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Select item 108937001.

Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson’s disease phenotypes in vivo and in cell models

Murni Tio, Rujing Wen, Cai Ning Choo, Jian Bin Tan, Aaron Chua, Bin Xiao, Jeyapriya Rajameenakshi Sundaram, Christine Hui Shan Chan, Eng-King Tan

J Biomed Sci. 2024; 31: 24. Published online 2024 Feb 23. doi: 10.1186/s12929-024-01010-z

PMCID:: PMC10893700

Abstract Article PDF–14M

Select item 108297692.

Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution

Tzu-Chiao Lu, Maria Brbić, Ye-Jin Park, Tyler Jackson, Jiaye Chen, Sai Saroja Kolluru, Yanyan Qi, Nadja Sandra Katheder, Xiaoyu Tracy Cai, Seungjae Lee, Yen-Chung Chen, Niccole Auld, Chung-Yi Liang, Sophia H. Ding, Doug Welsch, Samuel D’Souza, Angela Oliveira Pisco, Robert C. Jones, Jure Leskovec, Eric C. Lai, Hugo J. Bellen, Liqun Luo, Heinrich Jasper, Stephen R. Quake, Hongjie Li

Science. Author manuscript; available in PMC 2024 Jan 31.

Published in final edited form as: Science. 2023 Jun 16; 380(6650): eadg0934. Published online 2023 Jun 16. doi: 10.1126/science.adg0934

PMCID:: PMC10829769

Abstract Article PDF–1.6M

Select item 88359203.

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease

Mari Suzuki, Kazunori Sango, Yoshitaka Nagai

Int J Mol Sci. 2022 Feb; 23(3): 1519. Published online 2022 Jan 28. doi: 10.3390/ijms23031519

PMCID:: PMC8835920

Abstract Article PDF–354K

Select item 83571364.

Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive

Joe L. Webb, Simon M. Moe, Andrew K. Bolstad, Elizabeth M. McNeill

PLoS One. 2021; 16(8): e0255085. Published online 2021 Aug 11. doi: 10.1371/journal.pone.0255085

PMCID:: PMC8357136

Abstract Article PDF–1.9M

Select item 82328845.

Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster

Wei Hou, Jin Pei

Front Pharmacol. 2021; 12: 618123. Published online 2021 Jun 11. doi: 10.3389/fphar.2021.618123

PMCID:: PMC8232884

Abstract Article PDF–2.2M

Select item 79979896.

TDP-43 and PINK1 mediate CHCHD10^S59L mutation–induced defects in Drosophila and in vitro

Minwoo Baek, Yun-Jeong Choe, Sylvie Bannwarth, JiHye Kim, Swati Maitra, Gerald W. Dorn, II, J. Paul Taylor, Veronique Paquis-Flucklinger, Nam Chul Kim

Nat Commun. 2021; 12: 1924. Published online 2021 Mar 26. doi: 10.1038/s41467-021-22145-9

Correction in:: Nat Commun. 2021; 12: 3165.

PMCID:: PMC7997989

Abstract Article PDF–9.0M

Select item 72447607.

Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1

Wei Liu, Xiuying Duan, Lingna Xu, Weina Shang, Jiayao Zhao, Liquan Wang, Jian-Chiuan Li, Chun-Hong Chen, Jun-Ping Liu, Chao Tong

Cell Death Differ. 2020 Jun; 27(6): 2014–2029. Published online 2020 Jan 6. doi: 10.1038/s41418-019-0482-7

PMCID:: PMC7244760

Abstract Article PDF–13M

Select item 69615788.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 68746429.

Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a Drosophila model of Parkinson’s disease

Yuzuru Imai, Tsuyoshi Inoshita, Hongrui Meng, Kahori Shiba-Fukushima, Kiyotaka Y. Hara, Naoya Sawamura, Nobutaka Hattori

Commun Biol. 2019; 2: 424. Published online 2019 Nov 22. doi: 10.1038/s42003-019-0674-1

PMCID:: PMC6874642

Abstract Article PDF–2.0M

Select item 678990710.

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

Akio Mori, Taku Hatano, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Takahiro Koinuma, Hongrui Meng, Shin-ichiro Kubo, Spencer Spratt, Changxu Cui, Chikara Yamashita, Yoshimi Miki, Kei Yamamoto, Tetsuya Hirabayashi, Makoto Murakami, Yoshikazu Takahashi, Hideo Shindou, Takashi Nonaka, Masato Hasegawa, Ayami Okuzumi, Yuzuru Imai, Nobutaka Hattori

Proc Natl Acad Sci U S A. 2019 Oct 8; 116(41): 20689–20699. Published online 2019 Sep 23. doi: 10.1073/pnas.1902958116

PMCID:: PMC6789907

Abstract Article PDF–2.0M

Select item 570780511.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 568900212.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 546723713.

Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Hongrui Meng, Chikara Yamashita, Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Manabu Funayama, Shigeto Sato, Tomohisa Hatta, Tohru Natsume, Masataka Umitsu, Junichi Takagi, Yuzuru Imai, Nobutaka Hattori

Nat Commun. 2017; 8: 15500. Published online 2017 Jun 7. doi: 10.1038/ncomms15500

PMCID:: PMC5467237

Abstract Article PDF–9.1M

Select item 507911114.

C9orf72 dipeptide repeats impair the assembly, dynamics and function of membrane-less organelles

Kyung-Ha Lee, Peipei Zhang, Hong Joo Kim, Diana Mitrea, Mohona Sarkar, Brian Freibaum, Jaclyn Cika, Maura Coughlin, James Messing, Amandine Molliex, Brian Maxwell, Nam Chul Kim, Jamshid Temirov, Jennifer Moore, Regina-Maria Kolaitis, Timothy Shaw, Bing Bai, Junmin Peng, Richard Kriwacki, J. Paul Taylor

Cell. Author manuscript; available in PMC 2017 Oct 20.

Published in final edited form as: Cell. 2016 Oct 20; 167(3): 774–788.e17. doi: 10.1016/j.cell.2016.10.002

PMCID:: PMC5079111

Abstract Article PDF–2.3M

Select item 502578215.

Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster

Hirokazu Okada, H. Alexander Ebhardt, Sibylle Chantal Vonesch, Ruedi Aebersold, Ernst Hafen

Nat Commun. 2016; 7: 12649. Published online 2016 Sep 1. doi: 10.1038/ncomms12649

PMCID:: PMC5025782

Abstract Article PDF–2.2M

Select item 473800516.

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Sadhna Phanse, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Data Brief. 2016 Mar; 6: 715–721. Published online 2015 Dec 12. doi: 10.1016/j.dib.2015.11.062

PMCID:: PMC4738005

Abstract Article PDF–205K

Select item 452833017.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

Select item 452832918.

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data

Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929

PMCID:: PMC4528329

Abstract Article PDF–4.9M

Select item 435288719.

The Release 6 reference sequence of the Drosophila melanogaster genome

Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker

Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114

PMCID:: PMC4352887

Abstract Article PDF–1022K

Select item 419769820.

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos

Claire M. Lye, Huw W. Naylor, Bénédicte Sanson

Development. 2014 Oct; 141(20): 4006–4017. doi: 10.1242/dev.111310

PMCID:: PMC4197698

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