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Items: 1 to 20 of 117

1.
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
Sebastian B. Lacher, Janina Dörr, Gustavo P. de Almeida, Julian Hönninger, Felix Bayerl, Anna Hirschberger, Anna-Marie Pedde, Philippa Meiser, Lukas Ramsauer, Thomas J. Rudolph, Nadine Spranger, Matteo Morotti, Alizee J. Grimm, Sebastian Jarosch, Arman Oner, Lisa Gregor, Stefanie Lesch, Stefanos Michaelides, Luisa Fertig, Daria Briukhovetska, Lina Majed, Sophia Stock, Dirk H. Busch, Veit R. Buchholz, Percy A. Knolle, Dietmar Zehn, Denarda Dangaj Laniti, Sebastian Kobold, Jan P. Böttcher
Nature. 2024; 629(8011): 417–425. Published online 2024 Apr 24. doi: 10.1038/s41586-024-07254-x
PMCID:
PMC11078747
AbstractArticlePDF–17M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Needle biopsy accelerates pro-metastatic changes and systemic dissemination in breast cancer: Implications for mortality by surgery delay
Hiroyasu Kameyama, Priya Dondapati, Reese Simmons, Macall Leslie, John F. Langenheim, Yunguang Sun, Misung Yi, Aubrey Rottschaefer, Rashmi Pathak, Shreya Nuguri, Kar-Ming Fung, Shirng-Wern Tsaih, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka
Cell Rep Med. 2023 Dec 19; 4(12): 101330. Published online 2023 Dec 19. doi: 10.1016/j.xcrm.2023.101330
PMCID:
PMC10772461
AbstractArticlePDF–11M
4.
Increased COX‐2 after ureter obstruction attenuates fibrosis and is associated with EP2 receptor upregulation in mouse and human kidney
Signe S. Tofteng, Line Nilsson, Amalie K. Mogensen, Rikke Nørregaard, Rolf Nüsing, Mikhail Diatchikhine, Lars Lund, Claus Bistrup, Boye L. Jensen, Kirsten Madsen
Acta Physiol (Oxf) 2022 Aug; 235(4): e13828. Published online 2022 May 20. doi: 10.1111/apha.13828
PMCID:
PMC9542224
AbstractArticlePDF–53M
5.
Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti-tumor immunity in the tumor stroma
Maria Khan, Cecilia Engström, Johan Bourghardt Fagman, Ulrika Smedh, Kent Lundholm, Britt-Marie Iresjö
Oncol Rep. 2022 Jun; 47(6): 118. Published online 2022 May 11. doi: 10.3892/or.2022.8329
PMCID:
PMC9115633
AbstractArticlePDF–1.1M
6.
Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation
Lei Zhou, Wenqing Zhou, Ann M. Joseph, Coco Chu, Gregory G. Putzel, Beibei Fang, Fei Teng, Mengze Lv, Hiroshi Yano, Katrin I. Andreasson, Eisuke Mekada, Gerard Eberl, Gregory F. Sonnenberg
Nat Immunol. Author manuscript; available in PMC 2022 Aug 1.
Published in final edited form as: Nat Immunol. 2022 Feb; 23(2): 251–261. Published online 2022 Jan 31. doi: 10.1038/s41590-021-01110-0
PMCID:
PMC8842850
AbstractArticlePDF–5.4M
7.
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Paras S. Minhas, Amira Latif-Hernandez, Melanie R. McReynolds, Aarooran S. Durairaj, Qian Wang, Amanda Rubin, Amit U. Joshi, Joy Q. He, Esha Gauba, Ling Liu, Congcong Wang, Miles Linde, Yuki Sugiura, Peter K. Moon, Ravi Majeti, Makoto Suematsu, Daria Mochly-Rosen, Irving L. Weissman, Frank M. Longo, Joshua D. Rabinowitz, Katrin I. Andreasson
Nature. Author manuscript; available in PMC 2021 Aug 1.
Published in final edited form as: Nature. 2021 Feb; 590(7844): 122–128. Published online 2021 Jan 20. doi: 10.1038/s41586-020-03160-0
PMCID:
PMC8274816
ArticlePDF–6.0M
8.
Fever During Localized Inflammation in Mice Is Elicited by a Humoral Pathway and Depends on Brain Endothelial Interleukin-1 and Interleukin-6 Signaling and Central EP3 Receptors
Anna Eskilsson, Kiseko Shionoya, David Engblom, Anders Blomqvist
J Neurosci. 2021 Jun 16; 41(24): 5206–5218. doi: 10.1523/JNEUROSCI.0313-21.2021
PMCID:
PMC8211540
AbstractArticlePDF–5.4M
9.
Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection
Lan Chen, Xiaofang Ji, Manni Wang, Xiaoyan Liao, Cuiying Liang, Juanjuan Tang, Zhencheng Wen, Ferrandon Dominique, Zi Li
Parasit Vectors. 2021; 14: 279. Published online 2021 May 25. doi: 10.1186/s13071-021-04790-7
PMCID:
PMC8146234
AbstractArticlePDF–2.1M
10.
Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus
Nicholas H. Varvel, Claudia Espinosa-Garcia, Sarah Hunter-Chang, Di Chen, Ariel Biegel, Allison Hsieh, Lisa Blackmer-Raynolds, Thota Ganesh, Raymond Dingledine
J Neurosci. 2021 Feb 3; 41(5): 1105–1117. doi: 10.1523/JNEUROSCI.2040-20.2020
PMCID:
PMC7880294
AbstractArticlePDF–3.6M
11.
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell
Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290
PMCID:
PMC7519887
AbstractArticlePDF–928K
12.
PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
Loka R Penke, Jennifer M Speth, Christina Draijer, Zbigniew Zaslona, Judy Chen, Peter Mancuso, Christine M Freeman, Jeffrey L Curtis, Daniel R Goldstein, Marc Peters-Golden
Life Sci Alliance. 2020 Nov; 3(11): e202000800. Published online 2020 Aug 20. doi: 10.26508/lsa.202000800
PMCID:
PMC7441521
AbstractArticlePDF–1.7M
13.
Neuroprotective Function of the PGE2 EP2 Receptor in Cerebral Ischemia
Louise McCullough, Liejun Wu, Norman Haughey, Xibin Liang, Tracey Hand, Qian Wang, Richard M. Breyer, Katrin Andreasson
J Neurosci. 2004 Jan 7; 24(1): 257–268. doi: 10.1523/JNEUROSCI.4485-03.2004
PMCID:
PMC6729582
AbstractArticlePDF–536K
14.
Deletion of the Prostaglandin E2 EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease
Xibin Liang, Qian Wang, Tracey Hand, Liejun Wu, Richard M. Breyer, Thomas J. Montine, Katrin Andreasson
J Neurosci. 2005 Nov 2; 25(44): 10180–10187. doi: 10.1523/JNEUROSCI.3591-05.2005
PMCID:
PMC6725803
AbstractArticlePDF–335K
15.
COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex
Alexandre Lacroix, Xavier Toussay, Eitan Anenberg, Clotilde Lecrux, Nerea Ferreirós, Anastassios Karagiannis, Fabrice Plaisier, Patrick Chausson, Frédéric Jarlier, Sean A. Burgess, Elizabeth M. C. Hillman, Irmgard Tegeder, Timothy H. Murphy, Edith Hamel, Bruno Cauli
J Neurosci. 2015 Aug 26; 35(34): 11791–11810. doi: 10.1523/JNEUROSCI.0651-15.2015
PMCID:
PMC6705452
AbstractArticlePDF–14M
16.
Bidirectional Trafficking of Prostaglandin E2 Receptors Involved in Long-Term Potentiation in Visual Cortex
Yukio Akaneya, Tadaharu Tsumoto
J Neurosci. 2006 Oct 4; 26(40): 10209–10221. doi: 10.1523/JNEUROSCI.3028-06.2006
PMCID:
PMC6674642
AbstractArticlePDF–913K
17.
PGE2 signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia
Qingkun Liu, Xibin Liang, Qian Wang, Edward N. Wilson, Rachel Lam, Jing Wang, William Kong, Connie Tsai, Tingting Pan, Paul B. Larkin, Mehrdad Shamloo, Katrin I. Andreasson
Proc Natl Acad Sci U S A. 2019 May 14; 116(20): 10019–10024. Published online 2019 Apr 29. doi: 10.1073/pnas.1818544116
PMCID:
PMC6525498
AbstractArticlePDF–1.0M
18.
Small‐molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase‐associated malignant glioma growth
Jiange Qiu, Qianqian Li, Katherine A. Bell, Xue Yao, Yifeng Du, Erik Zhang, Jane J. Yu, Ying Yu, Zhi Shi, Jianxiong Jiang
Br J Pharmacol. 2019 Jun; 176(11): 1680–1699. Published online 2019 Apr 29. doi: 10.1111/bph.14622
PMCID:
PMC6514294
AbstractArticlePDF–3.7M
19.
T cell–intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell–driven inflammation
Jinju Lee, Tomohiro Aoki, Dean Thumkeo, Ratklao Siriwach, Chengcan Yao, Shuh Narumiya
J Allergy Clin Immunol. 2019 Feb; 143(2): 631–643. doi: 10.1016/j.jaci.2018.05.036
PMCID:
PMC6354914
AbstractArticle
20.
Contribution of prostanoid FP receptor and prostaglandins in transient inflammatory ocular hypertension
Reiko Yamagishi-Kimura, Megumi Honjo, Makoto Aihara
Sci Rep. 2018; 8: 11098. Published online 2018 Jul 23. doi: 10.1038/s41598-018-29273-1
PMCID:
PMC6056481
AbstractArticlePDF–1.3M

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