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Select item 78138571.

Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells

Clément Larrue, Nathan Guiraud, Pierre-Luc Mouchel, Marine Dubois, Thomas Farge, Mathilde Gotanègre, Claudie Bosc, Estelle Saland, Marie-Laure Nicolau-Travers, Marie Sabatier, Nizar Serhan, Ambrine Sahal, Emeline Boet, Sarah Mouche, Quentin Heydt, Nesrine Aroua, Lucille Stuani, Tony Kaoma, Linus Angenendt, Jan-Henrik Mikesch, Christoph Schliemann, François Vergez, Jérôme Tamburini, Christian Récher, Jean-Emmanuel Sarry

Nat Commun. 2021; 12: 422. Published online 2021 Jan 18. doi: 10.1038/s41467-020-20717-9

PMCID:: PMC7813857

Abstract Article PDF–16M

Select item 77922212.

Short tandem repeat near hypoxia response element (HRE) instead of HRE genetic variants in promoter calcitonin receptor-like receptor (CRLR) gene as risk factor in severe preeclampsia: a preliminary study

Herlambang, Amelia Dwi Fitri, Ahmad Syauqy, Yuwono, Anggelia Puspasari, Rina Nofri Enis, Ahmad Faried

BMC Res Notes. 2021; 14: 17. Published online 2021 Jan 7. doi: 10.1186/s13104-020-05437-z

PMCID:: PMC7792221

Abstract Article PDF–876K

Select item 61667903.

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Yi-Lynn Liang, Maryam Khoshouei, Giuseppe Deganutti, Alisa Glukhova, Cassandra Koole, Thomas S. Peat, Mazdak Radjainia, Jürgen M. Plitzko, Wolfgang Baumeister, Laurence J. Miller, Deborah L. Hay, Arthur Christopoulos, Christopher A Reynolds, Denise Wootten, Patrick M. Sexton

Nature. Author manuscript; available in PMC 2019 Mar 12.

Published in final edited form as: Nature. 2018 Sep; 561(7724): 492–497. Published online 2018 Sep 12. doi: 10.1038/s41586-018-0535-y

PMCID:: PMC6166790

Abstract Article PDF–6.3M

Select item 61229774.

hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia

Duncan I. Mackie, Fuad Al Mutairi, Reema B. Davis, Daniel O. Kechele, Natalie R. Nielsen, Joshua C. Snyder, Marc G. Caron, Harvey J. Kliman, Jonathan S. Berg, John Simms, David R. Poyner, Kathleen M. Caron

J Exp Med. 2018 Sep 3; 215(9): 2339–2353. doi: 10.1084/jem.20180528

PMCID:: PMC6122977

Abstract Article PDF–3.3M

Select item 57423725.

Genetic Variants of RAMP2 and CLR are Associated with Stroke

Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Wakiko Takeshita, Komei Iwai, Yoshiyuki Watanabe, Masahiro Nakatochi, Chisato Shimanoe, Keitaro Tanaka, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Sayo Kawai, Tae Sasakabe, Rieko Okada, Asahi Hishida, Mariko Naito, Kiyonori Kuriki, Kaori Endoh, Norihiro Furusyo, Hiroaki Ikezaki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko Nakamura, Michiaki Kubo, Kenji Wakai

J Atheroscler Thromb. 2017 Dec 1; 24(12): 1267–1281. doi: 10.5551/jat.41517

PMCID:: PMC5742372

Abstract Article PDF–356K

Select item 48824356.

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties

Harriet A. Watkins, Madhuri Chakravarthy, Rekhati S. Abhayawardana, Joseph J. Gingell, Michael Garelja, Meenakshi Pardamwar, James M. W. R. McElhinney, Alex Lathbridge, Arran Constantine, Paul W. R. Harris, Tsz-Ying Yuen, Margaret A. Brimble, James Barwell, David R. Poyner, Michael J. Woolley, Alex C. Conner, Augen A. Pioszak, Christopher A. Reynolds, Debbie L. Hay

J Biol Chem. 2016 May 27; 291(22): 11657–11675. Published online 2016 Mar 24. doi: 10.1074/jbc.M115.688218

PMCID:: PMC4882435

Abstract Article PDF–6.4M

Select item 45040057.

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

Jason M. Booe, Christopher S. Walker, James Barwell, Gabriel Kuteyi, John Simms, Muhammad A. Jamaluddin, Margaret L. Warner, Roslyn M. Bill, Paul W. Harris, Margaret A. Brimble, David R. Poyner, Debbie L. Hay, Augen A. Pioszak

Mol Cell. 2015 Jun 18; 58(6): 1040–1052. doi: 10.1016/j.molcel.2015.04.018

PMCID:: PMC4504005

Abstract Article PDF–6.0M

Select item 40225808.

Expression and Distribution of the Adrenomedullin System in Newborn Human Thymus

Sara De Martin, Giovanna Paliuri, Annasandra Belloni, Genny Orso, Erica Zanarella, Giovanni Stellin, Ornella Milanesi, Giuseppe Basso, Ezia Maria Ruga, Chiara Frasson, Daniela Gabbia, Giada Perdoncin, Pietro Palatini, Sergio Bova

PLoS One. 2014; 9(5): e97592. Published online 2014 May 15. doi: 10.1371/journal.pone.0097592

PMCID:: PMC4022580

Abstract Article PDF–1.9M

Select item 39828669.

Adrenomedullin Signaling Pathway Polymorphisms and Adverse Pregnancy Outcomes

Patricia M. Lenhart, Alison Wise, Amy H. Herring, Thutrang Nguyen, Kathleen M. Caron, Alison M. Stuebe

Am J Perinatol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Am J Perinatol. 2014 Apr; 31(4): 327–334. Published online 2013 Jun 24. doi: 10.1055/s-0033-1349345

PMCID:: PMC3982866

Abstract Article PDF–58K

Select item 396908810.

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology

H A Watkins, C S Walker, K N Ly, R J Bailey, J Barwell, D R Poyner, D L Hay

Br J Pharmacol. 2014 Feb; 171(3): 772–788. Published online 2014 Jan 13. doi: 10.1111/bph.12508

PMCID:: PMC3969088

Abstract Article PDF–2.2M

Select item 383622111.

The G-protein Coupled Receptor CLR is Up-regulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis

Leonid L. Nikitenko, Russell Leek, Stephen Henderson, Nischalan Pillay, Helen Turley, Daniele Generali, Sarah Gunningham, Helen R. Morrin, Andrea Pellagatti, Margaret C.P. Rees, Adrian L. Harris, Stephen B. Fox

Clin Cancer Res. Author manuscript; available in PMC 2014 Apr 15.

Published in final edited form as: Clin Cancer Res. 2013 Oct 15; 19(20): 10.1158/1078-0432.CCR-13-1712. Published online 2013 Aug 22. doi: 10.1158/1078-0432.CCR-13-1712

PMCID:: PMC3836221

Abstract Article PDF–2.5M

Select item 378582512.

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach

Michael. J. Woolley, Harriet A. Watkins, Bruck Taddese, Z. Gamze Karakullukcu, James Barwell, Kevin J. Smith, Debbie L. Hay, David R. Poyner, Christopher A. Reynolds, Alex C. Conner

J R Soc Interface. 2013 Nov 6; 10(88): 20130589. doi: 10.1098/rsif.2013.0589

PMCID:: PMC3785825

Abstract Article PDF–1.1M

Select item 342935713.

A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma

Mona S. Awadalla, Kathryn P. Burdon, Suman S. Thapa, Alex W. Hewitt, Jamie E. Craig

Mol Vis. 2012; 18: 2247–2254. Published online 2012 Aug 10.

PMCID:: PMC3429357

Abstract Article PDF–466K

Select item 341564414.

The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling

Kenji Kuwasako, Debbie L Hay, Sayaka Nagata, Tomomi Hikosaka, Kazuo Kitamura, Johji Kato

Br J Pharmacol. 2012 May; 166(1): 137–150. doi: 10.1111/j.1476-5381.2011.01803.x

PMCID:: PMC3415644

Abstract Article PDF–2.0M

Select item 341563715.

Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?

James Barwell, Joseph J Gingell, Harriet A Watkins, Julia K Archbold, David R Poyner, Debbie L Hay

Br J Pharmacol. 2012 May; 166(1): 51–65. doi: 10.1111/j.1476-5381.2011.01525.x

PMCID:: PMC3415637

Abstract Article PDF–4.8M

Select item 335648216.

LOCALIZATION OF CALCITONIN RECEPTOR-LIKE RECEPTOR (CLR) AND RECEPTOR ACTIVITY-MODIFYING PROTEIN 1 (RAMP1) IN HUMAN GASTROINTESTINAL TRACT

Graeme S. Cottrell, Farzad Alemi, Jacob G. Kirkland, Eileen F. Grady, Carlos U. Corvera, Aditi Bhargava

Peptides. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Peptides. 2012 Jun; 35(2): 202–211. Published online 2012 Mar 30. doi: 10.1016/j.peptides.2012.03.020

PMCID:: PMC3356482

Abstract Article PDF–1.8M

Select item 332476417.

Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding

Seisuke Kusano, Mutsuko Kukimoto-Niino, Nobumasa Hino, Noboru Ohsawa, Ken-ichi Okuda, Kensaku Sakamoto, Mikako Shirouzu, Takayuki Shindo, Shigeyuki Yokoyama

Protein Sci. 2012 Feb; 21(2): 199–210. Published online 2011 Nov 18. doi: 10.1002/pro.2003