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Select item 114388331.

Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis

Jianyuan Pan, Ming Liu, Huimin Su, Hao Hu, Hongwu Chen, Likun Ma

Cardiovasc Drugs Ther. 2024; 38(5): 861–872. Published online 2023 Mar 9. doi: 10.1007/s10557-023-07442-3

PMCID:: PMC11438833

Abstract Article PDF–1.6M

Select item 102937412.

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis

Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch

Front Immunol. 2023; 14: 1180886. Published online 2023 Jun 13. doi: 10.3389/fimmu.2023.1180886

PMCID:: PMC10293741

Abstract Article PDF–22M

Select item 83132393.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 76680355.

PtdIns(3,4,5)P₃-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, Christina A. Mitchell

Proc Natl Acad Sci U S A. 2020 Nov 10; 117(45): 28056–28067. Published online 2020 Oct 23. doi: 10.1073/pnas.2006445117

PMCID:: PMC7668035

Abstract Article PDF–2.7M

Select item 74159916.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 67251237.

Involvement of a Rac Activator, P-Rex1, in Neurotrophin-Derived Signaling and Neuronal Migration

Masato Yoshizawa, Takeshi Kawauchi, Masaki Sone, Yoshiaki V. Nishimura, Mami Terao, Kaori Chihama, Yo-ichi Nabeshima, Mikio Hoshino

J Neurosci. 2005 Apr 27; 25(17): 4406–4419. doi: 10.1523/JNEUROSCI.4955-04.2005

PMCID:: PMC6725123

Abstract Article PDF–824K

Select item 50452008.

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury

Yong Wu, Fan-Yan Wei, Layla Kawarada, Takeo Suzuki, Kimi Araki, Yoshihiro Komohara, Atsushi Fujimura, Taku Kaitsuka, Motohiro Takeya, Yuichi Oike, Tsutomu Suzuki, Kazuhito Tomizawa

PLoS Genet. 2016 Sep; 12(9): e1006355. Published online 2016 Sep 30. doi: 10.1371/journal.pgen.1006355

PMCID:: PMC5045200

Abstract Article PDF–2.9M

Select item 48657579.

Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis

Qing Liang, Ni Cheng, Gufang Zhang, Yurong Liang, Feng Qian, Dianqing Wu, Richard D. Ye

Sci Rep. 2016; 6: 25785. Published online 2016 May 13. doi: 10.1038/srep25785

PMCID:: PMC4865757

Abstract Article PDF–2.1M

Select item 481354510.

Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1

Dingxin Pan, Mark A. Barber, Kirsti Hornigold, Martin J. Baker, Judit M. Toth, David Oxley, Heidi C. E. Welch

J Biol Chem. 2016 Mar 18; 291(12): 6359–6375. Published online 2016 Jan 20. doi: 10.1074/jbc.M115.686592

PMCID:: PMC4813545

Abstract Article PDF–3.1M

Select item 475962711.

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Hadir Marei, Alejandro Carpy, Anna Woroniuk, Claire Vennin, Gavin White, Paul Timpson, Boris Macek, Angeliki Malliri

Nat Commun. 2016; 7: 10664. Published online 2016 Feb 18. doi: 10.1038/ncomms10664

PMCID:: PMC4759627

Abstract Article PDF–7.6M

Select item 468753912.

Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior

Jun Li, Anping Chai, Lifang Wang, Yuanlin Ma, Zhiliu Wu, Hao Yu, Liwei Mei, Lin Lu, Chen Zhang, Weihua Yue, Lin Xu, Yi Rao, Dai Zhang

Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50): E6964–E6972. Published online 2015 Nov 30. doi: 10.1073/pnas.1512913112

PMCID:: PMC4687539

Abstract Article PDF–2.2M

Select item 461808613.

The Interleukin-2-mTORc1 Axis Defines the Reciprocal Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

John P. Ray, Matthew M. Staron, Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, Joe Craft

Immunity. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Immunity. 2015 Oct 20; 43(4): 690–702. Published online 2015 Sep 22. doi: 10.1016/j.immuni.2015.08.017

PMCID:: PMC4618086

Abstract Article PDF–2.2M

Select item 432677414.

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation

Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, Heidi C. E. Welch

Blood. 2015 Feb 12; 125(7): 1146–1158. Prepublished online 2014 Dec 23. doi: 10.1182/blood-2014-07-591040

PMCID:: PMC4326774

Abstract Article

Select item 426980715.

A Rac1-Independent Role for P-Rex1 in Melanoblasts

Colin R Lindsay, Ang Li, William Faller, Brad Ozanne, Heidi Welch, Laura M Machesky, Owen J Sansom

J Invest Dermatol. 2015 Jan; 135(1): 314–318. Prepublished online 2014 Jul 30. Published online 2014 Sep 11. doi: 10.1038/jid.2014.323

PMCID:: PMC4269807

Article PDF–1.6M

Select item 387625416.

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

Hiromichi Ebi, Carlotta Costa, Anthony C. Faber, Madhuri Nishtala, Hiroshi Kotani, Dejan Juric, Patricia Della Pelle, Youngchul Song, Seiji Yano, Mari Mino-Kenudson, Cyril H. Benes, Jeffrey A. Engelman

Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52): 21124–21129. Published online 2013 Dec 10. doi: 10.1073/pnas.1314124110

PMCID:: PMC3876254

Abstract Article PDF–1.2M

Select item 367796017.

A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability

Ram P. Naikawadi, Ni Cheng, Stephen M. Vogel, Feng Qian, Dianqing Wu, Asrar B. Malik, Richard D. Ye

Circ Res. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Circ Res. 2012 Dec 7; 111(12): 1517–1527. Published online 2012 Sep 10. doi: 10.1161/CIRCRESAHA.112.273078

PMCID:: PMC3677960

Abstract Article PDF–4.8M

Select item 364486218.

Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis

Zhenglong Wang, Xuemei Dong, Zhong Li, Jonathan D. Smith, Dianqing Wu

Prostaglandins Other Lipid Mediat. Author manuscript; available in PMC 2013 May 6.

Published in final edited form as: Prostaglandins Other Lipid Mediat. 2008 Dec; 87(0): 9–13. Published online 2008 Apr 23. doi: 10.1016/j.prostaglandins.2008.04.001

PMCID:: PMC3644862

Abstract Article PDF–927K

Select item 359383319.

The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map

Gina E. Elsen, Rebecca D. Hodge, Francesco Bedogni, Ray A. M. Daza, Branden R. Nelson, Naoko Shiba, Steven L. Reiner, Robert F. Hevner

Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10): 4081–4086. Published online 2013 Feb 19. doi: 10.1073/pnas.1209076110

PMCID:: PMC3593833

Abstract Article PDF–1.0M

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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