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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102366362.

Pleckstrin‐2‐promoted PPM1B degradation plays an important role in transforming growth factor‐β‐induced breast cancer cell invasion and metastasis

Liping Du, Junyan Li, Yonglu Tian, Renqing Feng

Cancer Sci. 2023 Jun; 114(6): 2429–2444. Published online 2023 Mar 30. doi: 10.1111/cas.15791

PMCID:: PMC10236636

Abstract Article PDF–17M

Select item 99504473.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 95586844.

PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c‐Myc‐mediated positive feedback loop

Xinyuan Zhao, Dalong Shu, Wenjuan Sun, Shanshan Si, Wei Ran, Bing Guo, Li Cui

Cancer Commun (Lond) 2022 Oct; 42(10): 987–1007. Published online 2022 Aug 24. doi: 10.1002/cac2.12349

PMCID:: PMC9558684

Abstract Article PDF–5.2M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 85543846.

Pleckstrin 2 is a potential drug target for colorectal carcinoma with activation of APC/β-catenin

Bao Chai, Yarong Guo, Na Zhu, Junmei Jia, Zhuowei Zhang, Mei Ping, Kai Jia, Xiaolong Cui, Yuhong Suo

Mol Med Rep. 2021 Dec; 24(6): 862. Published online 2021 Oct 19. doi: 10.3892/mmr.2021.12502

PMCID:: PMC8554384

Abstract Article PDF–5.2M

Select item 84874277.

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2

Feng Wang, Chaoqi Zhang, Hong Cheng, Chengming Liu, Zhiliang Lu, Sufei Zheng, Sihui Wang, Nan Sun, Jie He

Cell Death Dis. 2021 Oct; 12(10): 901. Published online 2021 Oct 2. doi: 10.1038/s41419-021-04155-z

PMCID:: PMC8487427

Abstract Article PDF–5.1M

Select item 84464048.

Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis

Jingyun Wang, Zhuang Sun, Jing Wang, Qihai Tian, Runda Huang, Hanyu Wang, Xiaohui Wang, Fei Han

Cancer Med. 2021 Sep; 10(18): 6515–6533. Published online 2021 Jul 30. doi: 10.1002/cam4.4163

PMCID:: PMC8446404

Abstract Article PDF–4.0M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 758877010.

PLEK2 Gene Upregulation Might Independently Predict Shorter Progression-Free Survival in Lung Adenocarcinoma

Wenqian Zhang, Tong Li, Bin Hu, Hui Li

Technol Cancer Res Treat. 2020; 19: 1533033820957030. Published online 2020 Oct 21. doi: 10.1177/1533033820957030

PMCID:: PMC7588770

Abstract Article PDF–1009K

Select item 655880111.

PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway

Hui Shen, Min He, Ruirong Lin, Ming Zhan, Sunwang Xu, Xince Huang, Chu Xu, Wei Chen, Yanhua Yao, Man Mohan, Jian Wang

J Exp Clin Cancer Res. 2019; 38: 247. Published online 2019 Jun 10. doi: 10.1186/s13046-019-1250-8

PMCID:: PMC6558801

Abstract Article PDF–11M

Select item 638658812.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 629516513.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel

Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118

PMCID:: PMC6295165

Abstract Article PDF–3.5M

Select item 621963314.

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa

Cell Rep. Author manuscript; available in PMC 2018 Nov 6.

Published in final edited form as: Cell Rep. 2018 Sep 18; 24(12): 3224–3236. doi: 10.1016/j.celrep.2018.08.058

PMCID:: PMC6219633

Abstract Article PDF–1.1M

Select item 589141715.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 381740416.

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat

Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54

PMCID:: PMC3817404

Abstract Article PDF–13M

Select item 347780417.

A Census of Human Soluble Protein Complexes

Pierre C. Havugimana, G. Traver Hart, Tamás Nepusz, Haixuan Yang, Andrei L. Turinsky, Zhihua Li, Peggy I. Wang, Daniel R. Boutz, Vincent Fong, Sadhna Phanse, Mohan Babu, Stephanie A. Craig, Pingzhao Hu, Cuihong Wan, James Vlasblom, Vaqaarun-Nisa Dar, Alexander Bezginov, Gregory W. Clark, Gabriel C. Wu, Shoshana J. Wodak, Elisabeth R.M. Tillier, Alberto Paccanaro, Edward M. Marcotte, Andrew Emili

Cell. Author manuscript; available in PMC 2013 Aug 31.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 1068–1081. doi: 10.1016/j.cell.2012.08.011

PMCID:: PMC3477804

Abstract Article PDF–7.7M

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311596619.

Transcriptome Profiling of Whole Blood Cells Identifies PLEK2 and C1QB in Human Melanoma

Yuchun Luo, Steven Robinson, Junichi Fujita, Lisa Siconolfi, Jay Magidson, Carl K. Edwards, Karl Wassmann, Kathleen Storm, David A. Norris, Danute Bankaitis-Davis, William A. Robinson, Mayumi Fujita

PLoS One. 2011; 6(6): e20971. Published online 2011 Jun 15. doi: 10.1371/journal.pone.0020971

PMCID:: PMC3115966

Abstract Article PDF–574K

Select item 178514420.

PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization

Tami L. Bach, Wesley T. Kerr, Yanfeng Wang, Eve Marie Bauman, Purnima Kine, Eileen L. Whiteman, Renell S. Morgan, Edward K. Williamson, E. Michael Ostap, Janis K. Burkhardt, Gary A. Koretzky, Morris J. Birnbaum, Charles S. Abrams

Blood. 2007 Feb 1; 109(3): 1147–1155. Prepublished online 2006 Sep 28. doi: 10.1182/blood-2006-02-001339

PMCID:: PMC1785144

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