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Select item 113828871.

Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes

Laura Kind, Janne Molnes, Erling Tjora, Arne Raasakka, Matti Myllykoski, Kevin Colclough, Cécile Saint-Martin, Caroline Adelfalk, Petra Dusatkova, Stepanka Pruhova, Camilla Valtonen-André, Christine Bellanné-Chantelot, Thomas Arnesen, Petri Kursula, Pål Rasmus Njølstad

JCI Insight. 2024 Jun 10; 9(11): e175278. Published online 2024 Jun 10. doi: 10.1172/jci.insight.175278

PMCID:: PMC11382887

Abstract Article PDF–4.9M

Select item 112243042.

Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma

Tiantian Jing, Dianhui Wei, Xiaoli Xu, Chengsi Wu, Lili Yuan, Yiwen Huang, Yizhen Liu, Yanyi Jiang, Boshi Wang

Nat Commun. 2024; 15: 5631. Published online 2024 Jul 4. doi: 10.1038/s41467-024-49926-2

PMCID:: PMC11224304

Abstract Article PDF–7.5M

Select item 111784323.

Krüppel-like Factor 10 Protects Against Metabolic Dysfunction-Associated Steatohepatitis By Regulating HNF4α-mediated Metabolic Pathways

Xiaoli Pan, Shuwei Hu, Yanyong Xu, Raja Gopoju, Yingdong Zhu, Fathima N. Cassim Bawa, Hui Wang, Jiayou Wang, Zaid Batayneh, Alyssa Clark, Yuhao Zeng, Li Lin, Xinwen Wang, Liya Yin, Yanqiao Zhang

Metabolism. Author manuscript; available in PMC 2024 Jun 14.

Published in final edited form as: Metabolism. 2024 Jun; 155: 155909. Published online 2024 Apr 4. doi: 10.1016/j.metabol.2024.155909

PMCID:: PMC11178432

Abstract Article PDF–2.4M

Select item 110991684.

Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response

Charlotte Ehle, Aishwarya Iyer-Bierhoff, Yunchen Wu, Shaojun Xing, Michael Kiehntopf, Alexander S. Mosig, Maren Godmann, Thorsten Heinzel

Commun Biol. 2024; 7: 589. Published online 2024 May 16. doi: 10.1038/s42003-024-06288-1

PMCID:: PMC11099168

Abstract Article PDF–2.2M

Select item 110701325.

Functional characterization of HNF4A gene variants identify promoter and cell line specific transactivation effects

Alba Kaci, Marie Holm Solheim, Trine Silgjerd, Jorunn Hjaltadottir, Lorentze Hope Hornnes, Janne Molnes, Andre Madsen, Gry Sjøholt, Christine Bellanné-Chantelot, Richard Caswell, Jørn V Sagen, Pål R Njølstad, Ingvild Aukrust, Lise Bjørkhaug

Hum Mol Genet. 2024 May 15; 33(10): 894–904. Published online 2024 Mar 3. doi: 10.1093/hmg/ddae027

PMCID:: PMC11070132

Abstract Article PDF–1.2M

Select item 108786916.

Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1

Hui Han, Rong-Hua Luo, Xin-Yan Long, Li-Qiong Wang, Qian Zhu, Xin-Yue Tang, Rui Zhu, Yi-Cheng Ma, Yong-Tang Zheng, Cheng-Gang Zou

eLife. 2024; 13: e85985. Published online 2024 Feb 20. doi: 10.7554/eLife.85985

PMCID:: PMC10878691

Abstract Article PDF–3.6M

Select item 106377907.

The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma

Haitao Luo, Kai Huang, Mengqi Cheng, Xiaoyan Long, Xingen Zhu, Miaojing Wu

Aging (Albany NY) 2023 Oct 31; 15(20): 11052–11066. Published online 2023 Oct 17. doi: 10.18632/aging.205076

PMCID:: PMC10637790

Abstract Article PDF–1.8M

Select item 105618218.

Elucidating the Proximal Tubule HNF4A Gene Regulatory Network in Human Kidney Organoids

Yasuhiro Yoshimura, Yoshiharu Muto, Kohei Omachi, Jeffrey H. Miner, Benjamin D. Humphreys

J Am Soc Nephrol. 2023 Oct; 34(10): 1672–1686. Published online 2023 Jul 25. doi: 10.1681/ASN.0000000000000197

PMCID:: PMC10561821

Abstract Article

Select item 103266009.

Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

Omer Goldman, Lital N. Adler, Emma Hajaj, Tommaso Croese, Naama Darzi, Sivan Galai, Hila Tishler, Yarden Ariav, Dor Lavie, Liat Fellus-Alyagor, Roni Oren, Yuri Kuznetsov, Eyal David, Rami Jaschek, Chani Stossel, Oded Singer, Sergey Malitsky, Renana Barak, Rony Seger, Neta Erez, Ido Amit, Amos Tanay, Ann Saada, Talia Golan, Tamar Rubinek, Joo Sang Lee, Shay Ben-Shachar, Ido Wolf, Ayelet Erez

Cancer Discov. 2023 Jul 7; 13(7): 1616–1635. Published online 2023 Mar 27. doi: 10.1158/2159-8290.CD-22-1062

PMCID:: PMC10326600

Abstract Article PDF–16M

Select item 1028927610.

High-Throughput Sequencing Data Reveal an Antiangiogenic Role of HNF4A-Mediated CACNA1A/VEGFA Axis in Proliferative Diabetic Retinopathy

Yuan Yin, Shuai Wu, Lingzhi Niu, Shiwei Huang

Invest Ophthalmol Vis Sci. 2023 Jun; 64(7): 32. Published online 2023 Jun 21. doi: 10.1167/iovs.64.7.32

PMCID:: PMC10289276

Abstract Article PDF–3.4M

Select item 1025678611.

HNF4A-BAP31-VDAC1 axis synchronously regulates cell proliferation and ferroptosis in gastric cancer

Qingqing Zhou, Tengfei Liu, Wenjing Qian, Jun Ji, Qu Cai, Yangbing Jin, Jinling Jiang, Jun Zhang

Cell Death Dis. 2023 Jun; 14(6): 356. Published online 2023 Jun 9. doi: 10.1038/s41419-023-05868-z

PMCID:: PMC10256786

Abstract Article PDF–7.6M

Select item 1021854912.

Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (RARβ) Gene in Hepatocytes

Reza Zolfaghari, Jessica A. Bonzo, Frank J. Gonzalez, A. Catharine Ross

Int J Mol Sci. 2023 May; 24(10): 8608. Published online 2023 May 11. doi: 10.3390/ijms24108608

PMCID:: PMC10218549

Abstract Article PDF–2.8M

Select item 1017909713.

Interleukin-1ß Attenuates Expression of Augmenter of Liver Regeneration (ALR) by Regulating HNF4α Independent of c-Jun

Jonas Nimphy, Sara Ibrahim, Rania Dayoub, Marion Kubitza, Michael Melter, Thomas S. Weiss

Int J Mol Sci. 2023 May; 24(9): 8107. Published online 2023 Apr 30. doi: 10.3390/ijms24098107

PMCID:: PMC10179097

Abstract Article PDF–2.5M

Select item 1017406414.

Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase

Valeria Besskaya, Huan Zhang, Yunyi Bian, Jiaqi Liang, Guoshu Bi, Guangyao Shan, Cheng Zhan, Zongwu Lin

PeerJ. 2023; 11: e15377. Published online 2023 May 8. doi: 10.7717/peerj.15377

PMCID:: PMC10174064

Abstract Article PDF–5.9M

Select item 1004840315.

Genetic Variants of HNF4A, WFS1, DUSP9, FTO, and ZFAND6 Genes Are Associated with Prediabetes Susceptibility and Inflammatory Markers in the Saudi Arabian Population

Dalal N. Binjawhar, Mohammed G. A. Ansari, Shaun Sabico, Syed Danish Hussain, Amal M. Alenad, Majed S. Alokail, Abeer A. Al-Masri, Nasser M. Al-Daghri

Genes (Basel) 2023 Mar; 14(3): 536. Published online 2023 Feb 21. doi: 10.3390/genes14030536

PMCID:: PMC10048403

Abstract Article PDF–287K

Select item 1001017116.

HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway

Jiaqi Liang, Guangyin Zhao, Yunyi Bian, Guoshu Bi, Qihai Sui, Huan Zhang, Haochun Shi, Guangyao Shan, Yiwei Huang, Zhencong Chen, Lin Wang, Cheng Zhan

PeerJ. 2023; 11: e14996. Published online 2023 Mar 10. doi: 10.7717/peerj.14996

PMCID:: PMC10010171

Abstract Article PDF–1.8M

Select item 998623117.

TUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1

Xiaobo Wang, Jiawei Shi, Mingming Huang, Jiehong Chen, Jia Dan, Yunhua Tang, Zhiyong Guo, Xiaoshun He, Qiang Zhao

Cell Death Dis. 2023 Mar; 14(3): 179. Published online 2023 Mar 6. doi: 10.1038/s41419-023-05687-2

PMCID:: PMC9986231

Abstract Article PDF–4.6M

Select item 976531118.

Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis

Josepmaria Argemi, Komal Kedia, Marina A. Gritsenko, Ana Clemente-Sanchez, Aliya Asghar, Jose M. Herranz, Zhang-Xu Liu, Stephen R. Atkinson, Richard D. Smith, Trina M. Norden-Krichmar, Le Z. Day, Andrew Stolz, John A. Tayek, Ramon Bataller, Timothy R. Morgan, Jon M. Jacobs, the Southern California Alcoholic Hepatitis Consortium and the InTeam Consortium

Am J Pathol. 2022 Dec; 192(12): 1658–1669. doi: 10.1016/j.ajpath.2022.08.009

PMCID:: PMC9765311

Abstract Article PDF–2.8M

Select item 976215819.

Progressive loss of HNF4α activity in chronic liver diseases in humans

Sumedha Gunewardena, Ian Huck, Chad Walesky, Dakota Robarts, Steven Weinman, Udayan Apte

Hepatology. Author manuscript; available in PMC 2022 Dec 19.

Published in final edited form as: Hepatology. 2022 Aug; 76(2): 372–386. Published online 2022 Mar 4. doi: 10.1002/hep.32326

PMCID:: PMC9762158

Abstract Article PDF–3.0M

Select item 972620320.

Expression of p-STAT3 and c-Myc correlates with P2-HNF4α expression in nonalcoholic fatty liver disease (NAFLD)

Mamoun Younes, Lin Zhang, Baharan Fekry, Kristin Eckel-Mahan

Oncotarget. 2022; 13: 1308–1313. Published online 2022 Dec 6. doi: 10.18632/oncotarget.28324

PMCID:: PMC9726203

Abstract Article PDF–1.6M

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