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Select item 95865661.

Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling

Qiuyu Martin Zhu, Bryan T MacDonald, Taiji Mizoguchi, Mark Chaffin, Alison Leed, Alessandro Arduini, Edyta Malolepsza, Kasper Lage, Virendar K Kaushik, Sekar Kathiresan, Patrick T Ellinor

Cardiovasc Res. 2022 Sep; 118(13): 2833–2846. Published online 2021 Nov 26. doi: 10.1093/cvr/cvab344

PMCID:: PMC9586566

Abstract Article PDF–1.7M

Select item 91714112.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 82944913.

ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice

Jeffrey S. Bourgeois, Liuyang Wang, Agustin F. Rabino, Jeffrey Everitt, Monica I. Alvarez, Sahezeel Awadia, Erika S. Wittchen, Rafael Garcia-Mata, Dennis C. Ko

PLoS Pathog. 2021 Jul; 17(7): e1009713. Published online 2021 Jul 9. doi: 10.1371/journal.ppat.1009713

PMCID:: PMC8294491

Abstract Article PDF–4.5M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81297945.

Rab40–Cullin5 complex regulates EPLIN and actin cytoskeleton dynamics during cell migration

Erik S. Linklater, Emily D. Duncan, Ke-Jun Han, Algirdas Kaupinis, Mindaugas Valius, Traci R. Lyons, Rytis Prekeris

J Cell Biol. 2021 Jul 5; 220(7): e202008060. Published online 2021 May 17. doi: 10.1083/jcb.202008060

PMCID:: PMC8129794

Abstract Article PDF–6.5M

Select item 74273276.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 63865887.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 58269268.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 58163749.

SGEF is a potential prognostic and therapeutic target for lung adenocarcinoma

Qian Chen, Xiao Lu, Quan-Xing Liu, Dong Zhou, Yuan Qiu, Ji-Gang Dai, Hong Zheng

World J Surg Oncol. 2018; 16: 32. Published online 2018 Feb 17. doi: 10.1186/s12957-018-1331-8

PMCID:: PMC5816374

Abstract Article PDF–3.5M

Select item 557738310.

Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease

Derek Klarin, Qiuyu Martin Zhu, Connor A. Emdin, Mark Chaffin, Steven Horner, Brian J. McMillan, Alison Leed, Michael E. Weale, Chris C. A. Spencer, François Aguet, Ayellet V. Segrè, Kristin G. Ardlie, Amit V. Khera, Virendar K. Kaushik, Pradeep Natarajan, CARDIoGRAMplusC4D Consortium, Sekar Kathiresan

Nat Genet. Author manuscript; available in PMC 2018 Jan 17.

Published in final edited form as: Nat Genet. 2017 Sep; 49(9): 1392–1397. Published online 2017 Jul 17. doi: 10.1038/ng.3914

PMCID:: PMC5577383

Abstract Article PDF–1.0M

Select item 553161111.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522512.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 535833913.

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells

Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata

J Cell Sci. 2017 Mar 15; 130(6): 1064–1077. doi: 10.1242/jcs.195552

PMCID:: PMC5358339

Abstract Article

Select item 495468114.

Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration

Yusuke Okuyama, Kentaro Umeda, Manabu Negishi, Hironori Katoh

PLoS One. 2016; 11(7): e0159617. Published online 2016 Jul 20. doi: 10.1371/journal.pone.0159617

PMCID:: PMC4954681

Abstract Article PDF–2.1M

Select item 479436315.

SGEF is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide

Shannon P. Fortin Ensign, Alison Roos, Ian T. Mathews, Harshil D. Dhruv, Serdar Tuncali, Jann N. Sarkaria, Marc H. Symons, Joseph C. Loftus, Michael E. Berens, Nhan L. Tran

Mol Cancer Res. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Mol Cancer Res. 2016 Mar; 14(3): 302–312. Published online 2016 Jan 13. doi: 10.1158/1541-7786.MCR-15-0183

PMCID:: PMC4794363

Abstract Article PDF–2.2M

Select item 461721116.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 372464417.

The Src Homology 3 Domain-containing Guanine Nucleotide Exchange Factor Is Overexpressed in High-grade Gliomas and Promotes Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Fibroblast Growth Factor-inducible 14-induced Cell Migration and Invasion via Tumor Necrosis Factor Receptor-associated Factor 2

Shannon P. Fortin Ensign, Ian T. Mathews, Jennifer M. Eschbacher, Joseph C. Loftus, Marc H. Symons, Nhan L. Tran

J Biol Chem. 2013 Jul 26; 288(30): 21887–21897. Published online 2013 Jun 17. doi: 10.1074/jbc.M113.468686

PMCID:: PMC3724644

Abstract Article PDF–2.8M

Select item 328559118.

The Invasive Capacity of HPV Transformed Cells Requires the hDlg-Dependent Enhancement of SGEF/RhoG Activity

Vanitha Krishna Subbaiah, Paola Massimi, Siaw Shi Boon, Michael P. Myers, Lisa Sharek, Rafael Garcia-Mata, Lawrence Banks

PLoS Pathog. 2012 Feb; 8(2): e1002543. Published online 2012 Feb 23. doi: 10.1371/journal.ppat.1002543

PMCID:: PMC3285591

Abstract Article PDF–1.7M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 135612920.

Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes

Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano

Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406

PMCID:: PMC1356129

Abstract Article PDF–438K

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