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Select item 103904921.

Three-dimensional molecular architecture of mouse organogenesis

Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng

Nat Commun. 2023; 14: 4599. Published online 2023 Jul 31. doi: 10.1038/s41467-023-40155-7

PMCID:: PMC10390492

Abstract Article PDF–13M

Select item 103713372.

High-fat diet plus HNF1A variant promotes polyps by activating β-catenin in early-onset colorectal cancer

Heyu Song, Ricky A. Sontz, Matthew J. Vance, Julia M. Morris, Sulaiman Sheriff, Songli Zhu, Suzann Duan, Jiping Zeng, Erika Koeppe, Ritu Pandey, Curtis A. Thorne, Elena M. Stoffel, Juanita L. Merchant

JCI Insight. 2023 Jul 10; 8(13): e167163. Published online 2023 Jul 10. doi: 10.1172/jci.insight.167163

PMCID:: PMC10371337

Abstract Article PDF–7.8M

Select item 98203223.

Ribosomal Stress Couples with the Hypoxia Response in Dec1-Dependent Orthodontic Tooth Movement

Shigeru Nakamura, Keiji Tanimoto, Ujjal K. Bhawal

Int J Mol Sci. 2023 Jan; 24(1): 618. Published online 2022 Dec 29. doi: 10.3390/ijms24010618

PMCID:: PMC9820322

Abstract Article PDF–16M

Select item 95868744.

The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A

Anthony Beucher, Irene Miguel-Escalada, Diego Balboa, Matías G. De Vas, Miguel Angel Maestro, Javier Garcia-Hurtado, Aina Bernal, Roser Gonzalez-Franco, Pierfrancesco Vargiu, Holger Heyn, Philippe Ravassard, Sagrario Ortega, Jorge Ferrer

Nat Cell Biol. 2022; 24(10): 1528–1540. Published online 2022 Oct 6. doi: 10.1038/s41556-022-00996-8

PMCID:: PMC9586874

Abstract Article PDF–15M

Select item 91273695.

MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease

Md Golam Mostofa, Melanie Tran, Shaynian Gilling, Grace Lee, Ondine Fraher, Lei Jin, Hyunju Kang, Young-Ki Park, Ji-Young Lee, Li Wang, Dong-Ju Shin

J Biol Chem. 2022 Jun; 298(6): 101966. Published online 2022 Apr 20. doi: 10.1016/j.jbc.2022.101966

PMCID:: PMC9127369

Abstract Article PDF–2.9M

Select item 89015066.

The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis

Hanchao Gao, Mengtao Cao, Kai Deng, Yang Yang, Jinqi Song, Ming Ni, Chuntao Xie, Wenna Fan, Chunpei Ou, Dinggen Huang, Lizhong Lin, Lixia Liu, Yangyang Li, Huimin Sun, Xinyu Cheng, Jinmei Wu, Cuilan Xia, Xuefeng Deng, Lisha Mou, Pengfei Chen

Front Immunol. 2022; 13: 805451. Published online 2022 Feb 22. doi: 10.3389/fimmu.2022.805451

PMCID:: PMC8901506

Abstract Article PDF–31M

Select item 88650937.

HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1

Yoshifumi Sato, Md Mostafizur Rahman, Masaki Haneda, Tomonori Tsuyama, Tomoya Mizumoto, Tatsuya Yoshizawa, Tadahiro Kitamura, Frank J. Gonzalez, Ken-ichi Yamamura, Kazuya Yamagata

Biochim Biophys Acta Mol Basis Dis. Author manuscript; available in PMC 2022 Feb 23.

Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2020 Nov 1; 1866(11): 165898. Published online 2020 Jul 22. doi: 10.1016/j.bbadis.2020.165898

PMCID:: PMC8865093

Abstract Article PDF–1.8M

Select item 82515628.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre

J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629

PMCID:: PMC8251562

Abstract Article PDF–46M

Select item 81264799.

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini

Dis Model Mech. 2021 May 1; 14(5): dmm047498. Published online 2021 May 4. doi: 10.1242/dmm.047498

PMCID:: PMC8126479

Abstract Article

Select item 781279710.

T_FH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function

Fengyin Li, Xin Zhao, Yali Zhang, Peng Shao, Xiaoke Ma, William J. Paradee, Chengyu Liu, Jianmin Wang, Hai-Hui Xue

Proc Natl Acad Sci U S A. 2021 Jan 12; 118(2): e2014562118. Published online 2020 Dec 28. doi: 10.1073/pnas.2014562118

PMCID:: PMC7812797

Abstract Article PDF–3.6M

Select item 730531411.

Transcriptional Regulation of the Angptl8 Gene by Hepatocyte Nuclear Factor-1 in the Murine Liver

Takuya Watanabe, Atsushi Ozawa, Shinnosuke Masuda, Satoshi Yoshino, Emi Ishida, Yuri Kondo, Shunichi Matsumoto, Akiko Katano-Toki, Kazuhiko Horiguchi, Yasuyo Nakajima, Eijiro Yamada, Takuya Tomaru, Tsugumichi Saito, Sumiyasu Ishii, Nobuyuki Shibusawa, Shuichi Okada, Tetsurou Satoh, Masanobu Yamada

Sci Rep. 2020; 10: 9999. Published online 2020 Jun 19. doi: 10.1038/s41598-020-66570-0

PMCID:: PMC7305314

Abstract Article PDF–2.8M

Select item 721545012.

PDE2A Is Indispensable for Mouse Liver Development and Hematopoiesis

Federica Barbagallo, Valentina Rotilio, Maria Rita Assenza, Salvatore Aguanno, Tiziana Orsini, Sabrina Putti, Andrea M. Isidori, Andrea Lenzi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Int J Mol Sci. 2020 Apr; 21(8): 2902. Published online 2020 Apr 21. doi: 10.3390/ijms21082902

PMCID:: PMC7215450

Abstract Article PDF–3.3M

Select item 719691713.

HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer

Mark Kalisz, Edgar Bernardo, Anthony Beucher, Miguel Angel Maestro, Natalia del Pozo, Irene Millán, Lena Haeberle, Martin Schlensog, Sami Alexander Safi, Wolfram Trudo Knoefel, Vanessa Grau, Matías de Vas, Karl B Shpargel, Eva Vaquero, Terry Magnuson, Sagrario Ortega, Irene Esposito, Francisco X Real, Jorge Ferrer

EMBO J. 2020 May 4; 39(9): e102808. Published online 2020 Mar 10. doi: 10.15252/embj.2019102808

PMCID:: PMC7196917

Abstract Article PDF–10M

Select item 719656814.

TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation

Guotao Yu, Fang Wang, Menghao You, Tiansong Xu, Chunlei Shao, Yuning Liu, Ruiqi Liu, Min Deng, Zhihong Qi, Zhao Wang, Jingjing Liu, Yingpeng Yao, Jingjing Chen, Zhen Sun, Shanshan Hao, Wenhui Guo, Tianyan Zhao, Zhengquan Yu, Qian Zhang, Yaofeng Zhao, Feng Chen, Shuyang Yu

Protein Cell. 2020 May; 11(5): 380–386. Published online 2020 Jan 22. doi: 10.1007/s13238-020-00689-8