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Select item 106288471.

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice

Nicole K.H. Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J. Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M. Singer, Gary J. Patti, Shawn C. Burgess, Brian N. Finck

iScience. 2023 Nov 17; 26(11): 108196. Published online 2023 Oct 12. doi: 10.1016/j.isci.2023.108196

PMCID:: PMC10628847

Abstract Article PDF–4.6M

Select item 105611232.

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill

Mol Metab. 2023 Nov; 77: 101808. Published online 2023 Sep 15. doi: 10.1016/j.molmet.2023.101808

PMCID:: PMC10561123

Abstract Article PDF–2.6M

Select item 103078523.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 94819334.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 88081815.

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

Wesley T. Hodges, Chaowapong Jarasvaraparn, Daniel Ferguson, Kristine Griffett, Lauren E. Gill, Yana Chen, Ma. Xenia G. Ilagan, Lamees Hegazy, Bahaa Elgendy, Kevin Cho, Gary J. Patti, Kyle S. McCommis, Brian N. Finck

J Biol Chem. 2022 Feb; 298(2): 101554. Published online 2021 Dec 30. doi: 10.1016/j.jbc.2021.101554

PMCID:: PMC8808181

Abstract Article PDF–2.5M

Select item 79579606.

Nutritional Modulation of Heart Failure in Mitochondrial Pyruvate Carrier-Deficient Mice

Kyle S. McCommis, Attila Kovacs, Carla J. Weinheimer, Trevor M. Shew, Timothy R. Koves, Olga R. Ilkayeva, Dakota R. Kamm, Kelly D. Pyles, M. Todd King, Richard L. Veech, Brian J. DeBosch, Deborah M. Muoio, Richard W. Gross, Brian N. Finck

Nat Metab. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Nat Metab. 2020 Nov; 2(11): 1232–1247. Published online 2020 Oct 26. doi: 10.1038/s42255-020-00296-1

PMCID:: PMC7957960

Abstract Article PDF–5.9M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 76104048.

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

Mariana Fernandez-Caggiano, Alisa Kamynina, Asvi A. Francois, Oleksandra Prysyazhna, Thomas R. Eykyn, Susanne Krasemann, Maria G. Crespo-Leiro, Maria Garcia Vieites, Katiuscia Bianchi, Valle Morales, Nieves Domenech, Philip Eaton

Nat Metab. Author manuscript; available in PMC 2021 Mar 23.

Published in final edited form as: Nat Metab. 2020 Nov 1; 2(11): 1223–1231. Published online 2020 Oct 26. doi: 10.1038/s42255-020-00276-5

PMCID:: PMC7610404

Abstract Article PDF–3.5M

Select item 72950339.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 668547810.

RNA‐Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation

Hong‐Bin Liu, Tahir Muhammad, Yueshuai Guo, Meng‐Jing Li, Qian‐Qian Sha, Chuan‐Xin Zhang, Hui Liu, Shi‐Gang Zhao, Han Zhao, Hao Zhang, Yan‐Zhi Du, Kang Sun, Kui Liu, Gang Lu, Xue‐Jiang Guo, Jiahao Sha, Heng‐Yu Fan, Fei Gao, Zi‐Jiang Chen

Adv Sci (Weinh) 2019 Aug 7; 6(15): 1900295. Published online 2019 May 24. doi: 10.1002/advs.201900295

PMCID:: PMC6685478

Abstract Article PDF–3.0M

Select item 665555111.

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Derek J. Theisen, Jesse T. Davidson, IV, Carlos G. Briseño, Marco Gargaro, Elvin J. Lauron, Qiuling Wang, Pritesh Desai, Vivek Durai, Prachi Bagadia, Joshua R. Brickner, Wandy L. Beatty, Herbert W. Virgin, William E. Gillanders, Nima Mosammaparast, Michael S. Diamond, L. David Sibley, Wayne Yokoyama, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy

Science. Author manuscript; available in PMC 2019 Jul 24.

Published in final edited form as: Science. 2018 Nov 9; 362(6415): 694–699. doi: 10.1126/science.aat5030

PMCID:: PMC6655551

Abstract Article PDF–1020K

Select item 629804012.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 579538813.

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck

Mol Cell Proteomics. 2018 Feb; 17(2): 216–232. Published online 2017 Dec 8. doi: 10.1074/mcp.RA117.000470

PMCID:: PMC5795388

Abstract Article PDF–4.4M

Select item 577485214.

Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid

Yana Chen, Kyle S. McCommis, Daniel Ferguson, Angela M. Hall, Charles A. Harris, Brian N. Finck

Endocrinology. 2018 Feb; 159(2): 609–621. Published online 2017 Nov 8. doi: 10.1210/en.2017-00695

PMCID:: PMC5774852

Abstract Article

Select item 566791815.

The Beneficial Metabolic Effects of Insulin Sensitizers are not Attenuated by Mitochondrial Pyruvate Carrier 2 Hypomorphism

Patrick A. Vigueira, Kyle S. McCommis, Wesley T. Hodges, George G. Schweitzer, Serena L. Cole, Lalita Oonthonpan, Eric B. Taylor, William G. McDonald, Rolf F. Kletzien, Jerry R. Colca, Brian N. Finck

Exp Physiol. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Exp Physiol. 2017 Aug 1; 102(8): 985–999. Published online 2017 Jul 10. doi: 10.1113/EP086380

PMCID:: PMC5667918

Abstract Article PDF–912K

Select item 538122616.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 537776217.

Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION

Shraddha S. Vadvalkar, Satoshi Matsuzaki, Craig A. Eyster, Jennifer R. Giorgione, Lee B. Bockus, Caroline S. Kinter, Michael Kinter, Kenneth M. Humphries

J Biol Chem. 2017 Mar 17; 292(11): 4423–4433. Published online 2017 Feb 1. doi: 10.1074/jbc.M116.753509

PMCID:: PMC5377762

Abstract Article PDF–1.6M

Select item 513335218.

Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation

Sandip K. Bose, Irina Hutson, Charles A. Harris

Endocrinology. 2016 Dec; 157(12): 4943–4960. Published online 2016 Oct 18. doi: 10.1210/en.2016-1615

PMCID:: PMC5133352

Abstract Article

Select item 508140619.

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle

Cell Rep. 2016 Oct 18; 17(4): 1008–1021. Published online 2016 Oct 18. doi: 10.1016/j.celrep.2016.09.053

PMCID:: PMC5081406

Abstract Article

Select item 495653620.

Mitochondrial pyruvate import promotes long-term survival of antibody-secreting plasma cells

Wing Y. Lam, Amy M. Becker, Krista M. Kennerly, Rachel Wong, Jonathan D. Curtis, Elizabeth M. Llufrio, Kyle S. McCommis, Johannes Fahrmann, Hannah A. Pizzato, Ryan M. Nunley, Jieun Lee, Michael J. Wolfgang, Gary J. Patti, Brian N. Finck, Erika L. Pearce, Deepta Bhattacharya

Immunity. Author manuscript; available in PMC 2017 Jul 19.

Published in final edited form as: Immunity. 2016 Jul 19; 45(1): 60–73. Published online 2016 Jul 5. doi: 10.1016/j.immuni.2016.06.011

PMCID:: PMC4956536

Abstract Article PDF–2.6M

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