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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108237342.

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui-Chen Lu

Mol Neurodegener. 2024; 19: 13. Published online 2024 Jan 29. doi: 10.1186/s13024-023-00690-9

PMCID:: PMC10823734

Abstract Article PDF–8.0M

Select item 98166503.

Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development

Hiroshi Kuribayashi, Miku Katahira, Makoto Aihara, Yutaka Suzuki, Sumiko Watanabe

Mol Biol Cell. 2023 Jan 1; 34(1): ar4. Published online 2022 Dec 15. doi: 10.1091/mbc.E22-03-0078

PMCID:: PMC9816650

Abstract Article PDF–9.3M

Select item 97118844.

Macrophage depletion blocks congenital SARM1-dependent neuropathy

Caitlin B. Dingwall, Amy Strickland, Sabrina W. Yum, Aldrin K.Y. Yim, Jian Zhu, Peter L. Wang, Yurie Yamada, Robert E. Schmidt, Yo Sasaki, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt

J Clin Invest. 2022 Dec 1; 132(23): e159800. Published online 2022 Dec 1. doi: 10.1172/JCI159800

PMCID:: PMC9711884

Abstract Article PDF–23M

Select item 90773705.

NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function

Fang Fang, Pei Zhuang, Xue Feng, Pingting Liu, Dong Liu, Haoliang Huang, Liang Li, Wei Chen, Liang Liu, Yang Sun, Haowen Jiang, Jiangbin Ye, Yang Hu

Mol Ther. 2022 Apr 6; 30(4): 1421–1431. Published online 2022 Jan 31. doi: 10.1016/j.ymthe.2022.01.035

PMCID:: PMC9077370

Abstract Article PDF–1.9M

Select item 86927466.

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

Stacey Anne Gould, Jonathan Gilley, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Michael Coleman

Cell Rep. 2021 Dec 14; 37(11): 110108. Published online 2021 Dec 14. doi: 10.1016/j.celrep.2021.110108

PMCID:: PMC8692746

Abstract Article

Select item 85803547.

Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner

Xiang-Shu Cheng, Fang-Xiao Shi, Kun-Peng Zhao, Wang Lin, Xiao-Ying Li, Jun Zhang, Yao-Yao Bu, Rui Zhu, Xiao-Hong Li, Dong-Xiao Duan, Xin-Ying Ji, Jian-She Wei, Jian-Zhi Wang, Jin Du, Xin-Wen Zhou

Aging (Albany NY) 2021 Oct 31; 13(20): 23620–23636. Published online 2021 Oct 13. doi: 10.18632/aging.203634

PMCID:: PMC8580354

Abstract Article PDF–1.0M

Select item 83308448.

Lack of Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2): Consequences for Mouse Bladder Development and Function

Amy N. Hicks, Lysanne Campeau, David Burmeister, Colin E. Bishop, Karl-Erik Andersson

Neurourol Urodyn. Author manuscript; available in PMC 2021 Aug 3.

Published in final edited form as: Neurourol Urodyn. 2013 Nov; 32(8): 1130–1136. Published online 2013 Jan 31. doi: 10.1002/nau.22372

PMCID:: PMC8330844

Abstract Article PDF–1.9M

Select item 83132399.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 761177510.

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Colemana

Neurobiol Dis. Author manuscript; available in PMC 2021 Oct 6.

Published in final edited form as: Neurobiol Dis. 2020 Feb 1; 134: 104678. Published online 2019 Nov 15. doi: 10.1016/j.nbd.2019.104678

PMCID:: PMC7611775

Abstract Article PDF–10M

Select item 670515211.

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

Jonathan Gilley, Robert Adalbert, Gang Yu, Michael P. Coleman

J Neurosci. 2013 Aug 14; 33(33): 13410–13424. doi: 10.1523/JNEUROSCI.1534-13.2013

PMCID:: PMC6705152

Abstract Article PDF–6.2M

Select item 651616112.

NMNAT2‐mediated NAD⁺ generation is essential for quality control of aged oocytes

Xinghan Wu, Feifei Hu, Juan Zeng, Longsen Han, Danhong Qiu, Haichao Wang, Juan Ge, Xiaoyan Ying, Qiang Wang

Aging Cell. 2019 Jun; 18(3): e12955. Published online 2019 Mar 25. doi: 10.1111/acel.12955

PMCID:: PMC6516161

Abstract Article PDF–1.1M

Select item 611727813.

Roles of Nmnat1 in the survival of retinal progenitors through the regulation of pro-apoptotic gene expression via histone acetylation

Hiroshi Kuribayashi, Yukihiro Baba, Toshiro Iwagawa, Eisuke Arai, Akira Murakami, Sumiko Watanabe

Cell Death Dis. 2018 Sep; 9(9): 891. Published online 2018 Aug 30. doi: 10.1038/s41419-018-0907-0

PMCID:: PMC6117278

Abstract Article PDF–3.3M

Select item 564080114.

Sarm1 Deletion, but Not Wld^S, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman

Cell Rep. 2017 Oct 3; 21(1): 10–16. Published online 2017 Oct 3. doi: 10.1016/j.celrep.2017.09.027

PMCID:: PMC5640801

Abstract Article

Select item 507552515.

An atypical SCF-like ubiquitin ligase complex promotes Wallerian degeneration through regulation of axonal Nmnat2

Yuya Yamagishi, Marc Tessier-Lavigne

Cell Rep. Author manuscript; available in PMC 2016 Oct 23.

Published in final edited form as: Cell Rep. 2016 Oct 11; 17(3): 774–782. doi: 10.1016/j.celrep.2016.09.043

PMCID:: PMC5075525

Abstract Article PDF–2.5M

Select item 489085216.

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

Yousuf O. Ali, Hunter M. Allen, Lei Yu, David Li-Kroeger, Dena Bakhshizadehmahmoudi, Asante Hatcher, Cristin McCabe, Jishu Xu, Nicole Bjorklund, Giulio Taglialatela, David A. Bennett, Philip L. De Jager, Joshua M. Shulman, Hugo J. Bellen, Hui-Chen Lu

PLoS Biol. 2016 Jun; 14(6): e1002472. Published online 2016 Jun 2. doi: 10.1371/journal.pbio.1002472