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Select item 112510551.

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer

Nicla Lorito, Angela Subbiani, Alfredo Smiriglia, Marina Bacci, Francesca Bonechi, Laura Tronci, Elisabetta Romano, Alessia Corrado, Dario Livio Longo, Marta Iozzo, Luigi Ippolito, Giuseppina Comito, Elisa Giannoni, Icro Meattini, Alexandra Avgustinova, Paola Chiarugi, Angela Bachi, Andrea Morandi

EMBO Mol Med. 2024 Jul; 16(7): 1533–1559. Published online 2024 Jun 26. doi: 10.1038/s44321-024-00090-6

PMCID:: PMC11251055

Abstract Article PDF–9.2M

Select item 109402942.

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2

Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya

Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6

PMCID:: PMC10940294

Abstract Article PDF–6.0M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106157424.

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice

Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara

Mol Psychiatry. 2023; 28(7): 2848–2856. Published online 2023 Feb 21. doi: 10.1038/s41380-023-01988-2

PMCID:: PMC10615742

Abstract Article PDF–1.9M

Select item 94819335.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 74159916.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 71816927.

FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling

Rui Zhao, Linli Tian, Bo Zhao, Yanan Sun, Jing Cao, Kexin Chen, Fengqing Li, Minghua Li, Desi Shang, Ming Liu

Cell Death Dis. 2020 Apr; 11(4): 272. Published online 2020 Apr 24. doi: 10.1038/s41419-020-2457-5

PMCID:: PMC7181692

Abstract Article PDF–6.5M

Select item 62980408.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 57464319.

The Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Pro-Inflammatory and Pro-Resolving Lipid Mediators

Anthony D. Gromovsky, Rebecca C. Schugar, Amanda L. Brown, Robert N. Helsley, Amy C. Burrows, Daniel Ferguson, Renliang Zhang, Brian E. Sansbury, Richard G. Lee, Richard E. Morton, Daniela S. Allende, John S. Parks, Matthew Spite, J. Mark Brown

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Jan; 38(1): 218–231. Published online 2017 Oct 26. doi: 10.1161/ATVBAHA.117.309660

PMCID:: PMC5746431

Abstract Article PDF–1.4M

Select item 538122610.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 529582111.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 510442512.

A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice

Hiroaki Yashiro, Shuichi Takagahara, Yumiko Okano Tamura, Ikuo Miyahisa, Junji Matsui, Hideo Suzuki, Shota Ikeda, Masanori Watanabe

PLoS One. 2016; 11(11): e0166198. Published online 2016 Nov 10. doi: 10.1371/journal.pone.0166198

PMCID:: PMC5104425

Abstract Article PDF–2.0M

Select item 508786713.

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Hang Su, Dan Zhou, Yuan-Xiang Pan, Xingguo Wang, Manabu T. Nakamura

J Lipid Res. 2016 Nov; 57(11): 1995–2004. Published online 2016 Oct 27. doi: 10.1194/jlr.M064956

PMCID:: PMC5087867

Abstract Article PDF–913K

Select item 508140614.

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle

Cell Rep. 2016 Oct 18; 17(4): 1008–1021. Published online 2016 Oct 18. doi: 10.1016/j.celrep.2016.09.053

PMCID:: PMC5081406

Abstract Article

Select item 501097315.

A new model to study the role of arachidonic acid in colon cancer pathophysiology

Yang-Yi Fan, Evelyn Callaway, Jennifer M. Monk, Jennifer S. Goldsby, Peiying Yang, Logan Vincent, Robert S. Chapkin

Cancer Prev Res (Phila) Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Cancer Prev Res (Phila). 2016 Sep; 9(9): 750–757. Published online 2016 Jun 23. doi: 10.1158/1940-6207.CAPR-16-0060

PMCID:: PMC5010973

Abstract Article PDF–858K

Select item 492282216.

Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque

David R Powell, Jason P Gay, Melinda Smith, Nathaniel Wilganowski, Angela Harris, Autumn Holland, Maricela Reyes, Laura Kirkham, Laura L Kirkpatrick, Brian Zambrowicz, Gwenn Hansen, Kenneth A Platt, Isaac van Sligtenhorst, Zhi-Ming Ding, Urvi Desai

Diabetes Metab Syndr Obes. 2016; 9: 185–199. Published online 2016 Jun 22. doi: 10.2147/DMSO.S106653

PMCID:: PMC4922822

Abstract Article PDF–3.4M

Select item 412724017.

Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

Jennifer M. Monk, Harmony F. Turk, Yang-Yi Fan, Evelyn Callaway, Brad Weeks, Peiying Yang, David N. McMurray, Robert S. Chapkin

Mediators Inflamm. 2014; 2014: 917149. Published online 2014 Jul 17. doi: 10.1155/2014/917149

PMCID:: PMC4127240

Abstract Article PDF–2.1M

Select item 396495518.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 337124019.

Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model

Yang-Yi Fan, Jennifer M. Monk, Tim Y. Hou, Evelyn Callway, Logan Vincent, Brad Weeks, Peiying Yang, Robert S. Chapkin

J Lipid Res. 2012 Jul; 53(7): 1287–1295. doi: 10.1194/jlr.M024216

PMCID:: PMC3371240

Abstract Article PDF–1.0M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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