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Select item 114472561.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 110916372.

Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150

Shuangyu Li, Qiubo Ma, Zengwei Ma, Ying Shi, Xiaoyan Yu, Baohua Gu, Shanshan Sun, Chunlei Yu, Lei Pang

Clin Hemorheol Microcirc. 2024; 86(3): 369–382. Prepublished online 2023 Nov 10. Published online 2024 Apr 10. doi: 10.3233/CH-231979

PMCID:: PMC11091637

Abstract Article PDF–742K

Select item 108587333.

TRPC6 N338S is a gain-of-function mutant identified in patient with doxorubicin-induced cardiotoxicity

Tong Lu, Xiaojing Sun, Brian M. Necela, Hon-Chi Lee, Nadine Norton

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2024 Feb 10.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1; 1868(11): 166505. Published online 2022 Jul 23. doi: 10.1016/j.bbadis.2022.166505

PMCID:: PMC10858733

Abstract Article PDF–1.3M

Select item 107062544.

TRPC6 Deletion Enhances eNOS Expression and Reduces LPS—Induced Acute Lung Injury

Mengyuan Wang, Xingfang Zhang, Juan Guo, Shangze Yang, Fang Yang, Xingjuan Chen

Int J Mol Sci. 2023 Dec; 24(23): 16756. Published online 2023 Nov 25. doi: 10.3390/ijms242316756

PMCID:: PMC10706254

Abstract Article PDF–8.9M

Select item 106716815.

A Putative Role for TRPC6 in Immune-Mediated Kidney Injury

Daan C. ‘t Hart, Johan van der Vlag, Tom Nijenhuis

Int J Mol Sci. 2023 Nov; 24(22): 16419. Published online 2023 Nov 16. doi: 10.3390/ijms242216419

PMCID:: PMC10671681

Abstract Article PDF–1.4M

Select item 104499976.

An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis

Lilas Batool, Krithika Hariharan, Yao Xu, Mario Kaßmann, Dmitry Tsvetkov, Björn-Oliver Gohlke, Sylvia Kaden, Manfred Gossen, Bernd Nürnberg, Andreas Kurtz, Maik Gollasch

Cell Mol Life Sci. 2023 Sep; 80(9): 265. Published online 2023 Aug 24. doi: 10.1007/s00018-023-04901-w

PMCID:: PMC10449997

Abstract Article PDF–3.4M

Select item 94850007.

Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells

Tengteng Zhao, Sophia Parmisano, Zahra Soroureddin, Manjia Zhao, Lauren Yung, Patricia A. Thistlethwaite, Ayako Makino, Jason X.-J Yuan

Am J Physiol Cell Physiol. 2022 Oct 1; 323(4): C959–C973. Published online 2022 Aug 15. doi: 10.1152/ajpcell.00313.2022

PMCID:: PMC9485000

Abstract Article

Select item 90384278.

Klotho Ameliorates Podocyte Injury through Targeting TRPC6 Channel in Diabetic Nephropathy

Xingmei Yao, Hengjiang Guo, Mengyao Sun, Sixuan Meng, Bingbing Zhu, Ji Fang, Jiebo Huang, Hao Wang, Lina Xing

J Diabetes Res. 2022; 2022: 1329380. Published online 2022 Apr 18. doi: 10.1155/2022/1329380

PMCID:: PMC9038427

Abstract Article PDF–2.9M

Select item 84367079.

OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma

Wei Shao, Zhen-Yu Hao, Yi-Fei Chen, Jun Du, Qian He, Liang-Liang Ren, Yan Gao, Nan Song, Yan Song, Hua He, Yi-Zheng Wang

J Mol Cell Biol. 2021 Jun; 13(6): 409–421. Published online 2021 Jan 28. doi: 10.1093/jmcb/mjab001

PMCID:: PMC8436707

Abstract Article PDF–1008K

Select item 794874610.

Melatonin downregulates TRPC6, impairing store-operated calcium entry in triple-negative breast cancer cells

Isaac Jardin, Raquel Diez-Bello, Debora Falcon, Sandra Alvarado, Sergio Regodon, Gines M. Salido, Tarik Smani, Juan A. Rosado

J Biol Chem. 2021 Jan-Jun; 296: 100254. Published online 2021 Jan 8. doi: 10.1074/jbc.RA120.015769

PMCID:: PMC7948746

Abstract Article PDF–6.3M

Select item 705834411.

Munc13 mediates klotho-inhibitable diacylglycerol-stimulated exocytotic insertion of pre-docked TRPC6 vesicles

Jian Xie, Sung-Wan An, Xin Jin, Yuan Gui, Chou-Long Huang

PLoS One. 2020; 15(3): e0229799. Published online 2020 Mar 5. doi: 10.1371/journal.pone.0229799

PMCID:: PMC7058344

Abstract Article PDF–2.9M

Select item 681400512.

Role of TRPC6 in progression of diabetic kidney disease

Alexander Staruschenko, Denisha Spires, Oleg Palygin

Curr Hypertens Rep. Author manuscript; available in PMC 2020 May 21.

Published in final edited form as: Curr Hypertens Rep. 2019 May 21; 21(7): 48. Published online 2019 May 21. doi: 10.1007/s11906-019-0960-9

PMCID:: PMC6814005

Abstract Article PDF–690K

Select item 672727113.

Contribution of Coiled-Coil Assembly to Ca²⁺/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes

Onur K. Polat, Masatoshi Uno, Terukazu Maruyama, Ha Nam Tran, Kayo Imamura, Chee Fah Wong, Reiko Sakaguchi, Mariko Ariyoshi, Kyohei Itsuki, Jun Ichikawa, Takashi Morii, Masahiro Shirakawa, Ryuji Inoue, Katsuhiko Asanuma, Jochen Reiser, Hidehito Tochio, Yasuo Mori, Masayuki X. Mori

J Am Soc Nephrol. 2019 Sep; 30(9): 1587–1603. Published online 2019 Jul 2. doi: 10.1681/ASN.2018070756

PMCID:: PMC6727271

Abstract Article

Select item 670963514.

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6

Brianna E. Talbot, David H. Vandorpe, Brian R. Stotter, Seth L. Alper, Johannes S. Schlondorff

J Biol Chem. 2019 Aug 23; 294(34): 12655–12669. Published online 2019 Jul 2. doi: 10.1074/jbc.RA119.008299

PMCID:: PMC6709635

Abstract Article PDF–2.5M

Select item 666298415.

Soluble klotho regulates TRPC6 calcium signaling via lipid rafts, independent of the FGFR-FGF23 pathway

Jon D. Wright, Sung-Wan An, Jian Xie, Carmay Lim, Chou-Long Huang

FASEB J. 2019 Aug; 33(8): 9182–9193. Published online 2019 May 7. doi: 10.1096/fj.201900321R

PMCID:: PMC6662984

Abstract Article

Select item 617048116.

Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation

Xin Hou, Haitao Xiao, Yanhong Zhang, Xixi Zeng, Mengjun Huang, Xiaoyun Chen, Lutz Birnbaumer, Yanhong Liao

Cell Death Dis. 2018 Oct; 9(10): 1015. Published online 2018 Oct 3. doi: 10.1038/s41419-018-1052-5

PMCID:: PMC6170481

Abstract Article PDF–2.2M

Select item 607772217.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 602863218.

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

Qinglin Tang, Wenjun Guo, Li Zheng, Jing-Xiang Wu, Meng Liu, Xindi Zhou, Xiaolin Zhang, Lei Chen

Cell Res. 2018 Jul; 28(7): 746–755. Published online 2018 Apr 26. doi: 10.1038/s41422-018-0038-2

PMCID:: PMC6028632

Abstract Article PDF–2.4M

Select item 573112719.

Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression

Henning Hagmann, Nicole Mangold, Markus M. Rinschen, Tim Koenig, Karl Kunzelmann, Bernhard Schermer, Thomas Benzing, Paul T. Brinkkoetter

FASEB J. 2018 Jan; 32(1): 208–219. Published online 2017 Sep 6. doi: 10.1096/fj.201700309R

PMCID:: PMC5731127

Abstract Article

Select item 555729120.

Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors

Eun Young Kim, Hila Roshanravan, Stuart E. Dryer

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Sep; 1863(9): 2342–2354. Published online 2017 Jun 16. doi: 10.1016/j.bbadis.2017.06.010