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Items: 1 to 20 of 52

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
HER2-driven breast cancer suppression by the JNK signaling pathway
Zeynep Itah, Shanzah Chaudhry, Sithara Raju Ponny, Ozkan Aydemir, Alexandra Lee, Julie Cavanagh-Kyros, Cathy Tournier, William J. Muller, Roger J. Davis
Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4): e2218373120. Published online 2023 Jan 19. doi: 10.1073/pnas.2218373120
PMCID:
PMC9942916
AbstractArticlePDF–5.9M
3.
The schizophrenia risk gene Map2k7 regulates responding in a novel contingency-shifting rodent touchscreen gambling task
Rebecca L. Openshaw, Judith A. Pratt, Brian J. Morris
Dis Model Mech. 2022 Mar 1; 15(3): dmm049310. Published online 2022 Mar 11. doi: 10.1242/dmm.049310
PMCID:
PMC8922023
AbstractArticle
4.
Mitogen Kinase Kinase (MKK7) Controls Cytokine Production In Vitro and In Vivo in Mice
Amada D. Caliz, Hyung-Jin Yoo, Anastassiia Vertii, Ana C. Dolan, Cathy Tournier, Roger J. Davis, John F. Keaney, Jr., Shashi Kant
Int J Mol Sci. 2021 Sep; 22(17): 9364. Published online 2021 Aug 29. doi: 10.3390/ijms22179364
PMCID:
PMC8431745
AbstractArticlePDF–1.9M
5.
Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells
Rubén Darío Castro-Torres, Jordi Olloquequi, Miren Etchetto, Pablo Caruana, Luke Steele, Kyra-Mae Leighton, Jesús Ureña, Carlos Beas-Zarate, Antoni Camins, Ester Verdaguer, Carme Auladell
Int J Mol Sci. 2021 Sep; 22(17): 9545. Published online 2021 Sep 2. doi: 10.3390/ijms22179545
PMCID:
PMC8430506
AbstractArticlePDF–27M
6.
MKK7 deficiency in mature neurons impairs parental behavior in mice
Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D. Marth, Josef M. Penninger, Masami Kanai‐Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina
Genes Cells. 2021 Jan; 26(1): 5–17. Published online 2020 Nov 18. doi: 10.1111/gtc.12816
PMCID:
PMC7839552
AbstractArticlePDF–3.2M
7.
Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia
Rebecca L Openshaw, David M Thomson, Rhiannon Thompson, Josef M Penninger, Judith A Pratt, Brian J Morris, Neil Dawson
Schizophr Bull. 2020 Jan; 46(1): 211–223. Published online 2019 Jun 20. doi: 10.1093/schbul/sbz044
PMCID:
PMC6942167
AbstractArticlePDF–12M
8.
Stress-Activated Protein Kinase MKK7 Regulates Axon Elongation in the Developing Cerebral Cortex
Tokiwa Yamasaki, Hiroshi Kawasaki, Satoko Arakawa, Kimiko Shimizu, Shigeomi Shimizu, Orly Reiner, Hideyuki Okano, Sachiko Nishina, Noriyuki Azuma, Josef M. Penninger, Toshiaki Katada, Hiroshi Nishina
J Neurosci. 2011 Nov 16; 31(46): 16872–16883. doi: 10.1523/JNEUROSCI.1111-11.2011
PMCID:
PMC6633308
AbstractArticlePDF–4.7M
9.
The Loss of c-Jun N-Terminal Protein Kinase Activity Prevents the Amyloidogenic Cleavage of Amyloid Precursor Protein and the Formation of Amyloid Plaques In Vivo
Sonia Mazzitelli, Ping Xu, Isidre Ferrer, Roger J. Davis, Cathy Tournier
J Neurosci. 2011 Nov 23; 31(47): 16969–16976. doi: 10.1523/JNEUROSCI.4491-11.2011
PMCID:
PMC6623849
AbstractArticlePDF–1.3M
10.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
11.
Tulp3 regulates renal cystogenesis by trafficking of cystoproteins to cilia
Sun-Hee Hwang, Bandarigoda N. Somatilaka, Hemant Badgandi, Vivek Reddy Palicharla, Rebecca Walker, John M. Shelton, Feng Qian, Saikat Mukhopadhyay
Curr Biol. Author manuscript; available in PMC 2020 Mar 4.
Published in final edited form as: Curr Biol. 2019 Mar 4; 29(5): 790–802.e5. Published online 2019 Feb 21. doi: 10.1016/j.cub.2019.01.047
PMCID:
PMC6401225
AbstractArticlePDF–4.0M
12.
ATG5 is required for B cell polarization and presentation of particulate antigens
Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros
Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327
PMCID:
PMC6333460
AbstractArticlePDF–2.7M
13.
Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death
Stephanie B. Syc-Mazurek, Rebecca L. Rausch, Kimberly A. Fernandes, Michael P. Wilson, Richard T. Libby
Cell Death Dis. 2018 Nov; 9(11): 1095. Published online 2018 Oct 26. doi: 10.1038/s41419-018-1079-7
Correction in:
Cell Death Dis. 2019 Feb; 10(2): 64.
PMCID:
PMC6203745
AbstractArticlePDF–3.8M
14.
DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages
Yimin Lao, Kai Yang, Zhaojun Wang, Xueqing Sun, Qiang Zou, Xiaoyan Yu, Jinke Cheng, Xuemei Tong, Edward T. H. Yeh, Jie Yang, Jing Yi
J Biol Chem. 2018 Mar 16; 293(11): 3965–3980. Published online 2018 Jan 19. doi: 10.1074/jbc.M117.816769
PMCID:
PMC5857993
AbstractArticlePDF–2.9M
15.
A protein scaffold coordinates SRC-mediated JNK activation in response to metabolic stress
Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, Roger J. Davis
Cell Rep. Author manuscript; available in PMC 2017 Oct 27.
Published in final edited form as: Cell Rep. 2017 Sep 19; 20(12): 2775–2783. doi: 10.1016/j.celrep.2017.08.025
PMCID:
PMC5659285
AbstractArticlePDF–1.6M
16.
Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons
Derek S. Welsbie, Katherine L. Mitchell, Vinod Ranganathan, Valentin M. Sluch, Zhiyong Yang, Jessica Kim, Eugen Buehler, Amit Patel, Scott E. Martin, Ping-Wu Zhang, Yan Ge, Yukan Duan, John Fuller, Byung-Jin Kim, Eman Hamed, Xitiz Chamling, Lei Lei, Iain D.C. Fraser, Ze’ev A. Ronai, Cynthia A. Berlinicke, Donald J. Zack
Neuron. Author manuscript; available in PMC 2018 Jun 21.
Published in final edited form as: Neuron. 2017 Jun 21; 94(6): 1142–1154.e6. doi: 10.1016/j.neuron.2017.06.008
PMCID:
PMC5553555
AbstractArticlePDF–959K
17.
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7
Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D. Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M. Penninger, Shigenobu Shibata, Hiroshi Nishina
Sci Rep. 2017; 7: 7348. Published online 2017 Aug 4. doi: 10.1038/s41598-017-07845-x
PMCID:
PMC5544763
AbstractArticlePDF–2.3M
18.
Fibroblast growth factor 21 mediates glycemic regulation by hepatic JNK
Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Cathy Tournier, Roger J. Davis
Cell Rep. Author manuscript; available in PMC 2016 Mar 16.
Published in final edited form as: Cell Rep. 2016 Mar 15; 14(10): 2273–2280. Published online 2016 Mar 3. doi: 10.1016/j.celrep.2016.02.026
PMCID:
PMC4794343
AbstractArticlePDF–1.5M
19.
ZPK/DLK and MKK4 Form the Critical Gateway to Axotomy-Induced Motoneuron Death in Neonates
Takayuki Itoh, Makoto Horiuchi, Raymond H. Ikeda, Jr, Jie Xu, Peter Bannerman, David Pleasure, Josef M. Penninger, Cathy Tournier, Aki Itoh
J Neurosci. 2014 Aug 6; 34(32): 10729–10742. doi: 10.1523/JNEUROSCI.0539-14.2014
PMCID:
PMC4200111
AbstractArticlePDF–11M
20.
Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma
Clare C. Davies, Emma Harvey, Raymond F.T. McMahon, Katherine G. Finegan, Frances Connor, Roger J. Davis, David A. Tuveson, Cathy Tournier
Cancer Res. Author manuscript; available in PMC 2014 Dec 15.
Published in final edited form as: Cancer Res. 2014 Jun 15; 74(12): 3344–3356. Published online 2014 Apr 8. doi: 10.1158/0008-5472.CAN-13-2941
PMCID:
PMC4058314
AbstractArticlePDF–4.7M

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