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Select item 110870531.

Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

F Javier DeHaro-Arbona, Charalambos Roussos, Sarah Baloul, Jonathan Townson, María J Gómez Lamarca, Sarah Bray

eLife. 2024; 12: RP92083. Published online 2024 May 10. doi: 10.7554/eLife.92083

PMCID:: PMC11087053

Abstract Article PDF–6.6M

Select item 110264132.

Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila

Jenny Zhe Liao, Hyung-lok Chung, Claire Shih, Kenneth Kin Lam Wong, Debdeep Dutta, Zelha Nil, Catherine Grace Burns, Oguz Kanca, Ye-Jin Park, Zhongyuan Zuo, Paul C. Marcogliese, Katherine Sew, Hugo J. Bellen, Esther M. Verheyen

Nat Commun. 2024; 15: 3326. Published online 2024 Apr 18. doi: 10.1038/s41467-024-47623-8

PMCID:: PMC11026413

Abstract Article PDF–18M

Select item 110112023.

Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster

Sebastian Deichsel, Bernd M. Gahr, Helena Mastel, Anette Preiss, Anja C. Nagel

Cells. 2024 Apr; 13(7): 576. Published online 2024 Mar 26. doi: 10.3390/cells13070576

PMCID:: PMC11011202

Abstract Article PDF–5.5M

Select item 109898634.

A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster

Stacie E Hughes, Andrew Price, Salam Briggs, Cynthia Staber, Morgan James, Madelyn Anderson, R Scott Hawley

G3 (Bethesda) 2024 Apr; 14(4): jkae028. Published online 2024 Feb 9. doi: 10.1093/g3journal/jkae028

PMCID:: PMC10989863

Abstract Article PDF–1.3M

Select item 108477255.

Bone morphogenetic protein signaling: the pathway and its regulation

Takuya Akiyama, Laurel A Raftery, Kristi A Wharton

Genetics. 2024 Feb; 226(2): iyad200. Published online 2023 Dec 20. doi: 10.1093/genetics/iyad200

PMCID:: PMC10847725

Abstract Article PDF–6.8M

Select item 103805966.

Coregulators Reside within Drosophila Ecdysone-Inducible Loci before and after Ecdysone Treatment

Aleksey N. Krasnov, Aleksandra A. Evdokimova, Marina Yu Mazina, Maksim Erokhin, Darya Chetverina, Nadezhda E. Vorobyeva

Int J Mol Sci. 2023 Jul; 24(14): 11844. Published online 2023 Jul 24. doi: 10.3390/ijms241411844

PMCID:: PMC10380596

Abstract Article PDF–3.9M

Select item 97025407.

Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila

Xiao Li, Meng Zhang, Mengmeng Liu, Tzu-Hao Liu, Rajitha-Udakara-Sampath Hemba-Waduge, Jun-Yuan Ji

Dis Model Mech. 2022 Nov 1; 15(11): dmm049650. Published online 2022 Nov 14. doi: 10.1242/dmm.049650

PMCID:: PMC9702540

Abstract Article

Select item 86644868.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 86644559.

Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing

Cristina M Ostalé, Nuria Esteban, Ana López-Varea, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab348. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab348

PMCID:: PMC8664455

Abstract Article PDF–2.9M

Select item 797728710.

Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens

Chuqin Huang, Rui Xu, Samuel Liégeois, Di Chen, Zi Li, Dominique Ferrandon

Front Immunol. 2020; 11: 478958. Published online 2021 Mar 5. doi: 10.3389/fimmu.2020.478958

PMCID:: PMC7977287

Abstract Article PDF–2.3M

Select item 759000311.

All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site

Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji

Int J Mol Sci. 2020 Oct; 21(20): 7511. Published online 2020 Oct 12. doi: 10.3390/ijms21207511

PMCID:: PMC7590003

Abstract Article PDF–3.4M

Select item 750273812.

Multiplexed conditional genome editing with Cas12a in Drosophila

Fillip Port, Maja Starostecka, Michael Boutros

Proc Natl Acad Sci U S A. 2020 Sep 15; 117(37): 22890–22899. Published online 2020 Aug 25. doi: 10.1073/pnas.2004655117

PMCID:: PMC7502738

Abstract Article PDF–4.5M

Select item 728267613.

The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription

Xiao Li, Mengmeng Liu, Xingjie Ren, Nicolas Loncle, Qun Wang, Rajitha-Udakara-Sampath Hemba-Waduge, Stephen H. Yu, Muriel Boube, Henri-Marc G. Bourbon, Jian-Quan Ni, Jun-Yuan Ji

PLoS Genet. 2020 May; 16(5): e1008832. Published online 2020 May 28. doi: 10.1371/journal.pgen.1008832

PMCID:: PMC7282676

Abstract Article PDF–4.0M

Select item 721398114.

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein

eLife. 2020; 9: e53659. Published online 2020 Apr 16. doi: 10.7554/eLife.53659

PMCID:: PMC7213981

Abstract Article PDF–3.4M

Select item 721248115.

De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy

Hyung-lok Chung, Xiao Mao, Hua Wang, Ye-Jin Park, Paul C. Marcogliese, Jill A. Rosenfeld, Lindsay C. Burrage, Pengfei Liu, David R. Murdock, Shinya Yamamoto, Michael F. Wangler, Undiagnosed Diseases Network, Hsiao-Tuan Chao, Hongyu Long, Li Feng, Carlos A. Bacino, Hugo J. Bellen, Bo Xiao

Am J Hum Genet. 2020 May 7; 106(5): 717–725. Published online 2020 Apr 23. doi: 10.1016/j.ajhg.2020.04.001

PMCID:: PMC7212481

Abstract Article PDF–2.8M

Select item 696157816.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 654822717.

Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease

Claudia H Huichalaf, Ismael Al-Ramahi, Kyung-Won Park, Stacy D Grunke, Nan Lu, Maria de Haro, Karla El-Zein, Tatiana Gallego-Flores, Alma M Perez, Sung Yun Jung, Juan Botas, Huda Y Zoghbi, Joanna L Jankowsky

Hum Mol Genet. 2019 Jun 15; 28(12): 2014–2029. Published online 2019 Feb 12. doi: 10.1093/hmg/ddz034

PMCID:: PMC6548227

Abstract Article PDF–24M

Select item 642514418.

Drosophila Mediator Subunit Med1 Is Required for GATA-Dependent Developmental Processes: Divergent Binding Interfaces for Conserved Coactivator Functions

Clément Immarigeon, Sandra Bernat-Fabre, Benoit Augé, Christian Faucher, Vanessa Gobert, Marc Haenlin, Lucas Waltzer, Adeline Payet, David L. Cribbs, Henri-Marc G. Bourbon, Muriel Boube

Mol Cell Biol. 2019 Apr 1; 39(7): e00477-18. Prepublished online 2019 Jan 22. Published online 2019 Mar 19. doi: 10.1128/MCB.00477-18