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Select item 101774051.

A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome

Antoine Wagner, Michèle Rouleau, Lyne Villeneuve, Trang Le, Cheryl Peltier, Éric P. Allain, Caroline Beaudoin, Sophie Tremblay, Fréderic Courtier, Flora Nguyen Van Long, Isabelle Laverdière, Éric Lévesque, Versha Banerji, Katrina Vanura, Chantal Guillemette

Cells. 2023 May; 12(9): 1295. Published online 2023 May 2. doi: 10.3390/cells12091295

PMCID:: PMC10177405

Abstract Article PDF–5.4M

Select item 99026212.

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer

Michèle Rouleau, Flora Nguyen Van Long, Véronique Turcotte, Patrick Caron, Louis Lacombe, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Eric Lévesque, Chantal Guillemette

Br J Cancer. 2023 Jan 19; 128(2): 285–296. Published online 2022 Nov 8. doi: 10.1038/s41416-022-02040-w

PMCID:: PMC9902621

Abstract Article PDF–1.0M

Select item 94778193.

Pangenomic analysis of Chinese gastric cancer

Yingyan Yu, Zhen Zhang, Xiaorui Dong, Ruixin Yang, Zhongqu Duan, Zhen Xiang, Jun Li, Guichao Li, Fazhe Yan, Hongzhang Xue, Du Jiao, Jinyuan Lu, Huimin Lu, Wenmin Zhang, Yangzhen Wei, Shiyu Fan, Jing Li, Jingya Jia, Jun Zhang, Jun Ji, Pixu Liu, Hui Lu, Hongyu Zhao, Saijuan Chen, Chaochun Wei, Hongzhuan Chen, Zhenggang Zhu

Nat Commun. 2022; 13: 5412. Published online 2022 Sep 15. doi: 10.1038/s41467-022-33073-7

PMCID:: PMC9477819

Abstract Article PDF–3.8M

Select item 83485624.

Potential Assessment of UGT2B17 Inhibition by Salicylic Acid in Human Supersomes In Vitro

Hassan Salhab, Declan P. Naughton, James Barker

Molecules. 2021 Aug; 26(15): 4410. Published online 2021 Jul 21. doi: 10.3390/molecules26154410

PMCID:: PMC8348562

Abstract Article PDF–774K

Select item 79015435.

Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells

Farideh Shafiee-Kermani, Skyla T. Carney, Dereje Jima, Utibe C. Utin, LaNeisha B. Farrar, Melvin O. Oputa, Marcono R. Hines, Jr. H. Karimi Kinyamu, Kevin W. Trotter, Trevor K. Archer, Cathrine Hoyo, Beverly H. Koller, Stephen J. Freedland, Delores J. Grant

Epigenetics. 2021; 16(3): 289–299. Published online 2020 Jul 27. doi: 10.1080/15592294.2020.1795601

PMCID:: PMC7901543

Abstract Article PDF–1.0M

Select item 73740976.

UGT2B17 modifies drug response in chronic lymphocytic leukaemia

Eric P. Allain, Michèle Rouleau, Katrina Vanura, Sophie Tremblay, Joanie Vaillancourt, Vincent Bat, Patrick Caron, Lyne Villeneuve, Adrien Labriet, Véronique Turcotte, Trang Le, Medhat Shehata, Susanne Schnabl, Dita Demirtas, Rainer Hubmann, Charles Joly-Beauparlant, Arnaud Droit, Ulrich Jäger, Philipp B. Staber, Eric Lévesque, Chantal Guillemette

Br J Cancer. 2020 Jul 21; 123(2): 240–251. Published online 2020 May 18. doi: 10.1038/s41416-020-0887-6

PMCID:: PMC7374097

Abstract Article PDF–1.0M

Select item 71091007.

Alternative promoters control UGT2B17-dependent androgen catabolism in prostate cancer and its influence on progression

Eric Lévesque, Adrien Labriet, Hélène Hovington, Éric P. Allain, Luciana Melo-Garcia, Michèle Rouleau, Hervé Brisson, Véronique Turcotte, Patrick Caron, Lyne Villeneuve, Mickaël Leclercq, Arnaud Droit, Etienne Audet-Walsh, David Simonyan, Yves Fradet, Louis Lacombe, Chantal Guillemette

Br J Cancer. 2020 Mar 31; 122(7): 1068–1076. Published online 2020 Feb 12. doi: 10.1038/s41416-020-0749-2

PMCID:: PMC7109100

Abstract Article PDF–1.6M

Select item 67632428.

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development

Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong

J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107

PMCID:: PMC6763242

Abstract Article PDF–12M

Select item 66095989.

UGT2B17 and miR-224 contribute to hormone dependency trends in adenocarcinoma and squamous cell carcinoma of esophagus

Xiangyao Lian, Ancha Baranova, Jimmy Ngo, Guiping Yu, Hongbao Cao

Biosci Rep. 2019 Jul 31; 39(7): BSR20190472. Prepublished online 2019 Jun 4. Published online 2019 Jul 5. doi: 10.1042/BSR20190472

PMCID:: PMC6609598

Abstract Article PDF–703K

Select item 653445810.

Exemestane may be less detrimental than letrozole to bone health in women homozygous for the UGT2B17*2 gene deletion

Landry K. Kamdem, Jingyue Xi, Brandi L. Clark, Bryana J. Gregory, Kelley M. Kidwell, Ana-Maria Storniolo, Vered Stearns, Daniel F Hayes, Christina L. Gersch, James M. Rae, N. Lynn Henry, Daniel L. Hertz

Breast Cancer Res Treat. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Breast Cancer Res Treat. 2019 Jun; 175(2): 297–303. Published online 2019 Feb 12. doi: 10.1007/s10549-019-05158-3

PMCID:: PMC6534458

Abstract Article PDF–375K

Select item 593889111.

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex

Deepak Kumar Bhatt, Abdul Basit, Haeyoung Zhang, Andrea Gaedigk, Seung-been Lee, Katrina G. Claw, Aanchal Mehrotra, Amarjit Singh Chaudhry, Robin E. Pearce, Roger Gaedigk, Ulrich Broeckel, Timothy A. Thornton, Deborah A. Nickerson, Erin G. Schuetz, John K. Amory, J. Steven Leeder, Bhagwat Prasad

Drug Metab Dispos. 2018 Jun; 46(6): 888–896. Published online 2018 Jun. doi: 10.1124/dmd.118.080952

PMCID:: PMC5938891

Abstract Article PDF–896K

Select item 493833212.

UGT2B17 expression: a novel prognostic marker within IGHV-mutated chronic lymphocytic leukemia?

Sujata Bhoi, Panagiotis Baliakas, Diego Cortese, Mattias Mattsson, Marie Engvall, Karin E. Smedby, Gunnar Juliusson, Lesley-Ann Sutton, Larry Mansouri

Haematologica. 2016 Feb; 101(2): e63–e65. doi: 10.3324/haematol.2015.136440

PMCID:: PMC4938332

Article PDF–201K

Select item 450340413.

Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients

Alicia Romero-Lorca, Apolonia Novillo, María Gaibar, Fernando Bandrés, Ana Fernández-Santander

PLoS One. 2015; 10(7): e0132269. Published online 2015 Jul 15. doi: 10.1371/journal.pone.0132269

Correction in:: PLoS One. 2015; 10(10): e0140921.

PMCID:: PMC4503404

Abstract Article PDF–932K

Select item 438980314.

Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma

Aki Mafune, Takanori Hama, Toshihito Suda, Yutaka Suzuki, Masahiro Ikegami, Chikako Sakanashi, Satoko Imai, Akio Nakashima, Takashi Yokoo, Kota Wada, Hiromi Kojima, Mitsuyoshi Urashima

BMC Cancer. 2015; 15: 205. Published online 2015 Mar 31. doi: 10.1186/s12885-015-1220-2

PMCID:: PMC4389803

Abstract Article PDF–641K

Select item 438238015.

Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with body mass index in males

Andy Z.X. Zhu, Lisa Sanderson Cox, Jasjit S. Ahluwalia, Caroline C. Renner, Dorothy K. Hatsukami, Neal L. Benowitz, Rachel F. Tyndale

Pharmacogenet Genomics. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Pharmacogenet Genomics. 2015 May; 25(5): 263–269. doi: 10.1097/FPC.0000000000000135

PMCID:: PMC4382380

Abstract Article PDF–915K

Select item 401186116.

Meta-Analysis Reveals a Lack of Association between UGT2B17 Deletion Polymorphism and Tumor Susceptibility

Xiaheng Deng, Yidong Cheng, Xiao Yang, Shuang Li, Ruizhe Zhao, Kang Liu, Jinliang Liu, Qiang Cao, Chao Qin, Pengfei Shao, Xiaoxin Meng, Jie Li, Qiang Lu, Changjun Yin

PLoS One. 2014; 9(5): e96812. Published online 2014 May 6. doi: 10.1371/journal.pone.0096812

PMCID:: PMC4011861

Abstract Article PDF–821K

Select item 392434717.

Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study

Adriana C Vidal, Cocoa Tucker, Joellen M Schildkraut, Ricardo M Richardson, Megan McPhail, Stephen J Freedland, Cathrine Hoyo, Delores J Grant

BMC Cancer. 2013; 13: 556. Published online 2013 Nov 22. doi: 10.1186/1471-2407-13-556

PMCID:: PMC3924347

Abstract Article PDF–240K

Select item 390955318.

Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes

Ankit Malhotra, Yoshiyuki Shibata, Ira M Hall, Anindya Dutta

Cancer Biol Ther. 2013 Sep 1; 14(9): 840–852. Published online 2013 Jul 26. doi: 10.4161/cbt.25329

PMCID:: PMC3909553

Abstract Article PDF–3.0M

Select item 375180619.

UGT2B17 copy number gain in a large ankylosing spondylitis multiplex family

Mohammed Uddin, Walter P Maksymowych, Robert Inman, Dafna Gladman, Alexandra Munn, Ramin Yazdani, Fawnda Pellett, Sean Hamilton, Darren D O’Rielly, Proton Rahman

BMC Genet. 2013; 14: 67. Published online 2013 Aug 8. doi: 10.1186/1471-2156-14-67