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Select item 110639341.

ORAI1 inhibition as an efficient preclinical therapy for tubular aggregate myopathy and Stormorken syndrome

Roberto Silva-Rojas, Laura Pérez-Guàrdia, Alix Simon, Sarah Djeddi, Susan Treves, Agnès Ribes, Lorenzo Silva-Hernández, Céline Tard, Jocelyn Laporte, Johann Böhm

JCI Insight. 2024 Mar 22; 9(6): e174866. Published online 2024 Mar 22. doi: 10.1172/jci.insight.174866

PMCID:: PMC11063934

Abstract Article PDF–9.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108516873.

PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization

Dongyu Wei, Hareram Birla, Yannong Dou, Yixiao Mei, Xiaodong Huo, Victoria Whitehead, Patrick Osei-Owusu, Stefan Feske, Giovanna Patafio, Yuanxiang Tao, Huijuan Hu

J Neurosci. 2024 Jan 3; 44(1): e0329232023. doi: 10.1523/JNEUROSCI.0329-23.2023

PMCID:: PMC10851687

Abstract Article PDF–5.4M

Select item 107474754.

The Ca²⁺ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain

Ga-Yeon Son, Nguyen Huu Tu, Maria Daniela Santi, Santiago Loya Lopez, Guilherme H. Souza Bomfim, Manikandan Vinu, Fang Zhou, Ariya Chaloemtoem, Rama Alhariri, Youssef Idaghdour, Rajesh Khanna, Yi Ye, Rodrigo S. Lacruz

Sci Signal. Author manuscript; available in PMC 2023 Dec 23.

Published in final edited form as: Sci Signal. 2023 Sep 5; 16(801): eadf9535. Published online 2023 Sep 5. doi: 10.1126/scisignal.adf9535

PMCID:: PMC10747475

Abstract Article PDF–2.0M

Select item 106826445.

Loss of Ca²⁺ entry via Orai–TRPC1 induces ER stress, initiating immune activation in macrophages

Viviane Nascimento Da Conceicao, Yuyang Sun, Emily K. Zboril, Jorge J. De la Chapa, Brij B. Singh

J Cell Sci. 2020 Mar 1; 133(5): jcs237610. Published online 2019 Dec 18. doi: 10.1242/jcs.237610

PMCID:: PMC10682644

Abstract Article

Select item 106666726.

Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury

Mengya Niu, Xiuli Zhang, Zengkai Wu, Bin Li, Jingpiao Bao, Juanjuan Dai, Zihan Yang, Yue Zeng, Liang Li, Stephen Pandol, Robert Sutton, Li Wen

Function (Oxf) 2024; 5(1): zqad061. Published online 2023 Oct 23. doi: 10.1093/function/zqad061

PMCID:: PMC10666672

Abstract Article PDF–9.7M

Select item 104850217.

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya

Nat Commun. 2023; 14: 5500. Published online 2023 Sep 7. doi: 10.1038/s41467-023-40968-6

PMCID:: PMC10485021

Abstract Article PDF–4.0M

Select item 101745728.

The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1

Lisa J. Robinson, Jonathan Soboloff, Irina L. Tourkova, Quitterie C. Larrouture, Kelechi M. Onwuka, Dionysios J. Papachristou, Scott Gross, Robert Hooper, Elsie Samakai, Paul F. Worley, Peng Liu, Jan Tuckermann, Michelle R. Witt, Harry C. Blair

PLoS One. 2023; 18(5): e0264596. Published online 2023 May 11. doi: 10.1371/journal.pone.0264596

PMCID:: PMC10174572

Abstract Article PDF–3.1M

Select item 99980919.

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells

Scott M Emrich, Ryan E Yoast, Xuexin Zhang, Adam J Fike, Yin-Hu Wang, Kristen N Bricker, Anthony Y Tao, Ping Xin, Vonn Walter, Martin T Johnson, Trayambak Pathak, Adam C Straub, Stefan Feske, Ziaur SM Rahman, Mohamed Trebak

eLife. 2023; 12: e84708. Published online 2023 Feb 21. doi: 10.7554/eLife.84708

PMCID:: PMC9998091

Abstract Article PDF–5.5M

Select item 988305110.

Regulation of neuropathic pain by microglial Orai1 channels

Shogo Tsujikawa, Kaitlyn E. DeMeulenaere, Maria V. Centeno, Shahrzad Ghazisaeidi, Megan E. Martin, Martinna R. Tapies, Mohammad M. Maneshi, Megumi Yamashita, Kenneth A. Stauderman, Apkar V. Apkarian, Michael W. Salter, Murali Prakriya

Sci Adv. 2023 Jan; 9(4): eade7002. Published online 2023 Jan 27. doi: 10.1126/sciadv.ade7002

PMCID:: PMC9883051

Abstract Article PDF–1.6M

Select item 960009811.

Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1

Linlin Yang, Roger Ottenheijm, Paul Worley, Marc Freichel, Juan E. Camacho Londoño

Cells. 2022 Oct; 11(20): 3225. Published online 2022 Oct 14. doi: 10.3390/cells11203225

PMCID:: PMC9600098

Abstract Article PDF–2.5M

Select item 957477712.

Store-operated Ca²⁺ entry and Ca²⁺ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1−/− and heptaTRPC knockout mice

Lucía Núñez, Gary S. Bird, Elena Hernando-Pérez, Enrique Pérez-Riesgo, James W. Putney, Jr, Carlos Villalobos

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2022 Oct 17.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2019 Jul; 1866(7): 1124–1136. Published online 2018 Nov 17. doi: 10.1016/j.bbamcr.2018.11.006

PMCID:: PMC9574777

Abstract Article PDF–1.8M

Select item 954433913.

Distinct roles of ORAI1 in T cell–mediated allergic airway inflammation and immunity to influenza A virus infection

Yin-Hu Wang, Lucile Noyer, Sascha Kahlfuss, Dimitrius Raphael, Anthony Y. Tao, Ulrike Kaufmann, Jingjie Zhu, Marisa Mitchell-Flack, Ikjot Sidhu, Fang Zhou, Martin Vaeth, Paul G. Thomas, Sean P. Saunders, Kenneth Stauderman, Maria A. Curotto de Lafaille, Stefan Feske

Sci Adv. 2022 Oct; 8(40): eabn6552. Published online 2022 Oct 7. doi: 10.1126/sciadv.abn6552

PMCID:: PMC9544339

Abstract Article PDF–1.9M

Select item 936587414.

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

Maricela García-Castañeda, Antonio Michelucci, Nan Zhao, Sundeep Malik, Robert T. Dirksen

J Gen Physiol. 2022 Sep 5; 154(9): e202213081. Published online 2022 Aug 8. doi: 10.1085/jgp.202213081

PMCID:: PMC9365874

Abstract Article PDF–5.0M

Select item 926665815.

Silencing of the Ca²⁺ Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice

Roberto Silva-Rojas, Laura Pérez-Guàrdia, Emma Lafabrie, David Moulaert, Jocelyn Laporte, Johann Böhm

Int J Mol Sci. 2022 Jul; 23(13): 6968. Published online 2022 Jun 23. doi: 10.3390/ijms23136968

PMCID:: PMC9266658

Abstract Article PDF–2.9M

Select item 901197616.

ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca²⁺ entry in the immune system and beyond

Stefan Feske

Immunol Rev. Author manuscript; available in PMC 2022 Apr 15.

Published in final edited form as: Immunol Rev. 2009 Sep; 231(1): 189–209. doi: 10.1111/j.1600-065X.2009.00818.x

PMCID:: PMC9011976

Abstract Article PDF–1.3M

Select item 899647917.

Orai1 downregulation causes proliferation reduction and cell cycle arrest via inactivation of the Ras-NF-κB signaling pathway in osteoblasts

Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao

BMC Musculoskelet Disord. 2022; 23: 347. Published online 2022 Apr 11. doi: 10.1186/s12891-022-05311-y

PMCID:: PMC8996479

Abstract Article PDF–2.9M

Select item 899140718.

The volume regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling

Axel R. Concepcion, Larry E. Wagner, II, Jingjie Zhu, Anthony Y. Tao, Jun Yang, Alireza Khodadadi-Jamayran, Yin-Hu Wang, Menghan Liu, Rebecca E. Rose, Drew R. Jones, William A. Coetzee, David I. Yule, Stefan Feske

Nat Immunol. Author manuscript; available in PMC 2022 Apr 8.

Published in final edited form as: Nat Immunol. 2022 Feb; 23(2): 287–302. Published online 2022 Feb 1. doi: 10.1038/s41590-021-01105-x

PMCID:: PMC8991407

Abstract Article PDF–6.7M

Select item 891698219.

Ca²⁺ signaling augmented by ORAI1 trafficking regulates the pathogenic state of effector T cells

Beibei Wu, Jin Seok Woo, Zuoming Sun, Sonal Srikanth, Yousang Gwack

J Immunol. Author manuscript; available in PMC 2023 Mar 15.

Published in final edited form as: J Immunol. 2022 Mar 15; 208(6): 1329–1340. Published online 2022 Feb 25. doi: 10.4049/jimmunol.2100871

PMCID:: PMC8916982

Abstract Article PDF–2.3M

Select item 874188220.

Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons

Jingsheng Xia, Yannong Dou, Yixiao Mei, Frances M. Munoz, Ruby Gao, Xinghua Gao, Daling Li, Patrick Osei-Owusu, James Schiffenhaus, Alex Bekker, Yuan-Xiang Tao, Huijuan Hu

Pain. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Pain. 2022 Apr 1; 163(4): 652–664. doi: 10.1097/j.pain.0000000000002396

PMCID:: PMC8741882

Abstract Article PDF–2.8M

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