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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 82993982.

The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

Marvin Wirianto, Jiah Yang, Eunju Kim, Song Gao, Keshav Raj Paudel, Jong Min Choi, Jeehwan Choe, Gabrielle F. Gloston, Precious Ademoji, Randika Parakramaweera, Jianping Jin, Karyn A. Esser, Sung Yun Jung, Yong-Jian Geng, Hyun Kyoung Lee, Zheng Chen, Seung-Hee Yoo

Cell Rep. Author manuscript; available in PMC 2021 Jul 23.

Published in final edited form as: Cell Rep. 2020 Sep 15; 32(11): 108140. doi: 10.1016/j.celrep.2020.108140

PMCID:: PMC8299398

Abstract Article PDF–2.3M

Select item 66236293.

Tuning the Period of the Mammalian Circadian Clock: Additive and Independent Effects of CK1ε^Tau and Fbxl3^Afh Mutations on Mouse Circadian Behavior and Molecular Pacemaking

Elizabeth S. Maywood, Johanna E. Chesham, Qing-Jun Meng, Patrick M. Nolan, Andrew S. I. Loudon, Michael H. Hastings

J Neurosci. 2011 Jan 26; 31(4): 1539–1544. doi: 10.1523/JNEUROSCI.4107-10.2011

PMCID:: PMC6623629

Abstract Article PDF–972K

Select item 63368704.

The circadian E3 ligase complex SCF^FBXL3+CRY targets TLK2

Stephanie Papp Correia, Alanna B. Chan, Megan Vaughan, Norjin Zolboot, Valerie Perea, Anne-Laure Huber, Anna Kriebs, James J. Moresco, John R. Yates, III, Katja A. Lamia

Sci Rep. 2019; 9: 198. Published online 2019 Jan 17. doi: 10.1038/s41598-018-36618-3

PMCID:: PMC6336870

Abstract Article PDF–2.0M

Select item 62911575.

JMJD5 links CRY1 function and proteasomal degradation

Anand R. Saran, Diana Kalinowska, Sangphil Oh, Ralf Janknecht, Luciano DiTacchio

PLoS Biol. 2018 Nov; 16(11): e2006145. Published online 2018 Nov 30. doi: 10.1371/journal.pbio.2006145

Correction in:: PLoS Biol. 2019 Aug; 17(8): e3000454.

PMCID:: PMC6291157

Abstract Article PDF–2.3M

Select item 57367116.

The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis

Silvia Maggi, Edoardo Balzani, Glenda Lassi, Celina Garcia-Garcia, Andrea Plano, Stefano Espinoza, Liudmila Mus, Federico Tinarelli, Patrick M. Nolan, Raul R. Gainetdinov, Fuat Balci, Thierry Nieus, Valter Tucci

Sci Rep. 2017; 7: 17765. Published online 2017 Dec 19. doi: 10.1038/s41598-017-18130-2

PMCID:: PMC5736711

Abstract Article PDF–7.3M

Select item 55597607.

Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability

Sven Wegner, Mino D.C. Belle, Alun T.L. Hughes, Casey O. Diekman, Hugh D. Piggins

J Neurosci. 2017 Aug 16; 37(33): 7824–7836. doi: 10.1523/JNEUROSCI.0691-17.2017

PMCID:: PMC5559760

Abstract Article PDF–2.9M

Select item 51238598.

CRY2 and FBXL3 cooperatively degrade c-MYC

Anne-Laure Huber, Stephanie J. Papp, Alanna B. Chan, Emma Henriksson, Sabine D. Jordan, Anna Kriebs, Madelena Nguyen, Martina Wallace, Zhizhong Li, Christian M. Metallo, Katja A. Lamia

Mol Cell. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Mol Cell. 2016 Nov 17; 64(4): 774–789. Published online 2016 Nov 10. doi: 10.1016/j.molcel.2016.10.012

PMCID:: PMC5123859

Abstract Article PDF–2.0M

Select item 45524939.

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages

Jens-Erik Dietrich, Laura Panavaite, Stefan Gunther, Sebastian Wennekamp, Anna C Groner, Anton Pigge, Stefanie Salvenmoser, Didier Trono, Lars Hufnagel, Takashi Hiiragi

EMBO Rep. 2015 Aug; 16(8): 1005–1021. Published online 2015 Jul 3. doi: 10.15252/embr.201540162

PMCID:: PMC4552493

Abstract Article PDF–2.7M

Select item 410428410.

Distinct and Separable Roles for Endogenous CRY1 and CRY2 within the Circadian Molecular Clockwork of the Suprachiasmatic Nucleus, as Revealed by the Fbxl3^Afh Mutation

Sneha N. Anand, Elizabeth S. Maywood, Johanna E. Chesham, Greg Joynson, Gareth T. Banks, Michael H. Hastings, Patrick M. Nolan

J Neurosci. 2013 Apr 24; 33(17): 7145–7153. doi: 10.1523/JNEUROSCI.4950-12.2013

PMCID:: PMC4104284

Abstract Article PDF–892K

Select item 391875711.

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock

Peter C. St. John, Tsuyoshi Hirota, Steve A. Kay, Francis J. Doyle, III

Proc Natl Acad Sci U S A. 2014 Feb 4; 111(5): 2040–2045. Published online 2014 Jan 21. doi: 10.1073/pnas.1323618111

PMCID:: PMC3918757

Abstract Article PDF–1.5M

Select item 382091012.

Substrate Binding Promotes Formation of the Skp1-Cul1-Fbxl3 (SCF^Fbxl3) Protein Complex

Kanae Yumimoto, Tetsuya Muneoka, Tomohiro Tsuboi, Keiichi I. Nakayama

J Biol Chem. 2013 Nov 8; 288(45): 32766–32776. Published online 2013 Sep 30. doi: 10.1074/jbc.M113.511303

PMCID:: PMC3820910

Abstract Article PDF–1.3M

Select item 376287413.

Circadian mutant Overtime reveals F-box protein FBXL3 regulation of Cryptochrome and Period gene expression

Sandra M. Siepka, Seung-Hee Yoo, Junghea Park, Weimin Song, Vivek Kumar, Yinin Hu, Choogon Lee, Joseph S. Takahashi

Cell. Author manuscript; available in PMC 2013 Sep 4.

Published in final edited form as: Cell. 2007 Jun 1; 129(5): 1011–1023. Published online 2007 Apr 26. doi: 10.1016/j.cell.2007.04.030

PMCID:: PMC3762874

Abstract Article PDF–4.5M

Select item 369478114.

Competing E3 Ubiquitin Ligases Determine Circadian Period by Regulated Degradation of CRY in Nucleus and Cytoplasm

Seung-Hee Yoo, Jennifer A. Mohawk, Sandra M. Siepka, Yongli Shan, Seong Kwon Huh, Hee-Kyung Hong, Izabela Kornblum, Vivek Kumar, Nobuya Koike, Ming Xu, Justin Nussbaum, Xinran Liu, Zheng Chen, Zhijian J. Chen, Carla B. Green, Joseph S. Takahashi

Cell. Author manuscript; available in PMC 2013 Aug 28.

Published in final edited form as: Cell. 2013 Feb 28; 152(5): 1091–1105. doi: 10.1016/j.cell.2013.01.055

PMCID:: PMC3694781

Abstract Article PDF–4.2M

Select item 361850615.

SCF^Fbxl3 Ubiquitin Ligase Targets Cryptochromes at Their Cofactor Pocket

Weiman Xing, Luca Busino, Thomas R. Hinds, Samuel T. Marionni, Nabiha H. Saifee, Matthew F. Bush, Michele Pagano, Ning Zheng

Nature. Author manuscript; available in PMC 2013 Oct 4.

Published in final edited form as: Nature. 2013 Apr 4; 496(7443): 64–68. Published online 2013 Mar 17. doi: 10.1038/nature11964

PMCID:: PMC3618506

Abstract Article PDF–1.4M

Select item 360699516.

Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock

Guangsen Shi, Lijuan Xing, Zhiwei Liu, Zhipeng Qu, Xi Wu, Zhen Dong, Xiaohan Wang, Xiang Gao, Moli Huang, Jie Yan, Ling Yang, Yi Liu, Louis J. Ptáček, Ying Xu

Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12): 4750–4755. Published online 2013 Mar 5. doi: 10.1073/pnas.1302560110

PMCID:: PMC3606995

Abstract Article PDF–1.4M

Select item 359171517.

Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting

Clare Guilding, Fiona Scott, David A Bechtold, Timothy M Brown, Sven Wegner, Hugh D Piggins

J Physiol. 2013 Feb 15; 591(Pt 4): 1063–1080. Published online 2012 Dec 3. doi: 10.1113/jphysiol.2012.242198

PMCID:: PMC3591715

Abstract Article PDF–2.1M

Select item 337611718.

Reduced Anxiety and Depression-Like Behaviours in the Circadian Period Mutant Mouse Afterhours

Robert Keers, Inti Pedroso, Gerome Breen, Kathy J. Aitchison, Patrick M. Nolan, Sven Cichon, Markus M. Nöthen, Marcella Rietschel, Leonard C. Schalkwyk, Cathy Fernandes

PLoS One. 2012; 7(6): e38263. Published online 2012 Jun 15. doi: 10.1371/journal.pone.0038263

PMCID:: PMC3376117

Abstract Article PDF–1.8M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316153420.

A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits

Elizabeth S. Maywood, Johanna E. Chesham, John A. O'Brien, Michael H. Hastings

Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34): 14306–14311. Published online 2011 Jul 25. doi: 10.1073/pnas.1101767108

PMCID:: PMC3161534

Abstract Article PDF–1.1M

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