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Select item 109457071.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 108477252.

Bone morphogenetic protein signaling: the pathway and its regulation

Takuya Akiyama, Laurel A Raftery, Kristi A Wharton

Genetics. 2024 Feb; 226(2): iyad200. Published online 2023 Dec 20. doi: 10.1093/genetics/iyad200

PMCID:: PMC10847725

Abstract Article PDF–6.8M

Select item 104107063.

Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar

Jana Kubíková, Gabrielė Ubartaitė, Jutta Metz, Mandy Jeske

Proc Natl Acad Sci U S A. 2023 Aug 8; 120(32): e2304385120. Published online 2023 Jul 31. doi: 10.1073/pnas.2304385120

PMCID:: PMC10410706

Abstract Article PDF–2.9M

Select item 94628494.

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam

eLife. 2022; 11: e79843. Published online 2022 Sep 9. doi: 10.7554/eLife.79843

PMCID:: PMC9462849

Abstract Article PDF–10M

Select item 94453245.

Dose-dependent phosphorylation and activation of Hh pathway transcription factors

Mengmeng Zhou, Yuhong Han, Bing Wang, Yong Suk Cho, Jin Jiang

Life Sci Alliance. 2022 Nov; 5(11): e202201570. Published online 2022 Sep 5. doi: 10.26508/lsa.202201570

PMCID:: PMC9445324

Abstract Article PDF–2.3M

Select item 90965656.

Dissection of the microRNA Network Regulating Hedgehog Signaling in Drosophila

Tao He, Yu Fan, Yao Wang, Min Liu, Alan Jian Zhu

Front Cell Dev Biol. 2022; 10: 866491. Published online 2022 Apr 28. doi: 10.3389/fcell.2022.866491

PMCID:: PMC9096565

Abstract Article PDF–13M

Select item 87036577.

Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination

Qing Zhang, Jin Jiang

Int J Mol Sci. 2021 Dec; 22(24): 13338. Published online 2021 Dec 11. doi: 10.3390/ijms222413338

PMCID:: PMC8703657

Abstract Article PDF–1.5M

Select item 86644868.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 86644559.

Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing

Cristina M Ostalé, Nuria Esteban, Ana López-Varea, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab348. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab348

PMCID:: PMC8664455

Abstract Article PDF–2.9M

Select item 817247610.

Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: perspectives for future research

Svetlana Surkova, Jessica Görne, Sergey Nuzhdin, Maria Samsonova

Dev Biol. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Dev Biol. 2021 Aug; 476: 41–52. Published online 2021 Mar 18. doi: 10.1016/j.ydbio.2021.03.005

PMCID:: PMC8172476

Abstract Article PDF–2.0M

Select item 802077711.

Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division

Justin Sardi, Muhammed Burak Bener, Taylor Simao, Abigail E. Descoteaux, Boris M. Slepchenko, Mayu Inaba

Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13): e2006786118. Published online 2021 Mar 22. doi: 10.1073/pnas.2006786118

PMCID:: PMC8020777

Abstract Article PDF–2.7M

Select item 767913312.

Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing

Jamie C Little, Elisa Garcia-Garcia, Amanda Sul, Daniel Kalderon

eLife. 2020; 9: e61083. Published online 2020 Oct 21. doi: 10.7554/eLife.61083

PMCID:: PMC7679133

Abstract Article PDF–8.5M

Select item 755019213.

Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

Tarun Kumar, Leo Blondel, Cassandra G Extavour

eLife. 2020; 9: e54082. Published online 2020 Sep 9. doi: 10.7554/eLife.54082

PMCID:: PMC7550192

Abstract Article PDF–2.8M

Select item 733296814.

Regulation of the RNA‐binding protein Smaug by the GPCR Smoothened via the kinase Fused

Lucia Bruzzone, Camilla Argüelles, Matthieu Sanial, Samia Miled, Giorgia Alvisi, Marina Gonçalves‐Antunes, Fairouz Qasrawi, Robert A Holmgren, Craig A Smibert, Howard D Lipshitz, Graciela L Boccaccio, Anne Plessis, Isabelle Bécam

EMBO Rep. 2020 Jul 3; 21(7): e48425. Published online 2020 May 8. doi: 10.15252/embr.201948425

PMCID:: PMC7332968

Abstract Article PDF–2.2M

Select item 726148315.

E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation

Weirong Jiang, Xia Yao, Zhaoliang Shan, Wenting Li, Yuxue Gao, Qing Zhang

J Mol Cell Biol. 2019 Sep; 11(9): 791–803. Published online 2019 Mar 29. doi: 10.1093/jmcb/mjz024

PMCID:: PMC7261483

Abstract Article PDF–122M

Select item 673671416.

Phosphorylation of Ci/Gli by Fused family kinases promotes Hedgehog signaling

Yuhong Han, Bing Wang, Yong Suk Cho, Jian Zhu, Jiang Wu, Yongbin Chen, Jin Jiang

Dev Cell. Author manuscript; available in PMC 2020 Sep 9.

Published in final edited form as: Dev Cell. 2019 Sep 9; 50(5): 610–626.e4. Published online 2019 Jul 3. doi: 10.1016/j.devcel.2019.06.008

PMCID:: PMC6736714

Abstract Article PDF–3.0M

Select item 661179717.

AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis

Xiaoyu Tracy Cai, Hongjie Li, Abu Safyan, Jennifer Gawlik, George Pyrowolakis, Heinrich Jasper

Nat Commun. 2019; 10: 2988. Published online 2019 Jul 5. doi: 10.1038/s41467-019-10926-2

PMCID:: PMC6611797

Abstract Article PDF–6.2M

Select item 642956418.

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

Kent Nybakken, Steven A Vokes, Ting-Yi Lin, Andrew P McMahon, Norbert Perrimon

Nat Genet. Author manuscript; available in PMC 2019 Mar 22.

Published in final edited form as: Nat Genet. 2005 Dec; 37(12): 1323–1332. Published online 2005 Nov 20. doi: 10.1038/ng1682

PMCID:: PMC6429564

Abstract Article PDF–1.8M

Select item 612018719.

Activation of Smoothened in the Hedgehog pathway unexpectedly increases Gα_s-dependent cAMP levels in Drosophila

Samantha D. Praktiknjo, Farah Saad, Dominic Maier, Pamela Ip, David R. Hipfner

J Biol Chem. 2018 Aug 31; 293(35): 13496–13508. Published online 2018 Jul 17. doi: 10.1074/jbc.RA118.001953

PMCID:: PMC6120187

Abstract Article PDF–2.6M

Select item 593136920.

A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Masahiro Sonoshita, Alex P. Scopton, Peter M-U. Ung, Matthew A. Murray, Lisa Silber, Andres Y. Maldonado, Alexander Real, Avner Schlessinger, Ross L. Cagan, Arvin C. Dar

Nat Chem Biol. Author manuscript; available in PMC 2018 Jul 22.

Published in final edited form as: Nat Chem Biol. 2018 Mar; 14(3): 291–298. Published online 2018 Jan 22. doi: 10.1038/nchembio.2556