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Select item 111871771.

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity

Peiran Feng, Liang Luo, Quanli Yang, Wanqing Meng, Zerong Guan, Zhizhong Li, Guodong Sun, Zhongjun Dong, Meixiang Yang

Cell Death Dis. 2024 Jun; 15(6): 430. Published online 2024 Jun 19. doi: 10.1038/s41419-024-06828-x

PMCID:: PMC11187177

Abstract Article PDF–6.0M

Select item 110964222.

MST1/2 regulates fibro/adipogenic progenitor fate decisions in skeletal muscle regeneration

Kezhi Wang, Jingjing Yang, Yina An, Jing Wang, Shuyu Tan, Hui Xu, Yanjun Dong

Stem Cell Reports. 2024 Apr 9; 19(4): 501–514. Published online 2024 Mar 28. doi: 10.1016/j.stemcr.2024.02.010

PMCID:: PMC11096422

Abstract Article PDF–6.9M

Select item 109849673.

The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress

Dae Jin Jeong, Jee-Hyun Um, Young Yeon Kim, Dong Jin Shin, Sangwoo Im, Kang-Min Lee, Yun-Hee Lee, Dae-sik Lim, Donghoon Kim, Jeanho Yun

Exp Mol Med. 2024 Mar; 56(3): 674–685. Published online 2024 Mar 5. doi: 10.1038/s12276-024-01198-y

PMCID:: PMC10984967

Abstract Article PDF–4.8M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108092235.

Epinephrine inhibits PI3Kα via the Hippo kinases

Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves

Cell Rep. Author manuscript; available in PMC 2024 Jan 25.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113535. Published online 2023 Dec 4. doi: 10.1016/j.celrep.2023.113535

PMCID:: PMC10809223

Abstract Article PDF–2.3M

Select item 107976916.

Inactivation of MST1/2 Controls Macrophage Polarization to Affect Macrophage-Related Disease via YAP and Non-YAP Mechanisms

Yina An, Shuyu Tan, Pu Zhang, Jingjing Yang, Kezhi Wang, Ruicheng Zheng, Lu Qiao, Yang Wang, Yanjun Dong

Int J Biol Sci. 2024; 20(3): 1004–1023. Published online 2024 Jan 12. doi: 10.7150/ijbs.87057

PMCID:: PMC10797691

Abstract Article PDF–25M

Select item 106829337.

Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis

Samira Benhamouche-Trouillet, Evan O'Loughlin, Ching-Hui Liu, William Polacheck, Julien Fitamant, Mary McKee, Nabeel El-Bardeesy, Christopher S. Chen, Andrea I. McClatchey

Development. 2018 May 1; 145(9): dev162123. Published online 2018 Apr 30. doi: 10.1242/dev.162123

PMCID:: PMC10682933

Abstract Article

Select item 101144988.

Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer

Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, Raffaele A. Calogero, Ömer H. Yilmaz, Junhao Mao, Fernando D. Camargo

Cell Stem Cell. Author manuscript; available in PMC 2023 Apr 19.

Published in final edited form as: Cell Stem Cell. 2020 Oct 1; 27(4): 590–604.e9. Published online 2020 Jul 29. doi: 10.1016/j.stem.2020.07.003

PMCID:: PMC10114498

Abstract Article PDF–2.4M

Select item 100867479.

Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein 1 phosphorylation and nuclear factor erythroid 2-related factor 2 degradation

Hang Zhu, Zhe Dai, Xiaoman Liu, Hao Zhou, Yijin Wang

Int J Biol Sci. 2023; 19(5): 1369–1381. Published online 2023 Feb 21. doi: 10.7150/ijbs.80800

PMCID:: PMC10086747

Abstract Article PDF–6.4M

Select item 981691810.

A Stk4 -Foxp3-P65 Transcriptional Complex Promotes Treg Cell Activation and Homeostasis

Ye Cui, Mehdi Benamar, Klaus Schmitz-Abe, Varsha Poondi-Krishnan, Qian Chen, Bat-Erdene Jugder, Benoit Fatou, Jason Fong, Yuelin Zhong, Stuti Mehta, Altantsetseg Buyanbat, Beray Selver Eklioglu, Esra Karabiber, Safa Baris, Ayca Kiykim, Sevgi Keles, Emmanuel Stephen-Victor, Claudia Angelini, Louis-Marie Charbonnier, Talal A. Chatila

Sci Immunol. Author manuscript; available in PMC 2023 Jan 6.

Published in final edited form as: Sci Immunol. 2022 Sep 23; 7(75): eabl8357. Published online 2022 Sep 23. doi: 10.1126/sciimmunol.abl8357

PMCID:: PMC9816918

Abstract Article PDF–3.0M

Select item 899374211.

Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers

Fakhreddin Yaghoob Nezhad, Annett Riermeier, Martin Schönfelder, Lore Becker, Martin Hrabĕ de Angelis, Henning Wackerhage

Transgenic Res. 2022; 31(2): 227–237. Published online 2022 Jan 5. doi: 10.1007/s11248-021-00293-4

PMCID:: PMC8993742

Abstract Article PDF–3.8M

Select item 854953612.

STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development

Tohru Matsuki, Akio Iio, Masashi Ueda, Yumi Tsuneura, Brian W. Howell, Atsuo Nakayama

J Neurosci. 2021 Oct 27; 41(43): 8887–8903. doi: 10.1523/JNEUROSCI.0523-21.2021

PMCID:: PMC8549536

Abstract Article PDF–6.2M

Select item 838300213.

YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1

Jason J. Gokey, John Snowball, Anusha Sridharan, Parvathi Sudha, Joseph A. Kitzmiller, Yan Xu, Jeffrey A. Whitsett

iScience. 2021 Sep 24; 24(9): 102967. Published online 2021 Aug 11. doi: 10.1016/j.isci.2021.102967

PMCID:: PMC8383002

Abstract Article PDF–4.4M

Select item 797112914.

Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions

Jana L. Raynor, Chaohong Liu, Yogesh Dhungana, Cliff Guy, Nicole M. Chapman, Hao Shi, Geoffrey Neale, Hiromi Sesaki, Hongbo Chi

J Exp Med. 2020 Jun 1; 217(6): e20191157. Published online 2020 Apr 14. doi: 10.1084/jem.20191157

PMCID:: PMC7971129

Abstract Article PDF–7.3M

Select item 758233415.

Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice

Zakiyatul Faizah, Bella Amanda, Faisal Yusuf Ashari, Efta Triastuti, Rebecca Oxtoby, Anny Setijo Rahaju, M. Aminudin Aziz, Maria Inge Lusida, Delvac Oceandy

Molecules. 2020 Oct; 25(19): 4381. Published online 2020 Sep 24. doi: 10.3390/molecules25194381

PMCID:: PMC7582334

Abstract Article PDF–2.5M

Select item 753367916.

Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson’s disease

Eun Hee Ahn, Seong Su Kang, Qi Qi, Xia Liu, Keqiang Ye

Proc Natl Acad Sci U S A. 2020 Sep 29; 117(39): 24503–24513. Published online 2020 Sep 14. doi: 10.1073/pnas.2004087117

PMCID:: PMC7533679

Abstract Article PDF–2.1M

Select item 749222617.

Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway

Chenling Meng, Geng Tian, Chunhua Xu, Xiaofeng Li, Yu Zhang, Yang Wang, Jinzhong Qin, Ellis Kin Lam Fok, Barry T. Hinton, Kingston King-lun Mak, Winnie Waichi Shum, Wai-Yee Chan, Yin Xia

Cell Death Differ. 2020 Oct; 27(10): 2797–2809. Published online 2020 Apr 24. doi: 10.1038/s41418-020-0544-x

PMCID:: PMC7492226

Abstract Article PDF–5.0M

Select item 741599118.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 736717819.

Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers

Xiang Sun, Zhijun Ren, Yixian Cun, Cai Zhao, Xianglin Huang, Jiajian Zhou, Rong Hu, Xiaoxi Su, Lu Ji, Peng Li, King Lun Kingston Mak, Feng Gao, Yi Yang, He Xu, Junjun Ding, Nan Cao, Shuo Li, Wensheng Zhang, Ping Lan, Hao Sun, Jinkai Wang, Ping Yuan

Nucleic Acids Res. 2020 Jul 27; 48(13): 7182–7196. Published online 2020 Jun 8. doi: 10.1093/nar/gkaa482

PMCID:: PMC7367178

Abstract Article PDF–9.6M

Select item 721740720.

Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms

Chunhua Xu, Li Wang, Yu Zhang, Wenling Li, Jinhong Li, Yang Wang, Chenling Meng, Jinzhong Qin, Zhi-Hua Zheng, Hui-Yao Lan, Kingston King-Lun Mak, Yu Huang, Yin Xia

J Am Soc Nephrol. 2020 May; 31(5): 946–961. Published online 2020 Apr 6. doi: 10.1681/ASN.2019101052

PMCID:: PMC7217407

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