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Items: 1 to 20 of 1221

1.
Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell
Mayank Verma, Yoko Asakura, Xuerui Wang, Kasey Zhou, Mahmut Ünverdi, Allison P Kann, Robert S Krauss, Atsushi Asakura
eLife. 2024; 13: e73592. Published online 2024 Jun 6. doi: 10.7554/eLife.73592
PMCID:
PMC11216748
AbstractArticlePDF–3.6M
2.
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
Hoa T.T. Ha, SiYi Liu, Xuan T.A. Nguyen, Linh K. Vo, Nancy C.P. Leong, Dat T. Nguyen, Shivaranjani Balamurugan, Pei Yen Lim, YaJun Wu, Eunju Seong, Toan Q. Nguyen, Jeongah Oh, Markus R. Wenk, Amaury Cazenave-Gassiot, Zuhal Yapici, Wei-Yi Ong, Margit Burmeister, Long N. Nguyen
JCI Insight. 2024 Apr 22; 9(8): e175462. Published online 2024 Mar 7. doi: 10.1172/jci.insight.175462
PMCID:
PMC11141868
AbstractArticlePDF–2.8M
3.
Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways
M. Y. Lee, S. H. Lee, J. H. Park, H. J. Han
Cell Mol Life Sci. 2009 Apr; 66(8): 1467–1478. Published online 2009 Mar 9. doi: 10.1007/s00018-009-8691-8
PMCID:
PMC11131554
AbstractArticlePDF–2.6M
4.
Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells
Giovanni Di Maira, Francesca Brustolon, Lorenzo A. Pinna, Maria Ruzzene
Cell Mol Life Sci. 2009 Oct; 66(20): 3363–3373. Published online 2009 Aug 8. doi: 10.1007/s00018-009-0108-1
PMCID:
PMC11115639
AbstractArticlePDF–492K
5.
DNA‐PKcs/AKT1 inhibits epithelial–mesenchymal transition during radiation‐induced pulmonary fibrosis by inducing ubiquitination and degradation of Twist1
Ziyan Yan, Jiaojiao Zhu, Yuhao Liu, Zhongqiu Li, Xinxin Liang, Shenghui Zhou, Yifan Hou, Huixi Chen, Lin Zhou, Ping Wang, Xingkun Ao, Shanshan Gao, Xin Huang, Ping‐Kun Zhou, Yongqing Gu
Clin Transl Med. 2024 May; 14(5): e1690. Published online 2024 May 17. doi: 10.1002/ctm2.1690
PMCID:
PMC11101672
AbstractArticlePDF–6.9M
6.
Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice
Yi Lv, Qian Wang, Chensheng Lin, Xi Zheng, Yanding Zhang, Xuefeng Hu
Front Cell Dev Biol. 2024; 12: 1376814. Published online 2024 Apr 17. doi: 10.3389/fcell.2024.1376814
PMCID:
PMC11061347
AbstractArticlePDF–11M
7.
Deletion of Sarcolemmal Membrane-Associated Protein Isoform 3 (SLMAP3) in Cardiac Progenitors Delays Embryonic Growth of Myocardium without Affecting Hippo Pathway
Taha Rehmani, Ana Paula Dias, Marsel Kamal, Maysoon Salih, Balwant S. Tuana
Int J Mol Sci. 2024 Mar; 25(5): 2888. Published online 2024 Mar 1. doi: 10.3390/ijms25052888
PMCID:
PMC10932035
AbstractArticlePDF–4.4M
8.
A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis
Pengfei Guo, Rebecca C Lim, Keshari Rajawasam, Tiffany Trinh, Hong Sun, Hui Zhang
eLife. 2024; 13: e86168. Published online 2024 Feb 12. doi: 10.7554/eLife.86168
PMCID:
PMC10901513
AbstractArticlePDF–9.2M
9.
Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation
María Jesús Ruiz-Rodríguez, Jorge Oller, Sara Martínez-Martínez, Iván Alarcón-Ruiz, Marta Toral, Yilin Sun, Ángel Colmenar, María José Méndez-Olivares, Dolores López-Maderuelo, Christine B Kern, J Francisco Nistal, Arturo Evangelista, Gisela Teixido-Tura, Miguel R Campanero, Juan Miguel Redondo
EMBO Mol Med. 2024 Jan; 16(1): 132–157. Published online 2024 Jan 2. doi: 10.1038/s44321-023-00009-7
PMCID:
PMC10897446
AbstractArticlePDF–14M
10.
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy
Yan Guo, Pan Xiang, Xiaojiao Sun, Wei Liu, Jiafeng Zhou, Bin Yin, Lin Hou, Boqin Qiang, Huiliang Li, Pengcheng Shu, Xiaozhong Peng
Signal Transduct Target Ther. 2024; 9: 32. Published online 2024 Feb 14. doi: 10.1038/s41392-024-01742-2
PMCID:
PMC10864363
AbstractArticlePDF–9.9M
11.
PTEN Lipid Phosphatase Activity Suppresses Melanoma Formation by Opposing an AKT/mTOR/FRA1 Signaling Axis
Xiaonan Xu, Ilah Bok, Neel Jasani, Kaizhen Wang, Manon Chadourne, Nicol Mecozzi, Ou Deng, Eric A. Welsh, Fumi Kinose, Uwe Rix, Florian A. Karreth
Cancer Res. Author manuscript; available in PMC 2024 Aug 1.
Published in final edited form as: Cancer Res. 2024 Feb 1; 84(3): 388–404. doi: 10.1158/0008-5472.CAN-23-1730
PMCID:
PMC10842853
AbstractArticlePDF–3.5M
12.
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
Jaclyn A. Connelly, Xuejing Zhang, Yuzhou Chen, Yapeng Chao, Yejie Shi, Tija C. Jacob, Q. Jane Wang
Neurobiol Dis. Author manuscript; available in PMC 2024 Feb 2.
Published in final edited form as: Neurobiol Dis. 2023 Oct 15; 187: 106305. Published online 2023 Sep 18. doi: 10.1016/j.nbd.2023.106305
PMCID:
PMC10836334
AbstractArticlePDF–2.3M
13.
Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing
Abhinava K. Mishra, Melanie Rodriguez, Alba Yurani Torres, Morgan Smith, Anthony Rodriguez, Annalise Bond, Meghan A. Morrissey, Denise J. Montell
Proc Natl Acad Sci U S A. 2023 Dec 26; 120(52): e2310221120. Published online 2023 Dec 18. doi: 10.1073/pnas.2310221120
PMCID:
PMC10756302
AbstractArticlePDF–4.6M
14.
Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch
Ismael Bracho-Valdés, Rodolfo Daniel Cervantes-Villagrana, Yarely Mabell Beltrán-Navarro, Adán Olguín-Olguín, Estanislao Escobar-Islas, Jorge Carretero-Ortega, J. Alberto Olivares-Reyes, Guadalupe Reyes-Cruz, J. Silvio Gutkind, José Vázquez-Prado
Int J Mol Sci. 2023 Dec; 24(24): 17531. Published online 2023 Dec 15. doi: 10.3390/ijms242417531
PMCID:
PMC10743781
AbstractArticlePDF–3.1M
15.
A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration
Dokyun Na, Do‐Hwan Lim, Jae‐Sang Hong, Hyang‐Mi Lee, Daeahn Cho, Myeong‐Sang Yu, Bilal Shaker, Jun Ren, Bomi Lee, Jae Gwang Song, Yuna Oh, Kyungeun Lee, Kwang‐Seok Oh, Mi Young Lee, Min‐Seok Choi, Han Saem Choi, Yang‐Hee Kim, Jennifer M Bui, Kangseok Lee, Hyung Wook Kim, Young Sik Lee, Jörg Gsponer
Mol Syst Biol. 2023 Dec; 19(12): e11801. Published online 2023 Nov 20. doi: 10.15252/msb.202311801
PMCID:
PMC10698508
AbstractArticlePDF–7.0M
16.
Endothelial nitric oxide synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation
Tung D. Nguyen, Nur-Taz Rahman, William C. Sessa, Monica Y. Lee
Front Cardiovasc Med. 2023; 10: 1279868. Published online 2023 Nov 14. doi: 10.3389/fcvm.2023.1279868
PMCID:
PMC10683645
AbstractArticlePDF–66M
17.
FUNDC2, a mitochondrial outer membrane protein, mediates triple-negative breast cancer progression via the AKT/GSK3β/GLI1 pathway: FUNDC2 mediates TNBC progression via the AKT/GSK3β/GLI1 pathway
Liyang Yin, Renxian Cao, Zhuoqing Liu, Gang Luo, Yu Li, Xiaolong Zhou, Xiguang Chen, Ying Wu, Jun He, Xuyu Zu, Yingying Shen
Acta Biochim Biophys Sin (Shanghai) 2023 Nov 25; 55(11): 1770–1783. Published online 2023 Sep 11. doi: 10.3724/abbs.2023142
PMCID:
PMC10679879
AbstractArticlePDF–4.0M
18.
Dual roles of myocardial mitochondrial AKT on diabetic cardiomyopathy and whole body metabolism
Yu-Han Chen, Albert P. Ta, Yumay Chen, Hsiao-Chen Lee, Wenjun Fan, Phang-Lang Chen, Maria C. Jordan, Kenneth P. Roos, Grant R. MacGregor, Qin Yang, Robert A. Edwards, Junfeng Li, Ping H. Wang
Cardiovasc Diabetol. 2023; 22: 294. Published online 2023 Oct 27. doi: 10.1186/s12933-023-02020-1
PMCID:
PMC10612246
AbstractArticlePDF–7.7M
19.
Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction
Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker
Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120
PMCID:
PMC10589673
AbstractArticlePDF–6.8M
20.
Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki
Nat Commun. 2023; 14: 6584. Published online 2023 Oct 18. doi: 10.1038/s41467-023-42334-y
PMCID:
PMC10584811
AbstractArticlePDF–4.4M

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