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Items: 1 to 20 of 217

1.
Multimerization of TREM2 is impaired by Alzheimer's disease–associated variants
Hunter B. Dean, Rory A. Greer, Shan‐Zhong Yang, Daniel S. Elston, Thomas J. Brett, Erik D. Roberson, Yuhua Song
Alzheimers Dement. 2024 Sep; 20(9): 6332–6350. Published online 2024 Jul 20. doi: 10.1002/alz.14124
PMCID:
PMC11497687
AbstractArticlePDF–2.9M
2.
Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2
Jong‐Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang‐Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N. Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun‐Wha Im, Jong‐Il Kim, Inhee Mook‐Jung
Adv Sci (Weinh) 2024 Sep; 11(34): 2400064. Published online 2024 Jul 9. doi: 10.1002/advs.202400064
PMCID:
PMC11425970
AbstractArticlePDF–7.8M
3.
A systematic review of the role of TREM2 in Alzheimer’s disease
Yunsi Yin, Hanchen Yang, Ruiyang Li, Guangshan Wu, Qi Qin, Yi Tang
Chin Med J (Engl) 2024 Jul 20; 137(14): 1684–1694. Published online 2024 Jun 24. doi: 10.1097/CM9.0000000000003000
PMCID:
PMC11268819
AbstractArticlePDF–1.4M
4.
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Rebecca L. Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A. Gifford, Kimberly R. Pechman, Mabel Seto, Vladislav A. Petyuk, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman, the Alzheimer’s Disease Neuroimaging Initiative*
Mol Neurodegener. 2024; 19: 41. Published online 2024 May 18. doi: 10.1186/s13024-024-00727-7
PMCID:
PMC11101336
AbstractArticlePDF–2.4M
5.
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways
Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai, Liang Niu, Hongyu Wang, Qiang Dong, Hang Yin, Guoqiang Yuan, Yawen Pan
Cell Commun Signal. 2024; 22: 272. Published online 2024 May 15. doi: 10.1186/s12964-024-01642-6
PMCID:
PMC11094905
AbstractArticlePDF–3.4M
6.
TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas
Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Wenjing Zhang, Yuzhou Chang, Dale B Bosco, Tao Huang, Aastha Dheer, Shan Gao, Shengze Xu, Katayoun Ayasoufi, Rawan Al-Kharboosh, Fangfang Qi, Manling Xie, Aaron J Johnson, Haidong Dong, Alfredo Quiñones-Hinojosa, Long-Jun Wu
Neuro Oncol. 2024 May; 26(5): 811–825. Published online 2023 Nov 6. doi: 10.1093/neuonc/noad214
PMCID:
PMC11066911
AbstractArticlePDF–11M
7.
Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer’s Disease and Reflect Central Neuroinflammation
Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fuh
Am J Alzheimers Dis Other Demen. 2024 Jan-Dec; 39: 15333175241243183. Published online 2024 Apr 9. doi: 10.1177/15333175241243183
PMCID:
PMC11005501
AbstractArticlePDF–769K
8.
Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
Alma S. Popescu, Claire A. Butler, David H. Allendorf, Thomas M. Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M. Pocock, Peter Thornton, Guy C. Brown
Glia. 2023 Apr; 71(4): 974–990. Published online 2022 Dec 8. doi: 10.1002/glia.24318
PMCID:
PMC10952257
AbstractArticlePDF–3.5M
9.
Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages
Yunsheng Liang, Yongfei Hu, Jun Zhang, Haosen Song, Xiaoqian Zhang, Yishan Chen, Yu Peng, Lihua Sun, Yuzhe Sun, Ruzeng Xue, Suyun Ji, Chuanwei Li, Zhili Rong, Bin Yang, Yingping Xu
Theranostics. 2024; 14(5): 2232–2245. Published online 2024 Mar 11. doi: 10.7150/thno.94121
PMCID:
PMC10945340
AbstractArticlePDF–12M
10.
Lack of Genetic Association Between TREM2 and Alzheimer’s Disease in East Asian Population: A Systematic Review and Meta-Analysis
Man Huang, Dejun Wang, Zhijun Xu, Yongshan Xu, Xiaoping Xu, Yuefeng Ma, Zheng Xia
Am J Alzheimers Dis Other Demen. 2015 Sep; 30(6): 541–546. Published online 2015 Apr 7. doi: 10.1177/1533317515577128
PMCID:
PMC10852690
AbstractArticlePDF–453K
11.
Microglial TREM2 at the intersection of brain aging and Alzheimer’s disease
Wenhui Qu, Ling Li
Neuroscientist. Author manuscript; available in PMC 2024 Jan 25.
Published in final edited form as: Neuroscientist. 2023 Jun; 29(3): 302–316. Published online 2021 Sep 2. doi: 10.1177/10738584211040786
PMCID:
PMC10810316
AbstractArticlePDF–1.9M
12.
14-3-3 equation M2-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2
Marcel S. Woo, Johanna Nilsson, Joseph Therriault, Nesrine Rahmouni, Ann Brinkmalm, Andrea L. Benedet, Nicholas J. Ashton, Arthur C. Macedo, Stijn Servaes, Yi-Ting Wang, Cécile Tissot, Jaime Fernandez Arias, Seyyed Ali Hosseini, Mira Chamoun, Firoza Z. Lussier, Thomas K. Karikari, Jenna Stevenson, Christina Mayer, João Pedro Ferrari-Souza, Eliane Kobayashi, Gassan Massarweh, Manuel A. Friese, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
J Neuroinflammation. 2023; 20: 278. Published online 2023 Nov 24. doi: 10.1186/s12974-023-02962-z
PMCID:
PMC10675887
AbstractArticlePDF–1.4M
13.
Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2
Natalia Ogonowski, Hernando Santamaria-Garcia, Sandra Baez, Andrea Lopez, Andrés Laserna, Elkin Garcia-Cifuentes, Paola Ayala-Ramirez, Ignacio Zarante, Fernando Suarez-Obando, Pablo Reyes, Marcelo Kauffman, Nick Cochran, Michael Schulte, Daniel W Sirkis, Salvatore Spina, Jennifer S Yokoyama, Bruce L Miller, Kenneth S Kosik, Diana Matallana, Agustín Ibáñez
J Med Genet. 2023 Sep; 60(9): 894–904. Published online 2023 Feb 22. doi: 10.1136/jmg-2022-108627
PMCID:
PMC10447405
AbstractArticlePDF–2.8M
14.
TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain
Stefanie Fruhwürth, Line S. Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R. Paludan
Sci Adv. 2023 Aug; 9(33): eadf5808. Published online 2023 Aug 18. doi: 10.1126/sciadv.adf5808
PMCID:
PMC10438464
AbstractArticlePDF–1.7M
15.
Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain
Kostantin Kiianitsa, Irina Kurtz, Neal Beeman, Mark Matsushita, Wei-Ming Chien, Wendy H. Raskind, Olena Korvatska
J Leukoc Biol. Author manuscript; available in PMC 2023 Aug 17.
Published in final edited form as: J Leukoc Biol. 2021 Nov; 110(5): 829–837. Published online 2021 Jun 1. doi: 10.1002/JLB.2HI0720-463RR
PMCID:
PMC10433532
AbstractArticlePDF–1.2M
16.
Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer’s Patient-Derived Assay
Nicoleta-Carmen Cosma, Neriman Eren, Berk Üsekes, Susanna Gerike, Isabella Heuser, Oliver Peters, Julian Hellmann-Regen
Cell Mol Neurobiol. 2023; 43(6): 3047–3060. Published online 2023 May 17. doi: 10.1007/s10571-023-01351-7
PMCID:
PMC10333375
AbstractArticlePDF–2.5M
17.
The triggering receptor expressed on myeloid cells 2–apolipoprotein E signaling pathway in diseases
Shukai Lyu, Zhuoqing Lan, Caixia Li
Chin Med J (Engl) 2023 Jun 5; 136(11): 1291–1299. Published online 2023 May 2. doi: 10.1097/CM9.0000000000002167
PMCID:
PMC10309513
AbstractArticlePDF–905K
18.
Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM2
Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino
Commun Biol. 2023; 6: 616. Published online 2023 Jun 8. doi: 10.1038/s42003-023-04998-6
PMCID:
PMC10250343
AbstractArticlePDF–2.0M
19.
TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer’s Disease
Francesca La Rosa, Simone Agostini, Federica Piancone, Ivana Marventano, Ambra Hernis, Chiara Fenoglio, Daniela Galimberti, Elio Scarpini, Marina Saresella, Mario Clerici
Int J Mol Sci. 2023 May; 24(10): 8626. Published online 2023 May 11. doi: 10.3390/ijms24108626
PMCID:
PMC10218378
AbstractArticlePDF–1.1M
20.
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma
Rui Sun, Rowland Han, Colin McCornack, Saad Khan, G. Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M. Schoch, Diane D. Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin Luo, Allegra Petti, Timothy M. Miller, Jason D. Ulrich, David M. Holtzman, Albert H. Kim
Sci Adv. 2023 May; 9(19): eade3559. Published online 2023 May 12. doi: 10.1126/sciadv.ade3559
Correction in:
Sci Adv. 2024 May 24; 10(21): eadq2160.
PMCID:
PMC10181199
AbstractArticlePDF–3.4M

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