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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108532162.

Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment

Rudrarup Bhattacharjee, Lachlan A. Jolly, Mark A. Corbett, Ing Chee Wee, Sushma R. Rao, Alison E. Gardner, Tarin Ritchie, Eline J. H. van Hugte, Ummi Ciptasari, Sandra Piltz, Jacqueline E. Noll, Nazzmer Nazri, Clare L. van Eyk, Melissa White, Dani Fornarino, Cathryn Poulton, Gareth Baynam, Lyndsey E. Collins-Praino, Marten F. Snel, Nael Nadif Kasri, Kim M. Hemsley, Paul Q. Thomas, Raman Kumar, Jozef Gecz

Nat Commun. 2024; 15: 1210. Published online 2024 Feb 8. doi: 10.1038/s41467-024-45121-5

PMCID:: PMC10853216

Abstract Article PDF–11M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 72740244.

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Georgia R. Kafer, Anthony J. Cesare

Front Cell Dev Biol. 2020; 8: 416. Published online 2020 May 29. doi: 10.3389/fcell.2020.00416

PMCID:: PMC7274024

Abstract Article PDF–1.3M

Select item 63334605.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 49593166.

Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice

Meenalakshmi Chinnam, Xiaoling Wang, Xiaojing Zhang, David W. Goodrich

Mol Cell Biol. 2016 Jun 1; 36(11): 1621–1627. Prepublished online 2016 Mar 21. Published online 2016 May 16. doi: 10.1128/MCB.01003-15

PMCID:: PMC4959316

Abstract Article PDF–2.0M

Select item 45252037.

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells

Paulina A. Latos, Angela Goncalves, David Oxley, Hisham Mohammed, Ernest Turro, Myriam Hemberger

Nat Commun. 2015; 6: 7776. Published online 2015 Jul 24. doi: 10.1038/ncomms8776

PMCID:: PMC4525203

Abstract Article PDF–1.9M

Select item 45118338.

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPa N-terminal leukemia

Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil, Dalia Barsyte-Lovejoy, Fengling Li, Gennadiy Poda, Matthieu Schapira, Hong Wu, Aiping Dong, Guillermo Senisterra, Alexey Stukalov, Kilian V. M. Huber, Andreas Schönegger, Richard Marcellus, Martin Bilban, Christoph Bock, Peter J. Brown, Johannes Zuber, Keiryn L. Bennett, Rima Al-awar, Ruud Delwel, Claus Nerlov, Cheryl H. Arrowsmith, Giulio Superti-Furga

Nat Chem Biol. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Nat Chem Biol. 2015 Aug; 11(8): 571–578. Published online 2015 Jul 13. doi: 10.1038/nchembio.1859

PMCID:: PMC4511833

Abstract Article PDF–2.2M

Select item 42710319.

The Thoc1 Ribonucleoprotein and Prostate Cancer Progression

Meenalakshmi Chinnam, Yanqing Wang, Xiaojing Zhang, David L. Gold, Thaer Khoury, Alexander Yu Nikitin, Barbara A. Foster, Yanping Li, Wiam Bshara, Carl D. Morrison, Rochelle D. Payne Ondracek, James L. Mohler, David W. Goodrich

J Natl Cancer Inst. 2014 Nov; 106(11): dju306. Published online 2014 Oct 8. doi: 10.1093/jnci/dju306

PMCID:: PMC4271031

Abstract Article PDF–4.0M

Select item 402274210.

The Thoc1 Encoded Ribonucleoprotein Is Required for Myeloid Progenitor Cell Homeostasis in the Adult Mouse

Laura Pitzonka, Sumana Ullas, Meenalakshmi Chinnam, Benjamin J. Povinelli, Daniel T. Fisher, Michelle Golding, Michelle M. Appenheimer, Michael J. Nemeth, Sharon Evans, David W. Goodrich

PLoS One. 2014; 9(5): e97628. Published online 2014 May 15. doi: 10.1371/journal.pone.0097628

PMCID:: PMC4022742

Abstract Article PDF–4.5M

Select item 396279511.

The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming

Li Wang, Yi-liang Miao, Xiaofeng Zheng, Brad Lackford, Bingying Zhou, Leng Han, Chengguo Yao, James Ward, Adam Burkholder, Inna Lipchina, David C. Fargo, Konrad Hochedlinger, Yongsheng Shi, Carmen J. Williams, Guang Hu

Cell Stem Cell. Author manuscript; available in PMC 2014 Dec 5.

Published in final edited form as: Cell Stem Cell. 2013 Dec 5; 13(6): 676–690. doi: 10.1016/j.stem.2013.10.008

PMCID:: PMC3962795

Abstract Article PDF–3.2M

Select item 375385012.

The THO Ribonucleoprotein Complex Is Required for Stem Cell Homeostasis in the Adult Mouse Small Intestine

Laura Pitzonka, Xiaoling Wang, Sumana Ullas, David W. Wolff, Yanqing Wang, David W. Goodrich

Mol Cell Biol. 2013 Sep; 33(17): 3505–3514. doi: 10.1128/MCB.00751-13

PMCID:: PMC3753850

Abstract Article PDF–3.1M

Select item 358403813.

The Thoc1 Encoded Ribonucleoprotein Is a Substrate for the NEDD4-1 E3 Ubiquitin Protein Ligase

Fei Song, Chuandong Fan, Xinjiang Wang, David W. Goodrich

PLoS One. 2013; 8(2): e57995. Published online 2013 Feb 27. doi: 10.1371/journal.pone.0057995

PMCID:: PMC3584038

Abstract Article PDF–205K

Select item 357241014.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 322881615.

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

María S. Domínguez-Sánchez, Sonia Barroso, Belén Gómez-González, Rosa Luna, Andrés Aguilera

PLoS Genet. 2011 Dec; 7(12): e1002386. Published online 2011 Dec 1. doi: 10.1371/journal.pgen.1002386

PMCID:: PMC3228816

Abstract Article PDF–4.3M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 302253417.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

Select item 280624718.

THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo

Annalisa Mancini, Susanne C Niemann-Seyde, Rüdiger Pankow, Omar El Bounkari, Sabine Klebba-Färber, Alexandra Koch, Ewa Jaworska, Elaine Spooncer, Achim D Gruber, Anthony D Whetton, Teruko Tamura

BMC Biol. 2010; 8: 1. Published online 2010 Jan 5. doi: 10.1186/1741-7007-8-1

PMCID:: PMC2806247

Abstract Article PDF–3.2M

Select item 279924019.

An allelic series for studying the mouse Thoc1 gene

Xiaoling Wang, Yanping Li, Xiaojing Zhang, David W. Goodrich

Genesis. Author manuscript; available in PMC 2009 Dec 29.

Published in final edited form as: Genesis. 2007 Jan; 45(1): 32–37. doi: 10.1002/dvg.20262

PMCID:: PMC2799240

Abstract Article PDF–1.5M

Select item 268205020.

Thoc1 Deficiency Compromises Gene Expression Necessary for Normal Testis Development in the Mouse

Xiaoling Wang, Meenalakshmi Chinnam, Jianmin Wang, Yanqing Wang, Xiaojing Zhang, Edyta Marcon, Peter Moens, David W. Goodrich

Mol Cell Biol. 2009 May; 29(10): 2794–2803. Published online 2009 Mar 23. doi: 10.1128/MCB.01633-08

PMCID:: PMC2682050

Abstract Article PDF–1.1M

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