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Items: 1 to 20 of 28

1.
A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 as a Negative Regulator of Glucose Uptake in Brown Adipocytes
Matthew D. Lynes, Qian Huang, Carolina Cora, Sheng-Chiang Su, Peng Yi, Yu-Hua Tseng
Genes (Basel) 2023 Oct; 14(10): 1865. Published online 2023 Sep 26. doi: 10.3390/genes14101865
PMCID:
PMC10606202
AbstractArticlePDF–3.8M
2.
In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target
Xiaoqing Wang, Collin Tokheim, Shengqing Stan Gu, Binbin Wang, Qin Tang, Yihao Li, Nicole Traugh, Zexian Zeng, Yi Zhang, Ziyi Li, Boning Zhang, Jingxin Fu, Tengfei Xiao, Wei Li, Clifford A. Meyer, Jun Chu, Peng Jiang, Paloma Cejas, Klothilda Lim, Henry Long, Myles Brown, X. Shirley Liu
Cell. Author manuscript; available in PMC 2022 Oct 14.
Published in final edited form as: Cell. 2021 Oct 14; 184(21): 5357–5374.e22. Published online 2021 Sep 27. doi: 10.1016/j.cell.2021.09.006
PMCID:
PMC9136996
AbstractArticlePDF–3.1M
3.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
4.
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
Hong Lin, Yuan Yan, Yifan Luo, Wing Yan So, Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang, Feng Rao
Nat Commun. 2021; 12: 2461. Published online 2021 Apr 28. doi: 10.1038/s41467-021-22941-3
PMCID:
PMC8080631
AbstractArticlePDF–3.1M
5.
Stk40 deletion elevates c-JUN protein level and impairs mesoderm differentiation
Jing Hu, Shuang Li, Xiaozhi Sun, Zhuoqing Fang, Lina Wang, Feng Xiao, Min Shao, Laixiang Ge, Fan Tang, Junjie Gu, Hongyao Yu, Yueshuai Guo, Xuejiang Guo, Bing Liao, Ying Jin
J Biol Chem. 2019 Jun 21; 294(25): 9959–9972. Published online 2019 May 15. doi: 10.1074/jbc.RA119.007840
PMCID:
PMC6597834
AbstractArticlePDF–4.2M
6.
Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism
Luca Rizzini, Daniel C. Levine, Mark Perelis, Joseph Bass, Clara B. Peek, Michele Pagano
Curr Biol. Author manuscript; available in PMC 2020 Jun 17.
Published in final edited form as: Curr Biol. 2019 Jun 17; 29(12): 1954–1962.e4. Published online 2019 May 30. doi: 10.1016/j.cub.2019.04.073
PMCID:
PMC6581574
AbstractArticlePDF–1.1M
7.
The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export
Jennifer E Kung, Natalia Jura
EMBO J. 2019 Feb 15; 38(4): e99708. Published online 2019 Jan 29. doi: 10.15252/embj.201899708
PMCID:
PMC6376274
AbstractArticlePDF–1.6M
8.
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Kim Newton, Debra L. Dugger, Arundhati Sengupta-Ghosh, Ronald E. Ferrando, Felix Chu, Janet Tao, Wendy Lam, Susan Haller, Sara Chan, Susan Sa, Debra Dunlap, Jeffrey Eastham-Anderson, Hai Ngu, Jeffrey Hung, Dorothy M. French, Joshua D. Webster, Brad Bolon, Jinfeng Liu, Rohit Reja, Sarah Kummerfeld, Ying-Jiun Chen, Zora Modrusan, Joseph W. Lewcock, Vishva M. Dixit
Proc Natl Acad Sci U S A. 2018 Oct 30; 115(44): 11244–11249. Published online 2018 Oct 15. doi: 10.1073/pnas.1805033115
PMCID:
PMC6217379
AbstractArticlePDF–1.4M
9.
Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia
Ikuko Nakamae, Jun-ya Kato, Takashi Yokoyama, Hidenori Ito, Noriko Yoneda-Kato
Blood Adv. 2017 Sep 12; 1(20): 1682–1693. Published online 2017 Sep 1. doi: 10.1182/bloodadvances.2017007054
PMCID:
PMC5728337
AbstractArticlePDF–2.2M
10.
Transcription factor Etv5 is essential for the maintenance of alveolar type II cells
Zhen Zhang, Kim Newton, Sarah K. Kummerfeld, Joshua Webster, Donald S. Kirkpatrick, Lilian Phu, Jeffrey Eastham-Anderson, Jinfeng Liu, Wyne P. Lee, Jiansheng Wu, Hong Li, Melissa R. Junttila, Vishva M. Dixit
Proc Natl Acad Sci U S A. 2017 Apr 11; 114(15): 3903–3908. Published online 2017 Mar 28. doi: 10.1073/pnas.1621177114
PMCID:
PMC5393225
AbstractArticlePDF–1.9M
11.
E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors
Yan Zhang, Shigetoshi Yokoyama, John C. Herriges, Zhen Zhang, Randee E. Young, Jamie M. Verheyden, Xin Sun
Proc Natl Acad Sci U S A. 2016 Jul 5; 113(27): 7557–7562. Published online 2016 Jun 22. doi: 10.1073/pnas.1603310113
PMCID:
PMC4941481
AbstractArticlePDF–1.1M
12.
Formation of Arabidopsis Cryptochrome 2 Photobodies in Mammalian Nuclei: APPLICATION AS AN OPTOGENETIC DNA DAMAGE CHECKPOINT SWITCH
Irem Ozkan-Dagliyan, Yi-Ying Chiou, Rui Ye, Bachar H. Hassan, Nuri Ozturk, Aziz Sancar
J Biol Chem. 2013 Aug 9; 288(32): 23244–23251. Published online 2013 Jul 5. doi: 10.1074/jbc.M113.493361
PMCID:
PMC3743496
AbstractArticlePDF–1.3M
13.
Interaction of Constitutive Photomorphogenesis 1 Protein with Protein-Tyrosine Phosphatase 1B Suppresses Protein-Tyrosine Phosphatase 1B Activity and Enhances Insulin Signaling
Wenying Ren, Yingmin Sun, Sarwat Cheema, Keyong Du
J Biol Chem. 2013 Apr 12; 288(15): 10902–10913. Published online 2013 Feb 25. doi: 10.1074/jbc.M112.369371
PMCID:
PMC3624470
AbstractArticlePDF–2.8M
14.
Modulation of Fatty Acid Synthase Degradation by Concerted Action of p38 MAP Kinase, E3 Ligase COP1, and SH2-Tyrosine Phosphatase Shp2
Jianxiu Yu, Rong Deng, Helen H. Zhu, Sharon S. Zhang, Changhong Zhu, Marc Montminy, Roger Davis, Gen-Sheng Feng
J Biol Chem. 2013 Feb 8; 288(6): 3823–3830. Published online 2012 Dec 26. doi: 10.1074/jbc.M112.397885
PMCID:
PMC3567637
AbstractArticlePDF–3.0M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1
George D. Leikauf, Vincent J. Concel, Pengyuan Liu, Kiflai Bein, Annerose Berndt, Koustav Ganguly, An Soo Jang, Kelly A. Brant, Maggie Dietsch, Hannah Pope-Varsalona, Richard A. Dopico, Jr., Y. P. Peter Di, Qian Li, Louis J. Vuga, Mario Medvedovic, Naftali Kaminski, Ming You, Daniel R. Prows
Am J Respir Crit Care Med. 2011 Jun 1; 183(11): 1499–1509. Published online 2011 Feb 4. doi: 10.1164/rccm.201006-0912OC
PMCID:
PMC3137140
AbstractArticlePDF–1.8M
17.
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice
Domenico Migliorini, Sven Bogaerts, Dieter Defever, Rajesh Vyas, Geertrui Denecker, Enrico Radaelli, Aleksandra Zwolinska, Vanessa Depaepe, Tino Hochepied, William C. Skarnes, Jean-Christophe Marine
J Clin Invest. 2011 Apr 1; 121(4): 1329–1343. Published online 2011 Mar 14. doi: 10.1172/JCI45784
PMCID:
PMC3070608
AbstractArticlePDF–5.1M
18.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
19.
Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia
Priya H. Dedhia, Karen Keeshan, Sacha Uljon, Lanwei Xu, Maria E. Vega, Olga Shestova, Meirav Zaks-Zilberman, Candice Romany, Stephen C. Blacklow, Warren S. Pear
Blood. 2010 Aug 26; 116(8): 1321–1328. Prepublished online 2010 Apr 21. doi: 10.1182/blood-2009-07-229450
PMCID:
PMC2938240
AbstractArticle
20.
E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1
Da-Qiang Li, Kazufumi Ohshiro, Sirigiri Divijendra Natha Reddy, Suresh B. Pakala, Mong-Hong Lee, Yanping Zhang, Suresh K. Rayala, Rakesh Kumar
Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41): 17493–17498. Published online 2009 Sep 24. doi: 10.1073/pnas.0908027106
PMCID:
PMC2762678
AbstractArticlePDF–2.1M

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