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Items: 1 to 20 of 48

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Xanthine oxidase mediates chronic stress-induced cerebrovascular dysfunction and cognitive impairment
Emily N Burrage, Tyler Coblentz, Saina S Prabhu, Ryan Childers, Randy W Bryner, Sarah E Lewis, Evan DeVallance, Eric E Kelley, Paul D Chantler
J Cereb Blood Flow Metab. 2023 Jun; 43(6): 905–920. Published online 2023 Jan 18. doi: 10.1177/0271678X231152551
PMCID:
PMC10196752
AbstractArticlePDF–1.3M
3.
Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub
Redox Biol. 2023 Jun; 62: 102636. Published online 2023 Feb 13. doi: 10.1016/j.redox.2023.102636
PMCID:
PMC10025133
AbstractArticlePDF–5.8M
4.
The mechanism and significance of the conversion of xanthine dehydrogenase to xanthine oxidase in mammalian secretory gland cells
Teruo Kusano, Tomoko Nishino, Ken Okamoto, Russ Hille, Takeshi Nishino
Redox Biol. 2023 Feb; 59: 102573. Published online 2022 Dec 9. doi: 10.1016/j.redox.2022.102573
PMCID:
PMC9760657
AbstractArticlePDF–6.4M
5.
The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation
Jaekwang Jeong, Anil K. G. Kadegowda, Thomas J. Meyer, Lisa M. Jenkins, Jerry C. Dinan, John J. Wysolmerski, Roberto Weigert, Ian H. Mather
FASEB Bioadv. 2021 Dec; 3(12): 971–997. Published online 2021 Sep 8. doi: 10.1096/fba.2021-00059
PMCID:
PMC8664049
AbstractArticlePDF–3.0M
6.
Xanthine Oxidoreductase-Mediated Superoxide Production Is Not Involved in the Age-Related Pathologies in Sod1-Deficient Mice
Shuichi Shibuya, Kenji Watanabe, Yusuke Ozawa, Takahiko Shimizu
Int J Mol Sci. 2021 Apr; 22(7): 3542. Published online 2021 Mar 29. doi: 10.3390/ijms22073542
PMCID:
PMC8037342
AbstractArticlePDF–1.1M
7.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
8.
Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy
Takeo Ishii, Tomohiro Kumagae, Hiromichi Wakui, Shingo Urate, Shohei Tanaka, Eriko Abe, Toru Suzuki, Takahiro Yamaji, Sho Kinguchi, Ryu Kobayashi, Kotaro Haruhara, Takashi Nakamura, Shuzo Kobayashi, Kouichi Tamura
FEBS Open Bio. 2021 Feb; 11(2): 507–518. Published online 2021 Feb 1. doi: 10.1002/2211-5463.13083
PMCID:
PMC7876505
AbstractArticlePDF–816K
9.
Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2
Bojana Ristic, Sathish Sivaprakasam, Monisha Narayanan, Vadivel Ganapathy
Biochem J. 2020 Apr 30; 477(8): 1499–1513. Prepublished online 2020 Apr 2. Published online 2020 Apr 29. doi: 10.1042/BCJ20190873
PMCID:
PMC7200644
AbstractArticlePDF–6.1M
10.
Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
Teruo Kusano, Driss Ehirchiou, Tomohiro Matsumura, Veronique Chobaz, Sonia Nasi, Mariela Castelblanco, Alexander So, Christine Lavanchy, Hans Acha-Orbea, Takeshi Nishino, Ken Okamoto, Nathalie Busso
Nat Commun. 2019; 10: 4904. Published online 2019 Oct 28. doi: 10.1038/s41467-019-12565-z
PMCID:
PMC6817904
AbstractArticlePDF–2.2M
11.
Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities
Daniel B. Harmon, W. Kyle Mandler, Ian J. Sipula, Nikolaos Dedousis, Sara E. Lewis, Jeremy T. Eckels, Jianhai Du, Yekai Wang, Brydie R. Huckestein, Patrick J. Pagano, Eugenia Cifuentes-Pagano, Gregg E. Homanics, Thomas J. Van’t Erve, Maja Stefanovic-Racic, Michael J. Jurczak, Robert M. O’Doherty, Eric E. Kelley
Diabetes. 2019 Jun; 68(6): 1221–1229. Published online 2019 Apr 1. doi: 10.2337/db18-1198
PMCID:
PMC6610025
AbstractArticlePDF–1.5M
12.
Xanthine oxidase is hyper-active in Duchenne muscular dystrophy
Angus Lindsay, Preston M. McCourt, Peter Karachunski, Dawn A. Lowe, James M. Ervasti
Free Radic Biol Med. Author manuscript; available in PMC 2019 Dec 1.
Published in final edited form as: Free Radic Biol Med. 2018 Dec; 129: 364–371. Published online 2018 Oct 10. doi: 10.1016/j.freeradbiomed.2018.10.404
PMCID:
PMC6599518
AbstractArticlePDF–760K
13.
LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow
Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher
J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214
PMCID:
PMC6262777
AbstractArticle
14.
Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD
Tianqiao Yong, Dan Li, Muxia Li, Danling Liang, Xue Diao, Chenling Deng, Shaodan Chen, Yizhen Xie, Diling Chen, Dan Zuo
Molecules. 2018 Oct; 23(10): 2671. Published online 2018 Oct 17. doi: 10.3390/molecules23102671
PMCID:
PMC6222621
AbstractArticlePDF–4.1M
15.
Ripk3 promotes ER stress-induced necroptosis in cardiac IR injury: A mechanism involving calcium overload/XO/ROS/mPTP pathway
Pingjun Zhu, Shunying Hu, Qinhua Jin, Dandan Li, Feng Tian, Sam Toan, Yang Li, Hao Zhou, Yundai Chen
Redox Biol. 2018 Jun; 16: 157–168. Published online 2018 Mar 1. doi: 10.1016/j.redox.2018.02.019
PMCID:
PMC5952878
AbstractArticlePDF–2.9M
16.
Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα
Takumi Kanemitsu, Yuya Tsurudome, Naoki Kusunose, Masayuki Oda, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
J Biol Chem. 2017 Dec 29; 292(52): 21397–21406. Published online 2017 Nov 3. doi: 10.1074/jbc.M117.791285
PMCID:
PMC5766946
AbstractArticlePDF–1.9M
17.
Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice
Guido Lastra, Camila Manrique, Guanghong Jia, Annayya R. Aroor, Melvin R. Hayden, Brady J. Barron, Brett Niles, Jaume Padilla, James R. Sowers
Am J Physiol Regul Integr Comp Physiol. 2017 Aug 1; 313(2): R67–R77. Published online 2017 May 24. doi: 10.1152/ajpregu.00483.2016
PMCID:
PMC5582952
AbstractArticle
18.
Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages
Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Ning Wang, Junying Ding, Qingquan Liu
Mediators Inflamm. 2016; 2016: 8172706. Published online 2016 Jun 28. doi: 10.1155/2016/8172706
PMCID:
PMC4940575
AbstractArticlePDF–3.2M
19.
Xanthine Oxidoreductase Function Contributes to Normal Wound Healing
Michael C Madigan, Ryan M McEnaney, Ankur J Shukla, Guiying Hong, Eric E Kelley, Margaret M Tarpey, Mark Gladwin, Brian S Zuckerbraun, Edith Tzeng
Mol Med. 2015; 21(1): 313–322. Prepublished online 2015 Apr 14. Published online 2015 Apr 14. doi: 10.2119/molmed.2014.00191
PMCID:
PMC4503647
AbstractArticlePDF–4.0M
20.
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
Annette Ives, Johji Nomura, Fabio Martinon, Thierry Roger, Didier LeRoy, Jeffrey N. Miner, Gregoire Simon, Nathalie Busso, Alexander So
Nat Commun. 2015 Mar 24; 6: 6555. Published online 2015 Mar 24. doi: 10.1038/ncomms7555
PMCID:
PMC4382995
AbstractArticlePDF–1.1M

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