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Select item 113849061.

PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells

Mariia Stefanenko, Mykhailo Fedoriuk, Mykola Mamenko, Marharyta Semenikhina, Tamara K Nowling, Joshua H Lipschutz, Oleksandr Maximyuk, Alexander Staruschenko, Oleg Palygin

Function (Oxf) 2024; 5(5): zqae030. Published online 2024 Jun 10. doi: 10.1093/function/zqae030

PMCID:: PMC11384906

Abstract Article PDF–1.6M

Select item 111137062.

Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer

Mohammad Jaber, Miriam Maoz, Arun Kancharla, Daniel Agranovich, Tamar Peretz, Sorina Grisaru-Granovsky, Beatrice Uziely, Rachel Bar-Shavit

Cell Mol Life Sci. 2014 Jul; 71(13): 2517–2533. Published online 2013 Nov 1. doi: 10.1007/s00018-013-1498-7

Correction in:: Cell Mol Life Sci. 2017 Feb; 74(3): 571–577.

PMCID:: PMC11113706

Abstract Article PDF–1.6M

Select item 106580733.

Protease-Activated Receptor 1–Mediated Damage of Podocytes in Diabetic Nephropathy

Ruslan Bohovyk, Sherif Khedr, Vladislav Levchenko, Mariia Stefanenko, Marharyta Semenikhina, Olha Kravtsova, Elena Isaeva, Aron M. Geurts, Christine A. Klemens, Oleg Palygin, Alexander Staruschenko

Diabetes. 2023 Dec; 72(12): 1795–1808. Published online 2023 Sep 18. doi: 10.2337/db23-0032

PMCID:: PMC10658073

Abstract Article PDF–104M

Select item 105140144.

Protease-Activated Receptor 1 (PAR1) Expression Contributes to HPV-Associated Oropharyngeal Cancer Prognosis

Yoshinori Fujita, Yujiro Fukuda, Fumiaki Sanuki, Isao Irei, Yasumasa Monobe, Masako Uno, Takeshi Akisada, Koichiro Shimoya, Hirotaka Hara, Takuya Moriya

Head Neck Pathol. 2023 Sep; 17(3): 658–672. Published online 2023 Jul 24. doi: 10.1007/s12105-023-01567-5

PMCID:: PMC10514014

Abstract Article PDF–2.1M

Select item 89019125.

Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma

Yuxue Gao, Qingguo Xu, Xinqiang Li, Yuan Guo, Bowen Zhang, Yan Jin, Cunle zhu, Yuntai Shen, Pengxiang Yang, Ying Shi, Rifeng Jin, Daojie Liu, Yabo Ouyang, Xiaoni Liu, Wenjing Wang, Dexi Chen, Tongwang Yang

Cell Death Dis. 2022 Mar; 13(3): 213. Published online 2022 Mar 7. doi: 10.1038/s41419-022-04654-7

PMCID:: PMC8901912

Abstract Article PDF–7.9M

Select item 86165246.

Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1

Elisa D’Alessandro, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, Frans A. van Nieuwenhoven

Cells. 2021 Nov; 10(11): 2958. Published online 2021 Oct 30. doi: 10.3390/cells10112958

PMCID:: PMC8616524

Abstract Article PDF–2.3M

Select item 85840317.

Autoantibodies from Patients with Scleroderma Renal Crisis Promote PAR-1 Receptor Activation and IL-6 Production in Endothelial Cells

Michèle Simon, Christian Lücht, Isa Hosp, Hongfan Zhao, Dashan Wu, Harald Heidecke, Janusz Witowski, Klemens Budde, Gabriela Riemekasten, Rusan Catar

Int J Mol Sci. 2021 Nov; 22(21): 11793. Published online 2021 Oct 30. doi: 10.3390/ijms222111793

PMCID:: PMC8584031

Abstract Article PDF–3.1M

Select item 85097328.

Expression/Activation of PAR-1 in Airway Epithelial Cells of COPD Patients: Ex Vivo/In Vitro Study

Angela Marina Montalbano, Giuseppina Chiappara, Giusy Daniela Albano, Maria Ferraro, Caterina Di Sano, Patrizio Vitulo, Loredana Pipitone, Fabio Luigi Massimo Ricciardolo, Giulia Anzalone, Mirella Profita

Int J Mol Sci. 2021 Oct; 22(19): 10703. Published online 2021 Oct 2. doi: 10.3390/ijms221910703

PMCID:: PMC8509732

Abstract Article PDF–4.0M

Select item 84584329.

KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1

Qing Hua, Zhirong Sun, Yi Liu, Xuefang Shen, Weiwei Zhao, Xiaoyan Zhu, Pingbo Xu

Cell Death Dis. 2021 Oct; 12(10): 860. Published online 2021 Sep 22. doi: 10.1038/s41419-021-04149-x

PMCID:: PMC8458432

Abstract Article PDF–7.2M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 771703511.

Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation

Cansu Tekin, Hella L Aberson, Cynthia Waasdorp, Gerrit K J Hooijer, Onno J de Boer, Frederike Dijk, Maarten F Bijlsma, C Arnold Spek

Cell Oncol (Dordr) 2020; 43(6): 1161–1174. Published online 2020 Aug 18. doi: 10.1007/s13402-020-00549-x

PMCID:: PMC7717035

Abstract Article PDF–2.3M

Select item 758991012.

Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorder in Patients with Secondary Progressive Multiple Sclerosis

Angela Dziedzic, Elzbieta Miller, Michal Bijak, Lukasz Przyslo, Joanna Saluk-Bijak

Int J Mol Sci. 2020 Oct; 21(20): 7722. Published online 2020 Oct 19. doi: 10.3390/ijms21207722

PMCID:: PMC7589910

Abstract Article PDF–1.3M

Select item 745508113.

Arrestin domain containing 3 promotes Helicobacter pylori–associated gastritis by regulating protease-activated receptor 1

Yu-gang Liu, Yong-sheng Teng, Zhi-guo Shan, Ping Cheng, Chuan-jie Hao, Yi-pin Lv, Fang-yuan Mao, Shi-ming Yang, Weisan Chen, Yong-liang Zhao, Nan You, Quan-ming Zou, Yuan Zhuang

JCI Insight. 2020 Aug 6; 5(15): e135849. Published online 2020 Aug 6. doi: 10.1172/jci.insight.135849

PMCID:: PMC7455081

Abstract Article PDF–47M

Select item 726003214.

KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease

Allison C. Billi, Jessica E. Ludwig, Yi Fritz, Richard Rozic, William R. Swindell, Lam C. Tsoi, Dennis Gruzska, Shahla Abdollahi-Roodsaz, Xianying Xing, Doina Diaconu, Ranjitha Uppala, Maya I. Camhi, Philip A. Klenotic, Mrinal K. Sarkar, M. Elaine Husni, Jose U. Scher, Christine McDonald, J. Michelle Kahlenberg, Ronald J. Midura, Johann E. Gudjonsson, Nicole L. Ward

J Clin Invest. 2020 Jun 1; 130(6): 3151–3157. Published online 2020 May 11. doi: 10.1172/JCI133159

PMCID:: PMC7260032

Abstract Article PDF–12M

Select item 681809815.

Dysregulated protease activated receptor 1 (PAR1) promotes metastatic phenotype in breast cancer through HMGA2

E Yang, J Cisowski, N Nguyen, K O’Callaghan, J Xu, A Agarwal, A Kuliopulos, L Covic

Oncogene. Author manuscript; available in PMC 2019 Oct 29.

Published in final edited form as: Oncogene. 2016 Mar 24; 35(12): 1529–1540. Published online 2015 Jul 13. doi: 10.1038/onc.2015.217

PMCID:: PMC6818098

Abstract Article

Select item 669936816.

Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells

Anna Zhang, Yunfeng Hou, Chao Sun, Ying Pu, Yu Sun, Yuan Zhang, Yang Shen, Qingbo Zhou

Biomed Res Int. 2019; 2019: 2187306. Published online 2019 Aug 6. doi: 10.1155/2019/2187306

PMCID:: PMC6699368

Abstract Article PDF–1.5M

Select item 651239217.

Interleukin 8 is differently expressed and modulated by PAR‐1 activation in early and late endothelial progenitor cells

David M. Smadja, Ivan Bièche, Sophie Susen, Laetitia Mauge, Ingrid Laurendeau, Clément d’Audigier, Françoise Grelac, Joseph Emmerich, Martine Aiach, Pascale Gaussem

J Cell Mol Med. 2009 Aug; 13(8b): 2534–2546. Published online 2008 Jul 24. doi: 10.1111/j.1582-4934.2008.00429.x

PMCID:: PMC6512392

Abstract Article PDF–1.0M

Select item 626465418.

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk

Yingying Wang, Xiaoling Weng, Luoyang Wang, Mingang Hao, Yue Li, Lidan Hou, Yu Liang, Tianqi Wu, Mengfei Yao, Guowen Lin, Yiwei Jiang, Guohui Fu, Zhaoyuan Hou, Xiangjun Meng, Jinsong Lu, Jianhua Wang

J Clin Invest. 2018 Dec 3; 128(12): 5235–5250. Published online 2018 Oct 22. doi: 10.1172/JCI99974

PMCID:: PMC6264654

Abstract Article PDF–13M

Select item 607642519.

Noncanonical Matrix Metalloprotease 1–Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis

Rajashree Rana, Tianfang Huang, Georgios Koukos, Elizabeth K. Fletcher, Susan E. Turner, Andrew Shearer, Paul A. Gurbel, Jeffrey J. Rade, Carey D. Kimmelstiel, Kevin P. Bliden, Lidija Covic, Athan Kuliopulos

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Jun; 38(6): 1368–1380. Published online 2018 Apr 5. doi: 10.1161/ATVBAHA.118.310967

PMCID:: PMC6076425

Abstract Article PDF–2.0M

Select item 584677520.

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients

Sabine Buhner, Hannes Hahne, Kerstin Hartwig, Qin Li, Sheila Vignali, Daniela Ostertag, Chen Meng, Gabriele Hörmannsperger, Breg Braak, Christian Pehl, Thomas Frieling, Giovanni Barbara, Roberto De Giorgio, Ihsan Ekin Demir, Güralp Onur Ceyhan, Florian Zeller, Guy Boeckxstaens, Dirk Haller, Bernhard Kuster, Michael Schemann

PLoS One. 2018; 13(3): e0193943. Published online 2018 Mar 12. doi: 10.1371/journal.pone.0193943

PMCID:: PMC5846775

Abstract Article PDF–2.8M

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