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Select item 112933941.

Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50–IκBζ pathway

Allison E. Daly, George Yeh, Sofia Soltero, Stephen T. Smale

Genes Dev. 2024 Jun 1; 38(11-12): 536–553. doi: 10.1101/gad.351630.124

PMCID:: PMC11293394

Abstract Article PDF–9.5M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 101774943.

Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

Monika Adori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquin Castro Dopico, Gunilla B. Karlsson Hedestam

Cells. 2023 May; 12(9): 1229. Published online 2023 Apr 24. doi: 10.3390/cells12091229

PMCID:: PMC10177494

Abstract Article PDF–15M

Select item 98132284.

IκB_NS-deficiency protects mice from fatal Listeria monocytogenes infection by blunting pro-inflammatory signature in Ly6C^high monocytes and preventing exaggerated innate immune responses

Sarah Frentzel, Andreas Jeron, Alexander Pausder, Olivia Kershaw, Julia Volckmar, Ingo Schmitz, Dunja Bruder

Front Immunol. 2022; 13: 1028789. Published online 2022 Dec 22. doi: 10.3389/fimmu.2022.1028789

PMCID:: PMC9813228

Abstract Article PDF–7.1M

Select item 96341545.

IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens

Sharesta Khoenkhoen, Monika Ádori, Darío Solís-Sayago, Juliette Soulier, Jamie Russell, Bruce Beutler, Gabriel K. Pedersen, Gunilla B. Karlsson Hedestam

Front Immunol. 2022; 13: 1000755. Published online 2022 Oct 21. doi: 10.3389/fimmu.2022.1000755

PMCID:: PMC9634154

Abstract Article PDF–4.5M

Select item 93652696.

Nfkbid overexpression in NOD mice elicits complete type 1 diabetes resistance in part associated with enhanced thymic deletion of pathogenic CD8 T-cells and increased numbers and activity of regulatory T-cells.

Jennifer R Dwyer, Jeremy J Racine, Harold D Chapman, Anna Quinlan, Maximiliano Presa, Grace A Stafford, Ingo Schmitz, David V Serreze

J Immunol. Author manuscript; available in PMC 2023 Jul 15.

Published in final edited form as: J Immunol. 2022 Jul 15; 209(2): 227–237. Published online 2022 Jun 27. doi: 10.4049/jimmunol.2100558

PMCID:: PMC9365269

Abstract Article PDF–2.4M

Select item 86759337.

Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii

Scott P. Souza, Samantha D. Splitt, Juan C. Sànchez-Arcila, Julia A. Alvarez, Jessica N. Wilson, Safuwra Wizzard, Zheng Luo, Nicole Baumgarth, Kirk D. C. Jensen

PLoS Pathog. 2021 Dec; 17(12): e1010081. Published online 2021 Dec 6. doi: 10.1371/journal.ppat.1010081

PMCID:: PMC8675933

Abstract Article PDF–4.9M

Select item 68501868.

TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS

Sharesta Khoenkhoen, Elina Erikson, Monika Ádori, Julian M Stark, Jean L Scholz, Michael P Cancro, Gabriel K Pedersen, Gunilla B Karlsson Hedestam

Immunol Cell Biol. 2019 May-Jun; 97(5): 485–497. Published online 2019 Jan 30. doi: 10.1111/imcb.12228

PMCID:: PMC6850186

Abstract Article PDF–2.2M

Select item 68032509.

Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice

Ruoxi Pi, Akiko Iwasaki, Xaver Sewald, Walther Mothes, Pradeep D. Uchil

J Virol. 2019 Nov 1; 93(21): e00930-19. Prepublished online 2019 Aug 21. Published online 2019 Oct 15. doi: 10.1128/JVI.00930-19

PMCID:: PMC6803250

Abstract Article PDF–3.6M

Select item 677160010.

Essential role of IκB_NS for in vivo CD4⁺ T‐cell activation, proliferation, and Th1‐cell differentiation during Listeria monocytogenes infection in mice

Sarah Frentzel, Konstantinos Katsoulis‐Dimitriou, Andreas Jeron, Ingo Schmitz, Dunja Bruder

Eur J Immunol. 2019 Sep; 49(9): 1391–1398. Published online 2019 Jun 7. doi: 10.1002/eji.201847961

PMCID:: PMC6771600

Abstract Article PDF–2.0M

Select item 631774511.

Targeting IκBNS in allergic asthma: where it resides, matters

S. Sengupta, A. Haczku

Allergy. Author manuscript; available in PMC 2019 Jan 3.

Published in final edited form as: Allergy. 2017 Jul; 72(7): 1003–1005. doi: 10.1111/all.13126

PMCID:: PMC6317745

Article PDF–415K

Select item 614339712.

A hypermorphic Nfkbid allele contributes to impaired thymic deletion of autoreactive diabetogenic CD8⁺ T-cells in NOD mice

Maximiliano Presa, Jeremy J. Racine, Jennifer R. Dwyer, Deanna J. Lamont, Jeremy J. Ratiu, Vishal Kumar Sarsani, Yi-Guang Chen, Aron Geurts, Ingo Schmitz, Timothy Stearns, Jennifer Allocco, Harold D. Chapman, Dr. David V. Serreze

J Immunol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Immunol. 2018 Oct 1; 201(7): 1907–1917. Published online 2018 Aug 20. doi: 10.4049/jimmunol.1800465

PMCID:: PMC6143397

Abstract Article PDF–2.2M

Select item 574391213.

An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice

Koji Akita, Kikuo Isoda, Yayoi Sato-Okabayashi, Tomoyasu Kadoguchi, Kenichi Kitamura, Fumie Ohtomo, Kazunori Shimada, Hiroyuki Daida

Front Cardiovasc Med. 2017; 4: 84. Published online 2017 Dec 22. doi: 10.3389/fcvm.2017.00084

PMCID:: PMC5743912

Abstract Article PDF–1.2M

Select item 479989014.

The atypical IκB protein IκB_NS is important for Toll‐like receptor‐induced interleukin‐10 production in B cells

Minami Miura, Naoki Hasegawa, Mitsuo Noguchi, Kenkichi Sugimoto, Maki Touma

Immunology. 2016 Apr; 147(4): 453–463. Published online 2016 Feb 8. doi: 10.1111/imm.12578

PMCID:: PMC4799890

Abstract Article PDF–639K

Select item 477177215.

Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens

Gabriel K. Pedersen, Monika Ádori, Julian M. Stark, Sharesta Khoenkhoen, Carrie Arnold, Bruce Beutler, Gunilla B. Karlsson Hedestam

Front Immunol. 2016; 7: 65. Published online 2016 Mar 1. doi: 10.3389/fimmu.2016.00065

PMCID:: PMC4771772

Abstract Article PDF–3.2M

Select item 423459616.

p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation

Zhihua Tao, Amanda Fusco, De-Bin Huang, Kushol Gupta, Daniel Young Kim, Carl F. Ware, Gregory D. Van Duyne, Gourisankar Ghosh

Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45): 15946–15951. Published online 2014 Oct 27. doi: 10.1073/pnas.1408552111

PMCID:: PMC4234596

Abstract Article PDF–1.3M

Select item 421020717.

The Nuclear IκB Family Protein IκB_NS Influences the Susceptibility to Experimental Autoimmune Encephalomyelitis in a Murine Model

Shuhei Kobayashi, Akira Hara, Takayuki Isagawa, Ichiro Manabe, Kiyoshi Takeda, Takashi MaruYama

PLoS One. 2014; 9(10): e110838. Published online 2014 Oct 27. doi: 10.1371/journal.pone.0110838

Correction in:: PLoS One. 2015; 10(2): e0118159.

PMCID:: PMC4210207

Abstract Article PDF–758K

Select item 419177518.

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS

Gabriel K. Pedersen, Monika Àdori, Sharesta Khoenkhoen, Pia Dosenovic, Bruce Beutler, Gunilla B. Karlsson Hedestam

Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39): E4119–E4126. Published online 2014 Sep 16. doi: 10.1073/pnas.1415866111

PMCID:: PMC4191775

Abstract Article PDF–1.6M

Select item 357241019.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 341194620.

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Carrie N. Arnold, Elaine Pirie, Pia Dosenovic, Gerald M. McInerney, Yu Xia, Nathaniel Wang, Xiaohong Li, Owen M. Siggs, Gunilla B. Karlsson Hedestam, Bruce Beutler

Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31): 12286–12293. Published online 2012 Jul 3. doi: 10.1073/pnas.1209134109

PMCID:: PMC3411946

Abstract Article PDF–1.3M

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