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Select item 111226851.

An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol γ

Joon Park, Geoffrey K. Herrmann, Arkanil Roy, Christie K. Shumate, G. Andrés Cisneros, Y. Whitney Yin

Sci Adv. 2024 May 24; 10(21): eadl3214. Published online 2024 May 24. doi: 10.1126/sciadv.adl3214

PMCID:: PMC11122685

Abstract Article PDF–2.6M

Select item 110417662.

Ancestral allele of DNA polymerase gamma modifies antiviral tolerance

Yilin Kang, Jussi Hepojoki, Rocio Sartori Maldonado, Takayuki Mito, Mügen Terzioglu, Tuula Manninen, Ravi Kant, Sachin Singh, Alaa Othman, Rohit Verma, Johanna Uusimaa, Kirmo Wartiovaara, Lauri Kareinen, Nicola Zamboni, Tuula Anneli Nyman, Anders Paetau, Anja Kipar, Olli Vapalahti, Anu Suomalainen

Nature. 2024; 628(8009): 844–853. Published online 2024 Apr 3. doi: 10.1038/s41586-024-07260-z

PMCID:: PMC11041766

Abstract Article PDF–25M

Select item 109200753.

Polγ coordinates DNA synthesis and proofreading to ensure mitochondrial genome integrity

Joon Park, Geoffrey K. Herrmann, Patrick G. Mitchell, Michael B. Sherman, Y. Whitney Yin

Nat Struct Mol Biol. Author manuscript; available in PMC 2024 Mar 8.

Published in final edited form as: Nat Struct Mol Biol. 2023 Jun; 30(6): 812–823. Published online 2023 May 18. doi: 10.1038/s41594-023-00980-2

PMCID:: PMC10920075

Abstract Article PDF–2.6M

Select item 105069084.

DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?

Tekla Harju, Anri Hurme-Niiranen, Maria Suo-Palosaari, Stine Nygaard Nielsen, Reetta Hinttala, Kjeld Schmiegelow, Johanna Uusimaa, Arja Harila, Riitta Niinimäki

Pharmacogenomics J. 2023; 23(5): 105–111. Published online 2023 May 3. doi: 10.1038/s41397-023-00303-0

PMCID:: PMC10506908

Abstract Article PDF–845K

Select item 103640445.

Ataxia y neuropatía sensitiva de inicio en la edad adulta como manifestación clínica de mutaciones en el gen POLG

Carmen García-Cabo, Paula Carvajal-García, Iván Fernández-Vega, Jorge Peña-Suárez, Valentín Mateos-Marcos, Patricia Suárez-Santos, Victoria Álvarez-Martínez, Germán Morís-de la Tassa

Rev Neurol. 2023; 76(3): 75–81. Spanish. Published online 2023 Feb 1. doi: 10.33588/rn.7603.2022322

PMCID:: PMC10364044

Abstract Article PDF–1.0M

Select item 102374226.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516157.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 99768888.

Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB

Ismael Plaza-G.A., Kateryna M Lemishko, Rodrigo Crespo, Thinh Q Truong, Laurie S Kaguni, Francisco J Cao-García, Grzegorz L Ciesielski, Borja Ibarra

Nucleic Acids Res. 2023 Feb 28; 51(4): 1750–1765. Published online 2023 Feb 6. doi: 10.1093/nar/gkad037

PMCID:: PMC9976888

Abstract Article PDF–9.8M

Select item 93485769.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 930795710.

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication

Md. Mostafijur Rahman, Carolyn K.J. Young, Steffi Goffart, Jaakko L.O. Pohjoismäki, Matthew J. Young

J Biol Chem. 2022 Aug; 298(8): 102196. Published online 2022 Jun 24. doi: 10.1016/j.jbc.2022.102196

PMCID:: PMC9307957

Abstract Article PDF–4.8M

Select item 926261411.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 910349112.

POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition

Anbin Chen, Cecilie Katrin Kristiansen, Lena Elise Høyland, Mathias Ziegler, Jian Wang, Gareth John Sullivan, Xingang Li, Laurence A. Bindoff, Kristina Xiao Liang

Cell Cycle. 2022; 21(11): 1178–1193. Published online 2022 Mar 17. doi: 10.1080/15384101.2022.2044136

PMCID:: PMC9103491

Abstract Article PDF–3.0M

Select item 859581813.

Remdesivir triphosphate blocks DNA synthesis and increases exonucleolysis by the replicative mitochondrial DNA polymerase, Pol γ

Elena J. Ciesielska, Shalom Kim, Hyacintha-ghislaine M. Bisimwa, Cody Grier, Md. Mostafijur Rahman, Carolyn K. J. Young, Matthew J. Young, Marcos T. Oliveira, Grzegorz L. Ciesielski

Mitochondrion. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Mitochondrion. 2021 Nov; 61: 147–158. Published online 2021 Oct 5. doi: 10.1016/j.mito.2021.09.010

PMCID:: PMC8595818

Abstract Article PDF–1.4M

Select item 852637814.

Urine Cell-Free Mitochondrial DNA as a Marker of Weight Loss and Body Composition in Older Adults with HIV

Carrie D. Johnston, Eugenia L. Siegler, Michelle C. Rice, Heather M. Derry, Katie C. Hootman, Yuan-Shan Zhu, Chelsie O. Burchett, Samir K. Gupta, Mary E. Choi, Marshall J. Glesby

J Acquir Immune Defic Syndr. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: J Acquir Immune Defic Syndr. 2021 Nov 1; 88(3): 229–233. doi: 10.1097/QAI.0000000000002766

PMCID:: PMC8526378

Abstract Article PDF–365K

Select item 835296415.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795939617.

MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria

Mansoor Hussain, Aftab Mohammed, Shabnam Saifi, Aamir Khan, Ekjot Kaur, Swati Priya, Himanshi Agarwal, Sagar Sengupta

PLoS Biol. 2021 Mar; 19(3): e3001139. Published online 2021 Mar 3. doi: 10.1371/journal.pbio.3001139

PMCID:: PMC7959396

Abstract Article PDF–4.1M

Select item 794911518.

Poly(ADP-ribose) polymerase 1 regulates mitochondrial DNA repair in an NAD-dependent manner

Geoffrey K. Herrmann, William K. Russell, Nisha J. Garg, Y. Whitney Yin

J Biol Chem. 2021 Jan-Jun; 296: 100309. Published online 2021 Jan 19. doi: 10.1016/j.jbc.2021.100309

PMCID:: PMC7949115

Abstract Article PDF–1.7M

Select item 792248119.

De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans

Yeonmi Lee, Taeho Kim, Miju Lee, Seongjun So, Mustafa Zafer Karagozlu, Go Hun Seo, In Hee Choi, Peter C. W. Lee, Chong-Jai Kim, Eunju Kang, Beom Hee Lee

Genes (Basel) 2021 Feb; 12(2): 284. Published online 2021 Feb 17. doi: 10.3390/genes12020284

PMCID:: PMC7922481

Abstract Article PDF–3.4M

Select item 782443520.

Progressive External Ophthalmoplegia in Polish Patients—From Clinical Evaluation to Genetic Confirmation

Biruta Kierdaszuk, Magdalena Kaliszewska, Joanna Rusecka, Joanna Kosińska, Ewa Bartnik, Katarzyna Tońska, Anna M. Kamińska, Anna Kostera-Pruszczyk

Genes (Basel) 2021 Jan; 12(1): 54. Published online 2020 Dec 31. doi: 10.3390/genes12010054

PMCID:: PMC7824435

Abstract Article PDF–4.8M

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