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Select item 101469001.

ZFP750 affects the cutaneous barrier through regulating lipid metabolism

Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D’Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino

Sci Adv. 2023 Apr; 9(17): eadg5423. Published online 2023 Apr 28. doi: 10.1126/sciadv.adg5423

PMCID:: PMC10146900

Abstract Article PDF–2.3M

Select item 97575402.

Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function

Nuria Barbarroja, Sergio Rodriguez-Cuenca, Heli Nygren, Antonio Camargo, Ana Pirraco, Joana Relat, Irene Cuadrado, Vanessa Pellegrinelli, Gema Medina-Gomez, Chary Lopez-Pedrera, Francisco J. Tinahones, J. David Symons, Scott A. Summers, Matej Oresic, Antonio Vidal-Puig

Diabetes. 2015 Apr; 64(4): 1180–1192. Published online 2014 Oct 28. doi: 10.2337/db14-0359

PMCID:: PMC9757540

Abstract Article PDF–2.3M

Select item 90145593.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 74159914.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 67879185.

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

Bhagirath Chaurasia, Trevor S. Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Liping Wang, Joseph L. Wilkerson, C. Rufus Sweeney, Renato Felipe Pereira, Doris Hissako Sumida, J. Alan Maschek, James E. Cox, Vincent Kaddai, Graeme Iain Lancaster, Monowarul Mobin Siddique, Annelise Poss, Mackenzie Pearson, Santhosh Satapati, Heather Zhou, David G. McLaren, Stephen F. Previs, Ying Chen, Ying Qian, Aleksandr Petrov, Margaret Wu, Xiaolan Shen, Jun Yao, Christian N. Nunes, Andrew D. Howard, Liangsu Wang, Mark D. Erion, Jared Rutter, William L. Holland, David E. Kelley, Scott A. Summers

Science. Author manuscript; available in PMC 2020 Jul 26.

Published in final edited form as: Science. 2019 Jul 26; 365(6451): 386–392. Published online 2019 Jul 4. doi: 10.1126/science.aav3722

PMCID:: PMC6787918

Abstract Article PDF–1.6M

Select item 64366586.

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones

Philip D. Kiser, Alexander V. Kolesnikov, Jianying Z. Kiser, Zhiqian Dong, Bhagirath Chaurasia, Liping Wang, Scott A. Summers, Thanh Hoang, Seth Blackshaw, Neal S. Peachey, Vladimir J. Kefalov, Krzysztof Palczewski

FASEB J. 2019 Apr; 33(4): 5782–5792. Published online 2019 Jan 15. doi: 10.1096/fj.201802493R

PMCID:: PMC6436658

Abstract Article

Select item 62980407.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 61026448.

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis

Divya Pathak, Neelay Mehendale, Shubham Singh, Roop Mallik, Siddhesh S. Kamat

ACS Chem Biol. 2018 Aug 17; 13(8): 2280–2287. Published online 2018 Jul 2. doi: 10.1021/acschembio.8b00438

PMCID:: PMC6102644

Abstract Article PDF–1.1M

Select item 53812269.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 461397010.

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo

Leena P. Bharath, Ting Ruan, Youyou Li, Anindita Ravindran, Xin Wan, Jennifer Kim Nhan, Matthew Lewis Walker, Lance Deeter, Rebekah Goodrich, Elizabeth Johnson, Derek Munday, Robert Mueller, David Kunz, Deborah Jones, Van Reese, Scott A. Summers, Pon Velayutham Anandh Babu, William L. Holland, Quan-Jiang Zhang, E. Dale Abel, J. David Symons

Diabetes. 2015 Nov; 64(11): 3914–3926. Published online 2015 Aug 7. doi: 10.2337/db15-0244

PMCID:: PMC4613970

Abstract Article PDF–1.9M

Select item 444058311.

Regulation of Ceramide Synthase-Mediated Crypt Epithelium Apoptosis by DNA Damage Repair Enzymes

Jimmy A. Rotolo, Judith Mesicek, Jerzy Maj, Jean-Philip Truman, Adriana Haimovitz-Friedman, Richard Kolesnick, Zvi Fuks

Cancer Res. Author manuscript; available in PMC 2015 May 21.

Published in final edited form as: Cancer Res. 2010 Feb 1; 70(3): 957–967. Published online 2010 Jan 19. doi: 10.1158/0008-5472.CAN-09-1562

PMCID:: PMC4440583

Abstract Article PDF–823K

Select item 366530912.

Regulation of De Novo Ceramide Synthesis: The Role of Dihydroceramide Desaturase and Transcriptional Factors NFATC and Hand2 in the Hypoxic Mouse Heart

Raed Azzam, Fadi Hariri, Nehmé El-Hachem, Amina Kamar, Ghassan Dbaibo, Georges Nemer, Fadi Bitar

DNA Cell Biol. 2013 Jun; 32(6): 310–319. doi: 10.1089/dna.2013.1993

PMCID:: PMC3665309

Abstract Article PDF–726K

Select item 364806213.

Ablation of Dihydroceramide Desaturase 1, a Therapeutic Target for the Treatment of Metabolic Diseases, Simultaneously Stimulates Anabolic and Catabolic Signaling

Monowarul M. Siddique, Ying Li, Liping Wang, Jianhong Ching, Mainak Mal, Olga Ilkayeva, Ya Jun Wu, Boon Huat Bay, Scott A. Summers

Mol Cell Biol. 2013 Jun; 33(11): 2353–2369. doi: 10.1128/MCB.00226-13

PMCID:: PMC3648062

Abstract Article PDF–3.7M

Select item 355634314.

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development

Zhixing Wang, Jay S. Kirkwood, Alan W. Taylor, Jan F. Stevens, Mark Leid, Gitali Ganguli-Indra, Arup K. Indra

J Invest Dermatol. Author manuscript; available in PMC 2013 Sep 1.

Published in final edited form as: J Invest Dermatol. 2013 Mar; 133(3): 668–676. Published online 2012 Oct 25. doi: 10.1038/jid.2012.358

PMCID:: PMC3556343

Abstract Article PDF–608K

Select item 352277715.

Identification of DES1 as a Vitamin A Isomerase in Müller Glial Cells of the Retina

Joanna J. Kaylor, Quan Yuan, Jeremy Cook, Shanta Sarfare, Jacob Makshanoff, Anh Miu, Anita Kim, Paul Kim, Samer Habib, C. Nathaniel Roybal, Tongzhou Xu, Steven Nusinowitz, Gabriel H. Travis

Nat Chem Biol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Nat Chem Biol. 2013 Jan; 9(1): 30–36. Published online 2012 Nov 11. doi: 10.1038/nchembio.1114

PMCID:: PMC3522777

Abstract Article PDF–1.4M

Select item 343948416.

Ablation of Dihydroceramide Desaturase Confers Resistance to Etoposide-Induced Apoptosis In Vitro

Monowarul M. Siddique, Benjamin T. Bikman, Liping Wang, Li Ying, Erin Reinhardt, Guanghou Shui, Markus R. Wenk, Scott A. Summers

PLoS One. 2012; 7(9): e44042. Published online 2012 Sep 11. doi: 10.1371/journal.pone.0044042

PMCID:: PMC3439484

Abstract Article PDF–760K

Select item 337964817.

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

Quan-Jiang Zhang, William L. Holland, Lloyd Wilson, Jason M. Tanner, Devin Kearns, Judd M. Cahoon, Dix Pettey, Jason Losee, Bradlee Duncan, Derrick Gale, Christopher A. Kowalski, Nicholas Deeter, Alexandrea Nichols, Michole Deesing, Colton Arrant, Ting Ruan, Christoph Boehme, Dane R. McCamey, Janvida Rou, Kapil Ambal, Krishna K. Narra, Scott A. Summers, E. Dale Abel, J. David Symons

Diabetes. 2012 Jul; 61(7): 1848–1859. Published online 2012 Jun 15. doi: 10.2337/db11-1399