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Select item 107349781.

Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease

Magda L. Atilano, Alexander Hull, Catalina-Andreea Romila, Mirjam L. Adams, Jacob Wildfire, Enric Ureña, Miranda Dyson, Jorge Ivan-Castillo-Quan, Linda Partridge, Kerri J. Kinghorn

PLoS Genet. 2023 Dec; 19(12): e1011063. Published online 2023 Dec 21. doi: 10.1371/journal.pgen.1011063

PMCID:: PMC10734978

Abstract Article PDF–4.3M

Select item 102729012.

Humanization for neurological disease modeling: A roadmap to increase the potential of Drosophila model systems

Vladimir L. Katanaev

Animal Model Exp Med. 2023 Jun; 6(3): 230–236. Published online 2023 May 8. doi: 10.1002/ame2.12322

PMCID:: PMC10272901

Abstract Article PDF–877K

Select item 102317923.

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V. Lee, Yarong Li, Duc Duong, Bridget Phillips, Carlos Cruchaga, Genevera I. Allen, Nicholas T. Seyfried, Ismael Al-Ramahi, Juan Botas, Joshua M. Shulman

PLoS Genet. 2023 May; 19(5): e1010760. Published online 2023 May 18. doi: 10.1371/journal.pgen.1010760

PMCID:: PMC10231792

Abstract Article PDF–1.9M

Select item 102007724.

Dietary supplementation with milk lipids leads to suppression of developmental and behavioral phenotypes of hyperexcitable Drosophila mutants

Junko Kasuya, Wayne Johnson, Hung-Lin Chen, Toshihiro Kitamoto

Neuroscience. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Neuroscience. 2023 Jun 1; 520: 1–17. Published online 2023 Mar 31. doi: 10.1016/j.neuroscience.2023.03.027

PMCID:: PMC10200772

Abstract Article PDF–2.6M

Select item 99787935.

Sphingolipids in neurodegenerative diseases

Xueyang Pan, Debdeep Dutta, Shenzhao Lu, Hugo J. Bellen

Front Neurosci. 2023; 17: 1137893. Published online 2023 Feb 16. doi: 10.3389/fnins.2023.1137893

PMCID:: PMC9978793

Abstract Article PDF–6.2M

Select item 96326586.

Exploring therapeutic potential of mitophagy modulators using Drosophila models of Parkinson’s disease

Jyotsna Asthana, Bhupendra V. Shravage

Front Aging Neurosci. 2022; 14: 986849. Published online 2022 Oct 19. doi: 10.3389/fnagi.2022.986849

PMCID:: PMC9632658

Abstract Article PDF–1.2M

Select item 93783617.

‘Fly’ing from rare to common neurodegenerative disease mechanisms

Mengqi Ma, Matthew J. Moulton, Shenzhao Lu, Hugo J. Bellen

Trends Genet. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Trends Genet. 2022 Sep; 38(9): 972–984. Published online 2022 Apr 25. doi: 10.1016/j.tig.2022.03.018

PMCID:: PMC9378361

Abstract Article PDF–1.0M

Select item 87017488.

Guillaume Bordet, Niraj Lodhi, Andrew Kossenkov, Alexei Tulin

Genes (Basel) 2021 Dec; 12(12): 1982. Published online 2021 Dec 14. doi: 10.3390/genes12121982

PMCID:: PMC8701748

Abstract Article PDF–2.3M

Select item 82704849.

Loss of UCHL1 rescues the defects related to Parkinson’s disease by suppressing glycolysis

Su Jin Ham, Daewon Lee, Wen Jun Xu, Eunjoo Cho, Sekyu Choi, Soohong Min, Sunghyouk Park, Jongkyeong Chung

Sci Adv. 2021 Jul; 7(28): eabg4574. Published online 2021 Jul 9. doi: 10.1126/sciadv.abg4574

PMCID:: PMC8270484

Abstract Article PDF–7.4M

Select item 814818510.

The Impact of Microbiome and Microbiota-Derived Sodium Butyrate on Drosophila Transcriptome and Metabolome Revealed by Multi-Omics Analysis

Fan Zhou, Biaodi Liu, Xin Liu, Yan Li, Luoluo Wang, Jia Huang, Guanzheng Luo, Xiaoyun Wang

Metabolites. 2021 May; 11(5): 298. Published online 2021 May 6. doi: 10.3390/metabo11050298

PMCID:: PMC8148185

Abstract Article PDF–28M

Select item 800085011.

Exploiting the Potential of Drosophila Models in Lysosomal Storage Disorders: Pathological Mechanisms and Drug Discovery

Laura Rigon, Concetta De Filippis, Barbara Napoli, Rosella Tomanin, Genny Orso

Biomedicines. 2021 Mar; 9(3): 268. Published online 2021 Mar 7. doi: 10.3390/biomedicines9030268

PMCID:: PMC8000850

Abstract Article PDF–2.8M

Select item 800006612.

The Uncovered Function of the Drosophila GBA1a-Encoded Protein

Or Cabasso, Sumit Paul, Gali Maor, Metsada Pasmanik-Chor, Wouter Kallemeijn, Johannes Aerts, Mia Horowitz

Cells. 2021 Mar; 10(3): 630. Published online 2021 Mar 12. doi: 10.3390/cells10030630

PMCID:: PMC8000066

Abstract Article PDF–5.0M

Select item 799831613.

The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s Disease

Melissa Vos, Christine Klein

Cells. 2021 Mar; 10(3): 579. Published online 2021 Mar 6. doi: 10.3390/cells10030579

PMCID:: PMC7998316

Abstract Article PDF–1.7M

Select item 788866514.

Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Kathryn A. Jewett, Ruth E. Thomas, Chi Q. Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F. Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J. Pallanck, Marie Y. Davis

PLoS Genet. 2021 Feb; 17(2): e1008859. Published online 2021 Feb 4. doi: 10.1371/journal.pgen.1008859