquière, Sebastian Theurich, Jan Dudek, Georg Gasteiger, Alma Zernecke, Sebastian Kobold, Wolfgang Kastenmüller, Martin Vaeth

Nat Commun. 2023; 14: 6858. Published online 2023 Oct 27. doi: 10.1038/s41467-023-42634-3

PMCID:: PMC10611730

Abstract Article PDF–3.5M

Select item 105937707.

A novel mouse model of mitochondrial disease exhibits juvenile-onset severe neurological impairment due to parvalbumin cell mitochondrial dysfunction

Elizaveta A. Olkhova, Carla Bradshaw, Alasdair Blain, Debora Alvim, Doug M. Turnbull, Fiona E. N. LeBeau, Yi Shiau Ng, Gráinne S. Gorman, Nichola Z. Lax

Commun Biol. 2023; 6: 1078. Published online 2023 Oct 23. doi: 10.1038/s42003-023-05238-7

PMCID:: PMC10593770

Abstract Article PDF–9.3M

Select item 103308438.

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Yuanjiu Lei, Jordyn J. VanPortfliet, Yi-Fan Chen, Joshua D. Bryant, Ying Li, Danielle Fails, Sylvia Torres-Odio, Katherine B. Ragan, Jingti Deng, Armaan Mohan, Bing Wang, Olivia N. Brahms, Shawn D. Yates, Michael Spencer, Carl W. Tong, Marcus W. Bosenberg, Laura Ciaccia West, Gerald S. Shadel, Timothy E. Shutt, Jason W. Upton, Pingwei Li, A. Phillip West

Cell. Author manuscript; available in PMC 2024 Jul 6.

Published in final edited form as: Cell. 2023 Jul 6; 186(14): 3013–3032.e22. Published online 2023 Jun 22. doi: 10.1016/j.cell.2023.05.039

PMCID:: PMC10330843

Abstract Article PDF–4.7M

Select item 103078529.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 1025369210.

The C-Terminal Tail of Mitochondrial Transcription Factor A Is Dispensable for Mitochondrial DNA Replication and Transcription In Situ

Natalya Kozhukhar, Mikhail F. Alexeyev

Int J Mol Sci. 2023 Jun; 24(11): 9430. Published online 2023 May 29. doi: 10.3390/ijms24119430

PMCID:: PMC10253692

Abstract Article PDF–1.5M

Select item 1023235911.

Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis

Yavuz F. Yazicioglu, Eros Marin, Ciaran Sandhu, Silvia Galiani, Iwan G. A. Raza, Mohammad Ali, Barbara Kronsteiner, Ewoud B. Compeer, Moustafa Attar, Susanna J. Dunachie, Michael L. Dustin, Alexander J. Clarke

Nat Immunol. 2023; 24(6): 991–1006. Published online 2023 Apr 24. doi: 10.1038/s41590-023-01484-3

PMCID:: PMC10232359

Abstract Article PDF–7.6M

Select item 1020203412.

Loss of Fatty Acid Degradation by Astrocytic Mitochondria Triggers Neuroinflammation and Neurodegeneration

Yashi Mi, Guoyuan Qi, Francesca Vitali, Yuan Shang, Adam C. Raikes, Tian Wang, Yan Jin, Roberta D. Brinton, Haiwei Gu, Fei Yin

Nat Metab. Author manuscript; available in PMC 2023 Sep 23.

Published in final edited form as: Nat Metab. 2023 Mar; 5(3): 445–465. Published online 2023 Mar 23. doi: 10.1038/s42255-023-00756-4

PMCID:: PMC10202034

Abstract Article PDF–8.4M

Select item 1000299913.

PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson’s Disease

Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Kuan-Yin Tseng

Int J Mol Sci. 2023 Mar; 24(5): 4687. Published online 2023 Feb 28. doi: 10.3390/ijms24054687

PMCID:: PMC10002999

Abstract Article PDF–2.4M

Select item 998674214.

Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease

Nahed Khadhraoui, Alexandre Prola, Aymeline Vandestienne, Jordan Blondelle, Laurent Guillaud, Guillaume Courtin, Maxime Bodak, Bastien Prost, Hélène Huet, Mélody Wintrebert, Christine Péchoux, Audrey Solgadi, Frédéric Relaix, Laurent Tiret, Fanny Pilot-Storck

Mol Metab. 2023 Mar; 69: 101677. Published online 2023 Jan 21. doi: 10.1016/j.molmet.2023.101677

PMCID:: PMC9986742

Abstract Article PDF–3.1M

Select item 998037715.

TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway

Tianqi Lu, Ziqi Zhang, Zhenfei Bi, Tianxia Lan, Hao Zeng, Yu Liu, Fei Mo, Jingyun Yang, Siyuan Chen, Xuemei He, Weiqi Hong, Zhe Zhang, Ruyu Pi, Wenyan Ren, Xiaohe Tian, Yuquan Wei, Min Luo, Xiawei Wei

J Immunother Cancer. 2023; 11(3): e005430. Published online 2023 Mar 1. doi: 10.1136/jitc-2022-005430

PMCID:: PMC9980377

Abstract Article PDF–7.9M

Select item 990152716.

AJ76 and UH232 as potential agents for diagnosing early-stage Parkinson’s disease

Jingheng Zhou, Jicheng Li, Amy B. Papaneri, Guohong Cui

Neuropharmacology. Author manuscript; available in PMC 2024 Mar 15.

Published in final edited form as: Neuropharmacology. 2023 Mar 15; 226: 109397. Published online 2023 Jan 6. doi: 10.1016/j.neuropharm.2022.109397

PMCID:: PMC9901527

Abstract Article PDF–671K

Select item 982946917.

Maternal exercise improves epithelial development of fetal intestine by enhancing apelin signaling and oxidative metabolism

Song Ah Chae, Jun Seok Son, Jeanene Marie de Avila, Min Du, Mei-Jun Zhu

Am J Physiol Regul Integr Comp Physiol. 2022 Nov 1; 323(5): R728–R738. Published online 2022 Oct 3. doi: 10.1152/ajpregu.00128.2022

PMCID:: PMC9829469

Abstract Article

Select item 980148718.

TFAM-dependent mitochondrial metabolism is required for alveolar macrophage maintenance and homeostasis

Xiaochen Gao, Bibo Zhu, Yue Wu, Chaofan Li, Xian Zhou, Jinyi Tang, Jie Sun

J Immunol. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: J Immunol. 2022 Mar 15; 208(6): 1456–1466. Published online 2022 Feb 14. doi: 10.4049/jimmunol.2100741

PMCID:: PMC9801487

Abstract Article PDF–2.7M

Select item 974162819.

Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas

Haifeng Zhang, Busu Li, Qunhua Huang, Francesc López-Giráldez, Yoshiaki Tanaka, Qun Lin, Sameet Mehta, Guilin Wang, Morven Graham, Xinran Liu, In-Hyun Park, Anne Eichmann, Wang Min, Jenny Huanjiao Zhou

Nat Commun. 2022; 13: 7637. Published online 2022 Dec 10. doi: 10.1038/s41467-022-35262-w

PMCID:: PMC9741628

Abstract Article PDF–16M

Select item 972002020.

Enzymatically dissociated muscle fibers display rapid dedifferentiation and impaired mitochondrial calcium control

Charlotte Gineste, Sonia Youhanna, Sabine U. Vorrink, Sara Henriksson, Andrés Hernández, Arthur J. Cheng, Thomas Chaillou, Andreas Buttgereit, Dominik Schneidereit, Oliver Friedrich, Kjell Hultenby, Joseph D. Bruton, Niklas Ivarsson, Linda Sandblad, Volker M. Lauschke, Håkan Westerblad

iScience. 2022 Dec 22; 25(12): 105654. Published online 2022 Nov 22. doi: 10.1016/j.isci.2022.105654

PMCID:: PMC9720020

Abstract Article PDF–5.2M

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