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Items: 1 to 20 of 144

1.
Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24
Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frédéric Ebstein, Paul J. Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J. Calleja, Cassandra R. Harapas, Katherine R. Balka, Jacob Mitchell, Jacob T. Jackson, Niall D. Geoghegan, Fiona Moghaddas, Kelly L. Rogers, Katrin D. Mayer-Barber, Adriana A. De Jesus, Dominic De Nardo, Benjamin T. Kile, Anthony J. Sadler, M. Cecilia Poli, Elke Krüger, Raphaela Goldbach Mansky, Seth L. Masters
Sci Immunol. Author manuscript; available in PMC 2024 Apr 23.
Published in final edited form as: Sci Immunol. 2022 Feb 11; 7(68): eabi6763. Published online 2022 Feb 11. doi: 10.1126/sciimmunol.abi6763
PMCID:
PMC11036408
AbstractArticlePDF–1.6M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity
Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato
Sci Adv. 2024 Mar 1; 10(9): eadk0820. Published online 2024 Mar 1. doi: 10.1126/sciadv.adk0820
PMCID:
PMC10906915
AbstractArticlePDF–4.5M
4.
The protein kinase R modifies gut physiology to limit colitis
Howard Chi Ho Yim, Arindam Chakrabarti, Sean Kessler, Hiroyuki Morimoto, Die Wang, Dhanya Sooraj, Afsar U. Ahmed, Carol de la Motte, Robert H. Silverman, Bryan RG. Williams, Anthony J. Sadler
Front Immunol. 2023; 14: 1106737. Published online 2023 Feb 17. doi: 10.3389/fimmu.2023.1106737
PMCID:
PMC9981792
AbstractArticlePDF–3.1M
5.
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation
Zhouyangfan Peng, Xiqing Tan, Liangpeng Xie, Ze Li, Sufang Zhou, Yapei Li
iScience. 2023 Jan 20; 26(1): 105909. Published online 2022 Dec 30. doi: 10.1016/j.isci.2022.105909
PMCID:
PMC9860489
AbstractArticlePDF–4.9M
6.
A variant NS1 protein from H5N2 avian influenza virus suppresses PKR activation and promotes replication and virulence in mammals
Yun-Ting Chung, Chih-Ying Kuan, Guan-Ru Liao, Randy A. Albrecht, Yeu-Yang Tseng, Yu-Chen Hsu, Shan-Chia Ou, Wei-Li Hsu
Emerg Microbes Infect. 2022; 11(1): 2291–2303. Published online 2022 Oct 9. doi: 10.1080/22221751.2022.2114853
PMCID:
PMC9559317
AbstractArticlePDF–2.6M
7.
Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation
Berto Tejera-Hernández, Danielle E. Goodman, Juan M. Nevarez, Katherine R. Spindler
J Virol. 2022 Apr; 96(7): e02063-21. Published online 2022 Mar 14. doi: 10.1128/jvi.02063-21
Correction in:
J Virol. 2023 Oct; 97(10): e01265-23.
PMCID:
PMC9006929
AbstractArticlePDF–1.0M
8.
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation
Junchao Shi, Zi Li, Rongyi Xu, Jing Zhang, Qianyu Zhou, Rui Gao, Huijun Lu, Yungang Lan, Kui Zhao, Hongbin He, Feng Gao, Wenqi He
J Virol. 2022 Jan; 96(1): e01695-21. Prepublished online 2021 Oct 13. Published online 2022 Jan 12. doi: 10.1128/JVI.01695-21
PMCID:
PMC8754228
AbstractArticlePDF–6.3M
9.
Protein Kinase R and the Integrated Stress Response drive immunopathology caused by mutations in the RNA deaminase ADAR1
Megan Maurano, Jessica M. Snyder, Caitlin Connelly, Jorge Henao-Mejia, Carmela Sidrauski, Daniel B. Stetson
Immunity. Author manuscript; available in PMC 2022 Sep 14.
Published in final edited form as: Immunity. 2021 Sep 14; 54(9): 1948–1960.e5. Published online 2021 Aug 2. doi: 10.1016/j.immuni.2021.07.001
PMCID:
PMC8446335
AbstractArticlePDF–3.6M
10.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
11.
Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis
Yanliang Yang, Lingli Xie, Yanjun Zhong, Xiaoli Zhong, Ran Meng, Qianqian Xue, Fang Liang, Kai Zhao, Yiting Tang
J Innate Immun. 2021 Jan; 13(1): 26–37. Published online 2020 Dec 17. doi: 10.1159/000507932
PMCID:
PMC7879320
AbstractArticlePDF–679K
12.
Maternal Immune Activation in Mice Disrupts Proteostasis in the Fetal Brain
Brian T. Kalish, Eunha Kim, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Casey K. Gilman, Yeong Shin Yim, Lilin Tong, Randal J. Kaufman, Eric C. Griffith, Gloria B. Choi, Michael E. Greenberg, Jun R. Huh
Nat Neurosci. Author manuscript; available in PMC 2021 Jun 23.
Published in final edited form as: Nat Neurosci. 2021 Feb; 24(2): 204–213. Published online 2020 Dec 23. doi: 10.1038/s41593-020-00762-9
PMCID:
PMC7854524
AbstractArticlePDF–5.7M
13.
The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways
Jialu Zhou, Fan Zhang, Hongru Lin, Minxue Quan, Yaqin Yang, Yanni Lv, Zongnan He, Yisong Qian
Med Sci Monit. 2020; 26: e926254-1–e926254-9. Prepublished online 2020 Aug 18. Published online 2020 Oct 5. doi: 10.12659/MSM.926254
PMCID:
PMC7545781
AbstractArticlePDF–1.2M
14.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
15.
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
Ping Jun Zhu, Sanjeev Khatiwada, Ya Cui, Lucas C. Reineke, Sean W. Dooling, Jean J. Kim, Wei Li, Peter Walter, Mauro Costa-Mattioli
Science. Author manuscript; available in PMC 2020 Jun 17.
Published in final edited form as: Science. 2019 Nov 15; 366(6467): 843–849. doi: 10.1126/science.aaw5185
PMCID:
PMC7299149
AbstractArticlePDF–875K
16.
Blocking the eIF2α Kinase (PKR) Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory
Elad Stern, Adaikkan Chinnakkaruppan, Orit David, Nahum Sonenberg, Kobi Rosenblum
J Neurosci. 2013 Feb 6; 33(6): 2517–2525. doi: 10.1523/JNEUROSCI.2322-12.2013
PMCID:
PMC6619168
AbstractArticlePDF–2.5M
17.
Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis
Svenja Fritzlar, Turgut E. Aktepe, Yi-Wei Chao, Nathan D. Kenney, Michael R. McAllaster, Craig B. Wilen, Peter A. White, Jason M. Mackenzie
mBio. 2019 May-Jun; 10(3): e00960-19. Published online 2019 Jun 18. doi: 10.1128/mBio.00960-19
PMCID:
PMC6581855
AbstractArticlePDF–3.2M
18.
The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages
Songlin Yu, Dan Wang, Lingmin Huang, Yening Zhang, Ruiheng Luo, Dickson Adah, Yiting Tang, Kai Zhao, Ben Lu
J Biol Chem. 2019 May 24; 294(21): 8384–8394. Published online 2019 Apr 10. doi: 10.1074/jbc.RA118.006508
PMCID:
PMC6544858
AbstractArticlePDF–1.7M
19.
Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR)
Danielle E. Goodman, Carla D. Pretto, Tomas A. Krepostman, Kelly E. Carnahan, Katherine R. Spindler
mBio. 2019 Mar-Apr; 10(2): e00668-19. Published online 2019 Apr 23. doi: 10.1128/mBio.00668-19
PMCID:
PMC6479006
AbstractArticlePDF–1.6M
20.
Evidence for dispensability of protein kinase R in host control of tuberculosis
Shashirekha Mundhra, Ruslana Bryk, Natalie Hawryluk, Tuo Zhang, Xiuju Jiang, Dr. Carl F. Nathan
Eur J Immunol. Author manuscript; available in PMC 2019 Apr 1.
Published in final edited form as: Eur J Immunol. 2018 Apr; 48(4): 612–620. Published online 2018 Feb 28. doi: 10.1002/eji.201747180
PMCID:
PMC6361384
AbstractArticlePDF–1.0M

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