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Items: 1 to 20 of 45

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway
Tetsuya Kouno, Xiao Liu, Huayi Zhao, Tatiana Kisseleva, Edward E. Cable, Bernd Schnabl
J Biol Chem. 2022 Jul; 298(7): 102056. Published online 2022 May 20. doi: 10.1016/j.jbc.2022.102056
PMCID:
PMC9214809
AbstractArticlePDF–898K
3.
Vertebrate lonesome kinase modulates the hepatocyte secretome to prevent perivascular liver fibrosis and inflammation
Sophia Pantasis, Juliane Friemel, Salome Mirjam Brütsch, Zehan Hu, Sabrina Krautbauer, Gerhard Liebisch, Joern Dengjel, Achim Weber, Sabine Werner, Mattia Renato Bordoli
J Cell Sci. 2022 Apr 1; 135(7): jcs259243. Published online 2022 Apr 12. doi: 10.1242/jcs.259243
PMCID:
PMC9016620
AbstractArticle
4.
Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver
Kate Townsend Creasy, Jieyun Jiang, Hui Ren, Martha L. Peterson, Brett T. Spear
Gene Expr. 2016; 17(1): 7–17. Published online 2016 May 17. doi: 10.3727/105221616X691712
PMCID:
PMC5518317
AbstractArticlePDF–8.5M
5.
Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice
Xiaoying Liu, Anne S. Henkel, Brian E. LeCuyer, Susan C. Hubchak, Matthew J. Schipma, Eric Zhang, Richard M. Green
J Lipid Res. 2017 Mar; 58(3): 504–511. Published online 2017 Feb 27. doi: 10.1194/jlr.M071266
PMCID:
PMC5335580
AbstractArticlePDF–1003K
6.
Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis
Hailiang Liu, Preeti Pathak, Shannon Boehme, John Y. L. Chiang
J Lipid Res. 2016 Oct; 57(10): 1831–1844. doi: 10.1194/jlr.M069807
PMCID:
PMC5036364
AbstractArticlePDF–2.2M
7.
LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development
Da-Hye Lee, Jae Oh Park, Tae-Shin Kim, Sang-Kyum Kim, Tack-hoon Kim, Min-chul Kim, Gun Soo Park, Jeong-Hwan Kim, Shinji Kuninaka, Eric N. Olson, Hideyuki Saya, Seon-Young Kim, Ho Lee, Dae-Sik Lim
Nat Commun. 2016; 7: 11961. Published online 2016 Jun 30. doi: 10.1038/ncomms11961
PMCID:
PMC4931324
AbstractArticlePDF–3.4M
8.
Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders
Jessica M. Ferrell, Shannon Boehme, Feng Li, John Y. L. Chiang
J Lipid Res. 2016 Jul; 57(7): 1144–1154. doi: 10.1194/jlr.M064709
PMCID:
PMC4918844
AbstractArticlePDF–1.3M
9.
Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis
Karthikeyan Krishnamurthy, Shannon Glaser, Gianfranco D. Alpini, Arturo J. Cardounel, Zhenguo Liu, Govindasamy Ilangovan
Cardiovasc Res. 2016 Jul 1; 111(1): 74–83. Published online 2016 Apr 30. doi: 10.1093/cvr/cvw094
PMCID:
PMC4909164
AbstractArticlePDF–1.5M
10.
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure
Matthew McMillin, Gabriel Frampton, Matthew Quinn, Samir Ashfaq, Mario de los Santos, III, Stephanie Grant, Sharon DeMorrow
Am J Pathol. 2016 Feb; 186(2): 312–323. doi: 10.1016/j.ajpath.2015.10.005
PMCID:
PMC4729266
AbstractArticlePDF–2.5M
11.
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
Tatiana L. Fonseca, Gustavo W. Fernandes, Elizabeth A. McAninch, Barbara M. L. C. Bocco, Sherine M. Abdalla, Miriam O. Ribeiro, Petra Mohácsik, Csaba Fekete, Daofeng Li, Xiaoyun Xing, Ting Wang, Balázs Gereben, Antonio C. Bianco
Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45): 14018–14023. Published online 2015 Oct 27. doi: 10.1073/pnas.1508943112
PMCID:
PMC4653175
AbstractArticlePDF–1.0M
12.
Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver and Proximal Colon
Keith C. Summa, Peng Jiang, Karrie Fitzpatrick, Robin M. Voigt, Samuel J. Bowers, Christopher B. Forsyth, Martha Hotz Vitaterna, Ali Keshavarzian, Fred W. Turek
Alcohol Clin Exp Res. Author manuscript; available in PMC 2016 Oct 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Oct; 39(10): 1917–1929. Published online 2015 Sep 2. doi: 10.1111/acer.12834
PMCID:
PMC4562391
AbstractArticlePDF–927K
13.
Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis
Jun Hamazaki, Shoshiro Hirayama, Shigeo Murata
PLoS Genet. 2015 Jul; 11(7): e1005401. Published online 2015 Jul 29. doi: 10.1371/journal.pgen.1005401
PMCID:
PMC4519129
AbstractArticlePDF–11M
14.
Transient Gene Delivery for Functional Enrichment of Differentiating Embryonic Stem Cells
Eric J. Wallenstein, Jeffrey Barminko, Rene S. Schloss, Martin L. Yarmush
Biotechnol Bioeng. Author manuscript; available in PMC 2015 Jul 1.
Published in final edited form as: Biotechnol Bioeng. 2008 Dec 1; 101(5): 859–872. doi: 10.1002/bit.22027
PMCID:
PMC4487524
AbstractArticlePDF–1.7M
15.
Disruption of Cholesterol 7α-Hydroxylase Gene in Mice: II. BILE ACID DEFICIENCY IS OVERCOME BY INDUCTION OF OXYSTEROL 7α-HYDROXYLASE
Margrit Schwarz, Erik G. Lund, Kenneth D. R. Setchell, Herbert J. Kayden, Joseph E. Zerwekh, Ingemar Björkhem, Joachim Herz, David W. Russell
J Biol Chem. Author manuscript; available in PMC 2015 Jun 2.
Published in final edited form as: J Biol Chem. 1996 Jul 26; 271(30): 18024–18031. doi: 10.1074/jbc.271.30.18024
PMCID:
PMC4451191
AbstractArticlePDF–1.4M
16.
TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation
Daniil Alpern, Diana Langer, Benoit Ballester, Stephanie Le Gras, Christophe Romier, Gabrielle Mengus, Irwin Davidson
eLife. 2014; 3: e03613. Published online 2014 Sep 10. doi: 10.7554/eLife.03613
PMCID:
PMC4359380
AbstractArticlePDF–5.7M
17.
Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice
Ryan D. Jones, Adam M. Lopez, Ernest Y. Tong, Kenneth S. Posey, Jen-Chieh Chuang, Joyce J. Repa, Stephen D. Turley
Steroids. Author manuscript; available in PMC 2016 Jan 1.
Published in final edited form as: Steroids. 2015 Jan; 0: 87–95. Published online 2014 Nov 28. doi: 10.1016/j.steroids.2014.11.002
PMCID:
PMC4297738
AbstractArticlePDF–1.4M
18.
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels
Laurent Vergnes, Jessica M. Lee, Robert G. Chin, Johan Auwerx, Karen Reue
Cell Metab. Author manuscript; available in PMC 2014 Jun 4.
Published in final edited form as: Cell Metab. 2013 Jun 4; 17(6): 916–928. doi: 10.1016/j.cmet.2013.04.007
PMCID:
PMC3956443
AbstractArticlePDF–3.9M
19.
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment
Asha Seth, Jianming Ye, Nanjia Yu, Fanny Guez, David C. Bedford, Geoffrey A. Neale, Sabine Cordi, Paul K. Brindle, Frederic P. Lemaigre, Klaus H. Kaestner, Beatriz Sosa-Pineda
Development. 2014 Feb 1; 141(3): 538–547. doi: 10.1242/dev.099481
PMCID:
PMC3899812
AbstractArticle
20.
Regulation of cholesterol and bile acid homeostasis by the CYP7A1/SREBP2/miR-33a axis
Tiangang Li, Jessica M. Francl, Shannon Boehme, John Y. L. Chiang
Hepatology. Author manuscript; available in PMC 2014 Sep 1.
Published in final edited form as: Hepatology. 2013 Sep; 58(3): 1111–1121. Published online 2013 Jul 31. doi: 10.1002/hep.26427
PMCID:
PMC3735649
AbstractArticlePDF–2.6M

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