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Select item 111627831.

Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader

Xinglin Hu, Xingwei Huang, Yue Yang, Yuchen Sun, Yanhua Zhao, Zhijing Zhang, Dan Qiu, Yanshuang Wu, Guangming Wu, Lei Lei

Nucleic Acids Res. 2024 Jun 10; 52(10): 5529–5548. Published online 2024 Mar 21. doi: 10.1093/nar/gkae183

PMCID:: PMC11162783

Abstract Article PDF–4.5M

Select item 111496962.

The homeobox transcription factor DUXBL controls exit from totipotency

Maria Vega-Sendino, Felipe F. Lüttmann, Teresa Olbrich, Yanpu Chen, Carsten Kuenne, Paula Stein, Desiree Tillo, Grace I. Carey, Jiasheng Zhong, Virginia Savy, Lenka Radonova, Tianlin Lu, Bechara Saykali, Kee-Pyo Kim, Catherine N. Domingo, Leah Schüler, Stefan Günther, Mette Bentsen, Darko Bosnakovski, Hans Schöler, Michael Kyba, Tapan K. Maity, Lisa M. Jenkins, Mario Looso, Carmen J. Williams, Johnny Kim, Sergio Ruiz

Nat Genet. Author manuscript; available in PMC 2024 Jun 4.

Published in final edited form as: Nat Genet. 2024 Apr; 56(4): 697–709. Published online 2024 Mar 20. doi: 10.1038/s41588-024-01692-z

PMCID:: PMC11149696

Abstract Article PDF–8.6M

Select item 101950823.

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

Amy E Spens, Nicholas A Sutliff, Sean R Bennett, Amy E Campbell, Stephen J Tapscott

eLife. 2023; 12: e82057. Published online 2023 Apr 24. doi: 10.7554/eLife.82057

PMCID:: PMC10195082

Abstract Article PDF–3.6M

Select item 99505224.

Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription

Xiaorui Zhang, Changquan Zhang, Di Zhou, Tianlei Zhang, Xueqin Chen, Jinlin Ren, Caixia He, Fei Meng, Qinwei Zhou, Qiaohui Yang, Congling Dai, Ge Lin, Sicong Zeng, Lizhi Leng

iScience. 2023 Mar 17; 26(3): 106158. Published online 2023 Feb 8. doi: 10.1016/j.isci.2023.106158

PMCID:: PMC9950522

Abstract Article PDF–3.7M

Select item 88900895.

Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence

Isabel F. Masteika, Anvitha Sathya, Sachiko Homma, Bess M. Miller, Frederick M. Boyce, Jeffrey Boone Miller

Biol Open. 2022 Feb 15; 11(2): bio059145. Published online 2022 Feb 22. doi: 10.1242/bio.059145

PMCID:: PMC8890089

Abstract Article PDF–1.5M

Select item 87892836.

iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

Dongsheng Guo, Katelyn Daman, Jennifer JC Chen, Meng-Jiao Shi, Jing Yan, Zdenka Matijasevic, Amanda M Rickard, Monica H Bennett, Alex Kiselyov, Haowen Zhou, Anne G Bang, Kathryn R Wagner, René Maehr, Oliver D King, Lawrence J Hayward, Charles P Emerson, Jr

eLife. 2022; 11: e70341. Published online 2022 Jan 25. doi: 10.7554/eLife.70341

PMCID:: PMC8789283

Abstract Article PDF–14M

Select item 87180317.

RIPK3‐mediated cell death is involved in DUX4‐mediated toxicity in facioscapulohumeral dystrophy

Virginie Mariot, Romain Joubert, Laura Le Gall, Eva Sidlauskaite, Christophe Hourde, William Duddy, Thomas Voit, Maximilien Bencze, Julie Dumonceaux

J Cachexia Sarcopenia Muscle. 2021 Dec; 12(6): 2079–2090. Published online 2021 Oct 22. doi: 10.1002/jcsm.12813

PMCID:: PMC8718031

Abstract Article PDF–19M

Select item 86549878.

Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy

Nizar Y. Saad, Mustafa Al-Kharsan, Sara E. Garwick-Coppens, Gholamhossein Amini Chermahini, Madison A. Harper, Andrew Palo, Ryan L. Boudreau, Scott Q. Harper

Nat Commun. 2021; 12: 7128. Published online 2021 Dec 8. doi: 10.1038/s41467-021-27430-1

PMCID:: PMC8654987

Abstract Article PDF–2.9M

Select item 85136339.

p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models

Edward J. Grow, Bradley D. Weaver, Christina M. Smith, Jingtao Guo, Paula Stein, Sean C. Shadle, Peter G. Hendrickson, Nicholas E. Johnson, Russell J. Butterfield, Roberta Menafra, Susan L. Kloet, Silvère M. van der Maarel, Carmen J. Williams, Bradley R. Cairns

Nat Genet. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Nat Genet. 2021 Aug; 53(8): 1207–1220. Published online 2021 Jul 15. doi: 10.1038/s41588-021-00893-0

PMCID:: PMC8513633

Abstract Article PDF–5.3M

Select item 828320810.

Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model

Ngoc Lu-Nguyen, Alberto Malerba, Shan Herath, George Dickson, Linda Popplewell

Hum Mol Genet. 2021 Aug 1; 30(15): 1398–1412. Published online 2021 May 13. doi: 10.1093/hmg/ddab136

PMCID:: PMC8283208

Abstract Article PDF–1.8M

Select item 778625811.

Dux facilitates post-implantation development, but is not essential for zygotic genome activation

Darko Bosnakovski, Micah D Gearhart, Si Ho Choi, Michael Kyba

Biol Reprod. 2021 Jan; 104(1): 83–93. Published online 2020 Sep 30. doi: 10.1093/biolre/ioaa179

PMCID:: PMC7786258

Abstract Article PDF–1.5M

Select item 767312312.

Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice

Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman

Nat Commun. 2020; 11: 5836. Published online 2020 Nov 17. doi: 10.1038/s41467-020-19577-0

Correction in:: Nat Commun. 2021; 12: 3874.

PMCID:: PMC7673123

Abstract Article PDF–6.1M

Select item 752834313.

Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice

Linde F. Bouwman, Bianca den Hamer, Elwin P. Verveer, Lente J. S. Lerink, Yvonne D. Krom, Silvère M. van der Maarel, Jessica C. de Greef

Skelet Muscle. 2020; 10: 27. Published online 2020 Oct 1. doi: 10.1186/s13395-020-00247-0

PMCID:: PMC7528343

Abstract Article PDF–3.3M

Select item 731298614.

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion

Isabel Gómez-Redondo, Priscila Ramos-Ibeas, Eva Pericuesta, Raúl Fernández-González, Ricardo Laguna-Barraza, Alfonso Gutiérrez-Adán

Int J Mol Sci. 2020 Jun; 21(11): 4115. Published online 2020 Jun 9. doi: 10.3390/ijms21114115

PMCID:: PMC7312986

Abstract Article PDF–1.8M

Select item 719091215.

Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice

Darko Bosnakovski, Ahmed S. Shams, Ce Yuan, Meiricris T. da Silva, Elizabeth T. Ener, Cory W. Baumann, Angus J. Lindsay, Mayank Verma, Atsushi Asakura, Dawn A. Lowe, Michael Kyba

J Clin Invest. 2020 May 1; 130(5): 2465–2477. Published online 2020 Apr 6. doi: 10.1172/JCI133303

PMCID:: PMC7190912

Abstract Article PDF–11M

Select item 709994016.

DUX is a non-essential synchronizer of zygotic genome activation

Alberto De Iaco, Sonia Verp, Sandra Offner, Delphine Grun, Didier Trono

Development. Author manuscript; available in PMC 2020 Jul 23.

Published in final edited form as: Development. 2020 Jan 23; 147(2): dev177725. Published online 2020 Jan 23. doi: 10.1242/dev.177725

PMCID:: PMC7099940

Abstract Article PDF–1.4M

Select item 695444817.

Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse

Qian-Qian Sha, Ye-Zhang Zhu, Sen Li, Yu Jiang, Lu Chen, Xiao-Hong Sun, Li Shen, Xiang-Hong Ou, Heng-Yu Fan

Nucleic Acids Res. 2020 Jan 24; 48(2): 879–894. Published online 2019 Nov 28. doi: 10.1093/nar/gkz1111

PMCID:: PMC6954448

Abstract Article PDF–5.5M

Select item 688912318.

Precise temporal regulation of Dux is important for embryo development

Mingyue Guo, Yanping Zhang, Jianfeng Zhou, Yan Bi, Junqin Xu, Ce Xu, Xiaochen Kou, Yanhong Zhao, Yanhe Li, Zhifen Tu, Kuisheng Liu, Jiaming Lin, Peng Yang, Shaorong Gao, Yixuan Wang

Cell Res. 2019 Nov; 29(11): 956–959. Published online 2019 Oct 7. doi: 10.1038/s41422-019-0238-4

PMCID:: PMC6889123

Article PDF–1.4M

Select item 685099319.

SMCHD1 terminates the first embryonic genome activation event in mouse two-cell embryos and contributes to a transcriptionally repressive state

Meghan L. Ruebel, Kailey A. Vincent, Peter Z. Schall, Kai Wang, Keith E. Latham

Am J Physiol Cell Physiol. 2019 Oct 1; 317(4): C655–C664. Published online 2019 Jul 31. doi: 10.1152/ajpcell.00116.2019

PMCID:: PMC6850993

Abstract Article

Select item 570307020.

Conserved roles for murine DUX and human DUX4 in activating cleavage stage genes and MERVL/HERVL retrotransposons

Peter G. Hendrickson, Jessie A. Doráis, Edward J. Grow, Jennifer L. Whiddon, Jong-Won Lim, Candice L. Wike, Bradley D. Weaver, Christian Pflueger, Benjamin R. Emery, Aaron L. Wilcox, David A. Nix, C. Matthew Peterson, Stephen J. Tapscott, Douglas T. Carrell, Bradley R. Cairns

Nat Genet. Author manuscript; available in PMC 2017 Nov 28.

Published in final edited form as: Nat Genet. 2017 Jun; 49(6): 925–934. Published online 2017 May 1. doi: 10.1038/ng.3844

PMCID:: PMC5703070

Abstract Article PDF–2.7M

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